Felty Syndrome ni iki? Ibi ni ingenzi kuri mwe murwaye rubagimpande!

Ushobora kandi kugira ububabare mu ngingo, kubyimba, no kugorama gato mu maguru yawe mu gitondo, sibyo? Akenshi, ibi bishobora guterwa na rubagimpande. Ariko se wari uzi ko hari ikindi kibazo gishobora kuzanwa n'iyi ndwara ya rubagimpande, ariko ntabwo izwi cyane, ariko ni ingenzi cyane kubimenya? Iyo ni Felty Syndrome. Reka tubiganireho birambuye uyu munsi.

Ese koko indwara ya Felty Syndrome ni iki?

Muri make, Felty Syndrome ni uruvange rw'indwara eshatu ziba hamwe. Izo ni:

• Rumatizime ya Rumatike - Ububyimbirwe bw'ingingo benshi muri mwe mumenyereye.
• Neutropenia - Iki ni igabanuka ry'umubare wa neutrophils, ubwoko bw'uturemangingo tw'amaraso twera mu maraso.
• Splenomegali - Ibi bivuze ko uruhago, urugingo ruri mu mubiri, rurushaho kuba runini kuruta uko bisanzwe.

Akenshi bitangirana na rubagimpande (RA). Izindi ndwara ebyiri ziba nk'ingorane za RA. Abaganga bazita 'ibimenyetso bya extra-articular'. Ni ukuvuga ko rubagimpande ntirugarukira ku ngingo gusa, ahubwo rugira ingaruka ku ngingo ziri hanze yazo. Ibi biterwa n'uburyo bwo kubyimba butera rubagimpande. Nubwo bikunze kubaho ko izo ngaruka zibaho hanze y'ingingo zirimo RA, Felty Syndrome ni indwara idakunze kugaragara.

Ibi bikugiraho ingaruka ki?

Indwara ya Felty itangirana na rubagimpande. Hanyuma ugira ububabare bukomeye no kubyimba ingingo zawe. Hanyuma, iyo habayeho indwara nka Neutropenia na Splenomegaly, bigira ingaruka ku budahangarwa bw'umubiri wawe. Neutropenia ni ukugabanuka k'ubwoko bw'uturemangingo tw'amaraso tw'umweru twitwa neutrophils. Izi neutrophils ni ubwoko bw'ingenzi cyane bw'uturemangingo turinda umubiri wacu indwara. Rero iyo zigabanutse, amahirwe yo kurwara indwara ariyongera. Ubwinshi bw'uduheri nabwo bushobora kuba indi mpamvu ituma iyi neutrophils igabanuka.

Iyi ndwara ikunze kugaragara gute?

Indwara ya Felty igaragara ku bantu bagera kuri 2% barwaye rubagimpande. Kimwe na RA, Felty ikunze kugaragara ku bagore inshuro eshatu kurusha abagabo. Igishimishije ni uko abantu hafi ya bose barwaye RA barwaye Felty baba bafite "seropositive". Ibi bivuze ko ibizamini byemeza ko bafite ikintu cyitwa antibodies za rheumatoid factor mu maraso yabo. Abantu "bafite seronegative", bivuze abantu badafite izo antibodies, ni gake barwara Felty's syndrome.

Ni ibihe bimenyetso by'ibi?

Akenshi, ibimenyetso bya mbere bigaragara ni ibya rubagimpande. Ibi birimo:

• Ububabare bw'ingingo
• Kubyimba ingingo
• Kugorama kw'ingingo, cyane cyane mu gitondo

Hari abantu bashobora kugira ibindi bimenyetso usibye RA mu ngingo zabo. Urugero:

• Utubyimba twibasira munsi y'uruhu hafi y'ingingo (ibi byitwa rheumatoid nodules)
• Utunyangingo tw'imitsi tubyimba ahantu nko mu ijosi no mu kwaha
• Umwijima ushobora kubyimba kandi ukababara iyo uwukozeho.
• Amaso n'umunwa byumye (ibi byitwa Sjogren's syndrome)
• Amaso atukura, yabyimbye (ibi byitwa episcleritis)
• Ibisebe ku ruhu, cyane cyane ku maguru
• Ibimenyetso byo kuva amaraso munsi y'uruhu
• Kugorwa no guhumeka bitewe no kubyimba ibihaha
• Kubabara mu gituza bitewe no kubyimba hafi y'umutima
• Umuriro
• Umunaniro n'ubunebwe
• Kubura ubushake bwo kurya cyangwa kugabanya ibiro mu buryo butari bwo

Uretse ibi, Felty Syndrome ifite n'ibindi bimenyetso. Hari igihe ibi bimenyetso bishobora kugaragara mbere yuko ibimenyetso bya RA bitangira.

• Indwara zikunze kugaragara kandi zimara igihe kirekire. Urugero, harimo ibicurane, kubabara mu nda, n'indwara z'uruhu.
• Kubyimba imikaya. Bishobora kumvikana mu kiganza kandi bikaba byababaza.
• Guhindura ibara ry'uruhu (nk'utudomo).

Ariko igitangaje ni uko hari igihe ushobora gufatwa na Felty Syndrome nta bimenyetso. Ibipimo by'amaraso n'ibipimo bya scan bishobora kwerekana ko ufite indwara zose uko ari eshatu mbere yuko wumva ibimenyetso.

Ibi bikunze gutangira ku kigero kingana iki?

Indwara ya Felty Syndrome ikunze kugaragara mu bantu bakuze, bari hagati y'imyaka 50 na 70. Ku bantu benshi, Felty Syndrome igaragara nyuma y'uko bamaze imyaka 10 kugeza kuri 15 bafite ibimenyetso bya rubagimpande.

Kuki indwara ya Felty Syndrome ibaho?

Indwara ya rubagimpande ni 'indwara y’ubwirinzi bw’umubiri'. Ibi bivuze ko ubudahangarwa bwacu bw’umubiri bwibasira ibice by’umubiri wacu nk’aho ari umwanzi. Abahanga benshi bemeza ko Felty Syndrome ari ikibazo gikomeye cya RA. Muri izi ndwara zirwanya ubudahangarwa bw’umubiri, imibiri yacu ikora 'uturemangingo' turwanya poroteyine zimwe na zimwe. Izi antibodies zijya gufata izo poroteyine zikayitanga ikimenyetso cyo kuzitsemba. Uku niko ububyimbirwe bwiyongera.

Izi antibodies zishobora kuba zitari buri gihe muri RA. Ariko, ku bantu bafite Felty Syndrome, izi antibodies zirahari rwose. Kuba izi antibodies zihari ni impamvu ituma RA irushaho kuba mbi kandi izindi ngaruka zitari mu ngingo (extra-articular manifestations) ziyongera. RA ifite antibodies yitwa 'seropositive RA'. Ubushakashatsi bwerekana ko RA na Felty Syndrome byombi bifitanye isano na 'factors genetiki' zimwe na zimwe. Ibi bivuze ko zishobora guhererekanywa mu bisekuruza ku rugero runaka.

Ni gute indwara ya rubagimpande (RA) itera indwara ya neutropenia na splenomegaly?

Uburyo Neutropenia Ibaho

Neutropenia ni ukugabanuka k'umubare w'uturemangingo tw'amaraso tw'umweru twitwa neutrophils. Hari impamvu ebyiri z'ingenzi zibitera. Imwe ni uko umwotsi wo mu igufwa ryawe udakora neutrophils zihagije. Cyangwa, neutrophils mu mubiri wawe ziri kwangirika. Muri Felty Syndrome, ibi byombi bishobora kubaho. Uburyo bwo kwirwanaho bw'umubiri bwavuzwe haruguru bushobora kubangamira ikorwa rya neutrophils mu mwotsi wo mu igufwa, kandi neutrophils zimaze gukorwa zishobora kwangirika. Nanone, umwotsi wongerewe ni indi mpamvu ituma neutrophils zigabanuka.

Uburyo Splenomegali ibaho

Akazi k'agace kawe k'amaraso ni ukuvanamo uturemangingo tw'amaraso dushaje kandi tudafashije mu maraso yawe. Ariko iyo agace kawe kabaye kanini cyane (splenomegaly), gatangira gukora cyane gatangira gukuramo uturemangingo twinshi tw'amaraso twiza. Indwara ya rubagimpande rimwe na rimwe ishobora gutera agace kanini. Impamvu nyayo ntiramenyekana neza. Agace kawe gashobora no kwiyongera nta neutropenia. Nanone, ni gake cyane, Felty Syndrome ishobora kubaho nta gace kanini.

Ni izihe ngorane zikomeye ziterwa na Felty Syndrome?

Kubera ko Felty Syndrome igabanya ubudahangarwa bw'umubiri wawe, uba uri mu kaga ko kwandura indwara zikomeye kenshi . Nubwo waba ufite indwara ntoya kandi yoroshye kuvurwa, iyi ndwara ishobora gukomera ku buryo ikomeza rimwe na rimwe ikangiza ubuzima. Kwandura bagiteri zidakurikiranywe zishobora gutera indwara ikomeye yitwa sepsis. Abantu bafite Felty Syndrome nabo bari mu kaga ko kurwara ubwoko bumwe na bumwe bwa kanseri, nka lymphoma.

Ariko ntugatinye iyo wumvise ibi bintu. Ibyo byago birahari, ariko bishobora kugenzurwa iyo uvuwe neza kandi ukitabwaho.

Ni gute wabimenya?

Abaganga bapima indwara ya Felty Syndrome iyo basanze hari indwara ya rubagimpande, neutropenia, na splenomegaly. (Ni gake cyane, iyo ndwara ishobora kugaragara hatabayeho kwaguka k'umwobo.)

Ibizamini bikunze gukorwa ni ibi bikurikira:

• Gupima amaraso: Kubara amaraso yose, cyane cyane kugira ngo harebwe umubare wa neutrophils.
• Imirasire ya X-ray y'ingingo: Reba niba nta ndwara ya rubagimpande.
• Gupima imyakura: Urugero, gupima ultrasound cyangwa gupima CT.
• Isuzuma ry'umusemburo w'amagufwa:Ibi bifasha kwemeza ko nta zindi ndwara zibaho.

Ni ubuhe buryo bwo kuvura ibi?

Hari intego eshatu z'ingenzi mu kuvura indwara ya Felty Syndrome:

• Kugenzura indwara y’ihungabana ry’imitsi.
• Niba indwara ya neutropenia ikomeye, ivure neza.
• Gukumira indwara no kuzivura iyo zibaye.

Indwara ya Felty ishobora guterwa n’indwara ya rubagimpande idavuwe cyangwa idagenzurwa neza. Ku bantu benshi, neutropenia iragenda irushaho kuba nziza uko RA yabo igenda irushaho kuba nziza. Kubwibyo, abaganga babanza gushaka imiti igabanya indwara igabanya rubagimpande (DMARDs) kuri RA. Bagerageza kandi kwirinda imiti igabanya ubudahangarwa bw’umubiri uko bishoboka kose.

Hari ubwoko butandukanye bwa DMARD bushobora gukoreshwa mu kuvura Felty Syndrome:

• Methotrexate na aside folike (bigabanya ingaruka mbi za methotrexate)
• Abatacept
• Rituximab
• Leflunomide

Ariko niba indwara yawe ya neutropenia idakira ukoresheje iyi miti ya DMARD, cyangwa niba indwara yawe ya neutropenia ikomeye cyane, cyangwa niba usanzwe ufite ubwandu, muganga wawe azagerageza ubundi buryo bwo kuvura kugira ngo wongere umubare wa neutrophil. Ibi bishobora kuba birimo:

• Urukingo rwitwa G-CSF (granulocyte colony-stimulating factor).
• Imiti ya corticosteroid y'igihe gito.
• 'Splenectomy' - Ibi bivuze ko bakuyemo urwagashya rwinshi.

Nanone, abaganga bazafata ingamba zidasanzwe zo kukurinda indwara zandura, cyane cyane niba uburyo uvura bugira ingaruka ku budahangarwa bw'umubiri wawe. Bashobora kukugira inama nk'izi:

• Gufata imiti igabanya ubukana bw'indwara.
• Guhabwa inkingo zikenewe.
• Witondere cyane ubuzima bw'umunwa wawe n'amenyo yawe.

Iyo umuntu urwaye Felty Syndrome arwaye indwara, abaganga bayifata nk'ikintu gikomeye cyane. Ibi nibikubaho , ugomba guhita ubona ubuvuzi . Muganga wawe azakwandikira imiti ikomeye.

Icyizere cy'ubuzima umuntu afite Felty Syndrome ni ikihe?

Nta mibare iriho ubu ku mibereho y'abantu barwaye Felty Syndrome. Ariko, muri rusange, uburyo bwo kuvura bwateye imbere cyane mu myaka ya vuba aha. Bityo hari amahirwe menshi y'uko ubuvuzi ubwo aribwo bwose buzagufasha. Ingaruka nyamukuru zo gupfa muri Felty Syndrome ziracyari ukurwara indwara zikomeye . Kubwibyo, gufata ingamba zo kwirinda indwara bishobora kugira ingaruka zikomeye ku buzima bwawe bw'igihe kirekire.

Indwara ya Felty Syndrome ni ikibazo kidasanzwe kandi gikunze kwirengagizwa cya rubagimpande (RA). Niba umaze igihe kinini urwaye RA idakora neza, cyangwa imiti yawe ikareka gukora neza nk'uko byari bimeze mbere, ushobora kurwara Felty Syndrome. Hari abantu bayirwara nta bimenyetso. Bishobora gutera ubwoba kumenya ko indwara ifata ingingo zawe ishobora no kugira ingaruka ku turemangingo tw'amaraso.

Iyo usanzwe urwaye indwara ya RA, ndetse wenda n'ibindi bimenyetso, bishobora kukugora kubona ubundi buvuzi bushya. Ariko indwara ya Felty Syndrome ntabwo itera ibimenyetso bishya byinshi, kandi ishobora kudasaba ubundi buvuzi. Icy'ingenzi ni ukumenya ingaruka mbi. Ukoresheje umuganga wawe kugira ngo uvure indwara ya RA kandi wirinde kwandura, ushobora gucunga indwara ya Felty Syndrome.

Amaherezo, ibintu byo kwibuka

Indwara ya Felty Syndrome ni indwara ishobora kugaragara ku bantu bamwe na bamwe barwaye rubagimpande (rheumatoid arthritis). Irangwa no kugabanuka k'umubare w'uturemangingo tw'amaraso tw'umweru twitwa neutrophils mu maraso yawe (neutropenia) ndetse n'ubwiyongere bw'uturemangingo (splenomegaly).

• Ingaruka nyamukuru ni ukwandura kenshi, bityo rero ni ingenzi cyane kwirinda kwandura.
• Nubwo ibi bishobora gusa n'aho biteye ubwoba, iyi ndwara ishobora kugenzurwa neza iyo ubuvuzi n'inama bikwiye bivurwa neza .
• Niba ufite RA, komeza witondere izi zindi bimenyetso. Niba ufite impungenge , vugana na muganga wawe. Azagufasha.

` Indwara ya Felty, Rumatizime, Neutropenia, Splenomegaly, Rumatizime, Kubyimba ingingo, Neutrophils, Impatwe, Ubudahangarwa bw'umubiri