Ese umubiri wawe ntukira neza imisemburo ya Parathyroid? Reka tuvuge kuri iyi ndwara idasanzwe (Pseudohypoparathyroidism)!

Ese hari igihe wumva ikintu kiri mu mubiri wawe kidakora neza? Hari indwara zidasanzwe, amazina yazo akaba ashobora gutera ubwoba. Imwe muri izo ndwara idakunze kumvikana cyane, ariko ikaba ari ngombwa kumenya, ni Pseudohypoparathyroidism (PHP). Nubwo izina rishobora gusa nkaho ari rirerure, reka tubikomeze.

Pseudohypoparathyroidism ni iki?

Muri make, iyi ni indwara idakunze kubaho mu maraso . Dufite uturemangingo duto mu mibiri yacu twitwa parathyroid glands. Tuyikora imisemburo yitwa Parathyroid Hormone (PTH). Iyi misemburo ya PTH ni ingenzi cyane ku mibiri yacu. Kuko, iyi misemburo ifasha mu kugumana urugero rukwiye rwa Kalisiyumu, Fosifore, na Vitamine D mu maraso yacu.

None se, uzi uko bigenda ku muntu urwaye pseudohypoparathyroidism (PHP)? Nubwo ingirabuzimafatizo ze za parathyroid zikora imisemburo ya PTH mu buryo busanzwe, uturemangingo two mu mubiri we ntituyitabira neza, bivuze ko tudashobora "kuyibona". Ni nk'aho umuntu akuvugisha ariko ntumwumve. Ibi twita Parathyroid Hormone Resistance .

Ingaruka zabyo ni izihe? Igipimo cya kalisiyumu mu maraso kiragabanuka, mu gihe igipimo cya fosifore cyiyongera. Uku kutumvikana gushobora gutera imitsi kunyeganyega, gucika intege, gukubita, ndetse n'ibibazo by'amenyo.

Icy'ingenzi ni uko iyi ndwara yitwa PHP itandukanye n'indwara yitwa Hypoparathyroidism. Abantu bafite hypoparathyroidism ntibakora imisemburo ya PTH ihagije. Ariko, muri PHP, iyo misemburo irakorwa, ariko umubiri ntuyikoresha.

Ni ubuhe bwoko bw'ingenzi bwa PHP?

Hari ubwoko bwinshi bw'ingenzi bw'iyi status ya PHP. Reka turebe ibyo ari byo.

Ubwoko bwa PHP-1

Ubu ni bwo bwoko bwa PHP bukunze kugaragara cyane . Uretse kuba imisemburo ya PTH yavuzwe haruguru irwanya, hari impinduka zimwe na zimwe mu mikorere y'amagufwa zishobora kugaragara. Urugero:

• Ubuzenguruko bw'isura
• Kugabanuka k'uburebure (ubugufi bw'uburebure)
• Kubabara mu ijosi
• Kuvunika kw'amaboko n'ibirenge

Abaganga bita uruhurirane rw'ibimenyetso Albright Hereditary Osteodystrophy (AHO) . Abantu barwaye PHP-1 bafite iyi ndwara bitewe n'ubwoko bwa gene yitwa `GNAS` bakura ku babyeyi babo.

PPHP (Pseudopseudohypoparathyroidism)

Ubu ni ubwoko buke bwa PHP-1. Abantu barwaye PPHP (Pseudopseudohypoparathyroidism) bashobora kugira imiterere y'umubiri igaragara muri AHO (nk'isura izengurutse n'uburebure bugufi), ariko ntibagira ubudahangarwa ku misemburo ya PTH . Ibi bivuze ko urugero rwabo rwa kalisiyumu na fosifore ari rusanzwe.

Ubwoko bwa PHP-2

Abantu bafite PHP-2 bafite ubudahangarwa ku misemburo ya PTH, bivuze ko bafite kalisiyumu nkeya na fosifore nyinshi. Ariko ntibagira imiterere y'umubiri (nk'isura izengurutse n'uburebure bugufi) nk'uko bigaragara muri AHO. Abashakashatsi ntibaramenya neza ikibazo cy'uturemangingo gitera ubu bwoko bwa PHP-2.

Ni ibihe bimenyetso bya PHP?

Ibimenyetso bya PHP bishobora gutandukana bitewe n'umuntu ku wundi . Ibi bivuze ko abantu bose batazagira ibimenyetso bimwe. Bimwe mu bimenyetso bisanzwe birimo:

• Kubabara kw'imitsi
• Kubabara imitsi kenshi : Kumva nk'ukuguru kurimo gukururwa.
• Gucika intege cyangwa gucika intege mu maguru
• Indwara zo mu mutwe
• Kura amenyo bitinze
• Gucika intege kw'amenyo
• Umuvuduko w'amaraso uri hasi
• Umusatsi n'inzara byoroshye
• Guhangayika
• Ihungabana

Abantu barwaye PHP-1 bashobora kugira ibindi bimenyetso biherekeza indwara ya Albright hereditary osteodystrophy (AHO) yavuzwe haruguru. Bamwe mu bantu barwaye PHP nabo bashobora kugira ibi bimenyetso:

• Ubuzenguruko bw'isura
• Ubugufi (ubugufi bw'uburebure)
• Kubabara mu ijosi
• Amagufwa mu biganza no mu birenge : Amagufwa, cyane cyane ay'urutoki rwa kane n'urwa gatanu, ashobora gusa n'aho ahindukiye imbere.
• Umubyibuho ukabije : Bisobanura kuba ufite umubyibuho ukabije.
• Kutabona neza : ibintu nk'indwara ya katarakte, kutabona neza, no kumva urumuri.
• Utubyimba tw'amagufwa munsi y'uruhu rwawe
• Gutinda mu mikurire : Bamwe mu bana bashobora kugira ibibazo bimwe na bimwe mu mikurire.

Ni izihe mpamvu za PHP?

Impamvu nyamukuru y’iyi ndwara ni itandukaniro ry’uturemangingo twacu, cyane cyane muri gene yitwa `GNAS` . Hari abantu bayikura ku babyeyi babo . Ibyo bivuze ko ari umurage. Ariko rimwe na rimwe iyi ndwara ishobora kubaho nta mateka y’umuryango kandi nta mpamvu iboneka.

Ubusanzwe PHP ipimwa mu bwana cyangwa mu bwana , ariko rimwe na rimwe ishobora kugaragara mu bwana.

Ni izihe ngorane zishobora guterwa na PHP?

Niba ufite PHP, ushobora kugira izindi ndwara z’imikorere y’imisemburo . Ibi bibazo bifitanye isano n’imisemburo bishobora gutera ibimenyetso nko kubura imbaraga no kubura ubushake bwo gukora imibonano mpuzabitsina.

Bamwe mu bantu bafite PHP bafite ibyago byinshi byo kurwara indwara nka:

• Ububabare bwa Parkinson: Kugaragaza ibimenyetso bisa n'iby'indwara ya Parkinson.
• Ingorane mu bumenyi bw'imitsi : Ibi bivuze ingorane mu mirimo mito nko gukanda cyangwa kwandika.
• Indwara ya Carpal Tunnel : Cyane cyane ku bafite PHP-1. Iyi ni indwara aho imitsi yo mu kuboko ikandamizwa, igatera ibinya n'ububabare mu kiganza.
• Stenosis yo mu mugongo
• Indwara yo kubura umwuka mu gihe cyo gusinzira : Cyane cyane ku bana.

Ni gute abaganga basuzuma PHP?

Niba ukeka ko ufite PHP, muganga wawe azabanza agukorere isuzuma ry’umubiri . Azakubaza kandi amateka y’umuryango wawe. Hanyuma ashobora gukora ibindi bizamini byinshi kugira ngo yemeze ko wanduye. Ibi birimo:

• Gupima amaraso : Pima urugero rw'imisemburo, cyane cyane calcium, fosifore, na PTH.
• Ibizamini by'inkari : Reba urugero rwa kalisiyumu na fosifore mu nkari.
• Gupima imiterere y'uturemangingo : Reba impinduka muri gene ya `GNAS`.
• Electrocardiogram (EKG) : Isuzuma niba umutima utera nabi.
• Imirasire ya X-ray y'intoki : Reba niba amagufwa yavunitse n'izindi mpinduka.
• CT Scan (CT - Computed Tomography scan) : Kugira ngo harebwe niba hari impinduka mu bwonko.

Bishingiye ku makuru yavuye muri ibyo bizamini, muganga ashobora kwemeza neza uko PHP ihagaze.

PHP ivurwa ite?

Nta muti uraboneka w'iyi ndwara . Ariko ntugahangayike. Iyo uvuwe neza kandi ugafatwa neza, ushobora kugenzura ibimenyetso byawe no kubaho ubuzima busanzwe.

Intego nyamukuru y'ubuvuzi ni ugukomeza kugira urugero rwiza rwa kalisiyumu na fosifore mu maraso yawe . Kugumana uru rugero bishobora kugabanya cyane ibimenyetso. Ubu ni uburyo bwo kuvura ubuzima bwose .

Uburyo bwo kuvura bushobora kuba burimo:

• Inyongeramusaruro za kalisiyumu na vitamine D : mu binini cyangwa mu buryo bw'amazi.
• Kapisule za Calcitriol : Uyu ni umuti wongera ingano ya kalisiyumu mu mubiri.
• Urushinge rwa Calcitriol
• Uburyo bwo kuvura imisemburo ikura cyangwa imisemburo ya tiroyide : nibiba ngombwa.
• Indyo ifite kalisiyumu nyinshi kandi idafite fosifore nyinshi : Nk'uko impuguke mu by'imirire yabigiriye inama.

Igikuru ni ugukurikiza inama za muganga witonze no kwipimisha ku gihe.

Ni ryari ngomba kujya kwa muganga?

Niba ufite PHP, ni ngombwa kujya kwa muganga wawe buri gihe kugira ngo agenzure urugero rwa kalisiyumu na fosifore . Iri genzura rihoraho rizagufasha kugenzura ibintu byose.

Niba ugize ibimenyetso bikomeye nko kugorwa no guhumeka mu buryo butunguranye, kunyaragura cyane kw'imitsi, cyangwa gukubita igicuri , jya mu cyumba cy'ubutabazi bw'ibanze cy'ibitaro biri hafi yawe cyangwa uhamagare 1990.

Ni iki wakwitega mu gihe ubayeho mu gihe ufite ikibazo cya PHP?

Niba ufite PHP, ugomba gukomeza gukorana na Muganga wawe w’ibanze . Kubera ko PHP ishobora kugira ingaruka ku bice byinshi by’umubiri, ushobora gukenera kubonana n’inzobere nyinshi kugira ngo zikureho ibimenyetso byihariye. Itsinda ry’abaganga bawe rishobora kuba rigizwe na:

• Inzobere mu by'imiti igabanya ubukana bw'amaraso: Inzobere mu misemburo.
• Abaganga b'amagufwa : Ku bibazo bifitanye isano n'amagufwa.
• Abaganga b'abana : Niba ari umwana.
• Abaganga b'indwara z'imitsi : Ku bibazo bijyanye n'imitsi.
• Abavuzi b'umubiri
• Abavuzi b'inzobere mu by'ubuvuzi bw'akazi
• Abahanga mu by'imirire
• Abaganga b'amenyo
• Abahanga mu by'imiterere y'ibinyabuzima
• Inzobere mu kuvura ububabare

Birashoboka cyane ko uzakenera gufata izo nyongeramusaruro ubuzima bwawe bwose .

Ubushobozi bw'iterambere n'ubwenge bushobora gutandukana cyane bitewe n'ubwoko n'uburemere bw'indwara. Ariko , mu bihe byinshi, abantu bafite PHP baba bafite igihe cyo kubaho gisanzwe ugereranije n'abadafite PHP . Muganga wawe ashobora kukubwira icyo wakwitega bitewe n'uburwayi bwawe.

Kubera ko PHP ari indwara idakunze kugaragara, bishobora kugorana kubona abandi bafite iyo ndwara . Hari igihe ishobora no gutuma wumva ufite irungu. Niba wowe cyangwa umwana wawe musanzwe murwaye PHP, ganira na muganga wawe ku birebana n'amatsinda y'abaterankunga n'amasomo y'uburezi . Ibi bishobora kugufasha kubona uburyo bwo kunoza ibimenyetso byawe n'imibereho myiza muri rusange.

Ubutumwa bwo kujyana mu rugo

Noneho reka turebere hamwe ibintu bimwe na bimwe tugomba kwibuka kuri pseudohypoparathyroidism (PHP) twavuzeho.

• PHP ni indwara idakunze kugaragara mu buryo bw'uturemangingo aho umubiri udakira neza imisemburo ya parathyroid (PTH).
• Ibi bituma kalisiyumu mu maraso igabanuka kandi fosifore yiyongera.
• Hari ubwoko bwinshi bw'ingenzi : PHP-1, PHP-2, na PHP-3.Yego. PHP-1 ishobora guteza impinduka mu magufwa yitwa AHO.
• Ibimenyetso bitandukanye bishobora kubaho, nko kunyaragura imitsi, gucika intege, gucika intege, ibibazo by'amenyo, kuba mugufi, no kugaragara mu maso nk'uruziga .
• Impamvu nyamukuru ni impinduka mu ngirabuzimafatizo ya `GNAS` .
• Nubwo nta muti wuzuye uhari, ibimenyetso bishobora kugenzurwa no kuvurwa ubuzima bwose (calcium, vitamine D, indyo yihariye).
• Kwisuzumisha kwa muganga buri gihe no gufashwa n'abaganga b'inzobere ni ngombwa.
• Abantu benshi bashobora kubaho ubuzima busanzwe .
• Ubufasha buturuka mu matsinda y'abaterankunga ni ingenzi cyane kugira ngo umuntu akomeze kugira ubwenge buhamye.

Wibuke ko utari wenyine. Nubwo iyi ari indwara idakunze kugaragara, ishobora kwitabwaho neza uramutse uhawe inama n'ubufasha bukwiye n'abaganga. Wibuke ko abaganga, umuryango n'inshuti bagufasha igihe ukeneye imbaraga.

` Pseudohypoparathyroidism, PHP, imisemburo ya parathyroid, kalisiyumu, fosifore, indwara z'uturemangingo, AHO