Ese wumva ufite testosterone nkeya? Reka twige neza kuri iyi mpinduka mu mubiri w'umugabo (Hypogonadism y'abagabo)!

Ese hari igihe wumva unaniwe, nta kintu na kimwe ushishikajwe nacyo, cyangwa ufite ikibazo gito ku bintu bimwe na bimwe bifitanye isano n'ubugabo? Ahari impamvu ibi biterwa ni ukugabanuka kwa testosterone mu mubiri wawe. Uyu munsi, turaganira kuri uku kugabanuka kwa testosterone , cyangwa nk'uko abaganga babyita, indwara yitwa Male Hypogonadism . Ntugahangayike, iki ni ikintu gishobora kuba ku bantu benshi, kandi hari uburyo bwo kuvura.

Ese testosterone nkeya bivuze iki?

Mu magambo make, testosterone nkeya bivuze ko intanga zawe (uturemangingo dukora intanga mu bagabo) tudakora testosterone ihagije. Mu by'ukuri, iyi testosterone ikorwa n'uturemangingo twa Leydig turi mu ntanga.

Iyi ndwara ishobora kugaragaza ibimenyetso bitandukanye mu myaka itandukanye. Nanone, urugero rwa testosterone rugabanuka gato uko abagabo bakura. Ibi byitwa n'andi mazina, urugero:

• Indwara yo kubura testosterone
• Kubura testosterone
• Hypogonadism y'ibanze
• Hypogonadism ya kabiri

Kuki testosterone ari ingenzi cyane?

Testosterone ni yo misemburo y'abagabo y'ingenzi cyane. Ni ingenzi mu iterambere ry'imiterere y'abagabo no gukora intanga ngabo (spermatogenesis). Abagabo bafite urugero rwa testosterone ruri hejuru cyane mu mibiri yabo kurusha abagore.

Testosterone ifasha kubungabunga no guteza imbere ibi bintu mu mubiri w'umugabo:

• Imyanya ndangagitsina
• Ingano y'imitsi
• Urugero rwiza rw'uturemangingo dutukura tw'amaraso
• Ubucucike bw'amagufwa
• Ubuzima bwiza bwo mu mutwe
• Imikorere y'imibonano mpuzabitsina n'imyororokere

Ubusanzwe, imibiri yacu igenzura urugero rwa testosterone mu maraso yacu. Iba iri hejuru cyane mu gitondo kandi igenda igabanuka buhoro buhoro uko umunsi ugenda ushira.

Hypothalamus na pituitary gland mu bwonko bwawe bigenzura ingano ya testosterone ikorwa n'irekurwa ry'amabya yawe.

Hypothalamus irekura imisemburo isohora gonadotropin (GnRH) . Ibi bitanga ikimenyetso ku misemburo ya pituitary kugira ngo irekure imisemburo ya luteinizing (LH) . Hanyuma LH ijya mu mabya kugira ngo itere imbaraga mu gukora testosterone. Imisemburo ya pituitary inarekura imisemburo itera imbaraga za follicle (FSH) kugira ngo ifashe mu gukora intanga.

Rero, niba hari ikibazo ku mabya yawe, hypothalamus, cyangwa pituitary gland, urugero rwa testosterone yawe rushobora kugabanuka.

Ni uruhe rwego rufatwa nk'"testosterone nkeya"?

Nk’uko bivugwa n’Ishyirahamwe ry’Abanyamerika ryita ku ndwara z’imitsi (AUA), urugero rwa testosterone mu maraso y’umuntu mukuru rufatwa nk’ururi hasi iyo ruri munsi ya nanogarama 300 kuri desilita imwe (300 ng/dL).

Ariko, bamwe mu bashakashatsi n'abaganga ntibemeranya neza n'iki gitekerezo. Hari abemeza ko ikintu kiri munsi ya `250 ng/dL` gifatwa nk'aho kiri hasi. Ariko, abaganga bazasuzuma ibimenyetso byawe mu gihe bareba niba ufite testosterone nkeya.

Ni nde uri mu kaga gakomeye ko kugabanuka kwa testosterone?

Iyi ndwara ishobora kwibasira abagabo b'imyaka iyo ari yo yose, kuva bakivuka kugeza bageze mu zabukuru.

Ariko, aba bantu bafite amahirwe menshi yo kugira testosterone nke:

• Ku bantu bakuze
• Ku bantu bafite umubyibuho ukabije (babyibushye cyane)
• Ku bantu barwaye diyabete yo mu bwoko bwa 2 idagenzurwa neza
• Ku bafite ikibazo cyo kubura umwuka wo gusinzira neza
• Abantu bafite indwara zidakira nko kunanirwa kw'impyiko no kurwara indwara y'umwijima
• Ku babana n'ubwandu bwa virusi itera SIDA

Iyi ndwara ikunze kugaragara gute?

Biragoye kubashakashatsi kuvuga neza uburyo testosterone nke isanzwe igaragara, kuko ubushakashatsi butandukanye bwasobanuye "testosterone nke" mu buryo butandukanye.

Dukurikije amakuru amwe, abagabo bagera kuri 2% bashobora kuba bafite iyi ndwara. Ubundi bushakashatsi bwerekana ko abagabo barenga 8% bari hagati y'imyaka 50 na 79 bafite urugero ruke rwa testosterone.

Ni ibihe bimenyetso by'uko testosterone nkeya igaragara?

Ibimenyetso bya testosterone nkeya bishobora gutandukana cyane bitewe n'umuntu ku giti cye, cyane cyane bitewe n'imyaka.

Ibimenyetso ku bagabo bakuru

Niba ufite ibi bimenyetso, hari amahirwe menshi ko ushobora kugira testosterone nkeya:

• Kugabanuka k'ubushake bw'imibonano mpuzabitsina
• Kudakora neza kw'intanga ngore
• Gutakaza umusatsi mu kwaha no mu bice byihariye
• Kugabanuka kw'intanga ngore
• Gushyuha cyane
• Kugabanuka cyangwa kubura intanga ngabo (Azoospermia), bishobora gutera ingorane mu gutwita abana.

Ibindi bimenyetso bishobora kuba birimo:

• Ihungabana (indwara yo kwiheba)
• Kugorwa no gutekereza no kwibuka
• Ubwiyongere bw'ibinure mu mubiri
• Kwagura amabere y'abagabo (Gynecomastia)
• Kugabanuka kw'imbaraga n'ingano y'imitsi
• Kugabanuka k'ubushobozi bw'umubiri

Ibimenyetso ku bana (mbere cyangwa mu gihe cy'ubugimbi)

Iyo urugero rwa testosterone mu muhungu rugabanutse mbere cyangwa mu gihe cy'ubwangavu, ashobora kugira ibimenyetso nk'ibi:

• Uburebure bugenda buhoro, ariko amaguru n'amaboko bishobora gukura birebire cyane kurusha ibindi bice by'umubiri.
• Kugabanuka k'umusatsi mu mwanya wihariye.
• Kugabanuka k'ubukure bw'intanga n'amabya.
• Kugabanuka k'ubwiyongere bw'ijwi.
• Kugabanuka kw'imbaraga n'ubushobozi bwo kwihangana bifitanye isano n'izabukuru.

Ni izihe mpamvu zitera testosterone nkeya?

Hari impamvu nyinshi zishobora gutuma urugero rwa testosterone rugabanuka. Iyi ndwara igabanyijemo ibice bibiri by'ingenzi:

1. Hypogonadism y'ibanze: Ibi biterwa n'ikibazo kiri mu mabya ubwayo.

2. Kudakora neza kw'imisemburo: Ibi biterwa n'imikorere mibi y'agace ka pituitary cyangwa hypothalamus mu bwonko.

Ubwo bwoko bwombi bushobora guterwa n'impamvu zavutse cyangwa impamvu zavutse nyuma (mu bwana cyangwa mu bukuru).

Impamvu zitera hypogonadism y'ibanze

Ikiba muri iki kibazo ni uko hari ikibazo ku mabya, bigatuma adakora testosterone mu buryo busanzwe.

Irindi zina ry'ibi ni hypergonadotropic hypogonadism . Ibi ni igihe agahu k'ubwonko gakora imisemburo myinshi ya LH na FSH (izwi kandi nka gonadotropins) bitewe na testosterone nkeya. Ubusanzwe, iyo iyi misemburo iri hejuru, intanga zibwirwa gukora testosterone n'intanga nyinshi. Ariko, iyo intanga zangiritse (akenshi bitewe na chemotherapy ya kanseri) cyangwa iyo intanga zibuze, ntizishobora gusubiza iyi nganotropin yiyongera. Ingaruka zabyo ni uko testosterone n'intanga nke cyane cyangwa nta na kimwe bikorerwa.

Hari igihe mu gihe cy’ibanze cya hypogonadism, urugero rwa gonadotropin rushobora kwiyongera nubwo urugero rwa testosterone ruri mu rugero rusanzwe. Inzobere yawe izagusobanurira niba ubuvuzi ari ngombwa nubwo testosterone yaba ari isanzwe.

Impamvu zivukanwa:

• Kubura intanga mu gihe cyo kuvuka (Anorchia)
• Cryptorchidism (kunanirwa k'udusabo tw'intanga ngore kumanuka mu gituza)
• Iterambere rituzuye ry'uturemangingo twa Leydig mu mabya (Leydig cell hypoplasia)
• Indwara ya Klinefelter (abagabo bavukana chromosome ya X y'inyongera aho kuba XY - XXY)
• Indwara ya Noonan (indwara idakunze kugaragara mu buryo bw'uturemangingo, ishobora gutera gutinda kwangirika, imisemburo idakora neza, cyangwa ubugumba)
• Myotonic dystrophy (itsinda ry'indwara z'intege nke z'imitsi)

Impamvu zabonetse:

• Gukomeretsa cyangwa gukuraho udusabo tw'intanga.
• Kubyimba k'uruhinja rumwe cyangwa zombi (orchitis). Ibi akenshi biterwa n'indwara ya bagiteri (urugero: indwara zandurira mu mibonano mpuzabitsina), cyangwa bishobora guterwa n'indwara ya virusi nka mumps.
• Gutanga imiti igabanya ubukana bw'intanga cyangwa imirasire ku ntanga.
• Amoko amwe na amwe ya kanseri.
• Gukoresha steroide zikozwe muri anabolic.

Impamvu zitera hypogonadism ya kabiri

Hypogonadism ya kabiri iterwa n'ibintu bigira ingaruka ku mikorere ya hypothalamus na/cyangwa ingirabuzimafatizo ya pituitary. Ibi byitwa hypogonadism ya hypogonadotropic.Nanone yitwa "testosterone nkeya" kubera ko urugero rw'imisemburo `LH` na `FSH` ruri hasi hano. Urwo rugero ruri hasi rutuma testosterone n'intanga ngabo bigabanuka.

Impamvu zivukanwa:

• Hypogonadism yo mu bwoko bwa hypogonadotropic (urugero ruto rwa GnRH kuva umwana avutse)
• Kallmann syndrome (indwara idakunze kugaragara mu buryo bw'uturemangingo, kunanirwa gukura kw'uturemangingo tw'imitsi muri hypothalamus ikora GnRH. Kubura impumuro nabyo bishobora kubaho)
• Indwara ya Prader-Willi (indwara idakunze kugaragara mu buryo bw'uturemangingo twinshi ishobora kwangiza imikorere ya hypothalamus)

Impamvu zabonetse:

• Hypopituitarism (ibi bishobora guterwa n'ikibyimba cy'ubwonko (adenoma), ubwandu, imvune, kuvurwa hakoreshejwe imirasire, cyangwa kubagwa)
• Hyperprolactinemia (ubwiyongere bw'imisemburo ya prolactin)
• Ubutare bwinshi mu mubiri (Hemochromatosis)
• Igikomere cyo mu bwonko cyangwa ku mutwe
• Indwara ya Cushing
• Kurwara umwijima mu mwijima
• Kunanirwa kw'impyiko
• VIH/SIDA
• Indwara yo kunywa inzoga
• Diyabete idacungwa neza
• Umubyibuho ukabije (kuba umubyibuho ukabije)
• Kubura umwuka wo mu gihe cyo gusinzira
• Imiti imwe n'imwe (urugero: estrogen, imiti ihindura amarangamutima, metoclopramide, opioid, imiti imwe n'imwe ivura kanseri ya prostate)

Hypogonadism yo mu gihe cya nyuma (LOH) ni ubwoko bwa hypogonadism ya kabiri ibaho iyo umuntu ashaje neza. Uko abagabo bakura, testosterone cyangwa intanga zikorwa biragabanuka bitewe n'imikorere mibi ya hypothalamic-pituitary ndetse n'imikorere ya selile ya Leydig.

LOH na testosterone nkeya ni ibisanzwe mu bagabo barwaye diyabete yo mu bwoko bwa 2, umubyibuho ukabije, cyangwa umubyibuho ukabije.

Mu bushakashatsi bumwe, 30% by'abagabo bafite ibiro bikabije bari bafite urugero rwa testosterone ruke, ugereranije na 6% gusa by'abagabo bafite ibiro bisanzwe. Mu bundi bushakashatsi, 25% by'abagabo barwaye diyabete yo mu bwoko bwa 2 bari bafite urugero rwa testosterone ruke, ugereranije na 13% gusa by'abagabo badafite diyabete.

Wamenya ute neza niba ufite testosterone nkeya?

Niba ufite ibimenyetso bya testosterone nkeya, muganga azagusuzuma. Bazakubaza kandi ibibazo bijyanye n'amateka y'ubuzima bwawe, imiti ufata cyangwa wafashe, niba unywa itabi, n'ibimenyetso byose usanzwe ufite. Hanyuma bazagutegeka gupimwa amaraso kenshi.

Kugira ngo umuganga amenye ibimenyetso byawe n'ibisubizo by'amaraso yawe, azasuzuma ibimenyetso byawe.

Ni ubuhe bwoko bw'ibizamini bikorwa?

Ibi bizamini bishobora gufasha kwemeza testosterone nke no kumenya impamvu:

• Isuzuma ry’amaraso ku rugero rwa testosterone yose: Ibi akenshi bisaba ko ufata ibizamini bibiri by’amaraso hagati ya saa mbiri na saa yine za mu gitondo, kuko ari bwo urugero rwa testosterone ruba ruri hejuru cyane. Ugomba kubwira muganga wawe niba wararwaye cyangwa uherutse gukira indwara. Mu gihe cy’impanuka, ibisubizo bishobora kuba bike cyane.
• Isuzuma ry'amaraso rya hormone ya Luteinizing (LH): Ibi bifasha kumenya niba ikibazo kiri ku gahu k'ubwonko ari cyo gitera testosterone nkeya.
• Gupima amaraso ya Prolactin: Prolactin nyinshi ishobora kuba ikimenyetso cy'ikibazo cy'uturemangingo tw'ubwonko cyangwa ikibyimba.

Ni ubuhe buryo bwo kuvura testosterone nkeya?

Abaganga bavura testosterone nkeya bakoresheje Testosterone Replacement Therapy (TRT) . Hari uburyo bwinshi bwo kubikora:

• Jeli ya testosterone (ishyirwa ku ruhu): Iyi jeli igomba gusigwa buri munsi ku ruhu rusukuye kandi rwumye nk'uko muganga wawe yabigutegetse. Icy'ingenzi kurushaho, ntureke ngo jeli ikore ku wundi muntu unyuze mu ruhu. Ubu ni bwo buryo bukunze gukoreshwa cyane muri Leta Zunze Ubumwe za Amerika.
• Inshinge za testosterone zo mu nda: Wowe cyangwa muganga wawe mushobora kuguha uru rushinge mu mitsi buri cyumweru 1-2. Hariho kandi inshinge za testosterone zigira igihe kirekire zitangwa buri byumweru 10. Hariho kandi inshinge zo munsi y'uruhu zitangwa munsi y'uruhu.
• Igipande cya testosterone (igipande cy'uruhu): Iki gipande kigomba gusigwa ku ruhu buri munsi nk'uko muganga yabigutegetse. Aho gishyirwa hagomba kuzungurutswa buri gihe kugira ngo hirindwe ingaruka z'uruhu.
• Udupira twa testosterone (duto): Inzobere izashyira utwo dupira munsi y'uruhu mu gihe cy'amezi atatu kugeza kuri atandatu. Ibi bitanga urugero ruhoraho rwa testosterone mu gihe kirekire.
• Ibinini bya testosterone ya Buccal: Ibi ni ibinini bifata bishyirwa ku ishinya kabiri ku munsi. Testosterone yinjizwa vuba mu maraso binyuze mu ishinya.
• Jeli ya testosterone mu mazuru: Iyi jeli igomba gusigwa ku mazuru yombi gatatu ku munsi.
• Testosterone yo mu kanwa: Ubwoko bwa testosterone yitwa undecanoate buhabwa abagabo bafite testosterone nkeya bitewe n'indwara zimwe na zimwe, nka Klinefelter syndrome, cyangwa ibibyimba byangije igitsina cya pituitary.

Ariko, ushobora kutabona uburyo bwo gusimbuza testosterone niba ufite amateka y’imwe muri izi ndwara zikurikira:

• Kanseri ya porositate.
• Ikibyimba cya prostate kitarasuzumwa. (Buri wese agomba gusuzumwa prostate ye mbere yo gutangira imiti ya testosterone.)
• Kanseri y'ibere.
• Kunanirwa k'umutima mu buryo bugenzuwe.
• Indwara yo kubura umwuka wo gusinzira idavuwe.

Ingaruka mbi zo kuvura testosterone mu buryo bwo kuyisimbura ni izihe?

Ingaruka mbi zishobora guterwa n'ubu buvuzi ni izi zikurikira:

• Uruhu rukunda ibiheri cyangwa amavuta menshi.
• Kubyimba akaguru bitewe n'amazi make yirundanyije mu mubiri.
• Ibimenyetso nko kugorwa no kunyara bitewe no gukangurwa kwa prostate.
• Kubabara cyangwa kwangirika kw'ibere.
• Kurushaho kugaragara kw'indwara yo guhumeka mu gihe cyo gusinzira.
• Amasaya mato.
• Iyo ukoresheje testosterone ikoreshwa ku ruhu, ushobora kugira uruhu rushyuha kandi rukagira ububabare.

Impinduka zishobora kugaragara muri raporo za laboratwari:

• Ubwiyongere bwa antigen yihariye ya prostate (PSA).
• Ubwiyongere bw'uturemangingo dutukura mu maraso.
• Umubare muto w'intanga ngore, bigatera ubugumba (kudashobora kubyara). Ibi ni ingenzi cyane cyane ku basore bagerageza kubyara.

Ese kugabanuka kwa testosterone gushobora kwirindwa?

Abaganga n'abashakashatsi ntibaramenya uburyo bwo gukumira igabanuka rya testosterone, byaba biterwa n'impamvu za genetiki cyangwa kwangirika kw'intanga ngabo, hypothalamus, cyangwa imyakura ya pituitary.

Ariko, izi ngeso zo kubaho zishobora gufasha kugira urugero rwa testosterone ruhoraho:

• Kurya indyo yuzuye.
• Gukora imyitozo ngororamubiri.
• Kugenzura ibiro.
• Irinde kunywa inzoga nyinshi n'ibiyobyabwenge.

Bigenda bite iyo ufite testosterone nkeya? Ni iki wakwitega?

Nta muti umwe ukwiriye abantu bose wo kugabanya testosterone. Ariko, hamwe no gukomeza gukoresha uburyo bukwiye bwo gusimbuza imisemburo, ushobora kunoza ubushake bwawe bwo gukora imibonano mpuzabitsina, ukagabanya ibimenyetso byo kwiheba, kandi ukongera imbaraga zawe. Ubuvuzi bushobora kandi kongera imitsi n'ubucucike bw'amagufwa.

Abagabo bafite ikibazo cyo kubura testosterone bafite igipimo cy’impfu kiri hejuru cyane ugereranyije n’abagabo bafite igipimo cya testosterone gisanzwe. Ariko, ntibiramenyekana neza niba gusubiza igipimo cya testosterone ku gipimo gisanzwe bizagabanya iki gipimo cy’impfu cyiyongera. Ubuvuzi bwibanda ahanini ku kuvura ibimenyetso, aho kwibanda ku gipimo cya testosterone.

Mu gihe umuntu avukanye hypogonadism, ubuvuzi bwo gusimbuza testosterone bukunze gufasha gukumira ibibazo bijyana no gutinda k'ubugimbi.

Ni ryari wagombye kujya kwa muganga ku bijyanye na testosterone nkeya?

Niba ufata imiti isimbura imisemburo, ni ngombwa cyane kujya kwa muganga wawe buri gihe kugira ngo agusuzumishe.

Niba ufite ibimenyetso bya testosterone nkeya, nko kugabanuka k'ubushake bwo gukora imibonano mpuzabitsina cyangwa gushyuha, vugana na muganga. Azagusuzuma kandi agutegeke gupimwa amaraso.

Niba umwana wawe ataragaragaza ibimenyetso by'ubugimbi ku myaka 14, vugana na muganga w'abana we.

Abantu benshi ntibemera ibimenyetso bya testosterone nkeya nk'ikintu gisanzwe mu gusaza. Ariko, niba ufite ibimenyetso bigira ingaruka ku mibereho yawe, ni ngombwa rwose kwitondera. Niba ufite ibimenyetso biguhangayikishije bya testosterone nkeya, gana muganga kugira ngo baganire ku buryo bwo kuvura.

Ikintu cy'ingenzi cyo kwibuka muri iyi nkuru (Ubutumwa bwo kujyana mu rugo)

Indwara ya testosterone nkeya ni indwara ishobora kwibasira abagabo. Ishobora gutera ibibazo bitandukanye by'umubiri n'ibyo mu mutwe. Icyiza ni ukudatinya cyangwa ngo ugire isoni zo kubikora, ahubwo ni ukugisha inama kwa muganga. Niba ufite ibimenyetso, ntukabifate nk'ibisanzwe.

Iyo ubonye indwara neza kandi ukayivurwa neza, ushobora kubaho ubuzima bwiza. Wibuke ko utari wenyine, kandi ubufasha burahari.

Testosterone , imisemburo y'abagabo, hypogonadism, ubuzima bw'imibonano mpuzabitsina, kuvura imisemburo, ubuzima bw'abagabo, kubura imbaraga