Ese nawe uhangayikishijwe n'ubwiyongere bw'imisemburo y'abagabo mu mubiri? Reka tuvuge ku ndwara ya hyperandrogenism!

Ese hari impinduka mu mubiri wawe ufite? Impamvu ishobora kuba ari ukwiyongera kwa androgen, ubwoko bw'imisemburo y'abagabo, mu mubiri. Iyi ndwara yitwa hyperandrogenism mu buvuzi. Ntugahangayike, tuzabivugaho mu buryo bworoshye, mu buryo ushobora gusobanukirwa.

Hyperandrogenism ni iki mu by'ukuri?

Muri make, hyperandrogenism bivuze ko umubiri wawe ufite androgens nyinshi cyane, ubwoko bwa hormone y'imibonano mpuzabitsina. Androgens ni ingenzi mu bugimbi, ubuzima bw'imyororokere, no gukura k'umubiri.

Noneho reba, imisemburo ni imiti iri mu mibiri yacu. Imeze nk'intumwa. Inyura mu maraso ikabwira ingingo zacu, imitsi, n'izindi ngingo icyo gukora n'igihe cyo kubikora.

Androgens zikorwa mu mubiri wa buri wese. Ariko abagabo nibo bakora cyane. Abagore bakora kimwe cya cumi na bibiri by'ingano mu mubiri w'umugabo. Testosterone ni yo ngiro nyamukuru muri izi androgens.

Androjeni zikorwa n'udusabo tw'intanga mu bagabo, naho intanga ngabo mu bagore. Iyi misemburo ikorwa kandi n'uturemangingo tw'intanga ngabo tuba hejuru y'impyiko zacu. Ifasha kandi guhindura androgens zidakomeye ahantu nk'ibinure n'uruhu.

Ibimenyetso by'iyi ndwara, byitwa hyperandrogenism, bishobora gutandukana bitewe n'imyaka yawe n'igitsina cyawe. Hari impamvu nyinshi zishobora gutera, kandi hari n'uburyo bwo kuyivura.

Ese Hyperandrogenism na PCOS ni kimwe?

Abantu benshi batekereza ko indwara ya hyperandrogenism na polycystic ovary syndrome (PCOS) ari indwara imwe. Nubwo hari isano ya hafi hagati y’ibyo byombi, ntabwo ari bimwe.

Hyperandrogenism ni ikintu cy'ingenzi kiranga PCOS. PCOS ni ihindagurika ry'imisemburo riterwa n'uko intanga ngabo zikora imisemburo myinshi y'abagabo. Igira ingaruka ku bagore.

Nubwo PCOS ari impamvu ikunze gutera hyperandrogenism, hari izindi mpamvu zishobora gutera hyperandrogenism. Mu buryo nk'ubwo, PCOS ifite ibindi bimenyetso, nko kumera kw'uturemangingo tw'intanga, hiyongereyeho ibimenyetso bya hyperandrogenism.

Ni nde wibasirwa cyane n'iki kibazo? Ni iki gikunze kugaragara?

Hyperandrogenism ishobora kugira ingaruka ku muntu uwo ari we wese - abana bato, abantu bakuru, buri wese. Ariko, ikunze kugaragara ku bagore bari mu kigero cyo kubyara .

Hagati ya 5% na 10% by'abagore bari mu kigero cyo kubyaraIbi biragira ingaruka. Ibyo bivuze ko ibi atari ibintu bidasanzwe nkuko ushobora kubitekereza.

Iyi ndwara ntabwo ishobora kwibasira abahungu n'abagabo bakuru.

Ni ibihe bimenyetso by'ibi?

Ibimenyetso bya hyperandrogenism biratandukanye bitewe n'igitsina cyawe ndetse n'uko wageze mu bugimbi cyangwa umwangavu.

Ariko hari ikintu cy'ingenzi ugomba kwibuka. Nubwo waba ufite ibi bimenyetso, urugero rwa androgen mu maraso yawe rushobora kuba rusanzwe. Ibi biterwa nuko buri kimwe muri ibi bimenyetso gishobora kugira izindi mpamvu. Nanone, nubwo ibizamini by'amaraso byagaragaza ko urugero rwa androgen mu maraso yawe ruri hejuru, ushobora kutagira ibimenyetso bikomeye ufite.

Igikuru ni uko niba ibi bimenyetso bigaragaye mu buryo butunguranye kandi bwihuse, ugomba kujya kwa muganga vuba bishoboka, kuko muri ibyo bihe, impamvu ishobora kuba ikibyimba gitanga androgen.

Noneho reka turebe uburyo ibi bigira ingaruka ku bantu batandukanye.

Ku bakobwa (mbere y'ubugimbi)

• Imboro nini .
• Ibiheri n'uruhu rufite amavuta menshi.
• Ugukura k'ubwoya ku mubiri ku buryo butunguranye (hirsutism) . Ibi bivuze ko "ubwoya bw'umukara woroshye" busimburwa n'ubwoya bukabije kandi bukabije ahantu nko ku munwa wo hejuru, ku kananwa, mu gituza, mu nda no mu mugongo.

Ku bana b'abahungu (mbere y'ubugimbi)

• Imboro nini .
• Umusatsi ukura hakiri kare cyangwa ukabije mu mwanya wihariye no mu kwaha.
• Gushyira ijwi mu buryo bwimbitse.

Ku bagore bakuze

• Ibiheri n'uruhu rufite amavuta menshi.
• Gukura mu buryo butunguranye kw'imitsi y'ubwoya ku mubiri ( hirsutism) .
• Ukwezi kwa buri kwezi kutemewe.
• Ingorane zo kubyara (kutabyara) .
• Gutakaza umusatsi ku bagabo ( androgenic alopecia) .

Ku bagabo bakuru

Uburyo ibi bigira ingaruka ku bagabo bakuru biterwa nuko imisemburo yiyongereyeho iva mu ngirabuzimafatizo z'impyiko cyangwa iva ku kintu gifatwa hanze (nk'inshinge za steroide ). Iyo androgens zivuye mu ngirabuzimafatizo z'impyiko z'impyiko ziyongereye, abagabo bakuru bashobora kutabona impinduka zikomeye ku mubiri. Ariko, bishobora kugabanya imikorere y'intanga no kugorana kubyara.

Kuki ibi bibaho? Impamvu ni izihe?

Imisemburo ya Androgen ikorwa n'intanga ngore, imyakura y'inkende, n'uturemangingo tw'ibinure mu bagore, ndetse n'intanga ngabo n'imyakura y'inkende mu bagabo.

Hari indi misemburo myinshi igira ingaruka ku ikorwa n'irekurwa ry'iyi androgens. Urugero , imisemburo ya luteinizing (LH) na hormone ya adrenocorticotrophic (ACTH) . Iyi misemburo yombi irekurwa na pituitary gland.

Iyo kimwe cyangwa byinshi muri ibi bice by'umubiri, cyangwa imwe muri izi misemburo, idakora neza, hyperandrogenism ishobora kubaho.

Hari impamvu nyinshi z'ingenzi zibitera:

• Indwara ya Polycystic ovary syndrome (PCOS) - Iyi ni yo mpamvu ikunze kugaragara cyane.
• Hyperplasia y'intanga ngabo (CAH) ivuka .
• Indwara ya Cushing .
• Ibibyimba bisohora androjeni.
• Imiti imwe n'imwe.

Noneho reka turebe buri imwe muri izi mpamvu mu buryo burambuye.

Indwara y'intanga ngabo (PCOS)

Mu bagore bakiri bato n'abakuze, PCOS ni yo mpamvu ikunze gutera hyperandrogenism ihoraho nyuma y'ubugimbi. Hagati ya 80% na 90% by'abagore bafite hyperandrogenism nabo bafite PCOS .

Muri PCOS, intanga ngabo zikora androgens nyinshi bitewe n'urugero rwa LH na insuline ruhoraho (hyperinsulinemia). Byongeye kandi, kwiyongera kwa insuline binabuza umwijima gukora poroteyine yitwa Sex Hormone Binding Globulin (SHBG) . Ibi byongera urugero rwa testosterone y'ubuntu mu maraso.

Hyperplasia y'inkondo y'umura (CAH)` yo mu gihe cy'amavuko

Indwara yo mu bwoko bwa Congenital adrenal hyperplasia (CAH) ni itsinda ry'indwara ziterwa n'uturemangingo zigira ingaruka ku ngirabuzimafatizo z'inkondo y'umura.

Muri CAH, impinduka mu miterere y’uturemangingo zitera ibura rya enzyme yitwa 21-hydroxylase , ifasha umubiri gukora imisemburo. Ku bantu benshi bafite CAH, uku kubura kwa enzyme bituma adrenal glands ikora indi misemburo myinshi, nka testosterone.

Impamvu ikunze gutera hyperandrogenism ku bagore bafite adrenal hyperplasia ni non-classical congenital adrenal hyperplasia . Iyi ni indwara aho enzyme 21-hydroxylase iba idafite igice. Iyi ndwara igira ingaruka ku bagore bagera kuri 2% bafite hyperandrogenism.

Indwara ya Cushing

Indwara ya Cushing ni ubwoko bw'indwara yitwa Cushing syndrome . Indwara ya Cushing ni indwara idakunze kubaho iyo umubiri ufite cortisol nyinshi (nayo imisemburo).

Indwara ya Cushing iterwa n'ikibyimba kitari kanseri mu gasabo k'ubwonko. Iki kibyimba gisohora ACTH (hormone ya adrenocorticotropic) irenze urugero, yongera urugero rwa cortisol.

ACTH nyinshi ituma adrenal glands irekura androgens nyinshi, ari nabyo bitera hyperandrogenism.

Indwara ya Cushing ifite ibindi bimenyetso:

• Udukoryo tw'umuhengeri ku nda.
• Kwiyongera ibiro vuba mu maso, mu gifu no mu ijosi.
• Umuvuduko w'amaraso ukabije.

Niba ufite ibimenyetso nk'ibi, ni ngombwa cyane kubonana na muganga vuba bishoboka.

Ibibyimba bisohora androjeni

Bimwe mu bibyimba bya adrenal gland, cyangwa ibibyimba byo mu dusabo tw’intanga cyangwa udusabo tw’intanga, bishobora gukora no gusohora androgens. Ibi bituma urugero rwa androgens mu mubiri ruruta uko bisanzwe. Indwara ya hyperandrogenism iterwa n’ibi bibyimba akenshi iba ikomeye cyane kandi ikaza mu buryo butunguranye .

Hyperandrogenism, iterwa n'ibibyimba by'intanga ngore cyangwa adrenal, ni gake cyane. Ifata abantu bagera kuri 0.2% gusa. Ariko, niba ugize ibimenyetso bya hyperandrogenism mu buryo butunguranye, jya kwa muganga ako kanya.

Imiti imwe n'imwe

Imiti imwe na imwe ishobora gutera hyperandrogenism. Imiti y'ingenzi itera ibi ni:

• Steroid za Anabolic-androgenic (izi ni ubwoko bwa testosterone y’ubukorano, ikoreshwa nabi na bamwe mu bakinnyi kugira ngo bongere imikorere).
• Progestins za sintetike (iyi ni imiti itera impinduka mu mura kandi ikoreshwa mu bintu bitandukanye).
• Imiti igabanya igicuri ( imiti irinda indwara zo mu mutwe ).

Ubibona ute? (Isuzuma)

Niba uri umugore kandi ukaba ukeka ko ufite hyperandrogenism, muganga wawe azagusuzuma arebe ibimenyetso nko gukura k'umusatsi udashaka. Bazakubaza kandi ibibazo bike ku mateka yawe y'uburwayi:

• Imyaka amabere atangira kumera.
• Imyaka umusatsi utangira kugaragara mu mwanya wihariye.
• Imyaka mu mihango ya mbere.
• Ese ukuraho umusatsi (wogosha, waba warakuweho umusatsi hakoreshejwe laser)?
• Ese wigeze ukoresha imiti igabanya ubukana bwa anabolic steroids cyangwa testosterone udafite uruhushya rwa muganga?
• Ibintu nk'uko imihango yawe igenda, iminsi imara, n'amaraso menshi uva.

Niba umuganga wawe akeka ko ufite hyperandrogenism, azagutegeka gupima amaraso kugira ngo arebe urugero rw'imisemburo runaka. Ibi bizamini bishobora gufasha gusuzuma iyo ndwara.

Ni ubuhe bwoko bw'ibizamini bikorwa?

Niba ufite ibimenyetso bya hyperandrogenism, muganga wawe ashobora gutegeka ko upimwa amaraso nk'ibi bikurikira:

• Testosterone yose hamwe: Ibi bipima ingano yose ya testosterone mu maraso yawe. Iki gipimo gishobora kuba kiri hejuru gato ku bagore bafite PCOS. Iyo kiri hejuru cyane, gishobora kuba ikibyimba mu dusabo tw'intanga cyangwa mu mabya.
• Testosterone y'ubuntu : Iyi testosterone ntabwo ifatanye na poroteyine iyo ari yo yose. Iyi ni ingano nto ya testosterone yose. Uru rugero rushobora no kwiyongera ku bagore bafite PCOS.
• Androstenedione : Iyi ni imisemburo ya steroide idafite ingaruka nyinshi za androgenic ku mubiri. Ariko, ahanini ikora nk'intambwe y'ibanze mu gukora testosterone na estrogen mu mubiri. Iyo urugero rwayo ruri hejuru, PCOS ishobora kuba ihari.
• Dehydroepiandrosterone sulfate (DHEAS) : DHEAS ni imisemburo y'igitsina ikorwa n'uturemangingo tw'intanga ngabo. Kubwibyo, ni ikimenyetso cyiza cy'uko androgen ikorwa. Ni ibisanzwe ko abagore barwaye PCOS bagira urugero rwa DHEAS ruri hejuru gato. Iyo ruri hejuru cyane, bishobora kuba ikimenyetso cy'ikibyimba cy'intanga ngabo.
• 17-hydroxyprogesterone : Gupima urugero rwa 17-hydroxyprogesterone mu maraso ni ikizamini cy'ibanze cyo kugenzura niba hari indwara ya adrenal hyperplasia idakunze kugaragara, indwara imwe mu mpamvu zitera hyperandrogenism.

Kubera ko hari izindi mpamvu zishobora gutera ibimenyetso bya hyperandrogenism, muganga wawe azagutegeka ko hakorwa ibindi bipimo by'amaraso kugira ngo agaragaze ko ibyo bintu ntaho bihuriye.

Byongeye kandi, ibizamini nk'ibi bishobora gukorwa kugira ngo hamenyekane icyateye hyperandrogenism:

• Gupima imiterere y'ikibuno kugira ngo harebwe ko nta cysts zo mu miyoboro y'intanga (ikindi kimenyetso cya PCOS) cyangwa ibindi bibyimba.
• Kugira ngo harebwe niba hari ibibyimba by’inkondo y’umura , hakorwa ibizamini bya CT scan (computed tomography - CT) cyangwa MRI scan (Magnetic resonance imaging - MRI) .

Abaganga bagamije kugabanya umusaruro wa androgen uva mu dusabo tw’intanga cyangwa adrenal glands, kugabanya urugero rwa androgens, no kubuza androgen gukora.

Ariko, abantu bafite hyperandrogenism bakunze gushaka inama kwa muganga kugira ngo bavure ibimenyetso by'ingenzi, nko gukura k'umusatsi udashaka, ibiheri, no kujya mu mihango ku buryo butunguranye.

Ni ubuhe buryo bwo kuvura ibi?

Uburyo bwo kuvura hyperandrogenism buterwa n'impamvu. Urugero:

• Hyperandrogenism y'intanga ngabo ishobora kugenzurwa hakoreshejwe imiti ya corticosteroids ikoreshwa ku rugero ruto.
• Niba hari ibibyimba mu dusabo tw’intanga, mu mabya, cyangwa mu ndurwe z’impyiko, bishobora kuba ngombwa ko bibagwa. Ku bagore barembye cyangwa barembye cyane bafite hyperandrogenism ikomeye, na byo bishobora kuba ngombwa ko babanza kubaga intanga imwe cyangwa zombi .
• Niba hyperandrogenism iterwa n'umuti urimo gufata, muganga wawe azakugira inama yo guhagarika umuti cyangwa guhindura undi muti.

Imiti irwanya androgen nayo ni uburyo busanzwe bwo kuvura hyperandrogenism. Ibuza ingaruka za androgens, nka testosterone.

Hari ubwoko butandukanye bw'imiti irwanya androgen:

• Ibinini byo kuboneza urubyaro binyobwa/ibinini byo kuboneza urubyaro birimo ethinyl estradiol (estrogen) na progesterone irwanya androgenic: Urugero, harimo ibinini birimo cyproterone acetate (urugero: Diane®-35), drospirenone (urugero: Yasmin®, Yaz®) cyangwa dienogest (urugero: Valette®). Ibi bishobora kuvura ibiheri, gukura k'umusatsi utifuzwa no kujya mu mihango ku buryo budasanzwe.
• Spironolactone (Aldactone®) : Iyi antiandrogen ivura ibiheri n'imikurire y'umusatsi udashaka biterwa n'imisemburo.
• Cyproterone : Uyu muti ufasha kuvura PCOS, kugabanya urugero rwa testosterone, no kugabanya umusaruro w'amavuta atera ibiheri.

Kuvura ibimenyetso

Abantu bafite hyperandrogenism bashobora gushaka ubuvuzi bwihariye ku bimenyetso byabo:

• Indwara y'ibiheri : Uburyo bwo kuvura ibiheri burimo imiti ikoreshwa mu kuvura indwara zo mu mutwe, imiti igabanya ubukana bw'ibiyobyabwenge nka tetracycline , imiti igabanya androgens (harimo imiti igabanya ubukana bw'imisemburo, imiti yo kuboneza urubyaro), n'imiti igabanya ubukana bw'ibisebe .
• Hirsutism (ikura ry'umusatsi udakenewe) : Abagore benshi bafite hirsutism bakoresha uburyo nko gusiga imisatsi, kogosha, no gukuraho umusatsi hakoreshejwe laser. Bashobora kandi gufata ibinini byo kuboneza urubyaro.
• Gufata imihango idahwitse : Abagore bashobora gukoresha uburyo bwo kuboneza urubyaro bugizwe n'imisemburo kugira ngo bagenzure imihango yabo.

Iyo ibi bimenyetso bidasubije ku miti isanzwe bitewe n’ihindagurika ry’imisemburo, muganga wawe ashobora kugufasha gufata imiti ikomeye cyane igabanya androgen.

Ese ibi ntibishobora kwirindwa?

Ikibabaje ni uko nta buryo busobanutse neza bwo kwirinda hyperandrogenism.

Nta buryo bwemewe bwo kwirinda PCOS, impamvu ikunze gutera hyperandrogenism. Ariko ushobora gufata ingamba nto kugira ngo ugabanye ibimenyetso. Urugero, kurya indyo yuzuye intungamubiri,Gukora imyitozo ngororamubiri ihoraho no kugenzura ibiro byawe bishobora kugabanya ingaruka za PCOS na hyperandrogenism.

Ejo hazaza hazaba hameze hate? (Ibisobanuro ku ibizakurikiranwa)

Indwara nyinshi zitera hyperandrogenism zisaba kuvurwa ubuzima bwose. Hari igihe abagore bafite hyperandrogenism iterwa na PCOS batakaza ibiro byinshi kandi PCOS yabo ikavaho. Ariko, abantu benshi bazakenera kuvurwa ubuzima bwabo bwose kugira ngo bagabanye ibimenyetso bya hyperandrogenism.

Ibimenyetso bya hyperandrogenism bishobora kugira ingaruka ku kwiyubaha kwawe no ku buzima bwawe bwo mu mutwe. Niba ibi bimenyetso bigutera kumva ufite stress, guhangayika, cyangwa kwiheba, ni ngombwa gushaka ubufasha ku muganga w’indwara zo mu mutwe cyangwa umujyanama.

Ni ryari ngomba kujya kwa muganga?

Niba usanzwe urwaye hyperandrogenism kandi ukaba ufata imiti yayo, uzakenera kujya kwa muganga buri gihe kugira ngo umenye neza ko ubuvuzi bwawe bukora neza.

Niba hyperandrogenism igize ingaruka ku buzima bwo mu mutwe wawe, ni ngombwa kubonana n'umuganga w'indwara zo mu mutwe cyangwa umujyanama kugira ngo agufashe.

Hanyuma, ubutumwa bwo kujyana mu rugo:

Hyperandrogenism ni indwara ikunze kugaragara mu bagore. Ibimenyetso byayo bishobora gutuma wumva ufite isoni kandi ukumva utameze neza. Ariko ibuka ko utari wenyine, kandi iyi ndwara ishobora kuvurwa. Vugana na muganga wawe ku bijyanye n'uburyo bwo kuyivura. Nanone, niba igira ingaruka ku buzima bwawe bwo mu mutwe, menya neza ko wagiye kwa muganga w'indwara zo mu mutwe cyangwa umujyanama. Kwita ku buzima bwawe ni cyo kintu cy'ingenzi cyane.

` Hyperandrogenism, Androgen, Testosterone, PCOS, Hirsutism, ibiheri, Kudahuza kw'imisemburo, Ubuzima bw'abagore, Kudahuza kw'imisemburo