Kodi muli ndi vuto ndi mitsempha yanu yamagazi? Tiyeni tikambirane za GPA (Granulomatosis yokhala ndi Polyangiitis)!

Kodi nthawi zina mumamva ngati thupi lanu ndi lolemera kwambiri, mumakhala ndi ululu m'malo ena popanda chifukwa, kapena nthawi zonse mumamva ngati muli ndi chimfine, koma sichili ngati chimfine wamba? Nthawi zina, kumbuyo kwa zinthu izi, pakhoza kukhala matenda omwe sitimva zambiri za iwo, koma ndikofunikira kudziwa. Imeneyo ndi imodzi mwa matenda otchedwa GPA.

Kodi GPA (Granulomatosis yokhala ndi Polyangiitis) ndi chiyani? Tiyeni timvetse mosavuta!

Chabwino, tsopano tiyeni tiwone kuti GPA iyi (Granulomatosis yokhala ndi Polyangiitis) ndi chiyani. Musadandaule, ndifotokoza mwachidule. Kale inkatchedwa `(Wegener's Granulomatosis)`. Koma dzina lakuti `(Granulomatosis yokhala ndi Polyangiitis)` lomwe likugwiritsidwa ntchito tsopano likunena zambiri za matendawa.

Mwachidule, GPA ndi kutupa kapena kutupa kwa mitsempha yanu yamagazi. Madokotala amatcha izi "vasculitis." Taganizirani izi motere: mitsempha yamagazi m'thupi lathu lonse ili ngati mapaipi amadzi. Ngati china chake chalakwika ndi mapaipi awa, kuyenda kwa magazi kumasokonezeka, eti? Ndicho chimene chikuchitika apa.

Tsopano pali zinthu zina ziwiri zapadera zokhudza GPA iyi:

• Polyangiitis: Izi zikutanthauza kuti kutupa kumachitika m'mitsempha yosiyanasiyana yamagazi m'thupi lanu, makamaka yaying'ono . Sikuti kumangokhala m'dera limodzi lokha.
• Granulomatosis: Mawu awa angamveke ngati ovuta, koma amangotanthauza kuti tinthu tating'onoting'ono totupa totchedwa granulomas timapangika m'mitsempha yamagazi ndi ziwalo zina. Tinthu tating'onoting'onoti tingawononge mitsempha yamagazi ndi ziwalo zanu.

Kotero, pali mitundu yambiri ya vuto la "vasculitis" ili, koma mtundu wotchedwa GPA umakhudza makamaka mitsempha yamagazi yaying'ono kwambiri m'thupi lathu. Chifukwa mitsempha yamagazi yaying'ono iyi ili m'thupi lonse, GPA ingayambitse mavuto m'malo ambiri a thupi, makamaka ziwalo zomwe zili ndi mitsempha yamagazi yaying'ono yambiri. Nthawi zambiri, imakhudza dongosolo lanu lopumira (dongosolo lopumira) ndi impso.

Kutupa kumeneku kwa mitsempha yamagazi kungayambitse kutupa, kuphulika, komanso kutuluka magazi. Komanso, mitsempha yamagazi imatha kuchepetsedwa chifukwa cha zipsera. Nanga chimachitika ndi chiyani? Minofu yathu silandira mpweya ndi michere yomwe imafunika. Nthawi zina, GPA ingayambitse matenda otchedwa ``pulmonary-renal syndrome``, momwe magazi amatuluka kuchokera ku impso ndi mapapo.

Ndi zizindikiro ziti zomwe zimachitika pamene GPA ikukula?

Tsopano mwina mukuganiza kuti, 'Chabwino, ngati iyi ndi matenda ngati awa, tingawazindikire bwanji? Kodi zizindikiro zake ndi ziti?' Tiyeni tikambirane za zimenezo.

Monga tanenera kale, GPA nthawi zambiri imakhudza dongosolo la kupuma ndi impso. Komabe, imathanso kukhudza ziwalo zina zambiri ndi minofu, komanso thanzi lanu lonse. Izi zili choncho chifukwa imakhudza mitsempha yamagazi yaying'ono m'thupi lonse.

Nthawi zina, kupweteka kwa minofu ndi kupweteka kwa mafupa (arthritis) kungayambitsidwe ndi vasculitis m'maselo olumikizana.Pamodzi ndi zinthu ngati izi, mungamve ngati muli ndi vuto la kugona . Komanso, kutopa kosalekeza, kusowa chilakolako cha chakudya, ndi kuchepa thupi ndi zizindikiro zofala.

Zizindikiro za dongosolo la kupuma

Anthu ambiri amayamba kuganiza kuti ali ndi GPA ndipo amafuna chithandizo chifukwa cha zizindikiro za kupuma. Poyamba, zizindikirozi zingafanane ndi chimfine, chimfine, kapena chimfine. Komabe, nthawi zambiri zimakhala nthawi yayitali kuposa masiku onse. Yang'anani ngati muli ndi izi:

• Mutu waukulu kapena kupanikizika m'dera la sinus.
• Matenda a sinus amapezeka nthawi zambiri.
• Mphuno imakhala yotuluka madzi nthawi zonse, ndipo mphuno zake zimakhala ndi matuza.
• Mphuno yanga ikumva kutsekeka.
• Kutuluka magazi m'mphuno pafupipafupi popanda chifukwa.
• Ndili ndi ululu wa khutu.
• Ndikumva kupweteka pachifuwa panga.
• Ndili ndi chifuwa chosatha.
• Kumva kupuma movutikira (ngati chifuwa).

Pamene GPA ikukulirakulira, mutha kuyamba kutupa (polychondritis) kwa minyewa m'makutu, mphuno, ndi pakhosi. Izi zingayambitse zizindikiro zoopsa kwambiri, monga:

• Mphuno imatupa kwambiri moti pamwamba pa mphuno imalowa mkati (izi zimatchedwanso mphuno ya pahatchi).
• Pakhosi, kapena mbali ya pamwamba ya mphuno, imachepa (subglottic stenosis). Izi zingayambitse mawu okweza komanso phokoso la mluzu popuma (kupuma movutikira kapena stridor).
• Kutupa kwa khutu lamkati kungayambitse chizungulire (vertigo) ndi kutayika kwa kumva.

Komanso, mwina mukutuluka magazi m'mapapo mwanu. Ngati izi zitachitika, mungakhale ndi vuto lopuma kapena kutsokomola magazi .

Zizindikiro zokhudzana ndi impso

Simungamve kupweteka kulikonse mu impso zanu mukakhala ndi GPA. Komabe, mungazindikire kusintha kwa mkodzo wanu. Mwachitsanzo, mkodzo wokhala ndi thovu kapena magazi mu mkodzo wanu. Komanso, kutupa kwa nkhope kapena miyendo (edema) ndi chizindikiro china cha matenda a impso.

Ngati muli ndi GPA, madokotala adzayang'ana impso zanu nthawi zonse, ngakhale mutakhala kuti simunakhale ndi zizindikiro. Izi zili choncho chifukwa GPA siingakhudze impso zanu pachiyambi, koma pakapita nthawi, idzakhudza impso zanu.

Zizindikiro zokhudzana ndi maso

GPA ingakhudzenso maso anu. Ingayambitse kutupa pamwamba kapena mkati mwa diso. Izi zingayambitse kupweteka kwa maso, kupanikizika, kufiira, ndi kutupa . Pa milandu yoopsa, kutayika kwa masomphenya n'kotheka.

Zizindikiro za khungu

Vasculitis pakhungu lanu ingayambitse zizindikiro monga:

• Pamwamba pa khungu pamawoneka ngati mawonekedwe abuluu-ofiira (khungu lokhala ndi madontho).
• Madontho ofiirira, ofiira, kapena abulauni (purpura) amaonekera.
• Ziphuphu zolimba (tiziphuphu) kapena tinthu tating'onoting'ono tonga matuza (tiziphuphu) tingawonekere pakhungu.
• Mabala osachiritsa (zilonda) angachitike.

Zizindikiro za dongosolo lamanjenje

GPA ingakhudzenso dongosolo lanu la mitsempha. Nthawi zambiri, imakhudza dongosolo lanu la mitsempha la m'mphepete mwa msana - mitsempha yomwe imayenda kuchokera ku msana wanu kupita ku ziwalo zina za thupi lanu.

Kutupa ndi kutupa kumatha kuwononga mitsempha imodzi yokha, zomwe zimayambitsa zizindikiro m'dera limodzi (mononeuropathy). Komabe, nthawi zambiri, mitsempha yambiri imakhudzidwa (polyneuropathy). Zizindikiro zake zitha kukhala izi:

• Zizindikiro za kayendedwe ka thupi: Monga kufooka kwa minofu.
• Zizindikiro za kumverera: dzanzi, kumva kuwawa, kapena kupweteka kwa mitsempha.
• Kulephera kugwira ntchito kwa dongosolo la mitsempha lodziyimira palokha, lomwe limayang'anira kuthamanga kwa magazi, kugwira ntchito kwa chikhodzodzo, kapena thukuta.

Kodi ndi mavuto aakulu ati omwe angachitike chifukwa cha GPA?

Ngati GPA siyendetsedwa bwino, nthawi zina imatha kupha anthu komanso kuwononga ziwalo zawo kwambiri. Chifukwa chake ndikofunikira kudziwa izi. Nazi zina mwa zovuta zazikulu zomwe zingachitike:

• Kutuluka magazi m'mapapo: Izi zingayambitse kupuma movutikira komanso kulephera kupuma.
• Kutupa kwa glomerulonephritis komwe kumakula mofulumira: Izi zingayambitse kulephera kwa impso.
• Kutaya kosatha kwa maso kapena kumva.
• Kutaya kumva kwa khungu kapena kulephera kulamulira minofu (peripheral neuropathy).

Kodi n’chiyani chimayambitsa kukula kwa GPA?

Tsopano mwina mukudabwa kuti, 'N’chifukwa chiyani matenda amtunduwu amapezeka?' Kwenikweni, GPA, monga mitundu ina ya `(vasculitis)`, ndi `(matenda a autoimmune`) . Izi zingawoneke zovuta kumvetsetsa, koma ndizifotokoza mwachidule.

Kawirikawiri, chitetezo chathu chamthupi chimakhala ngati chitetezo chathu. Chimalimbana ndi matenda ndi majeremusi poyambitsa kutupa. Komabe, m'matenda odziteteza awa, chitetezo chathu chamthupi chimayamba molakwika kuukira maselo ndi minofu yathu yathanzi. Mu GPA, chitetezo chamthupi chimaukira mitsempha yathu yamagazi.

Kodi ndi zinthu ziti zomwe zimayambitsa GPA?

Ofufuza sakudziwabe chomwe chimayambitsa matenda a autoimmune. Komabe, amakhulupirira kuti pali zinthu zingapo zomwe zimayambitsa matendawa. Nthawi zina, chitetezo chathu chamthupi chimakhudzidwa kwambiri ndi nkhawa, zomwe zingayambitse mavuto amtunduwu. Matenda ena akuluakulu a bakiteriya ndi mavairasiKafukufuku wapezanso kuti GPA imachitika pambuyo pa ...

GPA ndi ya gulu la matenda otchedwa ANCA-associated vasculitis, kapena AAV . Izi ndi mitundu ya vasculitis yomwe imakhudza antibody inayake yotchedwa ANCA. Ofufuza amakhulupirira kuti ANCA iyi imagwira ntchito yofunika kwambiri pakuyambitsa kutupa m'matendawa, kuphatikizapo GPA.

Kodi mumadziwa bwanji ngati muli ndi GPA?

Ngati muli ndi zizindikiro za GPA, dokotala wanu adzakufunsani kaye za zizindikiro zanu ndikukuyesani thupi. Ngati zizindikiro zanu ndi mbiri yanu yachipatala zikusonyeza kuti mwina muli ndi GPA, adzalamula kuti muyesedwe kuti mufufuze zambiri.

Zina mwa mayeso omwe amagwiritsidwa ntchito kudziwa ngati muli ndi GPA ndi awa:

• Kuyezetsa magazi: Izi zimayang'ananso kupezeka kwa ma antibodies a ANCA omwe atchulidwa kale.
• Kusanthula mkodzo: Kufufuza magazi ndi mapuloteni mu mkodzo wanu.
• Kujambula pachifuwa ndi CT scan: Izi zimayang'ana momwe mapapo anu alili.
• Kujambula: Kachidutswa kakang'ono ka minofu kamatengedwa kuchokera m'mapapo, m'mphuno (m'mphuno), kapena m'impso ndikuwunikidwa pogwiritsa ntchito maikulosikopu kuti awone ngati pali matenda enaake otupa.

Kodi mankhwala a GPA (Wegener's Granulomatosis) ndi ati?

Chabwino, tsopano tiyeni tiwone momwe GPA imachizidwira. Madokotala amachizira GPA pogwiritsa ntchito mankhwala omwe amachepetsa kutupa ndikuletsa chitetezo chamthupi (corticosteroids ndi mankhwala ena oletsa chitetezo chamthupi).

Mankhwala ena ndi amphamvu kwambiri kuposa ena. Kuphatikiza kwa mankhwala omwe dokotala wanu amalimbikitsa kumadalira kuopsa kwa vuto lanu komanso chiopsezo chanu cha zotsatirapo zake.

Chithandizo chachikulu cha GPA yogwira ntchito:

• Mlingo waukulu wa corticosteroids (monga prednisone) umaperekedwa. Mlingo uwu umachepetsedwa pang'onopang'ono pakapita nthawi.
• `(Rituximab)`: Iyi ndi mankhwala atsopano achilengedwe. Iyi ndi njira yodziwika bwino yochizira matenda yomwe imagwiritsidwa ntchito kwambiri.
• Cyclophosphamide (pa milandu yoopsa) kapena methotrexate (pa milandu yofatsa): Mankhwalawa amagwiritsidwanso ntchito pochiza khansa. Komabe, akaperekedwa pa GPA (mu mlingo wochepa kwambiri), amagwira ntchito ngati mankhwala oletsa chitetezo chamthupi.
• Avacopan: Mankhwalawa angagwiritsidwe ntchito ngati mankhwala ena ochepetsa mlingo wa corticosteroids.

Ngati muli ndi mavuto aakulu, mungafunike chithandizo china. Mwachitsanzo:

• Dialysis (ngati impso zalephera kugwira ntchito)
• Kusamutsa chiwalo

Mkhalidwe wa GPAAkafika pa gawo la "kuchira" kutanthauza kuti zizindikiro zatha ndipo matendawa atha, mankhwala ofatsa amaperekedwa kuti asunge mkhalidwewo. Izi nthawi zambiri zimaphatikizapo:

• `(Rituximab)`
• Mankhwala ochepetsa mphamvu ya chitetezo chamthupi: Mwachitsanzo, `(azathioprine)`, `(methotrexate)` kapena `(mycophenolate mofetil)`.

Munthawi yonse ya chithandizo chanu, mupitiliza kuyesedwa kuti muwone momwe mukumvera komanso momwe mukumvera mukalandira chithandizo. Dokotala wanu adzasintha mankhwala anu ndi mlingo wanu kutengera momwe mukumvera.

Kumbukirani kuti mankhwala onse akhoza kukhala ndi zotsatirapo zake. Zitha kuchitika nthawi iliyonse panthawi ya chithandizo. Chifukwa chake, kungakhale kofunikira kusintha mankhwala kuti mupewe kapena kuchepetsa zotsatirapo zake. Zisankho zonsezi ziyenera kupangidwa pokambirana ndi dokotala wanu.

Kodi tsogolo la vutoli lidzakhala lotani? (Outlook)

GPA ndi matenda a moyo wonse omwe amafunika chisamaliro cha moyo wonse. Ndi chithandizo, matendawa amatha kuchira ndipo zizindikiro zimatha. Komabe, zizindikiro zimathanso kubwereranso (kubwereranso).

Mungafunike kumwa mankhwala nthawi ndi nthawi m'moyo wanu wonse kuti muchepetse kubwereranso kwa matendawa. Popeza mankhwalawa amaletsa chitetezo chamthupi chanu, muyeneranso kusamala kwambiri kuti mudziteteze ku matenda ena.

Kodi n'zotheka kukhala moyo wabwinobwino ndi GPA?

Ndi chithandizo chogwira mtima, mutha kukhala ndi moyo wabwinobwino ndi GPA. Monga momwe zimakhalira ndi matenda ambiri osatha, pakhoza kukhala nthawi yochira ndikubwereranso. Choncho matenda amatha kukwera ndi kutsika pang'ono.

Kodi munthu amene ali ndi GPA amakhala ndi moyo wotani?

Popanda chithandizo, anthu ambiri amakhala ndi moyo kwa miyezi isanu, ndipo anthu ochepera 50% amakhala ndi moyo kupitirira chaka chimodzi. Komabe, ndi chithandizo, kafukufuku wotsatira akuwonetsa kuti anthu opitilira 80% amakhalabe ndi moyo patatha zaka zisanu ndi zitatu . Kotero mutha kuwona kufunika kolandira chithandizo, eti?

Kodi chifukwa chachikulu cha imfa mu GPA ndi chiyani?

Musanayambe kulandira chithandizo, kulephera kwa ziwalo ndiye chiopsezo chachikulu cha imfa mu GPA. Pa nthawi ya chithandizo, chitetezo cha mthupi chanu chikafooka, mumakhala pachiwopsezo chachikulu cha matenda omwe angawononge moyo .

Kodi ndiyenera kudzisamalira bwanji ndikukhala ndi GPA?

Mukakhala ndi matenda osatha a autoimmune monga GPA, ndikofunikira kudziwa bwino za thupi lanu. Ngakhale mutakhala ndi thanzi labwino, muyenera kukhala otetezeka.

Chitanipo kanthu kuti mudziteteze ku matenda ofala pamene mukumwa mankhwala oletsa chitetezo chamthupi. Ngati muwona zizindikiro zatsopano kapena zachilendo,Uzani dokotala wanu nthawi yomweyo.

GPA ingakukhudzeni m'njira zambiri, zina zomwe zimakhala zoopsa pa moyo. Kuzindikira kuti pali vuto ndikupeza chithandizo msanga kungapangitse kusiyana kwakukulu.

Anthu ambiri amatha kukhala opanda zizindikiro, kwa kanthawi, akalandira chithandizo. Koma gulu lanu lachipatala lidzapitiriza kuyang'anira vuto lanu. Iwo adzakhala othandizana nanu moyo wanu wonse pakusunga thanzi lanu.

Zinthu zofunika kwambiri zomwe muyenera kukumbukira kuchokera munkhaniyi (Uthenga Wopita Nawo Kunyumba)

Chabwino, ndiloleni ndifotokoze mwachidule zina mwa zinthu zomwe muyenera kukumbukira kuchokera pa zomwe takambirana:

• GPA (Granulomatosis yokhala ndi Polyangiitis) ndi matenda omwe amayambitsa chitetezo chamthupi chomwe chimakhudza mitsempha yamagazi, makamaka mitsempha yaying'ono yamagazi. Kawirikawiri imakhudza dongosolo la kupuma ndi impso.
• Zizindikiro zimasiyana. Zizindikiro zake zingakhale monga zizindikiro zofala monga chimfine, kupuma movutikira, kutuluka magazi m'mphuno, ziphuphu pakhungu, kupweteka kwa mafupa, mavuto a maso, ndi kusintha kwa mkodzo.
• Imeneyi ikhoza kukhala vuto lalikulu, choncho ndikofunikira kwambiri kupeza upangiri wa dokotala mwachangu ngati muli ndi zizindikiro.
• Pali mankhwala othandiza. Mankhwalawa amatha kuletsa matendawa ndikupangitsa kuti asamavutike.
• Uwu ndi vuto lomwe limakhalapo kwa moyo wonse, kotero muyenera kupitiriza kuyang'aniridwa ndi dokotala, kugwiritsa ntchito mankhwala oyenera, komanso kusamalira thupi lanu.
• Musadandaule! Ndi chidziwitso ndi upangiri woyenera wachipatala, mutha kukhala ndi moyo wabwino ndi vutoli. Simuli nokha, ndipo pali madokotala oti akuthandizeni.

GPA , Granulomatosis yokhala ndi Polyangiitis, Granulomatosis ya Wegener, Vasculitis, Kutupa kwa Mitsempha ya Magazi, Matenda a Autoimmune, Matenda a Impso, Matenda a Kupuma