Kodi POEMS Syndrome ndi chiyani? Kodi mukufunanso kudziwa za izi?

Kodi mudamvapo za POEMS Syndrome? Iyi ndi matenda osowa omwe samveka kawirikawiri. Komabe, ndikofunikira kudziwa pang'ono za matendawa chifukwa amatha kukhudza ziwalo zambiri m'thupi lathu nthawi imodzi. Mwachidule, ndi matenda ovuta okhudzana ndi magazi athu. Lero, tikambirana za POEMS Syndrome, zizindikiro zake ndi ziti, momwe imapezekera, komanso ngati pali chithandizo.

Kodi POEMS Syndrome ndi chiyani kwenikweni?

Chabwino, tiyeni tiwone chomwe POEMS Syndrome ili. Iyi ndi matenda osowa kwambiri m'magazi. Tili ndi mtundu wa maselo amagazi otchedwa maselo a plasma m'thupi lathu. Pamene POEMS syndrome ichitika, maselo a plasma awa amagawikana ndikuchulukana modabwitsa, mosalamulirika. Maselo osadziwika bwino a plasma awa amatulutsa mapuloteni apadera m'magazi athu. Amatchedwa monoclonal protein, kapena M-protein mwachidule. Tsopano mutha kuganiza, sichoncho? Maselo osadziwika bwino a plasma awa, M-protein, akachuluka kwambiri m'magazi, amatha kuwononga mitsempha yathu ndi ziwalo zamkati.

Dzina lakuti POEMS limachokera ku zilembo zoyambirira za zizindikiro zisanu zazikulu za matendawa:

• P - Polyneuropathy: Izi zikutanthauza kuwonongeka kwa mitsempha m'thupi lonse. Mu NDANDANDA, kuwonongeka kumeneku kungayambitse kupweteka kapena kumva kusasangalala (monga kuyabwa, kutentha, ndi zina zotero) m'miyendo yanu, m'manja, m'mapazi, ndi m'manja.
• O - Organomegaly: Izi zikutanthauza kuti ziwalo zamkati zimakhala zazikulu kwambiri. Munthu amene ali ndi POEMS akhoza kukhala ndi ziwalo zazikulu monga chiwindi, ndulu, ndi ma lymph nodes.
• E - Endocrinopathy: Mwachidule, ili ndi vuto la mahomoni. Mu POEMS, kuchuluka kwa mahomoni omwe amatulutsidwa ndi ma endocrine glands athu kungakhale kosazolowereka. Ma hormone ena amatha kutulutsidwa mopitirira muyeso kapena pang'ono.
• M - Puloteni ya monoclonal (M-protein): Iyi ndi puloteni yapadera yomwe imasonkhana m'magazi mu POEMS. Pamene selo limodzi la plasma limapanga makope ambiri (clones) a lokha, selo lililonse mwa maselo amenewo limawonjezera puloteni ya M iyi m'magazi. Pamapeto pake, kuchuluka kwa puloteni ya M m'magazi kumawonjezeka kwambiri.
• S - Kusintha kwa khungu: Anthu omwe ali ndi NDANDANDA amatha kusintha khungu mosiyanasiyana, monga mdima wa khungu ndi kukhuthala kwa khungu.

Matenda a POEMS amadziwikanso kuti osteosclerotic myeloma , Crow-Fukase syndrome , PEP syndrome , ndi Takatsuki syndrome .

Ndani amene ali ndi mwayi waukulu wokhala ndi matenda a POEMS?

Matenda a POEMS ndi matenda osowa kwambiri. Amakhudza anthu ochepa okha padziko lonse lapansi. Amafala kwambiri mwa anthu azaka zapakati pa 50 ndi 60. Amatha kukhudza amuna ndi akazi onse, koma akuoneka kuti ndi ofala kwambiri mwa amuna.

Kodi zizindikiro za POEMS syndrome ndi ziti?

Monga tanenera kale, zilembo zomwe zili mu dzina lakuti POEMS zimasonyeza zizindikiro zina zazikulu. Izi zikutanthauza kuti, Polyneuropathy, Organomegaly, Endocrinopathy, M-protein elevation, ndi kusintha kwa khungu ndi zizindikiro zazikulu. Pafupifupi aliyense amene ali ndi POEMS ali ndi polyneuropathy ndi M-protein elevation. Zizindikiro zina zimatha kusiyana malinga ndi munthu.

Zizindikiro za polyneuropathy

Zizindikiro zomwe zimayambitsidwa ndi kuwonongeka kwa mitsempha imeneyi ndizofala kwambiri mu POEMS. Nthawi zambiri, ululu umamveka kwambiri m'miyendo ndi m'mapazi. Koma nthawi zina umakhudza manja ndi manja. Umu ndi momwe mungamvere mukakhala ndi vutoli:

• Kufooka
• Kulira
• Kusanza
• Kumva kuluma /kupweteka ndi singano
• Kumva kutentha

Organomegaly - kukula kwa ziwalo zamkati

Madokotala amatha kuzindikira ngati ziwalo izi zakula:

• Chiwindi (Chiwindi - `(Hepatomegaly)`)
• Spleen (Splenomegaly)
• Ma Lymph nodes (Ma Lymph nodes - `(Lymphadenopathy)`)

Endocrinopathy - mavuto a mahomoni

Vuto lalikulu la mahomoni lomwe limabwera ndi POEMS ndi kuchepa kwa kuchuluka kwa mahomoni ogonana. Ma mahomoni ogonana awa amatchedwa ``Testosterone`` mwa amuna ndi ``Estrogen`` mwa akazi. Kuphatikiza apo, mutha kuwona zizindikiro monga:

• Mavuto oletsa kuchuluka kwa shuga m'magazi (monga matenda a shuga)
• Mavuto a chithokomiro (monga Hypothyroidism)
• Matenda a Addison (Kulephera kwa Adrenal - `(Matenda a Addison)`)

Amuna amatha kukhala ndi vuto la kuchepa kwa chonde komanso kukula kwa mabere (Gynecomastia).

Kwa akazi , kusamba kumatha kutha (`(Amenorrhea)`), mabere amatha kukulirakulira. Pa nthawi ya mimba, mahomoni a `(Prolactin)`, omwe amathandiza kupanga mkaka, amatha kupangidwa mopitirira muyeso. Chifukwa chake, mkaka ukhoza kutuluka m'mabele ngakhale mutakhala kuti simuli ndi pakati.

Kuwonjezeka kwa M-Protein

Chinthu chofunika kwambiri pa POEMS ndi kuchuluka kwa mapuloteni a M m'magazi. Kuchuluka kwa mapuloteni a M kungayambitse kupangika kwa zotupa m'magazi. Komanso, chifukwa cha kuchuluka kwa mapuloteni a M,Mafupa amatha kukhala okhuthala komanso olimba (osteosclerosis) .

Kusintha kwa khungu

Kusintha kwa khungu kosiyanasiyana kungachitike, monga:

• Khungu lakuda kwambiri
• Khungu lokhuthala
• Zikhadabo zoyera
• Kuwonjezeka kwa kukula kwa tsitsi pankhope ndi miyendo yanu
• Kukula kwa mitsempha yamagazi yomwe imawoneka ngati ma cherries ang'onoang'ono pakhungu la pachifuwa

Zizindikiro zina

Kuwonjezera pa izi, zizindikiro zina zingawonekere:

• Kutupa kwa manja ndi mapazi
• Kuchepetsa thupi popanda chifukwa
• Ululu m'mafupa ndi m'malo olumikizirana mafupa
• Zofooka za maso
• Kuvuta kupuma
• Kutopa
• Malungo

Anthu ena omwe ali ndi matenda a POEMS angakhalenso ndi vuto lotchedwa Castleman Disease (CD), lomwe limakhudza ma lymph nodes. Ngati muli ndi zizindikiro za matenda a Castleman, dokotala wanu angaganizenso kuti POEMS ndi yoopsa.

Kodi n’chiyani chimayambitsa matenda a POEMS?

Mukakhala ndi POEMS, mumakumana ndi zizindikiro zosiyanasiyana ndi zotsatirapo zake chifukwa cha vuto la maselo a plasma a monoclonal . Mwachidule, selo losazolowereka la plasma limadzipanga lokha zambiri. Maselo amenewa akachuluka, amatha kuwononga minofu kwambiri. Maselo amenewa amawonjezera mapuloteni a M m'magazi, zomwe zimapangitsa kuti kuchuluka kwa mapuloteni a M m'magazi kukwere. Ndi maselo ochulukirapo ndi mapuloteni a M omwe amawononga machitidwe osiyanasiyana m'thupi.

Komabe, asayansi sakudziwabe chifukwa chake maselo a plasma amenewa amayamba kukula modabwitsa poyamba.

Ofufuza apeza kuti puloteni yotchedwa Vascular Endothelial Growth Factor (VEGF) ikhoza kukhalapo. Anthu ambiri omwe ali ndi POEMS syndrome ali ndi VEGF yambiri m'magazi mwawo. Kafukufuku wokhudza ubale pakati pa VEGF ndi POEMS syndrome akupitirirabe.

Kodi matenda a POEMS amawapeza bwanji? (Kuzindikira)

Dokotala wanu adzakufunsani kaye za mbiri yanu yachipatala komanso zizindikiro zomwe muli nazo panopa. Kenako, adzakuyesani thupi kuti aone ngati muli ndi zizindikiro za POEMS syndrome.

Komanso, dokotala akhoza kuchita mayeso angapo, monga:

• Kuyezetsa magazi ndi mkodzo: Kuyezetsa kumeneku kungathandize kuwona kuchuluka kwa mapuloteni a M kapena VEGF m'magazi kapena mkodzo wanu. Kungathenso kuwona kuchuluka kwa maselo amagazi osazolowereka kapena maselo amagazi osazolowereka. Izi zitha kukhala zizindikiro za POEMS.
• Mayeso ojambulira: Mayeso monga X-ray ndi CT scans angasonyeze ngati mafupa anu ndi olimba kapena olimba. Kusintha kumeneku kungachitike pamene kuchuluka kwa mapuloteni a M-protein kwakwera.
• Kufufuza za m'mafupa: Izi zingakuthandizeni kudziwa ngati muli ndi maselo a m'magazi omwe amawoneka osazolowereka m'mafupa anu, kapena ngati chiwerengero cha maselo a m'magazi chili chokwera kwambiri.
• Electromyogram (EMG): EMG ndi mayeso omwe amayesa momwe mitsempha imagwirira ntchito. Ingathandize dokotala wanu kuzindikira matenda a polyneuropathy.

Kutengera ndi zizindikiro zanu, dokotala wanu angachitenso mayeso ena, monga mayeso opumira, echocardiograms, kapena mayeso a endocrine.

Ngati mwapezeka ndi matenda otchedwa Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) , dokotala wanu angakuyezeninso kuti aone ngati muli ndi POEMS syndrome.

Kodi matenda a POEMS amathandizidwa kapena kuchiritsidwa bwanji?

Palibe mankhwala a POEMS syndrome. Komabe, mankhwala angathandize kuwongolera ndikuwongolera zizindikiro. Njira zina zochiritsira ndi izi:

• Chithandizo cha radiation: Izi zimaphatikizapo kutsogolera kuchuluka kwa radiation pa maselo osazolowereka a plasma kuti awawononge.
• Chemotherapy: Mankhwala oletsa khansa, omwe amadziwikanso kuti ``Chemotherapy,'' amagwiritsidwa ntchito kupha kapena kuchepetsa kukula kwa maselo osadziwika bwino a m'magazi. Chemotherapy ya POEMS ndi yofanana ndi mankhwala a multiple myeloma. Mankhwalawa ndi othandiza kwambiri ndipo nthawi zambiri samayambitsa zotsatirapo zoyipa.
• Kuika maselo oyambira a Autologous: Njirayi imalowa m'malo mwa maselo anu osazolowereka a plasma ndi maselo oyambira athanzi. Maselo oyambira ndi maselo omwe amakula kukhala maselo okhwima monga maselo a plasma. Pakuika maselo amenewa, dokotala wanu amachotsa kaye maselo oyambira athanzi m'thupi lanu. Kenako, amagwiritsa ntchito mankhwala a chemotherapy kapena radiation kuti awononge maselo osazolowereka a plasma. Pambuyo pa chithandizo, maselo oyambira omwe achotsedwa amabwezeretsedwanso m'thupi lanu. Kenako amakula kukhala maselo athanzi a plasma.
• Kuchiza thupi: Ngati mukuvutika kuyenda chifukwa cha polyneuropathy, chithandizochi chingathandize.

Kuphatikiza apo, dokotala angapereke mankhwala monga ma steroids kuti achepetse zizindikiro ndi ma diuretics (mapiritsi amadzi) kuti achepetse kutupa.

Kodi mavuto otani omwe amabwera chifukwa cha POEMS syndrome?

Ndi matenda a POEMS, kuwonongeka kwa mitsempha ndi kufooka kumatha kuwonjezeka pakapita nthawi. Zingapangitsenso kuti zikhale zovuta kuyenda. Ngati madzi ambiri asonkhana pafupi ndi mapapo kapena mkati mwa chifuwa, zingayambitse kupweteka pachifuwa komanso kupuma movutikira.

Koma kumbukirani,Chithandizo chogwira mtima chingathetse kapena kuchepetsa kuwonongeka kwa mitsempha. Chingathandizenso kuchepetsa zizindikiro zina. Ngakhale kuwonongeka kwa mitsempha kungachiritse pang'onopang'ono pakapita nthawi.

Kodi pali zinthu zomwe zingayambitse matenda a POEMS?

Pakadali pano palibe zinthu zomwe zadziwika kuti zimayambitsa matenda a POEMS.

Kodi matenda a POEMS angapewedwe?

Mwatsoka, matenda a POEMS sangapeweke.

Kodi chiyembekezo cha anthu omwe ali ndi matenda a POEMS ndi chiyani?

Thanzi lanu limadalira zinthu zambiri, kuphatikizapo ziwalo za thupi lanu zomwe zakhudzidwa, momwe matendawa amadziwikira mwachangu komanso momwe chithandizo chimayambira, komanso momwe mumayankhira chithandizo.

Ndikofunikira kupeza chithandizo cha POEMS. Matenda a POEMS akhoza kukhala pachiwopsezo chachikulu ngati sanachiritsidwe. Kumbali ina, mankhwala opambana omwe amawononga maselo a plasma osazolowereka angakuthandizeni kukhala ndi moyo wautali. Kuphatikiza apo, mankhwala amatha kuchepetsa zizindikiro ndikukweza moyo wanu.

Chiwerengero cha anthu ambiri omwe ali ndi POEMS ndi pafupifupi zaka 14. Izi zikutanthauza kuti pafupifupi theka la anthu amakhala ndi moyo wosakwana zaka 14, pomwe theka lina limakhala ndi moyo wautali. Nthawi yanu yokhala ndi moyo imadalira zomwe mwakumana nazo ndi matenda anu komanso chithandizo chanu.

Funsani dokotala wanu za tsogolo lanu monga munthu amene ali ndi matenda a POEMS.

Kodi muyenera kupita kwa dokotala liti pankhani ya matenda a POEMS?

Ngati mukuona zizindikiro zilizonse zokhudzana ndi POEMS syndrome, makamaka kufooka kwa manja ndi miyendo , pitani kwa dokotala nthawi yomweyo.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga okhudza matenda a POEMS?

Mungathe kufunsa mafunso monga awa:

• Kodi vuto langa ndi lalikulu bwanji?
• Kodi ndi njira ziti zochiritsira zomwe ndili nazo?
• Kodi ndiyenera kuchita chiyani kuti ndichepetse kapena kuchepetsa zotsatirapo zake?
• Ndi mautumiki ati othandizira omwe alipo kwa ine?
• Kodi ndiyenera kuonana ndi dokotala yemwe ndi katswiri wa matenda a maselo a plasma kuti anditsogolere chithandizo changa?

Kodi ndingabwerere liti ku zochita zanga zachizolowezi ngati ndili ndi POEMS syndrome?

Matenda a POEMS angakhudze luso lanu lochita zinthu zanu za tsiku ndi tsiku. Dokotala wanu adzakufotokozerani momwe vutoli lidzakhudzire moyo wanu watsiku ndi tsiku.

Kodi matenda a POEMS ndi matenda odziyimira pawokha?

POEMS ndi matenda a paraneoplastic.Si matenda a autoimmune. Paraneoplastic syndrome ndi mndandanda wa zizindikiro zomwe zimayambitsidwa ndi vuto linalake lachipatala. Mu POEMS, vuto lalikulu ndilakuti maselo osazolowereka a m'magazi amapanga mapuloteni ambiri a M m'magazi (vuto la maselo a plasma a monoclonal). Zizindikiro za POEMS zimayambitsidwa ndi maselo osazolowereka a m'magazi ndi mapuloteni a M omwe amawononga minofu ya thupi.

Kodi matenda a POEMS ndi ofanana ndi matenda a multiple myeloma?

Multiple myeloma ndi khansa yomwe imakhudza maselo a m'magazi. POEMS syndrome ndi mndandanda wa zizindikiro zomwe zimayambitsidwa ndi maselo a m'magazi osazolowereka komanso kuwonjezeka kwa mapuloteni a M. Kuchuluka kwa moyo wa POEMS syndrome kuli bwino kuposa nthawi yomwe munthu amakhala ndi myeloma yambiri.

Komabe, mankhwala a chemotherapy a POEMS ndi multiple myeloma nthawi zambiri amakhala ofanana. Zizindikiro zina zingakhalenso zofanana.

Matenda a POEMS ndi matenda ovuta kuwazindikira. Zingatenge nthawi kuti dokotala wanu adziwe kuti zizindikiro zanu zimayambitsidwa ndi matenda a POEMS osati matenda ena. Mukapezeka ndi matendawa, gwirani ntchito limodzi ndi gulu lanu lachipatala kuti mudziwe chithandizo chomwe chingakupatseni mpumulo waukulu ku zizindikiro zanu. Funsani dokotala wanu za mabungwe kapena magulu othandizira omwe amathandiza anthu ndi mabanja omwe akudwala matenda monga matenda a POEMS.

Uthenga Wopita Nawo Kunyumba

Chabwino, lero takambirana zambiri za POEMS Syndrome. Chofunika ndikumvetsetsa kuti iyi ndi vuto losowa, koma loopsa . Lingakhudze ziwalo zambiri m'thupi lathu.

• Dzina lakuti POEMS limachokera ku zilembo zoyambirira za mayina a Chingerezi a zizindikiro zisanu zazikulu (matenda a mitsempha, kukula kwa ziwalo zamkati, mavuto a mahomoni, kuchuluka kwa mapuloteni a M, ndi kusintha kwa khungu).
• Chifukwa chachikulu cha izi ndi maselo a plasma osakhazikika komanso mapuloteni a M omwe amapanga.
• Ngakhale kuti palibe mankhwala athunthu, pali mankhwala othandiza oletsa zizindikiro ndikuwongolera moyo wabwino.
• Ndikofunikira kwambiri kuzindikira matendawa ndikuyamba kulandira chithandizo msanga .

Ngati muli ndi zizindikiro izi, chonde funsani upangiri kwa dokotala. Musachite mantha, ndi chidziwitso choyenera komanso chithandizo chamankhwala, mutha kuthana ndi vutoli.

Matenda a POEMS , matenda a magazi, kuwonongeka kwa mitsempha, mavuto a mahomoni, mapuloteni a M, kusintha kwa khungu, maselo a plasma