Me kōrero tātou mō tēnei momo mate pukupuku 'pūtau mārama' e puta ana i roto i te whatukuhu (Clear Cell Renal Cell Carcinoma - ccRCC) i tēnei rā?

Ko ngā whatukuhu tētahi o ngā okana tino nui o tō tātou tinana. Ko ēnei okana iti e rua e tātari ana i ō tātou toto i ia rā, e whakaputa ana i ngā mea kāore e tika ana hei mimi, he rite ki ngā tātari e rua i roto i tō tātou tinana. Heoi anō, ka taea hoki e ēnei whatukuhu te whakawhanake i ngā mate maha. I tēnei rā ka kōrero tātou mō tētahi momo mate pukupuku whatukuhu he ahua kino, engari he mea tino nui kia mōhiotia. Ko tēnei ko te (Clear Cell Renal Cell Carcinoma), i roto i te poto (ccRCC).

He aha te 'matū pukupuku whatukuhu pūtau mārama' (ccRCC)?

He whakarāpopototanga noa iho, ko tēnei (Clear Cell Renal Cell Carcinoma - ccRCC) he momo mate pukupuku whatukuhu. Ina kōrero tātou mō te mate pukupuku whatukuhu, ko te tikanga ka kīia ko (Renal Cell Carcinoma - RCC). Ko tēnei (ccRCC) tētahi o ōna momo.

I mōhio koe he iti noa ngā awaawa o roto i ō tātou whatukuhu, pērā i te tātari? Koinei ngā awaawa e tātari ana i ngā para i roto i te toto, ā, e tukuna ana hei mimi. Ka tīmata tēnei mate pukupuku i roto i ngā pūtau e whakarārangi ana i aua awaawa. Ka tere te wehewehe me te whakanui o ēnei pūtau (ccRCC), ka hanga i tētahi, neke atu rānei ngā pukupuku. I te nuinga o te wā, ka pā ki te whatukuhu kotahi, engari i ētahi wā ka pā ki ngā whatukuhu e rua.

He aha ngā tohu o tēnei mate?

I te nuinga o te wā, i ngā wāhanga tōmua o tēnei (ccRCC), kāore he tohu nui e kitea. Koinei te mea e mataku ana. Nā te mea kāore pea koe e mōhio kei a koe te mate. Engari i te haere whakamua o te mate, ka pāngia pea koe e ngā āhuatanga penei:

• Toto i roto i te mimi. I ētahi wā ka whero, ka māwhero, ka parauri rānei te mimi. Ka kiia tēnei e ngā tākuta he "hematuria".
• Ko te ngenge te kare o te tino ngenge, ahakoa te nui o te moe. Tērā pea ka ngenge koe i te rā roa.
• He kirika e puta mai ana, kāore he take. Mēnā he kirika noa iho tōu, kāore he mate kē atu, he mea anō tēnā hei aro atu.
• He rite ki te puku e kitea ana i roto i te whatukuhu e pāngia ana .
• Ko te mamae o te taha o te whatukuhu he mamae kei te taha o te whatukuhu . Ka roa pea tēnei mamae, ka haere mai, ka haere atu rānei.
• Te whakahekenga taumaha kāore i te whakamāramahia. Mena kei te whakaheke taumaha noa koe, engari kāore koe e kai ana i tētahi kai iti, e whakakori tinana rānei, he mea tēnā hei tirotiro māu.

He aha i puta ai tēnei (ccRCC)? He aha ngā take?

Ki te pono, kāore i te mōhiotia te tino pūtake o te nuinga o ngā mate pukupuku whatukuhu, tae atu ki tēnei (ccRCC) . Heoi, kua kitea ētahi āhuatanga hei whakanui ake i te mōrearea o te whakawhanaketanga. Kia titiro tātou he aha ēnei?

• Te whakamahinga o ngā hua tupeka : Ehara i te mea ko te momi hikareti anake engari ko te vaping anō hoki. Ka taea e ngā matū kino o te tupeka te kino i ngā whatukuhu.
• Taupū Papatipu Tinana (BMI) neke atu i te 25 : Ki te kī ngāwari, he taumaha rawa/momona. Ka taea e te momona te whakaputa i ngā huringa homoni me ētahi atu raruraru ka piki ake te mōrearea o te mate pukupuku.
• Te toto toto tiketike (te toto toto tiketike): Koinei te wā ka piki ake tō toto toto. Ka puta pea tēnei mōrearea nā te mea ka kino ngā whatukuhu i te toto toto tiketike.
• Te mate whatukuhu mō te wā roa e pāngia ana e te mate whatukuhu : Ko te hunga e mate whatukuhu ana ka tūpono ki te mate pukupuku whatukuhu.
• Te pānga ki ētahi matū paitini i te wāhi mahi : Hei tauira, ko te hunga e pāngia ana e ngā whakarewa pēnei i te trichloroethylene, asbestos, me te cadmium ka nui ake te mōrearea.
• Te whakamahinga roa o ngā rongoā mamae mamae : Kāore ētahi rongoā mamae mamae, pērā i te acetaminophen (Tylenol®), e pai mōu mēnā ka tangohia tonutia, ka nui rawa rānei.

Ko wai ka taea te whakawhanake i tēnei (ccRCC)?

Ina hoki, ka taea e te tangata katoa te pāngia e tēnei mate, e kiia nei ko te (ccRCC). Heoi, kua kitea he rua te tūponotanga o te pāngia o ngā tāne e tēnei mate i ngā wāhine . Waihoki, he mea tino noa i waenga i te hunga i waenga i te 50 me te 70 tau te pakeke.

E ai ki te American Cancer Society, neke atu i te 81,000 ngā tāngata i te United States e kitea ana he mate pukupuku tākihi ia tau. O ēnei, ko te momo mate pukupuku tākihi tino noa ko te ccRCC .

He mate tuku iho tēnei e kiia nei ko te (ccRCC)?

Mena he whanaunga toto tōu e pangia ana e te mate pukupuku whatukuhu, tera pea he nui ake te tūponotanga ki te pāngia koe e te mate pukupuku whatukuhu. Heoi, kāore anō kia tino mārama ngā tākuta he aha.

He mate ira kei ētahi tāngata, ā, ka nui ake te tūponotanga kia pāngia rātou e te ccRCC. Hei tauira, ko te mate Von Hippel-Landau (VHL).

I ēnei āhuatanga, ka puta he whakarerekētanga ira e tukuna iho ana i roto i ngā whakatupuranga ka puta he pūmua me he pukupuku ki ngā wāhanga rerekē o te tinana. Ehara ēnei pukupuku i te mate pukupuku i te nuinga o te wā. Heoi, ka nui ake te pānga o te ccRCC ki te hunga o ēnei whānau, ā, ka puta pea i te wā taitamariki ake i te wā noa.

Mena kua tāpaetia koe kei te ccRCC i te wā taitamariki, ki te mea rānei he maha ō pukupuku, ka tūtohu pea tō tākuta kia whakamātauria he ira .

Me pēhea te tautuhi i tēnei mate (ccRCC)?

E ai ki tā mātou i kōrero ai i mua ake nei, he iti noa ngā tohu o te mate pukupuku whatukuhu i ōna wāhanga tōmua. Koia te take e kitea ai e ngā tākuta ngā pukupuku whatukuhu ina rapu ana rātou i ētahi atu mate. Hei tauira, ka kitea pea he pukupuku whatukuhu mā te tūpono i te wā o te MRI, CT rānei hei rapu i ngā kōhatu whatukuhu.

Ka taea e ngā whakamātautau whakaahua pēnei te kite i te aroaro o tētahi pukupuku. Heoi, he uaua ki te kī mā te matawai anake mēnā he pai, he kino rānei te pukupuku.

Hei whakatau tika i te mate , me toro atu te tākutaTērā pea ka mahia he koiora whatukuhu, ka tūtohutia rānei kia pokangahia hei tango i te pukupuku.

Ki te tangohia te pukupuku mā te pokanga, ka tangohia te kiko o te pukupuku ka whakamatautauria mō te mate pukupuku. Ka whakamahia ngā hua hei whakatau mēnā he mate pukupuku, ā, mēnā he momo e kiia nei ko te "ccRCC".

He mea whakamiharo, e 4 noa iho i roto i te 10 ngā pukupuku whatukuhu iti, he iti iho i te 4 henimita te rahi, he pea he pukupuku pai, pērā i te oncocytomas whatukuhu.

He aha ngā wāhanga o te matepukupuku (ccRCC)?

I muri i te tātaritanga o te mate pukupuku ki te (ccRCC), ka whakatauhia e te tākuta te wāhanga o te mate pukupuku . Arā, ka tirohia te rahi o te pukupuku, me te mea kua horapa ki ētahi atu wāhanga o te tinana.

E whā ngā momo matua o te Mate Pukupuku Pūtau Mārama me te Mate Pukupuku Tākihi.

• Ka iti ake te tūponotanga, ka iti ake te kino o te mate pukupuku.

Ka kōrero te tākuta ki a koe mō ēnei mea:

• Kei tehea wāhanga tō matepukupuku.
• He aha te mōrearea o tōna horapa ki ētahi atu wāhanga o te tinana?
• He aha ngā mahi e whai ake nei me mahi e koe ?

He aha ngā maimoatanga mō te (ccRCC)?

I te nuinga o te wā, ko ngā kōwhiringa maimoatanga e whakawhirinaki ana ki te horapa o te mate pukupuku ki tua atu i te whatukuhu. Āe, kia titiro tātou.

Mena kāore te mate pukupuku i horapa ki tua atu i te whatukuhu:

I roto i tēnei āhuatanga, ka taea te whakahaere maimoatanga penei:

• Pokanga - Nephrectomy : Ka tangohia e te taote pokanga te wāhanga anake o te whatukuhu e pangia ana e te mate pukupuku. Ka kiia tēnei ko te nephrectomy wāhanga. Waihoki, ka taea te tango i te whatukuhu katoa. Ka kiia tēnei ko te nephrectomy radical.
• Ngā whakaora ā-kiri : Ka whakamahia e ēnei maimoatanga he huarahi ā-kiri hei whakangaro i ngā pūtau matepukupuku mā te wero i te ngira mā roto i te kiri. He rerekē ngā tikanga mō tēnei. Hei tauira, ka taea te whakangaro i ngā pūtau matepukupuku mā te whakamahi i te makariri rawa (cryoablation) me te wera rawa (thermal ablation).

Mena kua horapa te mate pukupuku, he nui rānei te tūponotanga kia horapa:

I roto i ēnei āhuatanga, ko ngā kōwhiringa maimoatanga ko:

• Te Whakaora Ārai Mate : Kei roto i tēnei ko te whakaoho i te pūnaha ārai mate o tō tinana kia whakangaro i ngā pūtau matepukupuku. Ko ngā rongoā e whakamahia ana mō tēnei ko te pembrolizumab (Keytruda®) ko te nivolumab rānei (Opdivo®).
• Te rongoā arotahi : Mā te aukati i te tipu me te whakanui o ngā pūtau matepukupuku ka mahi tēnei maimoatanga. Ko ngā rongoā e whakamahia ana mō tēnei ko te axitinib (Inlyta®) me te cabozantinib (Cabometyx®).

He mate pukupuku kino, he tere te horapa te (ccRCC)?

Pērā i ngā momo (carcinoma) katoa, ka taea e tēnei (Clear Cell Renal Cell Carcinoma) te horapa (metastasize) ki ētahi atu wāhanga o te tinana. He uaua ake te rongoā i tētahi mate pukupuku kua horapa pēnei (mate pukupuku metastatic).

Ki te whakatauritea ki ētahi atu momo mate pukupuku whatukuhu, he kaha ake te "(ccRCC)" ā, he tere ake te horapa .

Ko te mate pukupuku pūtau whatukuhu ka horapa ki ngā wāhi e whai ake nei:

• Ngā pūnga lymph
• Ngā pūkahukahu
• Ngā repe adrenal (kei runga ake i ngā whatukuhu)
• Ate
• Roro
• Ngā wheua

Kia pēhea te tere o te tipu o te matepukupuku (ccRCC)?

Ka rerekē te tere tipu o te Clear Cell Renal Cell Carcinoma. E ai ki tētahi rangahau, ka taea e rātou te tipu mai i te 0.2 ki te 6.5 henimita (0.07 ki te 2.5 inihi) ia tau. Ko te tere tipu toharite he 2.13 henimita (0.83 inihi) ia tau.

He aha te auau oranga mō te (ccRCC)?

I te nuinga o te wā, ko te reiti oranga mō ngā tau e rima (ccRCC) kei waenga i te 50% me te 69% .

Heoi, ko te tūponotanga o tēnei whakaoranga e whakawhirinaki ana ki te rahi o tō pukupuku. I te nuinga o te wā, kāore i te tino angitu te maimoatanga mō ngā pukupuku nui ake, mēnā rānei kua horapa te (ccRCC) ki ētahi atu wāhanga o te tinana. I roto i ēnei āhuatanga, mēnā he pukupuku nui, mēnā rānei kua horapa te mate pukupuku, ko te reiti oranga mō ngā tau e rima ka tata ki te 10%. Koia te take he mea nui kia kitea wawe, kia tīmata wawe hoki te maimoatanga.

Me pēhea taku tiaki i ahau anō?

He mea noa te rongo i ngā momo kare ā-roto ina kitea he mate pukupuku pūtau whatukuhu tōu. Tērā pea ka rongo koe i ngā momo kare ā-roto, tae atu ki te wehi, te riri, te pōuri, te manukanuka, me te pouri.

He tokomaha te hunga e kitea ana te whakamarie mā te ako i ngā mea katoa e taea ana mō (ccRCC) me te tono āwhina mai i ō rātou whanaunga. He mea pai hoki te whakauru atu ki ngā rōpū tautoko (ccRCC) e mārama ana ki ō wheako.

He mea tino nui hoki te whakawhirinaki ki tō tīma hauora. Pātai atu ki a rātou i ngā pātai katoa e pā ana ki ngā kōwhiringa maimoatanga me te tukanga whakaora.

Anei ētahi atu huarahi hei tiaki i a koe anō:

• Tangohia ngā rongoā katoa i whakaritea e ngā tākuta kia rite ki ngā tohutohu .
• Kaua e hiroki mā te kai i ngā kai he nui te pūmua me te kaora.
• Moe pai rawa atu.
• Te ngana ki te whakahaere i te ahotea mā roto i ngā mahi pēnei i te manawa hōhonu, te whakaaroaro, te yoga, te whakaora toi, ngā mahi whakamarie rānei pēnei i te panga.
• Ahakoa te kaha o tō tinana.Te whai wāhi ki ngā mahi ā-tinana.

Āhea ahau me toro atu ki te tākuta?

Ki te pāngia koe e tētahi o ēnei tohu, me toro atu ki te tākuta tonu:

• Mena he toto kei roto i te mimi.
• Mena he puku, he mamae rānei kei roto i tō ringa, kāore e memeha .
• Mena kei te pāngia koe e te kirika kāore i te mārama, e te hekenga rānei o tō taumaha .

Mena kei te rongoatia kētia koe mō te (ccRCC), kōrero tonu atu ki tō tākuta mena ka puta he tohu hou, ka kino haere rānei ō tohu . Ka taea e rātou te tohutohu i a koe me pēhea te whakahaere i ō tohu, te whakarerekē i te horopeta o tō rongoā, te taunaki rānei i tētahi maimoatanga hou. Ko tētahi wāhanga nui o tō maimoatanga ko te noho hauora tonu.

He aha ngā pātai me pātai atu e au ki te tākuta?

He mea pai kia pātai atu koe ki tō tākuta i ēnei pātai:

• "He aha te rongoā pai rawa atu mōku?"
• "He aha ngā pānga taha o te maimoatanga e taunaki ana koe?"
• "Kei te tūpono ahau ki te pāngia e te mate pukupuku kua horapa?"
• "Me pēhea taku whakaiti i te mōrearea o te horapa o tēnei (ccRCC)?"
• "Kei te tūpono tetahi o tōku whānau toto ki te whakawhanake i te (ccRCC)?"
• "He tohu kei reira o ngā raruraru e tika ana kia tino mōhio ahau ki ēnei?"

Hei āwhina i a koe ēnei pātai. Kaua e mangere ki te pātai atu ki tō tākuta i ngā mea katoa kei roto i tō hinengaro, ahakoa te iti. He mea tino nui kia mārama koe ki ngā mea katoa.

He aha te rerekētanga i waenga i te mate pukupuku whatukuhu 'pūtau mārama' me te mate pukupuku whatukuhu 'papillary'?

Ko ēnei ko te "Clear Cell Renal Carcinoma" me te "Papillary Renal Cell Carcinoma". He tino ōrite ngā tohu o ngā mea e rua. He tino ōrite hoki ngā maimoatanga.

Ko te rerekētanga matua ko te āhua o ēnei pūtau matepukupuku ina tirohia i raro i te karuārai.

• Ko ngā pūtau matepukupuku papillary ka puta he tipu roa, angiangi, he rite ki te maihao.
• (ccRCC) He rite te āhua o ngā pūtau matepukupuku ki ngā mirumiru mārama.

Tata ki te kotahi i roto i te tekau ngā tāngata he mate pukupuku pūtau whatukuhu tō rātou momo papillary.

Hei whakamutunga, ētahi mea hei maumahara (Karere hei tango ki te kāinga)

E mārama ana ahau ki te uaua o te mōhio kei te pāngia koe e te mate pukupuku. Ka pā mai ngā kare ā-roto pēnei i te wehi, te pōuri, te riri, te pōhēhē, me te mokemoke ki a koe i te wā kotahi. Tērā pea ka pā mai ēnei mea katoa ki a koe i te wā kotahi. Tērā pea ka wehe atu koe i ō kare ā-roto i a koe e ngana ana ki te aro atu ki tēnei mate. Kia mārama koe ahakoa he aha ō kare ā-roto, he mea noa.

Ko te Mārama Pūtau Tākihi (CCRCC) te momo mate pukupuku tākihi tino noa. Ka tere ake te tipu, ā, ka kaha ake te kaha i ētahi atu mate pukupuku tākihi.

He nui ō raruraru, ā, me kōrero koe ki tētahi mō ō whakaaro me ō kare ā-roto.Kaua e mangere ki te tono āwhina i ō tākuta, me te whakawhirinaki ki tō pūnaha tautoko (te whānau, ngā hoa).

He haerenga uaua pea tēnei, engari me mahi i ia taahiraa, me te atawhai ki a koe anō. Kia maumahara he nui te rerekētanga ka puta mai i te kitenga wawe me te maimoatanga wawe. Kāore koe i te mokemoke.