Kodi mafuta anu a m'mafupa sakugwira ntchito bwino? Tiyeni tikambirane za kupsinjika kwa mitsempha yamagazi!

Kodi mumamvanso ngati simukumva bwino, mukudwala nthawi zonse, kapena mukutuluka magazi ngakhale chifukwa cha bala laling'ono, kaya mukulandira chithandizo cha khansa kapena matenda ena? Kumbuyo kwa zinthuzi, pakhoza kukhala myelosuppression , vuto lomwe mafuta a m'mafupa sagwira ntchito bwino . Musadandaule, tiyeni tikambirane za izi mosavuta.

Kodi myelosuppression ndi chiyani? Kunena zoona, kodi ndi kufooka kwa mafupa?

Mwachidule, inde! Mafupa ndi minofu yofewa, yosalala mkati mwa mafupa anu. Taganizirani ngati fakitale yopanga magazi m'thupi lathu. Fakitale iyi imapanga mabiliyoni ambiri a maselo ofiira amagazi, maselo oyera amagazi, ndi ma platelet, omwe ndi ofunikira kuti tipulumuke, ndipo amawawonjezera m'magazi athu. Mtundu uliwonse wa selo uli ndi ntchito yosiyana ndi thupi lathu. Mafupa amawonjezera kapena kuchepetsa kupanga kumeneku kutengera zosowa za thupi lathu.

Tsopano, mu vuto lotchedwa myelosuppression , ntchito ya fakitale ya mafupa iyi imasokonekera pazifukwa zina. Kenako, maselo amagazi ndi ma platelet sangapangidwe bwino. Chifukwa chachikulu cha izi ndi chithandizo cha chemotherapy cha khansa. Komabe, mitundu ina ya khansa yamagazi ndi mavairasi ena angayambitsenso kulephera kwa mafupa.

Kodi zizindikiro za myelosuppression ndi ziti?

Zizindikiro zimatha kusiyana malinga ndi munthu aliyense, kutengera ngati mafuta anu a m'mafupa amatulutsa maselo ofiira a magazi, maselo oyera a magazi, kapena ma platelet.

Ngati maselo ofiira a magazi achepa - Anemia

Maselo ofiira a m'magazi amanyamula mpweya m'thupi lonse. Maselo ofiira a m'magazi akachepa , magazi m'thupi amayamba kuchepa. Zizindikiro zake ndi izi:

• Kutopa
• Kupuma movutikira / kupuma movutikira
• Chizungulire
• Kugunda kwa mtima mwachangu kapena kosasinthasintha / arrhythmia
• Kumva phokoso la kulira m'makutu, nthawi zina limodzi ndi phokoso la "kugunda" ndi kugunda kwa mtima (Pulsatile tinnitus)
• Mutu
• Kutuwa kwa mtundu wa khungu
• Kupweteka pachifuwa

Neutropenia - kuchepa kwa maselo oyera a m'magazi (makamaka ma neutrophils)

Maselo oyera a m'magazi amalimbana ndi majeremusi omwe amalowa m'thupi mwathu ndipo amatiteteza ku matenda . Mtundu umodzi wa maselo oyera a m'magazi umatchedwa neutrophils . Pamene mafuta a m'mafupa apanga ma neutrophils ochepa chifukwa cha myelosuppression, vutoli limatchedwa neutropenia . Neutropenia ilibe zizindikiro zinazake, koma chifukwa cha iziMatenda obwerezabwereza amatha kuchitika, ndipo nthawi yomweyo zizindikiro zimawonekera.

• Malungo (nthawi zina amatchedwa febrile neutropenia )
• Kutopa
• Kupweteka pakhosi/matenda (Kupweteka pakhosi/pharyngitis)
• Ma lymph nodes otupa
• Zilonda mkamwa kapena mozungulira anus
• Kutsegula m'mimba
• Kupsa mtima mukamakodza, kumva ngati mukufuna kukodza mwachangu, kukodza pafupipafupi

Ngati ma platelet achepa - Thrombocytopenia

Ma platelet amathandiza kuchepetsa kutuluka kwa magazi . Pamene kuchuluka kumeneku kumachepa, matenda otchedwa thrombocytopenia amayamba. Izi zingayambitse:

• Kutuluka magazi komwe kumatenga nthawi yayitali, ngakhale kuchokera pachilonda chaching'ono, kapena kuvutika kuletsa kutuluka magazi m'mphuno.
• Mabala amaonekera mofulumira kuposa masiku onse.
• Kuoneka kwa madontho ofiira ang'onoang'ono (monga ziphuphu) pa miyendo ya m'munsi - izi zimatchedwa petechiae .
• Mawanga ofiira, ofiirira, kapena abulauni pakhungu - izi zimatchedwa purpura .

Ngati mitundu yonse ya maselo a m'magazi yachepa - Pancytopenia

Nthawi zina, maselo onse atatu a m'magazi—maselo ofiira a m'magazi, maselo oyera a m'magazi, ndi ma platelet—akhoza kukhala ochepa nthawi imodzi . Matendawa amatchedwa pancytopenia . Monga neutropenia, uwu si matenda okha, koma ukhoza kukhala chizindikiro cha matenda enaake.

N’chifukwa chiyani myelosuppression imachitika? Kodi zimayambitsa chiyani?

Monga tanenera kale, chemotherapy ndiye chifukwa chofala kwambiri . Komabe, palinso zifukwa zina.

Chemotherapy, immunotherapy, ndi myelosuppression

Mitundu ingapo ya mankhwala a chemotherapy ingayambitse izi. Zina mwa zomwe zimafala kwambiri ndi izi:

• Fluorouracil
• Oxaliplatin
• Irinotecan
• Capecitabine

Kuphatikiza apo, chithandizo cha maselo a CAR T, mtundu wa chithandizo cha immunotherapy , chingasokonezenso ntchito ya m'mafupa ndikuchepetsa kupanga maselo a m'magazi ndi ma platelet.

Khansa ya Magazi ndi Kuponderezedwa kwa Myelosuppression

Khansa zina za m'magazi zimathanso kusokoneza kupanga maselo a m'magazi mwachibadwa. Mwachitsanzo, mu khansa monga khansa ya m'magazi, lymphoma, ndi myeloma , maselo a khansa osazolowereka amakula kwambiri mu fupa la mafupa ndipo amaletsa kupanga maselo athanzi a m'magazi ndi ma platelet.

Mavairasi ndi kuponderezedwa kwa myelosuppression

Matenda ena a mavairasi amathanso kusokoneza njira yopangira magazi m'mafupa. Tangoganizirani kuti kachilombo kakalowa m'thupi, chitetezo cha thupi lathu, makamaka maselo oyera amagazi, chimalimbana ndi kachilomboka. Pankhondoyi, mafuta a m'mafupa amatha kupanga maselo ofiira amagazi ndi ma platelet ochepa. Kafukufuku wina akusonyeza kuti mavairasi ena amalowa mwachindunji m'maselo opanga magazi m'mafupa, zomwe zimachepetsa kuchuluka kwa maselo amagazi. Mavairasi ena omwe apezeka kuti akugwirizana ndi vutoli la myelosuppression ndi awa:

• Kachilombo ka Epstein-Barr (EBV)
• Kachilombo ka Hepatitis C
• Parvovirus B19
• Kachilombo ka Cytomegalovirus (CMV)
• Kachilombo kamene kamayambitsa nthenda ya nkhuku (Chickenpox / varicella zoster)
• Kachilombo ka HIV (Human immunodeficiency virus)
• Malungo a dengue

Kodi kuponderezedwa kwa myelosuppression kungayambitse mavuto aakulu?

Inde, nthawi zina izi zingayambitse mavuto omwe angawononge moyo . Mwachitsanzo, kuchepa mwadzidzidzi kwa maselo ofiira a m'magazi (kuchepa kwa magazi m'thupi) kapena kuchepa kwa ma platelet (kutuluka magazi mosalamulirika) .

Chofunika: Ngati mukukumana ndi zizindikiro izi, makamaka ngati mukulandira chithandizo cha khansa, ndikofunikira kwambiri kufunafuna upangiri wa dokotala nthawi yomweyo.

Kodi madokotala amazindikira bwanji vutoli molondola?

Izi zimazindikirika makamaka kudzera mu mayeso a magazi . Mayeso a magazi awa amafufuza ngati mafuta anu a m'mafupa akupanga maselo a magazi ndi ma platelet mwachizolowezi.

Mayeso a magazi monga awa akhoza kuchitika:

• Kuchuluka kwa magazi (CBC)
• Kuyesa kwa MCV (Kuyesa kwapakati pa corpuscular voliyumu / MCV)
• Mayeso a RDW (Kuchuluka kwa kugawa kwa maselo ofiira / mayeso a RDW)
• Chiwerengero cha ma reticulocyte
• Kupaka magazi m'mbali mwa thupi
• Kuyesa kwa MPV (Kuyesa kwapakati pa kuchuluka kwa ma platelet / MPV)

Kodi njira zochiritsira myelosuppression ndi ziti?

Madokotala amachiza matendawa pogwiritsa ntchito njira izi:

• Ngati chifukwa cha myelosuppression ndi chemotherapy, mlingo wa chemotherapy uyenera kuchepetsedwa kapena kuyimitsidwa kwakanthawi .
• Kuika magazi kuti kuwonjezere kuchuluka kwa maselo ofiira a magazi ndi ma platelet.
• Kukupatsani mankhwala omwe amathandiza mafuta anu a m'mafupa kupanga maselo ambiri a magazi ndi ma platelet.

Kodi vutoli lingalepheretsedwe kuchitika?

Kuchepetsa mitsempha yamagazi nthawi zambiri kumachitika chifukwa cha zotsatira zoyipa za chithandizo cha khansa. Chifukwa chake, madokotala nthawi zonse amakhala akuyang'anitsitsa zotsatira zoyipazi panthawi ya chithandizo cha khansa. Adzayang'ana magazi anu nthawi zonse ndikusintha dongosolo lanu la chithandizo ngati pakufunika kutero.

Kodi ndingayembekezere chiyani ngati ndili ndi myelosuppression?

Anthu ambiri amadwala matendawa chifukwa cholandira mankhwala a chemotherapy. Ngati ndi choncho, dokotala wanu adzayang'anira momwe mankhwala a chemotherapy akukhudzira mafupa anu. Mungafunike kupuma pang'ono kuchokera ku chithandizo cha khansa kuti mafupa anu abwererenso kuchuluka kwa maselo a m'magazi.

Kodi ndimadzisamalira bwanji?

Kuchepetsa myelosuppression kungakulitse chiopsezo chanu chotenga matenda ndi kutuluka magazi . Mutha kuchita izi kuti muchepetse chiopsezochi:

• Pezani katemera woteteza ku mavairasi ofala.
• Kuchita zinthu zaukhondo , monga kusamba m'manja pafupipafupi komanso kupewa anthu odwala.
• Dzitetezeni ku zinthu zomwe zingakupwetekeni kapena kukudulani . Mwachitsanzo, samalani mukamagwiritsa ntchito zida zakuthwa.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga?

Mungathe kufunsa dokotala mafunso monga:

• N’chifukwa chiyani ndili ndi vuto la myelosuppression?
• Kodi vutoli limakhudza bwanji thupi langa?
• Kodi ndi njira ziti zochiritsira zomwe ndili nazo?
• Kodi chithandizo chidzathetsa vuto langa la myelosuppression?

Chidule: Zoyenera kukumbukira (Uthenga Wopita Nawo Kunyumba)

Mafupa anu ndi gawo lofunika kwambiri m'thupi lanu. Maselo ofiira a m'magazi omwe amanyamula mpweya, maselo oyera a m'magazi omwe amalimbana ndi matenda, ma platelet omwe amathandiza magazi kuundana - zonsezi zimapangidwa pamenepo. Kuchepetsa kwa myelosuppression kumachitika pamene mafupa anu amasiya kugwira ntchito pazifukwa zina. Choyambitsa chachikulu ndi chemotherapy ya khansa, koma ikhozanso kuyambitsidwa ndi khansa zina za m'magazi ndi mavairasi. Musadandaule. Madokotala adzapeza chomwe chimayambitsa ndikuchichiza moyenera. Chofunika kwambiri ndikupita kuchipatala ngati muli ndi zizindikiro zachilendo ndikutsatira malangizo awo mosamala. Simuli nokha, ndipo pali madokotala omwe angakuthandizeni paulendowu.

Kuchepetsa Myelosuppression , Kuchepetsa Mafupa, Mafupa, Maselo Ofiira a Magazi, Maselo Oyera a Magazi, Mapulateleti, Chemotherapy, Khansa, Kuchepa kwa Magazi, Neutropenia, Thrombocytopenia, Matenda