Kodi muli ndi zizindikiro zachilendo izi? Tiyeni tikambirane za Carcinoid Syndrome!

Nthawi zina sitidziwa bwino zomwe zikuchitika m'thupi lathu, sichoncho? Kodi mudayamba mwakumanapo ndi kusamba mwadzidzidzi, kuvutika kupuma, kupweteka m'mimba, ndi kutsegula m'mimba? Izi sizinthu zongochitika mwangozi. Nthawi zina izi zitha kukhala zizindikiro za matenda osowa otchedwa Carcinoid Syndrome. Tiyeni tikambirane za izi mwatsatanetsatane lero.

Kodi Carcinoid Syndrome ndi chiyani?

Mwachidule, matenda a carcinoid ndi mndandanda wa zizindikiro zomwe zimayambitsidwa ndi mtundu wa khansa yomwe imakula m'thupi lanu yotchedwa neuroendocrine tumors (NETs) . Maselo a neuroendocrine awa ndi mtundu wapadera wa selo lomwe limakhudzidwa ndi machitidwe athu amitsempha ndi mahomoni. Ma NET amapezeka pamene maselowa amagawikana mwadzidzidzi ndikuchulukana mwachangu, ndikupanga zotupa.

Tsopano mwina mukudabwa ngati iyi ndi matenda omwe amakhudza aliyense. Ayi, kwenikweni ndi vuto losowa kwambiri . Kafukufuku akusonyeza kuti pafupifupi munthu m'modzi mwa asanu omwe ali ndi zotupa za neuroendocrine (NETs) amakhala ndi matenda a carcinoid. Matenda a NET nawonso si ofala kwambiri, ndipo akuti anthu 5 pa 100,000 amapezeka ku United States.

Ma NET awa, makamaka omwe ali m'mimba kapena m'mapapo, amatulutsa mahomoni ambiri monga serotonin ndi mankhwala ena m'thupi nthawi yomweyo. Pamenepo ndi pomwe zizindikiro za matenda a carcinoid zimawonekera. Nthawi zina, mumadziwa koyamba kuti muli ndi NET zizindikiro za matendawa zikaonekera.

Kawirikawiri, ngati matenda a carcinoid awa sanapezeke bwino ndi kuchiritsidwa, angayambitse ngozi yomwe ingawononge moyo yotchedwa 'carcinoid crisis'. Chifukwa chake, ndikofunikira kwambiri kudziwa izi.

Kodi zizindikiro za matenda a carcinoid ndi ziti?

Tiyeni tiwone zizindikiro zodziwika bwino za vutoli. Onani ngati muli ndi zizindikiro izi, chimodzi ndi chimodzi:

• Kutsuka: Izi zingakhale zosasangalatsa pang'ono. Zili ngati kutsuka nkhope ukakhala ndi manyazi, koma ngati zimachitika kawirikawiri popanda chifukwa, muyenera kuda nkhawa.
• Kupuma movutikira komanso kupuma movutikira (dyspnea): Kungamveke ngati kovuta kupuma, kapena ngati phokoso lochokera pachifuwa.
• Kupweteka m'mimba komanso kutsegula m'mimba mopitirira muyeso: Kupweteka m'mimba komanso kutsegula m'mimba kosalekeza komanso koopsa. Nthawi zina zimakhala zovuta kulamulira.
• Matumbo onenepa omwe amanunkha moyipa: Matumbowo angawoneke ngati mafuta ndipo ali ndi fungo losazolowereka.
• Kutupa kapena kutupa kwa mapazi ndi miyendo yanu:Izi nthawi zina zingakhale chizindikiro cha kulephera kwa mtima, choncho ndikofunikira kupeza upangiri wa dokotala mwachangu.
• Kuchepa kwa chilakolako chogonana kapena kusagwira bwino ntchito kwa amuna: Anthu ena amatha kukhala ndi vutoli.
• Kuoneka kwachikasu pakhungu ndi maso oyera (Jaundice): Ichi ndi chomwe timachitcha kuti 'jaundice'. Ikhoza kukhala vuto la chiwindi.
• Chizungulire kapena kumva kukomoka: Ichi chingakhale chizindikiro cha kuthamanga kwa magazi.
• Kumva ngati mtima wako ukuthamanga: Ungamve ngati chifuwa chako chikugunda mofulumira.

Ngati mukupitiriza kukhala ndi chimodzi kapena zingapo mwa zizindikirozi, onetsetsani kuti mwaonana ndi dokotala kuti akufotokozereni. Izi zitha kukhalanso zizindikiro za matenda ena, koma ndikofunikira kutsimikizira kuti muli ndi matenda a carcinoid.

Nchifukwa chiyani matenda a carcinoid awa amapezeka?

Monga ndanenera kale, matenda a carcinoid amapezeka ngati muli ndi zotupa za neuroendocrine (NETs). Ma NET awa ndi zotupa zomwe zimachokera ku maselo apadera mu dongosolo lanu la neuroendocrine. Maselo awa amapanga ndikutulutsa mahomoni m'thupi.

Kawirikawiri, ma NET amenewa amatha kufalikira m'malo monga m'mimba, m'mapapo, ndi m'mapapo. Komabe, matenda a carcinoid nthawi zambiri amayamba chifukwa cha ma NET m'mimba kapena m'mapapo omwe amatulutsa mahomoni ambiri (makamaka serotonin) m'magazi mwadzidzidzi.

Taganizirani ngati pompo yomwe imatsegula madzi pang'onopang'ono, maselo amenewa nthawi zambiri amatulutsa mahomoni pang'ono. Koma NET ikapangidwa, zimakhala ngati pompo imatsegulidwa mwadzidzidzi, ndipo mahomoni ambiri amatuluka nthawi imodzi. Pamenepo ndi pomwe zizindikiro za matendawa zimawonekera.

Ndani ali pachiwopsezo chachikulu chotenga matenda a carcinoid?

Choopsa chachikulu cha izi ndi kukhala ndi chotupa cha neuroendocrine (NET) m'mimba kapena m'mapapo . Mwa kuyankhula kwina, matenda a carcinoid nthawi zambiri samachitika popanda NET.

Izi zikutanthauza kuti, ngati mwapezeka ndi matenda a NET, muyeneranso kuda nkhawa ndi matendawa. Nthawi zina, ngati wina m'banjamo wakhala ndi matenda a NET, izi zingakhalenso chiopsezo pamlingo wina, koma sizichitika kawirikawiri.

Kodi mavuto omwe angakhalepo chifukwa cha matenda a Carcinoid Syndrome ndi ati?

Matenda a carcinoid si zizindikiro chabe, koma angayambitse mavuto ambiri akuluakulu. Chimodzi mwa matenda amenewa ndi 'matenda a carcinoid' omwe angawononge moyo omwe ndatchula kale.

Tiyeni tiwone zovuta zina zingapo:

• Matenda a mtima a carcinoid:Izi sizichitika kawirikawiri, koma zitha kukhala zoopsa pa moyo. Mahomoni omwe amatulutsidwa ndi ma NET amakhudza mkati mwa zipinda za mtima wanu, ma valve, ndi mitsempha yamagazi. Izi zingayambitsenso kulephera kwa mtima.
• Mesenteric fibrosis: NETs zingayambitse kutupa ndi zipsera za mesentery, minofu yomwe imalumikiza matumbo anu ndi khoma lanu la m'mimba. Izi zitha kusokoneza ntchito ya matumbo.
• Kuvutika maganizo: Matenda a carcinoid angakhudze momwe thupi lanu limagwiritsira ntchito amino acid yofunika yotchedwa tryptophan. Tryptophan imathandiza kupanga serotonin. Serotonin ndi mankhwala a muubongo omwe amalamulira zinthu monga momwe timamvera, khalidwe lathu, komanso tulo. Choncho kuchuluka kwa serotonin m'thupi kungayambitse kuvutika maganizo.

Vuto loopsa lotchedwa carcinoid crisis

Matenda a carcinoid ndi vuto losowa kwambiri koma lomwe lingathe kupha munthu . Lingachitike chifukwa cha opaleshoni, njira zina zachipatala, kapena kuvulala chifukwa cha ngozi.

Makhalidwe a izi ndi awa:

• Kusintha kwakukulu kwa kuthamanga kwa magazi: Kuthamanga kwa magazi kumatha kutsika mwadzidzidzi kwambiri (hypotension) kapena kukwera kwambiri.
• Kutuluka magazi kwambiri: Thupi lonse limafiira mwadzidzidzi ndipo likhoza kumva kutentha.
• Kuvuta kupuma (Dyspnea): Kupuma movutikira kwambiri kungachitike.
• Kusokonezeka: Mungamve ngati kuti chikumbumtima chanu chikusokonezeka.

Ndikofunikira kwambiri kuti munthu amene ali ndi matenda a carcinoid syndrome kapena chotupa cha neuroendocrine (NET) azinyamula khadi lofotokoza za matenda ake. Izi zitha kukhala zothandiza kwambiri ngati akufunika thandizo lachipatala mwachangu. Komanso, ngati mukufuna kuchitidwa opaleshoni, ndikofunikira kuuza madokotala anu za vutoli. Kenako angakupatseni mankhwala musanachite opaleshoni komanso panthawi yake kuti achepetse chiopsezo cha 'carcinoid crisis'.

Kodi matenda a Carcinoid amapezedwa bwanji?

Madokotala amagwiritsa ntchito mayeso angapo kuti adziwe vutoli. Tiyeni tiwone zomwe zili:

• Kuyesa mkodzo: Izi zimayesa kuchuluka kwa mahomoni ena mumkodzo wanu, makamaka serotonin yotchedwa 5-HIAA (5-hydroxyindoleacetic acid) .
• Kuyezetsa thupi ndi mbiri yachipatala: Zizindikiro za matenda a carcinoid zitha kufanana ndi za matenda ena osaopsa kwambiri, kotero dokotala wanu adzakufunsani mwatsatanetsatane za zizindikiro zanu, nthawi yomwe zakhalapo, komanso ngati zikuipiraipira.
• Mayeso a magazi:Izi zimayang'ana kuchuluka kwa zinthu zomwe zimatulutsidwa m'magazi kuchokera m'ziwalo zanu ndi minofu. Ngati kuchuluka kwa zinthu zina mwadzidzidzi kukwera kapena kutsika, kungakhale chizindikiro cha matenda. Mwachitsanzo, amafufuza chizindikiro chotchedwa Chromogranin A.
• Kujambula kwa Neuroendocrine Positron Emission Tomography (PET): Uku ndi kujambula kwapadera komwe kumagwiritsa ntchito utoto wotchedwa gallium 68 dotatate kuti mupeze komwe kuli zotupa za neuroendocrine (NETs).
• Kujambula kwa CT: Kujambula kwa CT kumagwiritsa ntchito X-ray ndi kompyuta kuti ipange zithunzi za ziwalo ndi mafupa anu za magawo atatu (3D). Izi zingathandizenso kudziwa komwe kuli ndi kukula kwa zotupa zilizonse.
• Kujambula kwa Ultrasound: Izi zimagwiritsa ntchito mafunde a phokoso popanga zithunzi za ziwalo.
• Kujambula kwa MRI (Magnetic Resonance Imaging (MRI): Izi zimagwiritsa ntchito maginito akuluakulu, mafunde a wailesi, ndi kompyuta kuti zipange zithunzi zatsatanetsatane za mkati mwa thupi.
• Endoscopy: Mu mayeso awa, dokotala amaika chubu chachitali, chopyapyala chokhala ndi kamera ndi kuwala m'thupi lanu kuti achiwone. Mwachitsanzo, njira iyi ingagwiritsidwe ntchito pofufuza m'mimba kapena m'matumbo.

Kodi mankhwala a Carcinoid Syndrome ndi ati?

Matenda a carcinoid amayamba chifukwa cha zotupa za neuroendocrine (NETs). Chifukwa chake, zotupazo zikachiritsidwa, matendawa amachiritsidwanso.

Pali njira zingapo zazikulu zochizira:

• Opaleshoni: Zotupa za neuroendocrine zitha kuchotsedwa kwathunthu kapena kuchepetsedwa kukula. Mtundu wa opaleshoni umadalira malo ndi kukula kwa chotupacho.
• Ma analogue a Somatostatin: Awa ndi mankhwala apadera. Mankhwalawa amatha kuletsa thupi lanu kupanga mahomoni ambiri. Angathandizenso kuwongolera kukula kwa zotupa pamene maselo a khansa afalikira ku ziwalo zina za thupi (metastasis). Zitsanzo ndi mankhwala otchedwa Octreotide ndi Lanreotide .
• Chithandizo cholunjika: Iyi ndi njira yapadera yochizira yomwe imagwiritsidwanso ntchito kupha maselo a khansa. Mu izi, mankhwala amaperekedwa kuti azitha kupha majini kapena mapuloteni enaake m'maselo a khansa.
• Chemotherapy: Izi zimagwiritsa ntchito mankhwala kupha maselo a khansa. Chemotherapy sigwira ntchito mofanana pa mitundu yonse ya ma NET.
• Kutulutsa magazi m'chiwindi: Mu njira iyi, mtsempha wamagazi womwe umapatsa magazi ku chotupacho umatsekedwa, zomwe zimawononga chotupacho. Uwu ndi mankhwala omwe amagwiritsidwa ntchito makamaka pa NETs m'chiwindi.

Kodi matenda a Carcinoid angapewedwe?

Zoonadi,Palibe njira yopewera matenda a carcinoid chifukwa amagwirizanitsidwa ndi zotupa za neuroendocrine (NETs). Popeza palibe njira yodziwika yopewera kukula kwa ma NET, ​​palibe njira yopewera zizindikiro zomwe zimabwera chifukwa cha iwo.

Komabe, ngati mukudziwa kuti muli ndi NET, kuzindikira zizindikiro za matenda a carcinoid msanga ndikuyamba chithandizo kungachepetse chiopsezo cha mavuto.

Kodi ndimadzisamalira bwanji? / Kodi ndimatha bwanji kuthana ndi zizindikiro?

Ngati muli ndi matenda a carcinoid syndrome, mwina muli ndi chotupa cha neuroendocrine (NET). Chifukwa chake, ngati muli ndi zizindikiro za matenda a carcinoid syndrome, uzani dokotala wanu nthawi yomweyo. Akhoza kuwunika momwe mulili ndikukulangizani mayeso ofunikira kuti aone ngati muli ndi NET.

Zizindikiro zitatu zazikulu za matenda a carcinoid ndi kutuluka magazi m'thupi, kupuma movutikira, komanso kutsegula m'mimba. Nazi zinthu zingapo zomwe mungachite kuti muchepetse izi:

• Kusamba m'manja: Iyi ndi njira yomwe mitsempha yanu imayankhira kupsinjika kwakuthupi kapena kwamaganizo. Kuti muchepetse izi, pumani mpweya wambiri, pukutani nkhope yanu ndi chifuwa chanu ndi nsalu yonyowa, kapena tulukani mpweya wabwino panja. Kupewa mowa kungathandizenso.
• Kupuma movutikira: Ngati mukupuma movutikira, yesani kumwa tiyi wa zitsamba kapena kugwiritsa ntchito inhaler kapena vaporizer . Ngati mukusuta, yesani kusiya. Kusuta kungapangitse kuti njira zanu zopumira ziwonjezeke.
• Kutsegula m'mimba: Ngati kutsegula m'mimba kuli vuto kwa inu, lankhulani ndi dokotala wanu za njira zochepetsera kufalikira kwake komanso kuopsa kwake. Pali mankhwala apadera omwe amapangidwira kuchepetsa kutsekula m'mimba komwe kumachitika chifukwa cha matenda a carcinoid. Komanso, zakudya zamafuta, zokometsera, ndi zakudya za mkaka zingapangitse vutoli kukhala loipa kwa anthu ena. Choncho samalani ndi zomwe mumadya.

Ndiyenera kupita liti kwa dokotala? / Ndiyenera kupita liti ku chipinda chadzidzidzi?

Ngati zizindikiro zanu za matenda a carcinoid zikuipiraipira, onetsetsani kuti mwaonana ndi dokotala. Ngati mukulandira chithandizo cha NET, uzani dokotala wanu ngati muwona kusintha kulikonse kwatsopano m'thupi lanu komwe kungamveke ngati zizindikiro za NET. Kusintha kumeneku sikungakhale kogwirizana ndi matenda anu a NET, koma njira yabwino yodziwira bwino ndikulankhula ndi dokotala wanu. Komanso, ngati zizindikiro zanu kapena zotsatirapo zake zikuipiraipira, uzani dokotala wanu.

Nthawi yoti mupite ku Emergency Treatment Unit (ETU)

Ngati matenda a carcinoid sachiritsidwa, zizindikiro zake zimatha kukulirakulira pakapita nthawi ndikukhala vuto lomwe lingayambitse imfa lotchedwa 'carcinoid crisis'. Choncho, pitani kuchipatala mwamsanga ngati muli ndi:

• Ngati muli ndi kugunda kwa mtima kapena kupweteka pachifuwa.
• Ngati muli ndi kutsegula m'mimba kwambiri kwa masiku angapo.
• Ngati muli ndi ululu waukulu m'mimba.
• Ngati mukumva kufooka.
• Ngati mwatuluka thukuta kwambiri pankhope, pakhosi, ndi pachifuwa mwadzidzidzi (thukuta thukuta kwambiri).

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga?

Matenda a carcinoid akhoza kukhala chizindikiro chakuti muli ndi chotupa cha neuroendocrine (NET). Chifukwa chake ngati muli ndi mafunso okhudza matenda a carcinoid, mungakhale ndi mafunso ambiri okhudza ma NET. Nazi mafunso ena omwe mungafunse dokotala wanu:

• Ngati ndili ndi matenda a carcinoid, ndingadziwe bwanji ngati ndili ndi chotupa cha neuroendocrine?
• Ngati ndili ndi chotupa, chili kuti m'thupi langa?
• Kodi mankhwala a chotupa changa ndi otani?
• Kodi zotsatirapo zake ndi ziti?
• Kodi chotupa cha neuroendocrine chomwe chinayambitsa matenda anga a carcinoid chingachiritsidwe kwathunthu?
• Kodi matenda a carcinoid angabwererenso pambuyo poti chotupa changa cha neuroendocrine chachiritsidwa?

Uthenga Womaliza Wopita Nawo Kunyumba

Matenda a Carcinoid ndi matenda osowa omwe angachitike mwa munthu amene ali ndi chotupa cha neuroendocrine (NET). Nthawi zambiri, anthu omwe ali ndi matenda a carcinoid amadziwa kale kuti ali ndi NET. Nthawi zina, anthu amayamba kudziwa kuti ali ndi NET atapezeka ndi matenda a carcinoid.

Chabwino kwambiri ndichakuti ma NET amatha kuchiritsidwa. Kudziwa kuti muli ndi matenda a carcinoid ndi sitepe yoyamba yodziwira ngati muli ndi khansa, ndipo ngati ndi choncho, momwe mungachiritsire. Chifukwa chake, ngati mwapezeka ndi matenda a carcinoid, musaope kulankhula ndi dokotala wanu ndikufunsani njira zotsatirazi kuti mutsimikizire ngati muli ndi ma NET. Chofunika kwambiri ndikupeza matendawa ndi kuchiritsidwa msanga.

Kumbukirani kuti simuli nokha. Mu mkhalidwe ngati uwu, ndikofunikira kwambiri kutsatira upangiri wa dokotala ndikupempha thandizo kwa banja lanu.

Matenda a Carcinoid, zotupa za neuroendocrine, NETs, ​​serotonin, zizindikiro, khansa, mahomoni