Kodi mukudziwa za khoma lodabwitsa ili lomwe limateteza ubongo? (Chotchinga cha Ubongo ndi Magazi)

Ganizirani ubongo wanu ngati linga lamtengo wapatali komanso lothandiza kwambiri. Ndipo pali mlonda wa pachipata amene amafufuza chilichonse chomwe chimalowa mu linga limenelo, akuletsa zinthu zoipa kulowa ndikulola zabwino kulowa. Mofananamo, lero tikambirana za mlonda wapadera wa pachipata, kapena fyuluta, yomwe ili m'mitsempha yamagazi yozungulira ubongo wathu, yoteteza ubongo. Mu zamankhwala, timatcha izi kuti Blood-Brain Barrier (BBB).

Mwachidule, kodi Blood-Brain Barrier (BBB) ​​ndi chiyani?

Izi si zotchinga chabe. Ndipotu, zili ngati chitetezo cha ubongo wathu. Khoma loteteza ili lili mkati mwa mitsempha yamagazi yozungulira ubongo. Ntchito yake yayikulu ndikuletsa zinthu zovulaza, majeremusi, ndi mankhwala osafunikira m'magazi kuti asalowe mu ubongo . Limalamuliranso kudya bwino michere ndi mpweya kupita ku ubongo komanso kuchotsa zinyalala mu ubongo.

M'zigawo zina za thupi lathu, maselo omwe ali m'mitsempha yathu yamagazi (omwe timawatcha maselo a ``endothelium``) ali ndi mipata yaying'ono pakati pawo. Koma m'mitsempha yamagazi muubongo, maselowa amakhala ogwirizana kwambiri, olumikizana, ndipo palibe mipata. Ali ngati khoma lopangidwa ndi pulasitala lopanda mabowo. Kotero ngakhale mamolekyu akuluakulu, kapena zinthu zomwe zimangosungunuka m'madzi, sizingadutse mosavuta.

Kodi n’chiyani chingalowe mkati mwa khoma lachitetezo ili?

Sizinthu zonse zomwe zimaima pa khoma ili. Zinthu zina zimatha kudutsamo.

• Mamolekyu ang'onoang'ono kwambiri: Mamolekyu ang'onoang'ono monga mpweya ndi carbon dioxide amatha kudutsa mosavuta mu izi.
• Kusungunuka kwa mafuta: Chophimba chakunja cha maselo oteteza awa chimapangidwa ndi mafuta, kotero zinthu zosungunuka ndi mafuta zimatha kudutsa mosavuta.

Ganizirani chifukwa chake zinthu monga mowa, mankhwala oletsa ululu, ndi caffeine zimakhudza ubongo wathu mwachangu. Chifukwa chake ndi chakuti zimatha kudutsa mosavuta mu Blood-Brain Barrier. Komanso, mankhwala ambiri, monga mankhwala oletsa kuvutika maganizo, anxiolytics, ndi mankhwala a khunyu, amapangidwira kudutsa chotchinga ichi ndikufikira ubongo.

Kodi ndi zinthu ziti zomwe zingafooketse khoma la chitetezoli?

Ngakhale kuti chotchinga ichi ndi champhamvu kwambiri, nthawi zina chimatha kufooka kapena kuyamba "kutuluka." Izi zimachitika makamaka chifukwa cha kutupa.Izi zitha kuchitika m'mikhalidwe ngati iyi. Chotchinga ichi chikafooka, zinthu zovulaza zomwe nthawi zambiri sizingalowe muubongo zimatha kulowa.

Gome ili m'munsimu likuwonetsa zina mwa matenda akuluakulu omwe angafooketse chotchinga magazi ndi ubongo.

Kodi pali zizindikiro zilizonse zosonyeza kuti izi zingakhale vuto?

Ndipotu, palibe zizindikiro zachindunji zomwe zimasonyeza vuto la Blood-Brain Barrier. Zimene timaona ndi zizindikiro za matenda omwe amakhudza matendawa (monga sitiroko kapena matenda a Alzheimer's). Ngakhale pakadali pano palibe njira yodziwikiratu yoyesera momwe vutoli lilili, njira zosiyanasiyana zikufufuzidwa pamlingo wofufuza.

Kodi tiyenera kuchita chiyani kuti chitetezo chamtengo wapatalichi chikhale cholimba?

Ngakhale sitingathe kuchiza mwachindunji Blood-Brain Barrier, tingapewe zinthu zomwe zimaifooketsa. Izi zikutanthauza kuti kukhala ndi moyo wathanzi ndiye chinthu chabwino kwambiri kuchita.

• Khalani ndi zakudya zoyenera komanso kulemera koyenera: Zinthu monga kuthamanga kwa magazi, matenda a shuga, ndi cholesterol zimawononga mitsempha yathu yamagazi. Kuwonongeka kumeneku kungakhudzenso mitsempha yamagazi muubongo. Chifukwa chake, ndikofunikira kwambiri kuwongolera matendawa kudzera mukudya bwino komanso kuchita masewera olimbitsa thupi.
• Musanyalanyaze matenda:Nthawi zina, ngati matenda a m'khutu, m'maso, kapena m'mano sanachiritsidwe bwino, majeremusi amatha kuyenda kudzera m'magazi kupita ku ubongo. Choncho, pitani kwa dokotala nthawi yomweyo ngati pali matenda aliwonse ndipo mupeze chithandizo.
• Valani zida zodzitetezera: Kuvulala kumutu kungawononge mwachindunji chotchinga ichi. Chifukwa chake, onetsetsani kuti mwavala chisoti mukakwera njinga kapena njinga yamoto, ndipo mangani lamba wanu mukakwera galimoto.
• Thandizani matenda anu osatha bwino: Ngati muli ndi matenda monga matenda a shuga, kuthamanga kwa magazi, kapena cholesterol, imwani mankhwala omwe dokotala wanu wakupatsani molondola komanso panthawi yake. Komanso, pitani kuzipatala nthawi yake kuti mukaone momwe mulili.

Kodi madokotala amagwiritsa ntchito bwanji chidziwitsochi?

Kudziwa za Blood-Brain Barrier n'kothandiza kwambiri kwa madokotala ndi asayansi. Ndi vuto komanso mwayi.

• Vuto: Nthawi zina, mankhwala a khansa ya muubongo kapena matenda sangathe kufika muubongo chifukwa cha chotchinga ichi. Chotchingacho chimaganiza kuti mankhwalawa ndi "oipa." Pazochitikazi, njira zapadera (monga njira ya "Trojan horse", yomwe imaphatikizapo kudziphatika ku molekyulu ina) zimagwiritsidwa ntchito popereka mankhwala kudzera mu chotchingacho.
• Nkhani: Matenda a Parkinson amapezeka pamene mankhwala a dopamine achepa mu ubongo. Ngakhale dopamine itaperekedwa mwachindunji ngati mankhwala, singathe kudutsa chotchinga ichi ndikulowa mu ubongo. Chifukwa chake, madokotala amapereka mankhwala otchedwa levodopa. Levodopa iyi imatha kudutsa chotchingacho. Ikalowa mu ubongo, levodopa imasanduka dopamine. Kodi iyi si lingaliro labwino?

Ndiko kuti, mankhwala ena amapangidwira kuti apewe chotchinga ichi. Mankhwala ena amapangidwira kuti apewe, chifukwa ngati mankhwalawa alowa muubongo, angayambitse zotsatira zoyipa zomwe sizikufunidwa.