Tiyeni tiphunzire bwino za matenda achilendo omwe amatsagana ndi khansa (Paraneoplastic Syndromes)!

Kodi mudamvapo za munthu amene ali ndi khansa akukumana ndi zizindikiro zomwe sizili chifukwa cha khansa yokha, koma zimayambitsidwa ndi matenda ena? Zili ngati khansa ili m'thupi limodzi, koma zotsatira zake zikufalikira ku ziwalo zina. Ndicho chimene timachitcha (Paraneoplastic Syndromes) . Izi zingamveke zovuta pang'ono, koma tiyeni tikambirane zomwe zikuchitika. Musachite mantha, ndikofunikira kwambiri kudziwa izi.

Kodi paraneoplastic syndrome ndi chiyani?

Mwachidule, mukakhala ndi khansa, timaitcha Paraneoplastic Syndrome , yomwe ndi pamene zizindikiro zina zimawonekera m'thupi popanda kuyambitsidwa mwachindunji ndi maselo a khansa. Tangoganizirani, pali khansa m'thupi, koma mahomoni kapena mapuloteni ena omwe amatulutsidwa ndi khansa amachititsa kuti dongosolo linalake m'thupi liyambe kugwira ntchito mosiyana. Kapena, nthawi zina chitetezo chathu cha mthupi, poyesa kuwononga maselo a khansa, chimaukiranso maselo abwino molakwika. Timaitcha kuti yankho la autoimmune . Zizindikirozi zimathanso kuchitika m'mikhalidwe yotere.

Matenda a Paraneoplastic angakhudze machitidwe osiyanasiyana m'thupi. Mwachitsanzo, dongosolo lanu la mitsempha , dongosolo la endocrine (dongosolo lomwe limapanga mahomoni), impso , mafupa , mafupa , khungu, ndi magazi zonse zimatha kukhudzidwa.

Kawirikawiri, zizindikiro za chimodzi mwa izi (Paraneoplastic Syndromes) ndi zizindikiro zoyamba za khansa. Chifukwa chake, ndikofunikira kwambiri kudziwa izi.

Ndani amene angakhudzidwe kwambiri ndi vutoli? (Ndani amene amakhudzidwa ndi matenda a paraneoplastic?)

Matenda a Paraneoplastic syndrome amapezeka kwambiri kwa anthu azaka zapakati komanso okalamba, makamaka omwe ali ndi matenda monga khansa ya m'mapapo , khansa ya lymphatic , khansa ya ovarian , kapena khansa ya m'mawere . Zinthu zomwezo zomwe zimayambitsa khansa zingayambitsenso matendawa.

Kodi izi ndi zofala bwanji? (Kodi matenda a paraneoplastic syndromes ndi ofala bwanji?)

Matenda a Paraneoplastic Syndromes amapezeka pakati pa 8% ndi 20% ya anthu omwe ali ndi khansa. Izi zikutanthauza kuti si odwala khansa onse omwe amadwala matendawa, koma amatha kukhudza anthu ambiri.

Ndi khansa ziti zomwe zimagwirizanitsidwa ndi paraneoplastic syndromes?

Aliyense amene ali ndi chotupa cha khansa (Paraneoplastic Syndrome)Ngakhale kuti khansa iliyonse ingachitike, pali mitundu ingapo ya khansa yomwe nthawi zambiri imagwirizanitsidwa ndi izi:

• Khansa ya m'mawere
• Khansa ya m'mimba
• Khansa ya m'magazi
• Lymphoma
• Khansa ya m'mapapo (makamaka khansa ya m'mapapo ya maselo ang'onoang'ono)
• Khansa ya m'chiberekero
• Khansa ya kapamba
• Khansa ya prostate
• Khansa ya impso
• Khansa ya m'matumbo

Kodi n’chiyani chimayambitsa matenda a paraneoplastic?

Takambirana kale kuti pali zifukwa ziwiri zazikulu zomwe zimapangitsa izi.

1. Zinthu zomwe zimatulutsidwa ndi maselo a khansa: Khansa zina zimatulutsa mahomoni ndi mapuloteni . Zinthuzi zimapangitsa ziwalo zina m'thupi kugwira ntchito molakwika. Ngati sizikuthandizidwa, izi zitha kuwononga thupi kwamuyaya.

2. Kulephera kwa chitetezo chamthupi: Chitetezo chamthupi lathu chilipo kuti chititeteze ku matenda. Dongosololi limapanga zinthu zotchedwa ma antibodies . Ma antibodies amenewa amazindikira ndikuwononga maselo osazolowereka, monga maselo a khansa. Koma nthawi zina, zizindikirozi zimasokonezeka ndipo ma antibodies amayamba kuukira maselo athanzi. Pamenepo ndi pomwe zizindikiro za (Paraneoplastic Syndrome) zimawonekera.

Kodi zizindikiro za paraneoplastic syndromes ndi ziti?

Zizindikiro zomwe zimawonekera pa izi zimatha kusiyana malinga ndi munthu. Zimatengera momwe thupi limakhudzidwira. Chodabwitsa n'chakuti, pa milandu yoposa 60% , zizindikiro za matendawa zimawonekera khansa isanadziwike nkomwe. Chifukwa chake, ngati zizindikirozi zizindikirika msanga, khansa imatha kuzindikirika ndikuchiritsidwa pachiyambi. Kenako mwayi wopambana chithandizocho umakhala wokwera.

Zizindikiro zodziwika bwino

Izi ndi zina mwa zizindikiro zodziwika bwino:

• Malungo
• Kutaya chilakolako cha chakudya ndi kuchepetsa thupi
• Thukuta la usiku

Pamene dongosolo la mitsempha lakhudzidwa

Ngati dongosolo lanu la mitsempha (ndiko kuti, ubongo wanu ndi chingwe cha msana) ndi dongosolo lanu la mitsempha (mitsempha yomwe imatuluka mu ubongo ndi chingwe cha msana) zakhudzidwa, mutha kukhala ndi zizindikiro monga:

• Chizungulire
• Masomphenya awiri
• Kuvuta kulankhula
• Kutaya kukumbukira
• Matenda a khunyu ( kugwidwa )
• Kufooka kwa minofu
• Kuchepetsa malingaliro, kumva kapena kugwirizana
• Kutaya kumva m'manja ndi miyendo yanu

Tangoganizirani, munthu ali ndi khansa ya m'mapapo, koma mwadzidzidzi amayamba kutaya kukumbukira, kusokoneza mawu ake akamalankhula, komanso kuvutika kukhala bwino akamayenda. Pamenepo madokotala amakayikira kuti iyi ndi (Paraneoplastic Syndrome) .

Pamene dongosolo la endocrine lakhudzidwa

Ngati dongosolo lanu la mahomoni lakhudzidwa, mutha kuwona zizindikiro monga:

• Kutopa kwambiri
• Kuthamanga kwa magazi
• Kufooka kwa minofu
• Kusanza ndi kusanza
• Kulemera kwadzidzidzi popanda chifukwa chilichonse

Pamene mafupa, mafupa ndi minofu zakhudzidwa (Mafupa, mafupa ndi minofu - rheumatologic)

Ngati machitidwe awa akhudzidwa:

• Matenda monga nyamakazi
• Kupweteka kwa mafupa, kutupa kapena kuuma kwa mafupa

Zikakhudza khungu (Khungu)

Nthawi zina khungu lingakhudzidwenso:

• Kuyabwa
• Kutsuka
• Khungu lokhuthala
• Zomera za khungu zosavulaza (zopanda khansa)

Kodi mitundu ya paraneoplastic syndromes ndi iti?

Pali mitundu ingapo ya Paraneoplastic Syndromes . Amagawidwa m'magulu malinga ndi momwe amakhudzira dongosolo lililonse.

Matenda a paraneoplastic a dongosolo lamanjenje

Zitsanzo zina:

• `(Kuwonongeka kwa ubongo)`: Uku ndi kuwonongeka kwa ubongo, komwe kumakhudza zinthu monga kuyenda bwino komanso kuyenda bwino.
• Dysautonomia: Imakhudza kugwira ntchito kwa dongosolo la mitsempha lodziyimira palokha.
• Encephalitis: Kutupa kwa ubongo.
• Encephalomyelitis: Kutupa kwa ubongo ndi msana.
• Matenda a myasthenic a Lambert-Eaton (LEMS): Amayambitsa kufooka kwa minofu.
• Myasthenia gravis (MG): Iyi ndi vuto lina lomwe limayambitsa kufooka kwa minofu.
• Matenda a Myelopathy: Matenda omwe amakhudza msana.
• Neuromyotonia: Kugwira ntchito kwa minofu nthawi zonse.
• `(Opsoclonus-myoclonus syndrome)`: Kusuntha kosazolowereka kwa maso ndi minofu.
• `(Neuropathy (peripheral neuropathy))`: Kuwonongeka kwa mitsempha ya m'mphepete.
• `(Stiff-person syndrome)`: Kuuma kwa minofu ndi kupweteka kwa minofu.

Matenda a paraneoplastic a dongosolo la endocrine

Zitsanzo:

• (Cushing's syndrome): Matenda omwe amayamba chifukwa cha kuchuluka kwa cortisol m'thupi.
• Hypercalcemia: Kuchuluka kwa calcium m'magazi.
• `(Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH))`: Matenda omwe amachititsa kuti madzi m'thupi azisungidwa kwambiri.

Matenda a paraneoplastic a rheumatic

(zimakhudza mafupa, minofu ndi minofu yolumikizana)

Zitsanzo:

• `(Eosinophilic fasciitis)`
• `(Erythromelalgia)`
• `(Hypertrophic osteoarthropathy)`
• `(Palmar fasciitis)`
• `(Paraneoplastic polyarthritis)`

Matenda a paraneoplastic m'magazi

Zitsanzo:

• `(Paraneoplastic erythrocytosis)`: Kuwonjezeka kwa maselo ofiira a magazi.
• `(Paraneoplastic thrombocytosis)`: Kuwonjezeka kwa ma platelet m'magazi.

Matenda a paraneoplastic pakhungu

Zitsanzo:

• Acanthosis nigricans: Madontho akuda komanso okhuthala pakhungu.
• Dermatomyositis: Kutupa kwa khungu ndi minofu.
• Leukocytoclastic vasculitis: Kutupa kwa mitsempha yamagazi yaying'ono.
• `(Paraneoplastic pemphigus)`: Matenda omwe amayambitsa kutupa pakhungu.
• `(Sweet syndrome)`: Malungo ndi zilonda zopweteka pakhungu.

Matenda a paraneoplastic a impso

Paraneoplastic glomerulonephritis ndi matenda omwe amakhudza impso.

Kodi matenda a paraneoplastic syndromes amapezedwa bwanji?

Dokotala wanu adzazindikira vutoli mwa kukufunsani za mbiri yanu yachipatala, kuchita mayeso akuthupi, ndikuchita mayeso ena angapo.

• Kuyezetsa ubongo: Popeza matendawa nthawi zambiri amakhudza mitsempha, dokotala wanu adzakufunsani kuti muchite zinthu zina kuti muwone momwe ubongo wanu ndi minofu yanu zikugwirira ntchito. Adzayang'ana kusintha kwa mphamvu zanu, kukumbukira kwanu, ndi kugwirizana kwanu.
• Mayeso ojambulira: Mayeso monga CT scans , MRIs , ndi ultrasound angagwiritsidwe ntchito kuti awone ngati pali chotupa chomwe chikuyambitsa zizindikiro.
• Kuyezetsa magazi: Kuyezetsa magazi kungavumbule zinthu zomwe zingayambitse kukayikira za khansa. Kungathenso kuyang'ana ma antibodies okhudzana ndi matenda a paraneoplastic . Kuyezetsa kumeneku kungathenso kudziwa ngati zizindikirozo zimayambitsidwa ndi zifukwa zina, monga matenda kapena kusalinganika kwa mahomoni.
• Kuboola kwa msana/kupopera msana: Nthawi zina, madzi a m'mitsempha yanu ya ubongo (CSF) amayesedwa kuti awone ngati pali ma antibodies omwe amaukira maselo athanzi. Izi zimaphatikizapo kulowetsa singano yaying'ono kumbuyo kwanu ndikutengera chitsanzo cha madziwo. Kenako amawunikidwa.

Kodi matenda amenewa amathandizidwa bwanji? (Kodi matenda a paraneoplastic syndrome amathandizidwa bwanji?)

Chofunika kwambiri ndi kuchiza khansa yomwe imayambitsa zizindikiro zanu. Nthawi yomweyo, mumayang'aniranso zizindikiro zanu kuti muchepetse kuwonongeka kwa ziwalo kapena machitidwe a thupi lanu.

Mankhwala ena omwe amagwiritsidwa ntchito pochiza Paraneoplastic Syndromes :

• Mankhwala a Corticosteroids:Mankhwala monga `(Cortisone)` kapena `(prednisone)`. Izi zimagwira ntchito pochepetsa kutupa m'thupi.
• Kuchepetsa chitetezo chamthupi: Mankhwala omwe amachepetsa mphamvu ya chitetezo chamthupi lanu. Dokotala wanu adzakupatsani mankhwala kutengera mtundu wa paraneoplastic syndrome yomwe muli nayo.
• Intravenous immunoglobulin (IVIG): Mankhwalawa amagwira ntchito powononga ma antibodies oopsa. Mu izi, ma antibodies athanzi amaperekedwa ngati jakisoni, yomwe imawononga ma antibodies oopsa.
• Plasmapheresis: Izi zimaphatikizapo kuchotsa plasma (gawo lamadzimadzi la magazi) m'magazi kuti muchepetse kuchuluka kwa ma antibodies, omwe amapezeka mu plasma iyi ndipo amatha kuwononga minofu yathanzi.
• Kuchiza thupi ndi kulankhula: Izi zimaphatikizapo kuchita masewera olimbitsa thupi a minofu kuti akonze zochita monga kulankhula ndi kuyenda. Mungafunike chithandizo ichi ngati muli ndi vuto la paraneoplastic lomwe limakhudzana ndi dongosolo lamanjenje.

Kodi ndingayembekezere chiyani ngati ndili ndi paraneoplastic syndrome?

Kuyezetsa matenda anu kumadalira kwambiri pa gawo la khansa yanu. Nthawi zina, zizindikiro zomwe zimayambitsa matendawa zingakhale zochepa komanso zosakhalitsa. Nthawi zina, zizindikirozo zingakhale zazikulu ndipo zimafuna chithandizo cha nthawi yayitali.

Lankhulani ndi dokotala wanu za momwe khansa yanu ikuyendera komanso momwe mungayankhire chithandizo chanu.

Kodi ndi mavuto ati omwe amagwirizanitsidwa ndi paraneoplastic syndromes?

Izi zingayambitse mavuto osiyanasiyana. Ena akhoza kukhala ang'onoang'ono, pomwe ena akhoza kukhala oopsa komanso oopsa ngati sanalandire chithandizo. Dokotala wanu adzakufotokozerani mavuto omwe angakhalepo komanso njira zina zochiritsira.

Kodi ndiyenera kuyimbira dokotala liti pankhani ya matenda a paraneoplastic?

Ngati mukupeza zizindikiro za paraneoplastic syndrome popanda chifukwa chomveka, pitani kwa dokotala. Makamaka ngati mwalandira chithandizo cha khansa m'zaka zisanu zapitazi ndipo mukukumana ndi zizindikirozi, ndi bwino kukayezetsanso. Izi zithandizanso dokotala wanu kudziwa ngati khansayo yabwerera.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga?

Mafunso ena omwe mungafunse dokotala wanu:

• Kodi chifukwa cha zizindikiro zanga n'chiyani?
• Kodi matenda anga a Paraneoplastic Syndrome amakhudza bwanji dongosolo langa lothandizira khansa?
• Kodi ndi njira ziti zochiritsira zomwe ndili nazo?
• ZangaKodi Paraneoplastic Syndrome imakhudza bwanji kuchira kwanga?
• Kodi zizindikiro zanga zidzatha pambuyo polandira chithandizo cha khansa?
• Kodi mungatani kuti muthane ndi zizindikiro kwa nthawi yochepa? Kodi mungatani kuti muthane ndi zizindikiro kwa nthawi yayitali?

Pomaliza, uthenga wopita nawo kunyumba

Zotupa za khansa zingayambitse kusintha kosayembekezereka m'thupi. Nthawi zina, zimatha kuphatikizapo zizindikiro za paraneoplastic syndrome . Popeza pali mitundu ingapo ya matendawa ndipo zizindikiro zake zimasiyana, zingatenge nthawi kuti dokotala wanu adziwe kuti zizindikiro zanu zikugwirizana ndi khansa. Komabe, akatsimikizira matendawa, amatha kuchiza zizindikirozo, ndipo chofunika kwambiri, kuchiza khansa yomwe imayambitsa matendawa .

Njira yabwino yothetsera Paraneoplastic Syndrome ndikupeza chithandizo chabwino kwambiri cha khansa. Choncho, musanyalanyaze zizindikiro zilizonse. Ngati muli ndi kukayikira kulikonse, pitani kwa dokotala mwamsanga. Pokhapokha titakhala ndi thanzi labwino.

Matenda a Paraneoplastic, khansa, zizindikiro, dongosolo lamanjenje, dongosolo la endocrine, chitetezo chamthupi, chithandizo cha khansa