Ese nawe ufite ikibazo aho n'agasebe gato kadahagarika kuva amaraso? (Ibura ry'impamvu ya VII)

Ese hari igihe wumva bifata igihe kirekire kugira ngo n'agasebe gato kareke kuva amaraso? Cyangwa uhinduka ubururu gusa ugakomereka? Wenda hari impamvu iri inyuma y'ibi bintu tutazi. Ni cyo gituma ikibazo cyo kubura Factor VII ari cyo.

Kubura Factor VII ni iki?

Muri make, ikibazo cyo kubura Factor VII ni indwara iterwa n’uturemangingo tw’amaraso aho amaraso yawe adafunga neza, bivuze ko adahagarika kuva amaraso vuba. Hari ubwoko bwinshi bwa poroteyine mu maraso yacu bwitwa 'ibintu bituma amaraso afunga' cyangwa 'ibintu bituma amaraso afungana' . Factor VII ni imwe muri izo poroteyine. Izi poroteyine zose zikorana na plaquettes zawe kugira ngo zikore akantu ko kugabanya amaraso kugira ngo zihagarike kuva amaraso iyo wakomeretse. Iyi nzira ni nko kubaka urukuta ukoresheje amatafari na sima. Rero, niba udafite iyi poroteyine y'ingenzi yitwa Factor VII mu mubiri wawe, cyangwa niba idakora neza, bifata igihe kirekire kugira ngo amaraso yawe afungane kuruta uko bisanzwe. Niyo mpamvu uvunika kandi uva amaraso byoroshye kurusha abandi.

Andi mazina y'ibi ni indwara ya Alexander na proconvertin deficiency .

Uku kubura kwa factor VII kugaragara gute?

Iyi ni indwara idakunze kugaragara . Ku isi yose, ifata umuntu umwe ku bantu 500.000 . Hari indwara nyinshi zo kuvura amaraso zivuka abaganga bazishyira mu byiciro "bidakunze kugaragara". Kubura factor VII ni imwe muri izi ndwara zikunze kugaragara cyane.

Ni ibihe bimenyetso by'ibi?

Kubura factor VII bishobora gutera kuva amaraso igihe kirekire no gukomereka byoroshye. Ibimenyetso by'ingenzi birimo:

• Ishinya zirimo kuva amaraso.
• Kuva amaraso mu mazuru (epistaxis) , no kugorwa no kubihagarika.
• Ku bagore, kuva amaraso menshi mu gihe cy'imihango (menorrhagia).
• Amaraso mu nkari (hematuria) cyangwa amaraso mu mwanda.
• Kuva amaraso bidashira nyuma yo gukomereka, kubagwa, cyangwa kubyara.
• Kuva amaraso imbere mu mubiri (urugero, mu gice cy'igifu, mu ngingo, mu mitsi, mu ngingo).
• Kuva amaraso mu bwonko na byo bishobora kubaho. Ibi ni bibi cyane.
• Kuva amaraso mu buryo butunguranye bibaho iyo kuva amaraso bitangiye mu buryo butunguranye nta mpamvu igaragara.

Uburemere bw'ibi bimenyetso n'igihe bigaragarira biratandukanye bitewe n'umuntu ku giti cye. Urugero, umwana ufite ikibazo gikomeye cya Factor VII ashobora kuvurwa akivuka. Ariko, umuntu ufite ibimenyetso byoroheje ashobora kutavurwa atarakura.

Ni iki gitera kubura kwa Factor VII?

Nubwo iyi ari indwara ikomoka ku murage , hari n'uburyo iyi ndwara ishobora kubaho mu buzima.

Niba waravutse ufite ikibazo cyo kubura factor VII , bivuze ko warazwe mutation, cyangwa inenge, muri gene yawe ya F7 . Iyi gene igenzura uburyo umubiri wawe ukora factor VII. Kugira ngo ugire ikibazo cyo kubura factor VII, ugomba kuragwa iyi gene mutation iva ku babyeyi bombi b'umubiri . Ibi byitwa autosomal recessive inheritance . Niba ababyeyi bombi bafite iyi gene mutation, bafite amahirwe agera kuri 25% yo kubyara umwana ufite ikibazo cyo kubura factor VII.

Ibura rya factor VII rigenda rikura uko igihe kigenda cyiyongera ryitwa 'acquired factor VII deficiency' . Hari impamvu nyinshi zishobora gutera:

• Indwara y'umwijima: Umwijima wawe utanga poroteyine ya Factor VII. Niba ufite indwara ikomeye y'umwijima, umwijima wawe ushobora kutabasha gukora uyu murimo neza.
• Kubura Vitamine K: Vitamine K ni ingenzi kugira ngo umubiri ukore Factor VII. Iyo utayibonye bihagije, ushobora kubura Factor VII.
• Imiti igabanya amaraso: Iyi ndwara ishobora no kubaho iyo ukoresheje imiti igabanya amaraso nka Warfarin (Coumadin®) .
• Indwara z'uturemangingo tw'amaraso na kanseri: Kubura kwa factor VII byagaragaye ku bantu bafite indwara nka aplastic anemia na leukemia .

Ni izihe ngorane ziterwa no kubura Factor VII?

Mu bihe bikomeye, kubura Factor VII bishobora gutera izindi ngorane z'ubuzima iyo bitavuwe. Urugero:

• Anemia: Iyo amaraso menshi asohotse mu mubiri, umubare w'uturemangingo dutukura tw'amaraso yawe ushobora kugabanuka cyane.
• Kwangirika kw'ingingo: Iyo hari amaraso mu ngingo, ingingo zishobora kwangirika kandi ingingo ntishobore kunama cyangwa kugororoka neza.
• Hematoma: Hematoma ni uruhurirane rw'amaraso apfundikiye munsi y'uruhu rwawe. Iyo hematoma nini ivutse, ishobora gushyira igitutu ku ngingo zegereye bigatuma habaho ibimenyetso bibabaza.

Icy'ingenzi kurushaho, kuva amaraso menshi bishobora gushyira ubuzima mu kaga iyo bitavuwe. Niyo mpamvu ari ngombwa gushaka inama kwa muganga niba kuva amaraso bitahagaze.

Ibura ry'umubiri rya Factor VII ripimwa gute?

Muganga wawe azakubaza ibimenyetso byawe kandi niba hari umuntu wo mu muryango wawe ufite amateka yo kuva amaraso. Ibura ry'ibice bya VII ripimwa hakoreshejwe ibizamini by'amaraso bipima uko amaraso yawe yacitse.

Ibi bizamini birimo:

• Ikizamini cya Prothrombin (PT / INR): Iki gipimo cy'igihe bifata kugira ngo amaraso yipfunde hashingiwe ku mikorere y'ikintu kivura amaraso cyitwa prothrombin. Niba ufite ikibazo cya factor VII, bifata igihe kirenze ibisanzwe kugira ngo amaraso yipfunde.
• Ikizamini cya PTT (Partial thromboplastin time): Iki gipimo cy'igihe bifata kugira ngo amaraso yipfunde hashingiwe ku mikorere y'ibintu bigabanya amaraso bitari prothrombin. Ibisubizo by'iki kizamini akenshi biba bisanzwe ku muntu ufite ikibazo cy'ubukene bwa factor VII.
• Isuzuma rya Factor VII: Iki kizamini kigaragaza uburyo poroteyine ya Factor VII ikora.

Ibura ry'umubiri rya factor VII rivurwa rite?

Ubusanzwe kuvura bisaba kongeramo factor VII ikora neza mu maraso yawe. Ushobora gukorana n'umuganga w'inzobere mu ndwara z'amaraso, witwa inzobere mu maraso , uzagena uburyo bwo kuvura ukeneye n'igihe uzabukenera.

Hari uburyo bwinshi bw'ingenzi bwo kuvura:

• Recombinant factor VIIa (NovoSeven®): Uyu muti wemejwe n'Ikigo gishinzwe ibiribwa n'imiti muri Amerika (FDA) kugira ngo uvure ikibazo cy'ibura rya factor VII. Wakozwe n'abahanga mu bya siyansi muri laboratwari. Ibi bivuze ko, bitandukanye n'ubundi buryo bwo kuvura busimbura factor VII, udakorwa mu maraso yatanzwe n'abantu.
• Inyongeramusaruro za Prothrombin (PCC): Ubu buvuzi bukubiyemo ibintu bine bigabanya amaraso, harimo na factor VII, biva mu maraso yatanzwe.
• Plasma ikiri mushya ikonje (FFP): Ushobora kandi guhabwa plasma mu mitsi kugira ngo igufashe kongera kubaka ububiko bwawe bwa Factor VII.

Ubundi buryo bwo kuvura:

• Imiti igabanya ubukana bw'amaraso: Iyi miti ikora mu guhagarika amaraso afunganye mu mubiri wawe. Ifasha mu gukumira kuva amaraso menshi mu kurinda amaraso afunganye mu mubiri wawe. Urugero, harimo imiti yitwa aside aminocaproic na aside tranexamic .
• Ibinini byo kuboneza urubyaro:Hari ubwoko bumwe na bumwe bw'ibinini byo kuboneza urubyaro birinda kuva amaraso menshi mu gihe cy'imihango.
• Inyongeramusaruro cyangwa inshinge za Vitamine K: Niba indwara yawe iterwa no kubura Vitamine K, kubona Vitamine K nyinshi bishobora gufasha umubiri wawe gukora factor VII nyinshi.

Ni izihe ngaruka mbi/ingaruka mbi z'ubuvuzi?

Uburyo bwo kuvura bwongera factor VII mu maraso rimwe na rimwe bushobora guteza ingorane. Ariko, ni ngombwa kwibuka ko muganga wawe azi izi ngaruka kandi arimo gufata ingamba zo kuzirinda.

Ingorane zishobora guterwa n'ubuvuzi bwa Factor VII zishobora kuba zirimo:

• Amaraso yangiza: Kongeramo factor VII bishobora kongera ibyago byo kuvura amaraso ashobora kuziba imiyoboro y'amaraso. Muganga wawe azakurikirana ingano y'imiti yawe kugira ngo agabanye iyi ngaruka.
• Kwibasirwa n’udukoko: Iyo umuntu ahawe amaraso, hari ibyago byo kwandura udukoko twangiza mu maraso (urugero: virusi cyangwa bagiteri) . Abaganga basuzuma neza ibikomoka ku maraso kugira ngo birinde ibi.
• Uburyo bwo guterwa amaraso: Ushobora kugira ubwivumbure ku maraso yatanzwe.
• Kurenza urugero rw'amaraso mu maraso: Factor VII irashwanyagurika vuba cyane kandi ikavanwa mu maraso yawe. Kugira ngo wirinde ibi, ushobora gukenera plasma nyinshi kugira ngo ugume ufite factor VII ihagije mu mubiri wawe. Ibi bishobora gutuma plasma yiyongera mu mubiri wawe. Ingaruka zo kurenza urugero rw'amaraso mu maraso zishobora kuba zirimo umuvuduko ukabije w'amaraso no kubyimba ibihaha (pulmonary edema) .

Ni iki nakwitega mu gihe mfite ikibazo cyo kubura ingano ya VII?

Kubura factor VII ni indwara ibaho ubuzima bwose . Nubwo nta muti uhari, ushobora gukorana na muganga wawe kugira ngo uyicunge.

Imwe mu mbogamizi zikomeye mu kumenya ubukana bw'indwara ni uko bidashoboka kumenya ubukana bw'ibimenyetso bitewe n'uko urugero rwa Factor VII ufite ruri hasi. Ahubwo, abaganga bakorana n'abantu bafite iyi ndwara ku giti cyabo. Uko ubona ibintu bizaterwa n'ibintu byihariye kuri wewe, nko kuba warahuye n'ibibazo, icyateye iyo ndwara, uko witwara mu kuvurwa, n'uburyo amaraso yawe asanzwe aba akomeye.

Nitwara nte?

Ni ngombwa kubwira abavuzi bose bakuvura ikibazo cyawe. Niba umwana wawe afite ikibazo cyo kubura ubushobozi bwo kwita ku bana (factor VII deficiency), bwira umuntu wese umwitayeho (harimo abarimu n'abakozi bo mu bigo byita ku bana).

Baza muganga wawe ibintu ushobora gukora kugira ngo wite ku buzima bwawe bwa buri munsi. Ashobora kukugira inama y'ibintu nk'ibi:

• Irinde ibikorwa bishobora guteza akaga gakomeye:Ushobora kuba ukeneye kwirinda ibikorwa byongera ibyago byo gukomereka (urugero: siporo yo gukomeretsa).
• Irinde imiti imwe n'imwe: Ushobora kuba ugomba kwirinda imiti igabanya amaraso yawe (urugero: aspirine , NSAIDs , SSRI depressive ). Ushobora kandi kwirinda inyunganiramirire zirimo amavuta y'amafi, vitamine E, na turmeric, kuko ibi bishobora kongera amaraso.
• Bika kopi y'uburyo bwo kuvura: Ni ngombwa kubika inyandiko z'abaganga b'indwara z'amaraso zivuga uburyo wakwitabwaho n'abaganga mu gihe cy'impanuka.
• Shaka inama cyangwa isuzuma ry’uturemangingo: Mbere yo kugerageza kubyara, ushobora kuvugana n’umujyanama mu by’uturemangingo kugira ngo arebe ibyago by’umwana wawe byo kurwara indwara ya VII.

Ni ryari ngomba kubonana na muganga wanjye?

Niba wowe cyangwa umwana wawe mubonye ibimenyetso byo kuva amaraso bidashira cyangwa ubururu bukabije, reba muganga wawe. Kuva amaraso mu mazuru no kugira ubururu rimwe na rimwe ni ibisanzwe. Ariko iyo bibaye kenshi kuruta uko bisanzwe, bishobora kuba ikimenyetso cy'ikibazo cy'amaraso.

Ni ryari nkwiye kujya mu Ishami ry’Ubuvuzi bw’Ingoboka (ETU) ?

Niba kuva amaraso kwawe ari ikibazo ku buzima bwawe, jya kwa muganga wita ku barwayi b’incuke. Shaka ibimenyetso nk'ibi:

• Kuva amaraso mu mazuru bimara isaha imwe cyangwa irenga.
• Gutoseza amapadi arenga abiri cyangwa tamponi ebyiri ku isaha mu gihe cy'amasaha abiri cyangwa arenga (ku bagore).

Ni ibihe bibazo ngomba kubaza muganga wanjye?

Dore ibibazo bimwe na bimwe ushobora kubaza muganga wawe:

• Ese ikibazo cyanjye cya Factor VII cyaravutse cyangwa cyaraje nyuma?
• Ni ubuhe bwoko bw'ubuvuzi nkeneye?
• Nzamara igihe kingana iki nkeneye kuvurwa?
• Ni izihe ngaruka mbi nkwiye kumenya mu gihe cyo kuvurwa?
• Ni izihe mpinduka mu mibereho ngomba kugira ngo menye uko merewe?

Ese kubura kwa Factor VII ni kimwe na 'hemophilia'?

Kubura factor VII na hemophilia ni indwara ebyiri z’amaraso zifitanye isano, ariko zitandukanye. Kubura factor VII biterwa no kubura poroteyine Factor VII (7), mu gihe hemophilia A , ubwoko bukunze kugaragara bwa hemophilia, biterwa no kubura poroteyine Factor VIII (8).

Hemophilia A ikunze kugaragara cyane kurusha ikibazo cy’ibura ry’indwara ya factor VII, ikaba yibasira umuntu umwe mu bantu 100.000. Ikunze no kugaragara ku bagabo .

Ariko icy'ingenzi ni uko izi ndwara zombi zishobora gutera kuva amaraso menshi, bityo zigomba kwitabwaho neza hifashishijwe umuganga.

Ibintu by'ingenzi cyane ugomba kwibuka

Nta buryo bwo kwirinda kuvuka ufite ikibazo cyo kubura amaraso mu mubiri (blood clotting disorder VII). Ariko ibyo ntibivuze ko wowe (cyangwa umwana wawe) udashobora kubaho ubuzima bwiza kandi bukora neza ufite iyi ndwara. Umuganga wawe w’amaraso ashobora kugufasha kwirinda no gucunga kuva amaraso. Ashobora kandi kugufasha gutegura gahunda y’icyo wakora niba uva amaraso menshi cyane. Ntugahangayike, ushobora kubaho neza ufite iyi ndwara.

Ubukene bw'ibice bya VII, Kuziba kw'amaraso, Kuva amaraso, Indwara z'uruhererekane, Indwara ya Alexander, Inzobere mu by'amaraso, Indwara z'amaraso