Kia ako tātou mō te Acetylcholine (ACh): te karere ngaro a tō tātou tinana!

Kua whakaaro kē koe ki te nui o te mahi e mahia ana i roto i tō tinana, me te kore koe e mōhio? Whakaarohia, te pao o tō ngākau, tō manawa, tō mahara ki tētahi kanohi kua kitea e koe, tō nekenekehanga o ō ringa me ō waewae... Kāore ēnei mea katoa e tupu noa iho. Kei muri i ēnei mea katoa ko ngā karere matū ririki. I tēnei rā, ka kōrero tātou mō tētahi o aua karere tino nui i roto i ō tātou tinana. Ko tōna ingoa ko te acetylcholine, ko te (ACh) rānei hei whakarapopototanga.

Nā wai rā tēnei acetylcholine (ACh)?

He whakarāpopototanga noa iho, ko te acetylcholine (ACh) he momo matū e kiia nei he neurotransmitter. Whakaarohia he rite ki te hononga waea i waenga i tō tātou roro me te toenga o tō tātou tinana. Nō reira, he rite ēnei (ngā neurotransmitter) ki ngā 'karere' e kawe ana i ngā karere ki mua, ki muri puta noa i taua hononga.

He neurotransmitter whakaohooho te Acetylcholine. Ko te tikanga ka haere tēnei karere ki te pūtau io e whai ake nei, ka "whakaara ake," ka "tōia he pana pai," me te kī, "Āe, ko tō wā tēnei, kawe i tēnei karere ki mua."

I ahu mai tōna ingoa i ngā matū e rua e hangaia ai. He rōpū acetyl me te matūkai e kiia nei ko te choline. Ka taea e tātou te tiki i tēnei choline mai i te kai. Ka kitea i roto i ngā mea pēnei i te toene hua manu, te pīni soya, me ngā huawhenua me ngā nati. Ka hangaia hoki e tō tātou ate.

He maha ngā mahi nui a te Acetylcholine i roto i ō tātou tinana. He mea nui rawa atu mō te nekehanga o ngā uaua tūao . He mahi nui anō hoki tāna mō ngā mahi roro pēnei i te mahara, te whakaaro, me te ako i ngā mea hou .

Me pēhea te hanganga o tēnei i roto i ō tātou tinana?

Kei roto i ō tātou tinana tētahi whākōkī e kīia ana ko te 'choline acetyltransferase'. Whakaarohia he rite ki tētahi kaimahi tunu kai. Ko tēnei whākōkī te mea e whakakotahi ana i te choline me te rōpū acetyl kua whakahuatia ake nei hei hanga i te acetylcholine karere reka (ACh). Ka puta tēnei tukanga i ngā pito o ō tātou pūtau io.

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Āe, kia kite tātou me pēhea te haere o tēnei karere.

I muri i te hanganga o te acetylcholine (ACh), ka rongoatia ki te pito o te pūtau io, pērā i te puranga reta i roto i te tari poutapeta. Ka tukuna tēnei ACh kua rongoatia ina tae mai he karere mai i te roro.

Kātahi ka peke tēnei ACh ki roto i tētahi āputa iti i waenganui i ngā pūtau io e rua. Ka kiia tēnei āputa ko te kapiti synaptic. Whakaarohia he rite ki tētahi karere e peke ana i te awa.

Kei te pūtau io i tōna taha he wāhi motuhake hei hopu i tēnei ACh e haere mai ana. Hei whakamārama, he rite ki tētahi kī e uru ana ki tētahi kī. Ka karangatia ēnei e mātou he kaiwhakawhiwhi. E rua ngā momo matua o ngā kaiwhakawhiwhi mō te acetylcholine:

1. Ngā kaiwhakawhiwhi nikotīni

2. Ngā kaiwhakawhiwhi Muscarinic

Ina herea te kī ACh ki tētahi o ēnei kī Ibi e rua, ka tukuna te karere ki te pūtau e whai ake nei. Mā tēnei ara, ka tukuna te karere mai i te pūtau ki te pūtau, ka tae ki te wāhi e tika ana (hei tauira, he uaua).

I muri i te tukunga o te karere, ka whai tetahi hei whakakore i te ACh e toe ana i taua āputa. He whākōkī e kiia nei ko te 'acetylcholinesterase.' Ko tā tēnei mahi he wawahi i te ACh e toe ana, ka huri hei wāhanga hou . Kātahi ka taea te whakamahi anō i aua wāhanga hei hanga ACh hou. He rite ki te whakakore i te huarahi i muri i te tukunga o te karere, me te tuku i te karere e whai ake nei kia puta mai.

He aha ngā mahi matua a te acetylcholine (ACh) ki ō tātou tinana?

He whānuitia ngā mahi a te Acetylcholine (ACh). Ka rerekē tana mahi i runga i te kaiwhakawhiwhi e herea ana e ia. Me titiro tātou ki ana mahi matua.

E rua ngā momo kaiwhakawhiwhi e whai wāhi ana ki ngā mahi katoa mai i te pupuri i ō tātou mahara, ki te hanga mahara hou, te penapena, me te maumahara . He mea nui hoki ēnei i roto i te roro, mō tō tātou aro, mō tō tātou hiahia ki te ako, me te wāhanga moe hohonu e kiia nei ko te moe REM (Rapid Eye Movement).

He aha ngā mate ka pā mai mēnā ka whakaitihia tēnei?

Mā te hekenga o te taumata o te acetylcholine (ACh) i roto i te tinana ka arahi pea ki ētahi mate hauora kino. Ko ngā mea matua ko:

• Te mate a Alzheimer: He mate tēnei e pā nui ana ki te mahara. Kua kitea he iti ake te nui o te acetylcholine i roto i te roro o te hunga e pangia ana e te mate a Alzheimer.
• Myasthenia gravis: He mate pūnaha ārai mate tēnei. Ko te tikanga o tēnei ka mahi te pūnaha ārai mate o tō tātou tinana ki a tātou. Ko te mea ka tupu i konei ko te haere o ā tātou paturopi ka kino i ngā kaiwhakawhiwhi acetylcholine (ACh) i roto i ngā uaua. Kātahi ka kore e taea e te ACh te tuku karere, ā, ka ngoikore haere ngā uaua.
• Te mate myasthenic Lambert-Eaton: Ka ngoikore hoki ngā uaua i tēnei. Engari he rerekē te take. Ko te mea e tupu ana i konei, kāore e nui te ACh e tukuna ana e ngā pūtau io.

Ētahi atu mea e pā ana ki te acetylcholine (ACh)

Heoi, kua whakamahia e ētahi te mōhiotanga ki te mahi a te acetylcholine hei whara i te tangata.

Hei tauira, ka mahi ngā hau io pērā i te sarin me ētahi patu pepeke mā te whakakore i te whākōkī horoi acetylcholinesterase i kōrerohia e tātou i mua ake nei. Mā tēnei ka kohia te ACh, ka pararutiki ngā uaua, ā, ka mate pea.

Waihoki, ina kainga, ka piki ake ngā taumata ACh i te paitini o te pūngāwerewere pouaru pango. Ka taea e tēnei te whakawhāiti i ngā uaua, te wiri, te pararutiki, tae atu ki te mate.

Mēnā he āhuatanga ohorere pērā i te paihana, ko te mea pai ko te haere tonu ki te Wāhanga Maimoatanga Ohotata (ETU) o te hōhipera tata . Mēnā e tika ana, ka whakapā atu ngā tākuta ki te Pokapū Mōhiohio Paihana ā-Motu i te Hōhipera ā-Motu o Colombo mō ētahi tohutohu.

He rongoā kei reira hei aro ki tēnei?

Āe. Ka whakamahia ngā rongoā e aro ana ki te acetylcholine hei rongoā i ētahi mate hauora.

Ko te momo rongoā matua ko ngā 'aukati cholinesterase'. Mā te aukati i te whākōkī e wawahi ana i te ACh ka roa ake te noho o te ACh ki te wāhi i waenga i ngā pūtau io, ka nui ake te mahi. Ka whakamahia ēnei rongoā (hei tauira, donepezil, rivastigmine) hei rongoā i ngā āhuatanga e iti ana te taumata ACh, pērā i te mate a Alzheimer me te myasthenia gravis .

Ko tētahi atu tauira ko te paitini Botulinum , e mōhiotia whānuitia ana rānei, ko te 'Botox'. Mā te aukati i te tukunga o te ACh mai i ngā pito io ka mahi. Mā tēnei ka whakangāwari ngā uaua, kaua e whakawhāiti. Ka whakamahia mō ngā mahi whakapaipai (hei whakaiti i ngā kita) me te rongoā i ngā mate pēnei i te migraines.

Ka taea e tātou te tango i tēnei i roto i te ahua pire? Ka taea e tātou te tiki mai i te kai?

Kāore e taea te tango i te Acetylcholine (ACh) hei pire. Heoi, ko te matūkai e āwhina ana ki te hanga, ko te choline, ka taea te tango hei tāpiringa. Ko ētahi tāpiringa otaota, pērā i te Ginkgo biloba, e whakaponohia ana ka pā ki ngā taumata ACh.

Engari, anei tētahi mea me maumahara koe . Kaua rawa e whakamahi i tētahi tāpiringa me te kore e kōrero tuatahi ki tō tākuta, ki tō kaiwhakahaere rongoā rānei . Ka taea e ēnei te taunekeneke me ētahi atu rongoā e tangohia ana e koe, ka kino rānei ki a koe.

Engari ka taea e tātou te whiwhi i te choline mā te taiao mai i te kai. Ko ētahi o ngā kai matua kei roto ko:

• Ate kau
• Ngā hua manu
• Mīti kau
• Pīni soya, pīni tīhi
• Heihei
• Ika kōtare
• Kuinoa
• Harore, pūrokoro
• Miraka