Tiyeni tiphunzire za mtundu watsopano wa mankhwala omwe amaletsa magazi kuundana? (Direct Thrombin Inhibitors)

Kodi mukudziwa kuti magazi omwe amayenda m'mitsempha yanu nthawi zina amatha kuuma mosafunikira? Ngati magazi oundana oterewa apita ku ubongo, angayambitse sitiroko, ndipo ngati apita kumtima, angayambitse matenda a mtima. Kotero lero tikambirana za mtundu wapadera wa mankhwala omwe madokotala amagwiritsa ntchito popewa matenda oopsa awa. Izi zimatchedwa Direct Thrombin Inhibitors.

Mwachidule, kodi ma Direct Thrombin Inhibitors awa ndi chiyani?

Izi ndi gulu la mankhwala omwe amaletsa magazi kuundana. Ndi omwe nthawi zambiri timawatcha "mankhwala ochepetsa magazi." Koma momwe amagwirira ntchito ndi osiyana pang'ono. Lingaliro lopangira mankhwalawa limachokera ku puloteni yomwe imapezeka m'malovu a mimbulu. Mwina munamvapo kuti mimbulu imagwiritsidwanso ntchito pochiza matenda m'mbuyomu.

Anthu ambiri padziko lonse lapansi amafa ndi matenda a mtima. Chifukwa chachikulu cha zimenezi ndi magazi kuundana. Choncho madokotala amapereka mankhwala ngati amenewa kuti apulumutse anthu ku chiopsezochi.

Kodi mankhwalawa amagwiritsidwa ntchito pa matenda otani?

Mankhwala a gulu ili, otchedwa direct thrombin inhibitors, nthawi zambiri amagwiritsidwa ntchito popewa kapena kuchiza magazi kuundana chifukwa cha matenda osiyanasiyana. Tiyeni tiwone zomwe zili.

Kuphatikiza apo, mutha kupatsidwa mankhwalawa panthawi ya chithandizo monga angioplasty, chomwe chimatsegula mitsempha ya mtima.

Ndi mankhwala ati omwe ali m'gulu ili?

Pali mitundu ingapo ya mankhwala oletsa thrombin omwe amagwiritsidwa ntchito kwambiri ku Sri Lanka ndi padziko lonse lapansi.

• Argatroban (iyi imaperekedwa ngati jakisoni wa IV)
• Bivalirudin (iyi imaperekedwanso ngati jakisoni wa mtsempha - jakisoni wa mtsempha)
• Dabigatran (ichi ndi chomwe mumamwa ngati piritsi)

Kodi mankhwalawa amagwira ntchito bwanji m'thupi?

Zosavuta kwambiri. Monga momwe dzinalo likusonyezera, mankhwalawa amapita mwachindunji ku enzyme yotchedwa Thrombin ndikuyimitsa ntchito.

Tsopano mwina mukufunsa kuti Thrombin iyi ndi chiyani. Mwachidule, Thrombin ndi chinthu chofunikira kwambiri pakupanga magazi m'thupi lathu. Zili ngati wophika wamkulu akukonza chakudya. Chomwe mankhwalawa amachita ndikusunga wophika pambali. Kenako njira yopangira magazi siichitika bwino. Kotero kupanga magazi osafunikira kumasiya. Kodi mukumvetsa?

Koma nthawi zina mankhwalawa angayambitse magazi ambiri. Pali jakisoni wapadera womwe ungasinthe zotsatira za piritsi la Dabigatran. Amatchedwa `Idarucizumab`. Komabe, palibe mankhwala apadera otere a mankhwala operekedwa kudzera m'mitsempha. Komabe, mankhwalawo akangoyimitsidwa, zotsatira zake zimatha m'thupi pakapita nthawi.

Ndiyenera kumwa mankhwalawa kwa nthawi yayitali bwanji?

Zimasiyana malinga ndi munthu. Anthu ena amangofunika kumwa mankhwalawa kwa kanthawi kochepa, monga mwezi umodzi pambuyo pa opaleshoni yobwezeretsa chiuno. Koma munthu amene ali pachiwopsezo chachikulu cha magazi kuundana angafunike kumwa mankhwalawa kwa moyo wake wonse . Dokotala wanu adzasankha chomwe angachite.

Kodi ubwino wa mankhwala amtunduwu ndi wotani?

Mankhwala atsopanowa ali ndi ubwino wambiri poyerekeza ndi mankhwala akale.

• Zotsatira zake ndi zofanana: Popeza izi zimakhudza Thrombin mwachindunji, mutha kuyembekezera zotsatira zomwezo kuchokera ku mlingo womwewo nthawi iliyonse.
• Palibe kuchepa kwa ma platelet: Mosiyana ndi mankhwala ena akale, awa sachepetsa kuchuluka kwa ma platelet, omwe amathandiza magazi kuundana.
• Simukuyenera kuyezetsa magazi anu pafupipafupi: Mankhwala ena, monga Warfarin, amafunika kuyezetsa magazi nthawi zonse kuti aone momwe magazi anu akutsekerera msanga. Koma mankhwalawa safuna zimenezo.
• Zotsatirapo zochepa: Dabigatran, yomwe imatengedwa ngati piritsi, ili ndi chiopsezo chochepa cha kutuluka magazi komanso kuyanjana ndi mankhwala ena poyerekeza ndi Warfarin.
• Kugwiritsa ntchito kosavuta: N'kosavuta kugwiritsa ntchito chifukwa mumangofunika kumwa piritsi kamodzi kapena kawiri patsiku.
• Njira ina: Izi ndi njira yabwino kwa iwo omwe sangagwiritse ntchito mankhwala monga Heparin.

Kodi mankhwalawa ndi othandiza bwanji? Ndipo zoopsa zake ndi ziti?

Kafukufuku wapeza kuti mankhwalawa ndi otetezeka komanso ogwira ntchito ngati Warfarin kapena Heparin. Komabe, si oyenera anthu omwe ali ndi matenda enaake a mtima.

Kodi izi zikutanthauza chiyani? Simungathe kuphonya tsiku limodzi lomwa mankhwalawa. Ngati simunamwe tsiku limodzi lomwa mankhwalawa, chiopsezo chanu chokhala ndi magazi oundana chimawonjezeka kwambiri.

Zotsatirapo zomwe zingatheke

Monga mankhwala ena aliwonse, mankhwalawa akhoza kukhala ndi zotsatirapo zina, zomwe zingakhale zoopsa.

Ndiyenera kupita kwa dokotala liti?

Ngati mukukumana ndi zotsatirapo zilizonse mukamagwiritsa ntchito mankhwalawa, dziwitsani dokotala wanu nthawi yomweyo.

Makamaka, ngati mukutuluka magazi ambiri (monga ngati simungathe kuletsa kutuluka magazi kuchokera pabala, ngati muli ndi magazi m'chimbudzi chanu, ngati muli ndi mphuno yomwe ikupangitsani kukhala ndi vuto la kugwedezeka kwa mutu) kapena ngati muli ndi zizindikiro zina zazikulu (kupweteka pachifuwa, kuvutika kupuma), pitani ku chipatala chapafupi cha Emergency Department (ETU) mwamsanga.

Pomaliza, palibe chifukwa choopa kuti magazi angaundane. Mankhwala amakono monga oletsa magazi mwachindunji amatha kuwongolera zoopsazo kwambiri. Koma dokotala wanu adzasankha mankhwala omwe ali abwino kwa inu komanso nthawi yomwe muyenera kumwa. Choncho nthawi zonse tsatirani malangizo a dokotala wanu.