Ese hari ikibazo ku turemangingo tw’imitsi mu mubiri wawe? Reka tuvuge ku ndwara za Lymphoproliferative (LPDs)!

Ese wigeze wumva ko mu mibiri yacu hari abasirikare bato baturinda indwara? Abo basirikare bitwa uturemangingo tw’amaraso twera. Muri utwo turemangingo tw’amaraso twera, harimo ubwoko bwihariye bwitwa lymphocytes . Akazi kabo gakomeye ni ugukomeza ubudahangarwa bw’umubiri wacu mu kurwanya abanzi nka virusi na bagiteri binjira mu mubiri wacu, ndetse no gusenya uturemangingo twa kanseri. Ariko, rimwe na rimwe utwo turemangingo duhagarika gukora neza, cyangwa tugatangira kwiyongera cyane. Ni bwo twita itsinda ry’indwara zitwa Lymphoproliferative Disorders (LPDs) . Iyi ni indwara idasanzwe. Reka tubiganireho birambuye, si byo se?

Indwara za Lymphoproliferative (LPD) ni iki? Hari ubwoko bwazo?

Muri make, LPD ni itsinda ry'indwara zibaho iyo uturemangingo twacu twa lymphocytes, twitwa lymphocytes, tudakora neza cyangwa ngo dukure mu buryo butunguranye. Izi ndwara zishobora kugabanywamo ibice bibiri by'ingenzi.

1. LPD (Indwara z'ubudahangarwa bw'umubiri) zijyanye n'ubudahangarwa bw'umubiri

Ubwo bwoko bwa LPD bubangamira uburyo ubudahangarwa bw'umubiri wacu bwitwara ku batera indwara z'abanyamahanga. Abantu bafite ibi bibazo baba bafite ibyago byinshi byo kurwara kanseri nka lymphoma .

• Indwara ya lymphoproliferative ifite isano na X (XLP): Iyo umuntu ufite iyi ndwara yandujwe na virusi ya Epstein-Barr , ishobora kuzamuka ikaba lymphoma.
• Indwara ya Autoimmune lymphoproliferative syndrome (ALPS): Ibi bibaho igihe umubare munini wa lymphocytes wirundanyije ahantu nka lymph nodes zacu, urwagashya, n'umwijima, bigatuma izo ngingo zibyimba. Ni nk'aho uturemangingo twacu tuba turimo guteranira ahantu hatagenzurwa.
• Indwara zo gutera amaraso nyuma yo gutera amaraso (PTLD): Iyi ni indwara idasanzwe ariko ikomeye. Ishobora kubaho nyuma yo gutera ingingo (urugero: impyiko, umwijima) cyangwa gutera uturemangingo tw’umubiri duto . Ibi ni ukuri cyane cyane iyo wowe cyangwa uwatanze uturemangingo cyangwa uturemangingo tw’umubiri twanduye virusi ya Epstein-Barr, yibasira uturemangingo twa B.

2. Kanseri y'amaraso ya Lymphoid

Izi ni indwara zikomeye dukunze kumva, nka Leukemia na Lymphoma . Ikibaho hano ni uko uturemangingo tw’amaraso twera mu igufwa ryacu no mu maraso, ari two B-cells, T-cells na Natural killer cells (NK cells), twangiritse.Impinduka mu mikorere y'umubiri, uturemangingo tudasanzwe twiyongera mu buryo butunguranye. Utwo turemangingo tudasanzwe twirukana uturemangingo tw'amaraso tuzima. Nubwo rimwe na rimwe dushobora gukira, ni indwara zikomeye zishobora gushyira ubuzima mu kaga.

Kanseri zifitanye isano n'uturemangingo twa B

Izindi ndwara za lymphoma zitari iza Hodgkin ziri muri iki cyiciro ni izi:

• Kukwirakwiza lymphoma nini ya B-cell
• Lymphoma ya follicular
• Lymphoma y'urumogi rw'umuhondo

Hariho kandi ubwoko bwa leukemia y’uturemangingo twa B:

• Leukemia y'urutirigongo ihoraho (CLL): Aha, uturemangingo twa B dusanzwe mu musokoro w'amagufwa twiyongera cyane, bigatuma uturemangingo tw'amaraso n'udupira tw'amaraso tuzima bisohoka.
• Leukemia yo mu bwoko bwa B-cell prolymphocytic: Aha kandi, uturemangingo twa B-cells tudasanzwe twirundanya mu musokoro w'amagufwa, tugatuma uturemangingo tuzima tubura.
• Leukemia y'uturemangingo tw'ubwoya: Nk'uko izina ribigaragaza, utu turemangingo tw'amaraso tw'umweru tudasanzwe twitwa amazina kuko gisa n'ubwoya iyo turebye hakoreshejwe mikorosikopi. Nanone twibasira mu musokoro w'amagufwa kandi tukiyongera cyane.

Kanseri ziterwa na T-cell

Indwara ziterwa na T-cell zigabanyijemo ibice bibiri:

• Lymphoma zo mu bwoko bwa T-cell lymphomas: Izi zishobora kugira ingaruka ku mitsi yawe, urwagashya, umwotsi wo mu magufwa, amaraso, n'izindi ngingo mu mubiri.
• Limfoma ya T-cells yo mu gituza: Izi zigira ingaruka cyane cyane ku ruhu, ariko rimwe na rimwe zishobora kugira ingaruka ku mitsi, amaraso, umwongo w'amagufwa, n'ingingo z'imbere.

Hariho ubwoko butandukanye bwa lymphoma ya T-cell systemic. Bumwe mu bwoko bukunze kugaragara ni ubu:

• Lymphoma y'uturemangingo twa T two mu gice cy'imbere, bitavuzwe ukundi (PTCL NOS)
• Lymphoma ya T-cell angioimmunoblastic (AITL)
• Lymphoma nini ya Anaplastic

Hariho kandi ubwoko budasanzwe:

• Lymphoma y'uturemangingo twa T mu ihepatosplenike (HSTCL)
• Lymphoma ya T-cell T ifitanye isano na enteropathy (EATL)

Zimwe mu ndwara za lymphoma zo mu bwoko bwa T-cell lymphoma zitwa kandi kanseri y’uturemangingo twa T-cell chronic . Ingero:

• Leukemia yo mu bwoko bwa T-cell prolymphocytic leukemia (T-PLL)
• Leukemia y'urumogi runini rwa T (T-LGL)

Hari ubwoko bubiri bw'ingenzi bwa lymphoma ya T-cell lymphoma y'uruhu:

• Mycosis fungoides
• Indwara ya Sézary

Indwara ziterwa na NK-cell

Ibi ni gake cyane kandi bigira ingaruka ku turemangingo twa NK.

• Ubwoko bw'izuru bwa lymphoma ya Extranodal NK T-cell
• Leukemia y'uturemangingo twa NK ikabije (AKNL)
• Leukemia y'uruhererekane runini rwa NK-cell (NK-LGL)

Ubu urabona ko hari indwara nyinshi zitandukanye muri LPD. Ntabwo ukeneye kumenya buri kimwe mu buryo bwimbitse, ariko ni ngombwa kumenya ko iyi ndwara ihari.

Ni ibihe bimenyetso bya LPD? Ubimenya ute?

Ibimenyetso by'izi LPD bishobora gutandukana cyane, bitewe n'ubwoko bwa LPD ufite. Ariko hari ibimenyetso bimwe na bimwe ushobora kubona. Reka turebe ibyo ari byo:

• Kubira ibyuya byinshi nijoro: Si ibyuya gusa, ahubwo ni ibyuya byinshi ku buryo amashuka agwa.
• Uduce tw’imitsi, umwijima, cyangwa urwagashya: Niba ubonye utubyimba ahantu nko mu ijosi, mu kwaha, cyangwa mu kibuno, cyangwa niba ufite kubyimba kudasanzwe mu nda yawe, ugomba guhangayika.
• Kuva amaraso menshi cyangwa menshi cyane: Niba uva amaraso menshi nubwo waba wakomeretse gato, cyangwa niba ufite ibisebe by'ubururu gusa ku mubiri wawe.
• Umunaniro uhoraho: Kumva unaniwe uko waba usinziriye kose.
• Guhorana umuriro: Niba ufite umuriro udashira nta mpamvu.
• Kwandura virusi kenshi: Bitewe n'uko ubudahangarwa bw'umubiri buke, ushobora kurwara indwara nk'ibicurane n'inkorora kenshi.
• Anorexia: Kumva udashaka kurya.
• Kugabanya ibiro mu buryo butunguranye: Niba ugabanyije ibiro mu buryo butunguranye udakoze indyo cyangwa ngo ugire imyitozo ngororamubiri, icyo nacyo ni ikimenyetso cyo kwitondera.

Icy'ingenzi: Ntugatinye niba ufite kimwe cyangwa bibiri muri ibi bimenyetso. Bishobora no guterwa n'izindi mpamvu zoroshye. Ariko, niba ibi bimenyetso bikomeje, ni byiza kujya kwa muganga kugira ngo akugire inama.

Ni izihe mpamvu zitera LPD?

Biragoye kumenya impamvu imwe itera indwara nyinshi za LPD, ariko hari ibintu bitandukanye bishobora kugira uruhare muri ibyo.

• Indwara: Ubwoko bumwe bwa LPD bushobora guterwa n'indwara nka virusi ya Epstein-Barr cyangwa bagiteri ya H. pylori . Tekereza, ubwo bwoko bwa mikorobe zinjira mu mibiri yacu zirimo guhungabanya uturemangingo tw'uturemangingo.
• Indwara zimwe na zimwe ziterwa n’ubwiyongere bw’umubiri: rubagimpande, lupusAbantu bafite indwara zimwe na zimwe baba bafite ibyago byo kurwara ubwoko bumwe na bumwe bwa LPD (urugero: marginal zone lymphomas). Iki ni cyo gihe ubudahangarwa bw'umubiri wacu bwibasira uturemangingo twacu.
• Imiti: Imiti imwe n'imwe igabanya ubudahangarwa bw'umubiri (urugero, imiti itangwa kugira ngo ihagarike ubudahangarwa bw'umubiri nyuma yo guterwa urugingo) ishobora gutera indwara nka lymphoma ya T-cell hepatosplenic.
• Impinduka zimwe na zimwe mu maraso: Ni gake cyane ushobora kuragwa impinduka mu maraso itera ubwo bwoko bwa LPD. Urugero, abantu bafite indwara ya X-linked lymphoproliferative disorder (XLP) bagira impinduka mu maraso abiri. Ibi bituma bagira amahirwe menshi yo kugira igisubizo gikomeye ku virus ya Epstein-Barr no kurwara lymphoma. Impinduka mu maraso zigira ingaruka ku mikurire y'uturemangingo tw'amaraso twera na zo zifitanye isano na lymphoma na leukemia.

Ni gute abaganga bapima LPD? (Isuzuma)

Kubera ko hari ubwoko bwinshi bwa LPD, iyo abaganga basuzuma indwara, babanza kureba ubwoko bwa LPD butera ibimenyetso byawe.

Kugira ngo ibi bishoboke, umuganga azasuzuma ibimenyetso byawe, nko kubyimba kw'uturemangingo tw'amaraso, ibimenyetso byerekana ko umwijima wawe cyangwa urwagashya ari binini kuruta ibisanzwe, kandi abaza amateka yawe y'ubuzima bwa kera ndetse niba hari umuntu wo mu muryango wawe wigeze kugira indwara nk'izo.

Hanyuma birashoboka gukora ibizamini nk'ibi:

• Gupima: Gupima umwongo w'amagufwa bishobora gukorwa kugira ngo harebwe ibimenyetso bya kanseri y'amaraso nka kanseri y'amaraso cyangwa kanseri y'amaraso. Ibi bisaba gufata urugero ruto rw'umusongo w'amagufwa no kuwupima. Hari igihe umuntu ashobora no gufata agace gato k'umusongo w'amagufwa wabyimbye.
• Ibizamini by'amaraso: Umubare wuzuye w'amaraso (CBC) , Isuzuma ry'imikorere y'umubiri (CMP) , isuzuma ry'umubiri urwanya Epstein-Barr, isuzuma ry'umwijima, isuzuma rya VIH, isuzuma rya Lactate dehydrogenase (LDH) , n'ibindi. Ibi bishobora kukubwira byinshi ku mpinduka mu turemangingo tw'amaraso, indwara zandura, n'imikorere y'umwijima n'impyiko.
• Ibizamini byo gupima: Ibizamini nka scan ya computed tomography (CT) na scan ya positron emission tomography (PET) birashobora gukorwa. Ibi bishobora kureba ibintu nk'ingingo ziri mu mubiri, imiterere y'uturemangingo tw'amaraso, ndetse no kumenya niba uturemangingo twa kanseri twarakwirakwiriye. Ni nko gufata ifoto y'imbere mu mubiri.
• Ibizamini bya laboratwari: Ibizamini byihariye nka flow cytometry bishobora gufasha kumenya ubwoko bwihariye bwa LPD.

Indwara za LPD zivurwa zite?

Uburyo bwo kuvura LPD buterwa n'ubwoko bwihariye bwa LPD ufite. Abantu bose si ko bavura kimwe. Urugero, niba urwaye leukemia cyangwa lymphoma, ushobora kuvurwa nk'ibi bikurikira:

• Chimiotherapie: Imiti itangwa kugira ngo isenye uturemangingo twa kanseri.
• Ubudahangarwa bw'umubiri: Ubuvuzi butuma ubudahangarwa bw'umubiri bwawe bushobora kurwanya uturemangingo twa kanseri.
• Ubuvuzi bushingiye ku mirasire: Gusenya uturemangingo twa kanseri hakoreshejwe imirasire ifite ingufu nyinshi.
• Gutera uturemangingo tw’umusemburo (umusemburo w’amagufwa): Gutera uturemangingo tw’umusemburo tuzima kugira ngo dusimbuze uturemangingo tw’umusemburo twangiritse.
• Ubuvuzi bwibasira: Imiti yibasira molekile zihariye zifasha uturemangingo twa kanseri gukura no kubaho.

Wibuke ko muganga wawe ari we uzaguhitiramo uburyo bwiza bwo kuvura. Ni we uzi neza uko umerewe.

Ese umuntu urwaye LPD ahura n'iki kibazo? Ese kirakira?

Iki kibazo kiragoye gusubiza kuko hari ubwoko bwinshi bwa LPD, kandi ibintu byinshi nk'ubuzima bwawe, imyaka, n'urwego rw'indwara bishobora kugira ingaruka ku ngaruka.

Hari ubwoko bumwe na bumwe bwa LPD bushobora gukira burundu. Urugero, ubuvuzi bwa chemo-immunotherapy bushobora kuvura ubwoko bumwe na bumwe bwa lymphoma, nka lymphoma nini ya B-cell na lymphoma ya Burkitt. ​​Umuntu ufite indwara ya X-linked lymphoproliferative disorder (XLP) ashobora gukira hakoreshejwe uburyo bwo gutera uturemangingo tw’umubiri.

Ariko rimwe na rimwe, kuvurwa bishobora gutuma lymphoma zimwe na zimwe zigabanuka , bivuze ko ibimenyetso bishira kandi ibizamini ntibibashe kubona indwara. Ariko indwara ntikira burundu. Hari LPD zimwe zishobora kongera kugaruka nyuma y'amezi cyangwa imyaka ubuvuzi burangiye.

Niba ufite LPD, ushobora kuba wibaza niba ishobora kuvurwa n'igihe ushobora kurama. Ahantu heza ho kubona amakuru kuri ibi ni kwa muganga wawe. Azi neza wowe n'uko umeze. Ntutinye rero kumubaza ikibazo icyo ari cyo cyose ufite.

Nikwitaho nte? (Kwitaho)

LPD ni indwara zikomeye. Nubwo kuvurwa bishobora kugabanya ibimenyetso ndetse bigatera gukira, ushobora guhura n'imbogamizi mu gihe cyo kuvurwa. Dore inama zimwe na zimwe zishobora kugufasha:

• Baza ibijyanye no kwita ku ndwara igabanya ububabare: Umuntu urwaye LPD ashobora gukenera ubufasha mu kuvura ibimenyetso n'ingaruka mbi zo kuvurwa. Ubuvuzi bugabanya ububabare ni ubwoko bwihariye bw'ubuvuzi bufasha kunoza ubuzima bw'umuntu no kugabanya ububabare n'ibindi bibazo, aho kugerageza gukiza indwara. Itsinda ryawe ryita ku ndwara igabanya ububabare rishobora kuguha inama nziza.
• Rya neza: Ushobora kubura ubushake bwo kurya iyo urwaye cyangwa urimo kuvurwa. Niba ari uko bimeze, gana inzobere mu by'imirire . Azakugira inama ku biribwa n'ibinyobwa bikwiye.
• Kora imyitozo ngororamubiri: Imyitozo ngororamubiri yoroheje ishobora kugabanya stress iterwa n'indwara ikomeye. Ariko banza uganire na muganga mbere yo gutangira gahunda nshya y'imyitozo ngororamubiri.
• Irinde indwara: Ubudahangarwa bw'umubiri bwawe bushobora gucika intege bitewe n'indwara cyangwa uburyo bwo kuvurwa. Baza muganga wawe uburyo bwo kwirinda indwara zandura. Kwirinda ahantu hahurira abantu benshi no gukaraba intoki kenshi ni ingenzi.

Ni ryari ngomba kubonana na muganga?

Niba uri kuvurwa LPD, baza muganga wawe ibimenyetso bigaragaza ko indwara yawe igenda irushaho kuba mbi (urugero: umuriro udashira) kugira ngo umenye igihe cyo kumuvugisha.

Iyo umuganga akoresheje ijambo "lymphoproliferation" cyangwa "lymphoproliferative disorders (LPDs)," aba avuga ku itsinda ry'indwara zifata uturemangingo tw'amaraso tw'umweru dushobora kugira ingaruka ku burwayi bw'umubiri wawe cyangwa tukarwara kanseri.

Niba ufite ikibazo nk'iki, ushobora kuba ushishikajwe no kumenya neza imiterere y'indwara yawe kuruta amagambo akoreshwa mu buvuzi. Ariko iyo urwaye, ubumenyi ni imbaraga. Muri iki gihe, kumenya icyo izina risobanura bishobora kugufasha gusobanukirwa neza ibirimo kuba mu mubiri wawe.

Urugero, LPD zifite ibimenyetso n'imiti bisanzwe. Ariko zose si zimwe. Nanone, ibyakubayeho bishobora kuba bitandukanye n'iby'abandi bantu. Niba muganga wawe akoresha ijambo "lymphoproliferative disorder (LPD), saba ibisobanuro birambuye ku ndwara yawe. Bazakwishimira gusubiza ibibazo byawe.

Hanyuma, ubutumwa bwo kujyana mu rugo:

Indwara za Lymphoproliferative (LPDs) ni itsinda ry'indwara zikomeye zishobora guterwa n'imikorere mibi ya lymphocytes, uturemangingo tw'umubiri wacu.

• Menya ibimenyetso: Ntukagire ubunebwe niba ufite umuriro udashira, umunaniro ukabije, ugabanya ibiro, cyangwa ufite utunyangingo tw’imitsi tubyimba.
• Ni ngombwa gushaka inama kwa muganga: Niba ushidikanya, jya kwa muganga vuba bishoboka kugira ngo agusuzume. Uko indwara igaragaye hakiri kare, niko ubuvuzi burushaho kugira icyo bugeraho.
• Si ubwoko bwose bwa LPD bumwe: hari ubwoko butandukanye, kandi buri bumwe bufite uburyo butandukanye bwo kuvura. Muganga wawe ni we uzagena uburyo bwiza bwo kuvura.
• Ntabwo uri wenyine: Iyo uhuye n'ikibazo nk'iki, inkunga y'umuryango, inshuti n'abaganga ni ingenzi cyane.

Igikuru ni ukudatinya, gukomeza gukomera no gukurikiza inama z'abaganga. Iyo uvuwe neza kandi ufite imbaraga zo mu mutwe, ushobora gutsinda iki kibazo.

` indwara za lymphoproliferative, LPD, uturemangingo twa lymph, lymphocytes, ubudahangarwa bw'umubiri, kanseri, leukemia, lymphoma