Chiyembekezo chatsopano cha kuchepetsa mphumu: Zomwe muyenera kudziwa zokhudza Tezspire

Kodi muli ndi mphumu yoopsa? Kodi mumadwalabe mphumu nthawi zambiri ngakhale mukugwiritsa ntchito mankhwala anu opumira ndi mankhwala ena? Kodi mwatopa ndi kusagona bwino usiku komanso kulephera kuchita ngakhale ntchito zazing'ono? Okhawo omwe akudwala matendawa ndi omwe amadziwa momwe zimakhalira zovuta kukhala ndi mphumu yovuta kuilamulira komanso yovuta. Koma musachite mantha, chifukwa cha kupita patsogolo kwa sayansi ya zamankhwala, mankhwala atsopano tsopano abwera kudzathandiza. Lero, tikambirana za chithandizo chatsopano komanso chapamwamba chotere. Ndicho Tezspire.

Kodi mankhwala otchedwa Tezspire amagwira ntchito bwanji kwenikweni?

Chabwino, choyamba tiyeni timvetse mosavuta zomwe zimachitika m'thupi lathu tikakhala ndi mphumu. Mphumu ndi vuto lomwe njira zathu zopumira mpweya, kapena payipi ya mpweya, zimatupa, zimatupa, komanso zimakhala zofewa. Chinthu chomwe chili ndi ziwengo (monga fumbi, utsi) chikalowa m'thupi, njira zimenezi zimakhala zochepa ndipo zimakhala zovuta kupuma.

Kawirikawiri, timagwiritsa ntchito mitundu iwiri ikuluikulu ya mankhwala pochiza mphumu. Imodzi ndi mankhwala oletsa kutupa . Izi zimagwiritsidwa ntchito tsiku lililonse poletsa mphumu komanso kupewa matenda. Mtundu wina ndi mankhwala opulumutsa . Izi zimagwiritsidwa ntchito kuchepetsa zizindikiro mwachangu pamene mphumu yayamba.

Tezspire ndi mankhwala owonjezera pa mankhwala oletsa omwe mukumwa kale. Amathandiza kupewa matenda a mphumu, osati mankhwala 'opulumutsa' omwe mungamwe mukakhala nawo.

Mwachidule, Tezspire ndi mankhwala opangidwa kuchokera ku mtundu winawake wa puloteni. Kunena zoona, izi zimatchedwa (monoclonal antibody) . Thupi lathu lili ndi mankhwala otchedwa (Thymic Stromal Lymphopoietin - TSLP) . TSLP iyi ndiye yomwe imayambitsa kutupa (kutupa) ndi kusamva kosayenera m'njira zopumira. Mankhwala a Tezspire amaletsa kugwira ntchito kwa mankhwala otchedwa TSLP. TSLP ikatsekedwa, kutupa ndi kuchepa kwa njira zopumira kumachepa ndipo zizindikiro za mphumu zimawongoleredwa bwino.

Kodi munadziwa bwanji kuti mankhwalawa ndi othandiza?

Mankhwala atsopano asanagulitsidwe, maphunziro akuluakulu azachipatala amachitidwa kuti adziwe ngati ndi otetezeka kugwiritsidwa ntchito mwa anthu komanso ngati ndi othandizadi. Maphunziro awiri akuluakulu achitika ndi Tezspire.

Anthu omwe adachita nawo kafukufukuyu anali anthu azaka 12 kapena kuposerapo omwe anali ndi mphumu yoopsa . Izi zikutanthauza kuti, omwe anali ndi mphumu yobwerezabwereza yomwe inkafunika mapiritsi a steroid kapena kugonekedwa kuchipatala.

Kafukufukuyu adafufuza zinthu zingapo:

• Kuwonjezeka kwa Matenda a Mphumu: Tinaona momwe kuchuluka kwa matenda a mphumu kumachepera pambuyo pomwa mankhwala.
• Ntchito ya mapapo : Kuyesa kwapadera kumayesa kuchuluka kwa mpweya womwe ungatulutsidwe mwamphamvu mu sekondi imodzi. Izi zimatchedwa Forced Expiratory Volume mu sekondi imodzi - FEV1 .
• Kuwongolera zizindikiro: Pogwiritsa ntchito mafunso apadera (`Phumulo Lowongolera Chifuwa 6` kapena ACQ-6 ), odwala adawunikidwanso kuti awone momwe zizindikiro zawo zikuwongoleredwa.

Maphunziro awa adaphatikizapo anthu ochokera m'mitundu yosiyanasiyana komanso m'mabanja osiyanasiyana, koma osuta fodya ndi omwe ali ndi matenda ena opuma sanalowe nawo maphunzirowa.

Kodi zotsatira za kafukufukuyu ndi ziti?

Ophunzira mu kafukufukuyu adapitiliza kumwa mankhwala awo oletsa mphumu (monga corticosteroids yopumidwa ). Gulu limodzi linapatsidwa katemera wa Tezspire, pomwe gulu lina linapatsidwa placebo . Ma placebo ndi chinthu chomwe chimawoneka ngati mankhwala koma sichili ndi mankhwala ogwira ntchito. Amagwiritsidwa ntchito poyesa molondola zotsatira za mankhwala enieni.

Zotsatira zake kumapeto kwa masabata 52, kutanthauza chaka chimodzi, n’zolimbikitsa kwambiri.

• Poyerekeza ndi gulu la placebo, omwe adalandira Tezspire adachepetsa 56% mpaka 72% ya kuchuluka kwa matenda a mphumu (kuukira).
• Komanso, ntchito ya mapapo , yomwe ndi FEV1, inawonjezeka ndi pafupifupi malita 0.13 mwa omwe adamwa Tezspire.
• Malinga ndi mafunso a ACQ-6, 86% ya omwe adamwa Tezspire adanenanso kuti zizindikiro zawo zidasintha, poyerekeza ndi 77% omwe adamwa placebo.

Zotsatirazi zikusonyeza bwino kuti Tezspire ndi mankhwala othandiza kwambiri polimbana ndi mphumu yoopsa. Koma kumbukirani kuti zotsatira za kafukufuku sizili zofanana kwa aliyense. Zotsatira zanu zingakhale zosiyana.

Kodi Tezspire ndi yotani? Kodi mungayigwiritse ntchito bwanji?

Ngati mphumu yanu ndi yovuta kuyilamulira ndipo mukufuna kudziwa zambiri za Tezspire, mutha kulankhula ndi dokotala wa banja lanu kapena katswiri wa matenda a m'mapapo . Ngati dokotala wanu asankha kuti mankhwalawa ndi oyenera matenda anu, adzakonza zofunikira kuti mulandire.

Tezspire ndi jakisoni woperekedwa pansi pa khungu kwa milungu inayi iliyonse.Izi nthawi zambiri zimatha kuperekedwa ku ofesi ya dokotala, kuchipatala, kapena kuchipatala. Nthawi zina, dokotala wanu angaganize kuti ndikotetezeka komanso koyenera kuti mudzipatse katemera kunyumba. Ngati zili choncho, dokotala wanu kapena namwino wophunzitsidwa bwino adzakuphunzitsani momwe mungaperekere katemera moyenera.

Zotsatirapo zake ndi zinthu zomwe muyenera kuzidziwa

Monga mankhwala ena aliwonse, Tezspire ingayambitse zotsatirapo zazing'ono komanso nthawi zina zoopsa. Ndikofunikira kudziwa izi.

Kodi pangakhale mavuto ndi mankhwala ena?

Malinga ndi zomwe zapezeka pano, palibe lipoti la Tezspire lomwe lanena kuti limayambitsa kuyanjana kwakukulu ndi mankhwala ena. Komabe, ndi bwino kuuza dokotala wanu za mankhwala onse, mavitamini, ndi zowonjezera zomwe mukumwa. Nthawi zonse funsani dokotala wanu musanayambe mankhwala atsopano.

Ngati mukukayikira kuti mwakumana ndi zotsatirapo zoyipa kuchokera ku mankhwalawa, ngakhale simukutsimikiza 100% kuti ndi chifukwa cha Tezspire, mutha kunena izi ku National Poisons Information Centre ku Colombo National Hospital . Izi zidzakhala zofunika kwambiri pakusonkhanitsa zambiri zokhudza mankhwalawa mtsogolo.