Kodi inunso mwadzidzidzi mumamva kudwala? Kodi matenda amenewa omwe amabwera popanda chifukwa ndi ati? (Mast Cell Activation Syndrome)

Kodi nthawi zina mumamva kudwala kwambiri mwadzidzidzi? Zili ngati kukhala ndi vuto lalikulu la ziwengo. Mwina thupi lanu lonse limasanduka lofiira, kuyabwa, kutupa, kupweteka m'mimba, kusanza, kapena kuvutika kupuma. Koma zinthuzi sizichitika chifukwa choti mwadya chinachake kapena kukhudza china chake. Ngati zinthuzi zitachitika popanda chifukwa chomveka, zitha kukhala vuto lotchedwa `Mast Cell Activation Syndrome (MCAS).` Tiyeni tikambirane za izi mwatsatanetsatane lero.

Kodi ``Mast Cell Activation Syndrome (MCAS)'' ndi chiyani?

Mwachidule, MCAS ndi vuto lomwe mtundu wa selo m'thupi lathu lotchedwa ``mast cells'' limakhala lochita zinthu mopitirira muyeso popanda chifukwa chomveka bwino, zomwe zimapangitsa zizindikiro zoopsa. Tsopano mwina mukuganiza kuti, "Ndicho chimene chimayambitsa ziwengo." Inde, ziwengo zimaphatikizaponso kuyambitsa ``mast cells.'' Koma ziwengo nthawi zambiri zimakhala ndi chifukwa chomveka bwino . Mwachitsanzo, anthu ena amakhala ndi ziwengo ku shrimp, mtedza, kapena fumbi. Koma mu MCAS, zimakhala zovuta kupeza chifukwa chenicheni. Zizindikirozi zimawonekera mwadzidzidzi.

Nthawi zina, kuyambika kwa mast cells amenewa kungayambitse vuto lalikulu la ziwengo lomwe limaika moyo pachiswe lotchedwa anaphylaxis. Izi zingayambitse kupuma movutikira komanso kutsika kwa kuthamanga kwa magazi. Ngati mukukumana ndi vuto lalikulu la anaphylaxis, muyenera kuyimba 911 kapena kupita ku chipinda chapafupi chadzidzidzi nthawi yomweyo.

Maselo a mast ali ngati asilikali omwe ali mu chitetezo chathu chamthupi. Amathandiza kulimbana ndi matenda. Chifukwa chake, ndikwachibadwa kuchita mantha mukakhala ndi zizindikiro izi zomwe simukuzidziwa. Koma ndikwachibadwa kuti maselo a mast ayambe kugwira ntchito. Mwachitsanzo, maselo a mast amayamba kugwira ntchito m'mikhalidwe monga chifuwa cha rhinitis, mphumu, anaphylaxis ku mankhwala kapena zakudya, komanso mastocytosis. Izi ndi zomwe zimatipangitsa kukhala ndi zizindikiro zokhumudwitsa, nthawi zina zoopsa.

Komabe, ``Mast Cell Activation Syndrome (MCAS)`` ndi vuto losowa kwambiri . Madokotala amazindikira MCAS ngati pali zinthu zotsatirazi:

• Ngati muli ndi zizindikiro zobwerezabwereza zomwe mukuganiza kuti zingakhale anaphylaxis popanda chifukwa chomveka.
• Ngati zizindikirozi zimakhudza ziwalo zambiri za thupi lanu nthawi imodzi (monga khungu ndi matumbo).
• Ngati mayeso akusonyeza umboni wa mast cells omwe akuyatsidwa.
• Ngati zizindikiro zanu zachepa ndi mankhwala omwe amakhudza maselo a mast.

Maselo a Mast ndi Ntchito Yawo

Maselo a m'mimba ndi maselo a chitetezo chamthupi chathu.Gawo. Ntchito yawo yanthawi zonse ndikuteteza matupi athu ku tizilombo toyambitsa matenda (monga tizilombo toyambitsa matenda, mavairasi) kapena zinthu zina zovulaza zomwe zimalowa m'thupi mwathu. Maselo amenewa amakhala m'thupi mwathu, ndipo akaona chinthu chomwe akuganiza kuti ndi choopsa, amatulutsa mankhwala monga histamine, omwe amachititsa chitetezo cha mthupi kugwira ntchito ndikuyesera kulimbana ndi wolowa m'thupi.

Nthawi zina, amachita zinthu zomwe sayenera kuchita. Pamenepo ndi pamene timapeza ziwengo . Koma ziwengo nthawi zambiri zimayambitsa zizindikiro zazing'ono monga kuyabwa m'maso ndi mphuno yotuluka madzi. Chomwe chimachitika mu MCAS ndikuti pali zizindikiro zoopsa kwambiri popanda chifukwa chomveka.

Kodi vuto la ``Mast Cell Activation Syndrome (MCAS)'' ndi lalikulu bwanji?

Kuopsa kwa MCAS kumadalira zizindikiro zomwe mumakumana nazo. Anthu ena akhoza kukhala ndi zizindikiro zochepa, koma amakhala ndi zizindikiro za pakhungu zokha. Ena akhoza kukhala ndi matenda oopsa kwambiri, monga anaphylaxis. Anaphylaxis ikhoza kupha ngati sichithandizidwe bwino. Komabe, zotsatira zoopsa ku MCAS zimakhala zochepa kwambiri .

Kodi zizindikiro za `Mast Cell Activation Syndrome (MCAS)` ndi ziti?

MCAS ingayambitse zizindikiro zoopsa komanso zobwerezabwereza m'mbali zosiyanasiyana za thupi lanu. Zizindikiro izi zingaphatikizepo:

• Kuthamanga kwa magazi pang'ono.
• Khungu limakhala lofiira, lofiirira, komanso lofunda (`Flushing`).
• Khungu loyabwa.
• Kutsekeka kwa mphuno.
• Kutupa - makamaka nkhope, milomo, maso, lilime kapena pakhosi (`Angioedema`).
• Kudzimbidwa kapena kutsegula m'mimba (mwina kusinthana pakati pa ziwirizi).
• Kupweteka m'mimba.
• Kuvuta kupuma.
• Kufooka kapena kukomoka.
• Kulephera kukumbukira kapena kuganiza movutikira (chifunga cha ubongo).
• Kusamva bwino.
• Kupweteka kwa mafupa.
• Anaphylaxis (kutupa kwambiri komwe kumachitika chifukwa cha chimodzi kapena zingapo mwa zizindikiro zomwe zili pamwambapa).

Kuti muganize kuti pali MCAS, zizindikirozi ziyenera kukhudza ziwalo ziwiri kapena zingapo za thupi lanu. Izi ndi izi:

• Matenda a mitsempha (ubongo ndi mitsempha).
• Mapumulo (mapapo ndi njira zopumira).
• Matenda a mtima (mtima ndi mitsempha yamagazi).
• Chimbudzi (m'mimba ndi m'matumbo).

Kodi zimamveka bwanji pamene maselo a mast ayamba kugwira ntchito mwadzidzidzi?

Ngati munakhalapo ndi vuto la ziwengo, mwina mukudziwa momwe zimakhalira maselo a mast akayamba kugwira ntchito. Koma kwa anthu omwe ali ndi MCAS, vutoli ndi lalikulu kuposa vuto la ziwengo wamba, ndipo limakhudza ziwalo zingapo za thupi. Khungu lanu likhoza kutupa, kufiira, kuyamba kuyabwa, kapena kutuluka magazi. Mungakhale ndi kutsegula m'mimba ndi kusanza. Pa milandu yoopsa, nkhope ndi pakhosi panu zimatha kutupa, ndipo kuthamanga kwa magazi kungachepe. Kumbukirani, ngati mukukumana ndi zizindikiro zoopsazi, muyenera kuyimba 911 kapena kupita kuchipatala chapafupi nthawi yomweyo.

Kodi zifukwa za `Mast Cell Activation Syndrome (MCAS)` ndi ziti?

MCAS imayamba chifukwa cha maselo anu a mast omwe amachitapo kanthu pamene sakuyenera. Maselo a mast amaganiza kuti pali chinthu choopsa chomwe chalowa m'thupi ndipo chiyenera kutetezedwa. Pamenepo ndi pomwe amamasula mapuloteni omwe amayambitsa zizindikiro. Mu ziwengo, titha kudziwa chomwe chikuchititsa thupi kuchita mopitirira muyeso. Koma mu MCAS, n'zovuta kupeza chifukwa chomveka bwino chomwe maselo a mast amatulutsira mapuloteni awa.

Ndipotu, palibe amene akudziwabe chifukwa chake maselo a mast amakhala okhudzidwa kwambiri ndi zinthu zosafunikira.

Kodi ndi zifukwa ziti zomwe zingayambitse kuyambitsa mast cell?

Ngakhale zinthu zambiri, monga zakudya ndi mungu, zimatha kuyambitsa mast cells ndikutulutsa histamine, sizingatheke kunena kuti zizindikiro zazikulu za MCAS zimayambitsidwa ndi allergen inayake. Komabe, mutha kupeza kuti zizindikirozi zimakhala zoopsa kwambiri pakakhala kusintha kwa moyo wanu kapena malo anu, mwachitsanzo, panthawi yamavuto akulu kapena nyengo ikasintha. Ngati zizindikiro zanu zimachitika pokhapokha mutakumana ndi chinthu china, uzani dokotala wanu. Pankhaniyi, mwina simungakhale ndi MCAS, koma muli ndi allergy.

Kodi matenda a Mast Cell Activation Syndrome (MCAS) amawapeza bwanji?

Dokotala angaganize kuti muli ndi MCAS atakufufuzani, akufotokoza za zizindikiro zanu, komanso mbiri yanu yachipatala. Madokotala adzakudziwitsani kuti muli ndi MCAS ngati zinthu zotsatirazi zakwaniritsidwa:

• Ngati muli ndi zizindikiro za kuyambitsa mast cell.
• Ngati muyankha bwino mankhwala ochizira mast cell.
• Ngati mayeso akuwonetsa zizindikiro za kuyambika kwa mast cell.
• Ngati muli ndi chiwerengero chabwinobwino cha maselo a mast m'thupi lanu (kukhala ndi maselo a mast ambiri kumatanthauza kuti mungakhale ndi vuto lina la maselo a mast, monga mastocytosis).

Kuyesa kwa MCAS

Kuti muone ngati muli ndi MCAS, dokotala wanu angachite mayeso a magazi kuti aone ngati pali mankhwala otchedwa ``tryptase'' m'magazi mwanu. ``tryptase'' ndi chinthu chomwe chimawonjezeka pamene ``mast cells'' ayambitsidwa. Kuyesaku kuyenera kuchitika kangapo - mukakhala bwino komanso mukakhala ndi zizindikiro zoopsa. Koma kumbukirani kuti ``tryptase'' ikhozanso kukwera m'matenda ena. Chifukwa chake kuchuluka kwa ``tryptase'' kokha sikungadziwe ngati muli ndi MCAS. Anthu ena akhoza kukhala ndi kuchuluka kwa ``tryptase'' kokwera kuposa momwe amayembekezera ngakhale opanda zizindikiro.

Dokotala wanu angachitenso mayeso a khungu a ziwengo kapena magazi a ziwengo kuti aone zifukwa zina.

Chofunika: Ngakhale mayeso a magazi a histamine atasonyeza kuti muli ndi histamine yambiri, madokotala sanena kuti muli ndi MCAS.

Kodi Mast Cell Activation Syndrome (MCAS) imachiritsidwa bwanji?

Madokotala amagwiritsa ntchito mankhwala kuti azindikire MCAS ndikuchepetsa zizindikiro zanu. Ngati simukuchira ndi mankhwala omwe amakhudza maselo a mast, mwina mulibe MCAS.

Malinga ndi zizindikiro zanu, dokotala wanu akhoza kukupatsani mankhwala monga awa:

• Mankhwala oletsa histamine type 1 receptor (Antihistamines) : Awa ndi mankhwala omwe amagwiritsidwa ntchito pochiza zizindikiro za ziwengo. Zitsanzo: Loratadine, Cetirizine, Fexofenadine.
• Mankhwala oletsa histamine type 2 receptor (antihistamines omwe amachepetsa asidi m'mimba) : Mankhwalawa amaperekedwa chifukwa cha nseru ndi kupweteka m'mimba. Zitsanzo: Ranitidine kapena Famotidine.
• Aspirin : Aspirin ingaperekedwe kuti ichepetse kusamba.
• Ma Leukotriene modifiers : Izi zimathandiza kuti kupuma kukhale kosavuta. Zitsanzo: Montelukast, Zafirlukast.
• Omalizumab (XOLAIR®) : Izi zitha kuchepetsa chiopsezo cha anaphylaxis.
• Epinephrine : Madokotala amagwiritsa ntchito epinephrine kuti aletse anaphylaxis. Mungathe kusunga epinephrine injector (EpiPen®, Auvi-Q®) pafupi ngati mutakumana ndi anaphylaxis.
• Mankhwala okhazikika a mast cell : Mankhwala monga cromolyn sodium amaletsa kutulutsidwa kwa mankhwala kuchokera ku mast cell (degranulation).
• Corticosteroids : Izi zimachepetsa kutupa, zimatsegula njira zopumira, komanso zimachepetsa madzi m'thupi. Komabe, chifukwa cha chiopsezo cha zotsatirapo zoyipa, madokotala nthawi zambiri sapereka ma steroids a MCAS.

Kodi Mast Cell Activation Syndrome (MCAS) idzachiritsidwa kotheratu?

Ayi, palibe mankhwala a MCAS. Ngati muli ndi MCAS, muyenera kuigwiritsa ntchito ndi mankhwala.

Kodi munthu amene ali ndi MCAS amakhala ndi moyo wautali bwanji?

Madokotala amayembekezera kuti anthu ambiri omwe ali ndi MCAS adzakhala ndi moyo wautali ngati munthu amene alibe. Koma chifukwa chakuti iyi ndi matenda atsopano omwe apezeka, sitinganene motsimikiza momwe angakhudzire moyo wawo.

Kodi ndimadzisamalira bwanji?

Nazi njira zina zomwe mungadzisamalire nokha ndi MCAS:

• Lembani zizindikiro zanu. Lembani zizindikiro zanu, zomwe mudadya ndi kumwa panthawiyo, komanso zomwe mudakumana nazo. Ganizirani zomwe zinali zosiyana panthawiyi poyerekeza ndi nthawi yomwe simunali ndi zizindikiro. Ngati muwona zizindikiro zilizonse, uzani dokotala wanu.
• Uzani anzanu apamtima, achibale anu, kapena anthu omwe mumakhala nawo nthawi zambiri momwe mungachitire pankhaniyi, komanso komwe kuli jekeseni yanu ya epinephrine kapena mankhwala ena adzidzidzi.

Kodi ndiyenera kupita ku Dipatimenti Yothandiza Anthu Odwala Pangozi (ETU) liti?

Ngakhale kuti zotsatira zoopsa za MCAS sizichitika kawirikawiri, ngati mukumva zizindikiro za vuto lalikulu la ziwengo kapena anaphylaxis, gwiritsani ntchito epinephrine injector ngati muli nayo. Kenako imbani 911 kapena pitani ku chipinda chapafupi chadzidzidzi nthawi yomweyo. Zizindikiro za anaphylaxis ndi izi:

• Kutupa kwa nkhope, milomo, lilime, kapena pakhosi.
• Kuvuta kupuma kapena kumeza.
• Kugunda kwa mtima.
• Kuthamanga kwa magazi pang'ono.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga?

Zingakhale zothandiza kufunsa dokotala wanu mafunso monga awa:

• Ndiyenera kuchita chiyani ngati vutoli likuipiraipira/kuwonjezeka mwadzidzidzi kwa ine?
• Kodi ndiyenera kumwa mankhwala anga bwanji ?
• Kodi ndiyenera kugwiritsa ntchito bwanji komanso liti jakisoni wanga wa epinephrine?
• Kodi ndiyenera kupita ku chipinda chadzidzidzi liti?
• Ndiyenera kubweranso liti kudzakuonaninso?

Kodi ``Kuyambitsa maselo a Mast'' ndi matenda a autoimmune?

Ayi, MCAS si matenda a autoimmune.

Tangoganizirani belu. Asilikali akubwera. "Maselo anu a mast" apeza ngozi ndipo akupempha thandizo. Koma ... palibe ngozi iliyonse. Monga chisewero chovutitsa, "maselo anu a mast" akungolira mabelu ochenjeza popanda kufulumira. M'malo mokutetezani ku matenda, ndi omwe akukudwalitsani.

Ngakhale sitikudziwa chifukwa chake maselo a mast a anthu ena amachita zinthu mopitirira muyeso, pali njira zothanirana ndi MCAS. Dziwani zizindikiro zoyambirira za zomwe zimachitika. Ngati mukumva ngati zizindikiro zanu zikutha, lankhulani ndi dokotala wanu. Chofunika kwambiri ndikukhala ndi epinephrine injector nthawi zonse ndikudziwa momwe mungagwiritsire ntchito komanso nthawi yake. Simungachifunikire, koma kukhala wokonzeka kuchita zinthu mosayembekezereka kungakupatseni mtendere wamumtima.

Zinthu Zomwe Muyenera Kudziwa (Uthenga Wopita Nawo Kunyumba)

• Matenda a Mast cell activation syndrome (MCAS) ndi matenda osowa omwe amayambitsa zizindikiro zoopsa za ziwengo popanda chifukwa chodziwika bwino.
• Izi zingakhudze machitidwe angapo a thupi nthawi imodzi.
• Matenda oopsa monga `Anaphylaxis` angachitike, choncho funsani upangiri wa dokotala nthawi yomweyo ngati zizindikiro zazikulu zachitika.
• Ngakhale kuti MCAS singathe kuchiritsidwa kwathunthu, zizindikiro zake zimatha kuthetsedwa ndi mankhwala.
• Dziwani zizindikiro zanu, sungani jekeseni wa epinephrine pafupi kuti mugwiritse ntchito mwadzidzidzi, ndipo dziwitsani banja lanu za izi.
• Ngati muli ndi mafunso okhudza MCAS, musaope kufunsa dokotala wanu.

Maselo a m'mimba , MCAS, ziwengo, anaphylaxis, histamine, tryptase, chitetezo chamthupi