Kua whakaaro koe ka taea e tō tātou tinana te whawhai ki te mate pukupuku i a ia anō? Inaa, he ope taua whakamiharo tō tō tātou tinana e kiia nei ko te pūnaha ārai mate. Engari i ētahi wā, nā te kaha rawa o te hoariri e kiia nei ko te mate pukupuku, ka uaua ki tō tātou ope te toa i te pakanga ko ia anake. I ēnei wā, ka kōrero tātou mō tētahi maimoatanga e hoatu ana ki tō tātou ake ope he whakangungu motuhake, e whakanui ana i tōna kaha, ā, e tuku ana i a ia ki te pakanga.
He aha tēnei maimoatanga TIL?
He māmā noa iho, he momo hou te rongoā ārai mate mō te mate pukupuku te rongoā TIL. Mā te āwhina i te pūnaha ārai mate o tō tinana kia kite me te whakangaro i ngā pūtau mate pukupuku.
Ko te toa o tēnei maimoatanga he momo pūtau motuhake e kiia nei ko ngā Tumor-Infiltrating Lymphocytes , e kiia nei e mātou ko ngā TIL .
Whakaarohia he rite ki ngā hōia (ngā pūtau ārai mate) e tirotiro haere ana i ō tātou tinana. Engari ko ēnei hōia, e kiia nei ko ngā TIL, he mea motuhake ake. Ka uru atu rātou ki roto i te pukupuku, ka ako i ōna ngoikoretanga, ka ako me pēhea te whakangaro pai. Arā, he rite rātou ki ngā ope motuhake e tomo hōhonu ana ki roto i te puni hoariri, ka tutei i a ia.
Engari ko te raruraru, kāore e taea e ō tātou tinana te whakaputa i ngā pūtau TIL e ranea ana hei whawhai ki ēnei mate pukupuku whakamate.
Koinei te wāhi e whai wāhi mai ai te rongoā TIL. Ko te whakanui hangai i te maha o ō pūtau TIL mā te piriona. Ka tangohia e te taote pokanga tētahi wāhanga iti o tō pukupuku. Kātahi ka tukuna ki tētahi taiwhanga, ka wehea ngā hōia TIL, ka whakatupuhia kia tae ki te piriona te maha. Hei whakamutunga, ka whakahokia mai tēnei ope taua nui, i hangaia mai i ō ake pūtau, ki roto i tō tinana.
He aha ngā momo mate pukupuku e rongoāhia ana e tēnei maimoatanga?
Hei te tau 2024, kua whakaaetia e te US Food and Drug Administration (FDA) tētahi maimoatanga TIL e kiia nei ko te lifileucel (Amtagvi®) . He mea motuhake tēnei mō te melanoma, he momo mate pukupuku kiri. Arā, ko te melanoma kāore e taea te whakaora mā te pokanga anake, kua horapa rānei ki ētahi atu wāhanga o te tinana (mate pukupuku metastatic). Tērā pea he pai tēnei maimoatanga mō te tangata kāore e aro ki ngā maimoatanga e tukuna ana e ngā tohunga pukupuku.
Hei tāpiritanga, kei te rangahau ngā tākuta i te whai huatanga o tēnei maimoatanga TIL mō ētahi atu momo mate pukupuku, tae atu ki:
- Matepukupuku ū
- Matepukupuku kōpū
- Matepukupuku koroni
- Matepukupuku o te upoko me te kaki
- Matepukupuku pūkahukahu ehara i te pūtau iti
Me pēhea te mahi a te tukanga maimoatanga?
Ehara tēnei i te mea e mahia katoatia ana i te wā kotahi. Ahakoa ko te mea nui ko te werohanga i ngā pūtau TIL, he maha ngā mahi hei mahi i mua i tēnā. Me titiro tātou ki tēnei tukanga katoa taahiraa i ia taahiraa.
| Ngā Hipanga | Whakaahuatanga o ngā mea e tupu ana |
|---|---|
| 1. Te tango i tētahi wāhanga o te pukupuku matepukupuku | Ka tangohia e te taote pokanga tētahi wāhanga iti o tō puku, he rite te rahi ki te karepe, ka tukuna ki te taiwhanga. Ka whakamoea koe, nō reira kāore koe e mamae i tēnei wā. |
| 2. Te wehewehe me te tipu o ngā pūtau TIL | I roto i te taiwhanga, ka wehea ngā pūtau TIL mai i te puku, ka whakatupuhia kia piriona. E rima wiki te roa o tēnei tukanga. Kātahi ka tukuna ēnei pūtau ki te hōhipera ka rongoatia koe. |
| 3. Te hoatu i te rongoā chemotherapy | Ka whakaurua koe ki te hōhipera, ā, ka tukuna he rongoā chemotherapy mō ngā rā e rima ki te whitu. Hei whakarite i tō tinana mō te taenga mai o ngā pūtau TIL hou. |
| 4. Te whakaurunga anō o ngā pūtau TIL | Nā, ko te wāhanga nui tēnei. Ka werohia ngā pūtau TIL kua tipu ki roto i tō tinana i te wā kotahi, pērā i te wai tote. E rua hāora te roa o tēnei. |
| 5. Te hoatutanga o te Interleukin-2 | Hei whakamutunga, mō ngā rā e toru ki te rima, ka hoatu he rongoā ki a koe e kīia nei ko te interleukin-2 (IL-2). He momo rongoā ārai mate tēnei. Mā te "whakahohe" i aua pūtau TIL hou kua whakauruhia, ka whakatenatena i a rātou ki te whawhai ki te mate pukupuku. |
Me noho koe ki te hōhipera mō ētahi rā i muri i te maimoatanga. I tēnei wā, ka āta tirotirohia e te tīma hauora te urupare a tō tinana ki te maimoatanga. Mō ngā wiki e whai ake nei, he mea nui kia noho tata ki te hōhipera kia taea ai e koe te whiwhi maimoatanga tere mēnā ka puta he pānga taha.
He aha ngā painga me ngā mōrearea o tēnei maimoatanga?
He aha ngā painga?
He maimoatanga tino whaiaro , tino kaha hoki te rongoā TIL. Nā te mea e whakamahi ana i ō ake pūtau, he iti noa te kino ki ngā pūtau hauora. Nō reira, he iti te mōrearea o ngā pānga taha.
Heoi anō, he roa te mau o ngā hua o tēnei maimoatanga . Ka noho ngā pūtau TIL i werohia ki roto i tō tinana mō ngā tau, e whawhai ana ki ngā pūtau matepukupuku.
Nā tēnei maimoatanga i homai he tumanako hou ki te tini o ngā tūroro melanoma i whakaaro i mua kāore he rongoā. E ai ki tētahi rangahau i te tau 2023, e whā tau i muri i te whiwhinga o te maimoatanga TIL, e whitu i roto i te tekau ngā tāngata i whakahaeretia, i ora rānei tō rātou mate.
Ngā tūponotanga me ngā pānga taha
Pērā i ngā maimoatanga katoa, he tūponotanga kei ia taahiraa o te tukanga. Ko ngā pānga taha ka puta mai i te chemotherapy me te rongoā IL-2. He tino onge ngā pānga taha mai i te whakahaerenga pūtau TIL.
| Ngā pānga taha noa | |
|---|---|
| Korere | Ngenge |
| Te kirika me te makariri | Te pā o te manawa kāore i te tika (arrhythmia) |
| Te toto toto iti | Whakapairuaki me te ruaki |
| Ponana kiri | |
He tino onge, nā te maimoatanga IL-2Tērā pea ka puta he raruraru nui, pērā i te mate turuturu o te uaua toto. Kaua e manukanuka, ka matapakihia e tō tākuta ēnei mōrearea katoa ki a koe i mua i te tīmatanga o te maimoatanga.
Kia pēhea te roa ka hoki ahau ki te āhua noa?
Ka tīmata koe ki te pai ake i te rua wiki i muri i tō horopeta whakamutunga o te IL-2. Nā te mea he maha ngā mahi e pā ana ki tēnei tukanga maimoatanga, pērā i te pokanga me te chemotherapy, ka roa te wā e ora ai te tinana.
Āhea koe me toro atu ki te tākuta?
I muri i te maimoatanga, ki te puta he tohu o te mate pāwera (kirika, mamae tinana), ki te pāngia rānei koe e ētahi pānga kino kāore i te tumanakohia, me waea atu ki tō tākuta tonu.
Ki te pā mai he huringa, he mamae rānei ki a koe, kaua e mangere ki te kōrero ki tō tākuta. Kaua e ngana ki te whakatau mēnā he mea noa, kāore rānei. Ko te mea haumaru ko te ripoata tonu atu.
Mena he mate pukupuku tōu, ā, kāore anō kia pāngia e ētahi atu maimoatanga, he kōwhiringa pai pea te TIL māu. Mena ka tūtohu tō tākuta i tēnei maimoatanga, pātai atu ki a koe mēnā he pātai āu mōna. Kōrero ki tō tākuta mō ngā painga me ngā mōrearea. Ko tō tākuta te puna mōhiohio pai rawa atu māu.
Karere Tangohia ki te Kāinga
- He maimoatanga hou, he kaha hoki te whakaora TIL e whakamahi ana i ō ake pūtau ārai mate hei whawhai i te mate pukupuku.
- Kei roto i tēnei ko te whakatipu i ngā piriona pūtau i tangohia mai i tētahi pukupuku matepukupuku i roto i tētahi taiwhanga, kātahi ka werohia anō ki roto i te tinana.
- I tēnei wā, kua whakaaetia te nuinga mō te mate pukupuku melanoma kāore anō kia arohia e ētahi atu maimoatanga, engari kei roto hoki i te wāhanga rangahau mō ētahi atu mate pukupuku.
- He tukanga uaua tēnei, he maha ngā mahi e whai ake nei, tae atu ki te pokanga, te rongoā mate pukupuku, me te rongoā.
- I ngā wā katoa, kōrerotia whānuitia ngā painga, ngā huakore, me ngā mōrearea o tēnei maimoatanga ki tō tākuta, ā, me whakatau i runga i te whai whakaaro.
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