Kodi mukudziwa za matenda a impso osowa awa? (Atypical Hemolytic Uremic Syndrome - aHUS)

Tangoganizirani magazi oundana omwe amapangika mkati mwa mitsempha yaing'ono yamagazi m'thupi lanu. Makamaka m'mitsempha yamagazi m'impso zanu. Pamene magazi oundanawa amaletsa kuyenda kwa magazi kupita ku impso zanu, mavuto akuluakulu monga kulephera kwa impso amatha kuchitika. Izi ndi zomwe zimachitika mu Atypical Hemolytic Uremic Syndrome, kapena aHUS. Ngakhale kuti palibe mankhwala a vutoli, lingathe kuthandizidwa bwino ndi chithandizo choyenera .

Kodi kusiyana pakati pa HUS "Yodziwika" ndi "Yosazolowereka" ndi kotani?

Matendawa, otchedwa aHUS, ndi osiyana pang'ono ndi a HUS "Yachizolowezi" yomwe timaiona nthawi zambiri. Chifukwa chachikulu cha HUS yachizolowezi ndi mitundu ina ya mabakiteriya omwe amayambitsa kutsegula m'mimba, mwachitsanzo, matenda a bakiteriya monga `(E. coli)` ndi `(Shigella)`. Komabe, chomwe chimayambitsa aHUS ndi chovuta kwambiri.

Matendawa, otchedwa aHUS, amatha kuchitika pa msinkhu uliwonse. Mwa ana aang'ono, amakhudza anyamata ndi atsikana mofanana. Komabe, akamakula, akazi amakhala ndi mwayi waukulu wopeza matendawa. Izi zili choncho chifukwa mimba ikhoza kukhala chifukwa cha matendawa. Ndi matenda osowa kwambiri. Ngakhale kuti sizikudziwika bwino kuti ndi anthu angati omwe ali ndi matendawa, kafukufuku wina akusonyeza kuti anthu awiri okha pa anthu miliyoni m'mayiko ngati United States ndi omwe ali ndi matendawa.

Kodi chimayambitsa aHUS ndi chiyani?

Milandu yambiri ya aHUS imayamba chifukwa cha kusintha kwa majini, komwe kumatchedwa kusintha kwa majini . Komabe, si aliyense amene ali ndi kusintha kwa majini amene adzadwala matendawa. Kuti zizindikiro ziwonekere, pamafunika choyambitsa.

Mwachidule, munthu amene ali ndi chibadwa chotenga matendawa akhoza kudwala matendawa ngati chimodzi mwa zinthu izi chichitika:

• Mimba
• Matenda ena opatsirana
• Khansa
• Mankhwala ena
• Kusamutsa chiwalo
• Matenda ena osatha, monga "systemic sclerosis" kapena "malignant hypertension"

Koma nthawi zina, pafupifupi theka la odwala aHUS, madokotala sapeza kusintha kwa majini komwe angapeze. Timawatcha kuti "idiopathic." Izi zikutanthauza kuti palibe chifukwa chomwe chingapezeke. Ofufuza amakhulupirira kuti vutoli limayamba chifukwa cha kusintha kwa majini komwe sikunadziwikebe.

Kodi zizindikiro za aHUS ndi ziti?

Zizindikiro za aHUS nthawi zambiri zimawonekera mwadzidzidzi pambuyo pa choyambitsa. Kuphulika kumeneku kungakhale kofatsa kapena koopsa. Pakakhala kofatsa, impso sizingakhudzidwe kwambiri. Pakakhala koopsa, zimatha kupangitsa kuti impso zilephere kugwira ntchito.

Pa gawo loyamba la matendawa, zizindikiro zotsatirazi zingawonekere:

• Kufooka kwakukulu ndi kusowa moyo
• Kumva kuti simukudwala

Imeneyi ndi matenda opitirira muyeso. Izi zikutanthauza kuti zizindikiro zimakula pakapita nthawi, makamaka ngati matendawa sanazindikirike msanga. Ngakhale kuti impso ndi zomwe zimakhudzidwa kwambiri ndi aHUS, ziwalo zina monga ubongo, chiwindi, mapapo, ndi mtima zimathanso kukhudzidwa ndi kutsekeka kwa mitsempha yamagazi.

Kodi aHUS imapezedwa bwanji?

Ngati palibe m'banja mwanu amene adadwalapo matendawa, zingakhale zovuta kupeza matenda a HUS. Dokotala yemwe ndi katswiri wa matenda a impso (nephrologist) kapena dokotala yemwe ndi katswiri wa matenda a magazi (hematologist) ndiye woyenera kwambiri kupeza matendawa. Iwo makamaka adzayang'ana zizindikiro zitatu izi:

1. Kuchepa kwa magazi m'thupi

2. Kuchepa kwa kuchuluka kwa ma platelet

3. Mavuto a impso

Dokotala wanu angakupatseni mayeso osiyanasiyana kuti atsimikizire vutoli.

Kodi njira zochiritsira ndi ziti?

Pali mitundu iwiri ya mankhwala ovomerezedwa ndi FDA kuti athandize aHUS.

• `Eculizumab (Soliris)`
• `Ravulizumab-cwcz (Ultomiris)`

Mankhwala onsewa ali m'gulu lotchedwa ``monoclonal antibodies.'' Mwachidule, awa ndi mapuloteni apadera opangidwa mu labotale omwe amagwira ntchito ngati ma antibodies omwe amapangidwa mwachilengedwe m'matupi athu. Mankhwalawa amatha kuwonjezera kuchuluka kwa ma platelet ndi maselo ofiira amagazi m'magazi. Ngati chithandizochi chiyamba msanga matendawa, chingathenso kubwezeretsa kuwonongeka kwa impso.

Mankhwalawa amaperekedwa ngati jakisoni. Komabe, angayambitse mavuto monga mutu, kutentha thupi, nseru, ndi kupweteka kwa thupi. Dokotala wanu adzakudziwitsani za izi.

Kuphatikiza apo, chithandizo cha plasma chimagwiritsidwanso ntchito pochiza zizindikiro. Pankhaniyi, wodwalayo amapatsidwa plasma yotengedwa kuchokera kwa munthu wathanzi kapena plasma imachotsedwa m'magazi a wodwalayo ndikusinthidwa ndi plasma yathanzi.

Ngati impso sizikuyankha ku chithandizochi, dialysis ya impso kapena kusintha impso kungakhale kofunikira.

Nthawi zina pamene mukufunika kupita kuchipatala nthawi yomweyo

Ngati zizindikiro zotsatirazi zikuonekera, pitani ku Dipatimenti Yodzidzimutsa (ETU) ya chipatala chapafupi nthawi yomweyo.

• Mkodzo wochepa kwambiri.
• Kusokonezeka kapena kutayika kwa chidziwitso cha maganizo.
• Kutupa kwambiri kwa thupi.
• Kuvuta kupuma.

Kodi mungasunge bwanji thanzi la maganizo pamene mukukhala ndi matendawa?

Ndizachilendo kumva kupsinjika maganizo komanso kuda nkhawa mukakhala ndi matenda osatha monga aHUS. Matendawa akakula kwambiri komanso zizindikiro zake zimakhala zambiri, thanzi lanu la maganizo limakhudzidwa kwambiri. Koma simuyenera kukumana ndi vutoli nokha.

• Lankhulani ndi banja lanu ndi anzanu: Kuuza munthu amene mumamudalira maganizo anu ndi mmene mukumvera kungakhale mpumulo waukulu.
• Lankhulani ndi madokotala ndi alangizi: Lankhulani ndi dokotala wanu za izi. Angakutumizireni kwa alangizi azaumoyo wamaganizo ngati pakufunika kutero.
• Ganizirani za thanzi lanu lonse: Gonani mokwanira. Pezani njira zochepetsera nkhawa. Idyani zakudya zabwino ku impso zanu. Chitani masewera olimbitsa thupi ngati mungathe. Kukhala wathanzi kumakuthandizaninso kukhala ndi thanzi la maganizo.

Ngakhale kuti vutoli ndi la moyo wonse, ngati mutapezeka ndi matendawa msanga, kulandira chithandizo choyenera , komanso kutsatira malangizo a dokotala, mutha kuthana ndi zotsatira za matendawa ndikukhala moyo wabwinobwino. Chifukwa chake, lankhulani ndi dokotala wanu ndikutsatira dongosolo lanu la chithandizo.