Une kenza yeadrenal gland yako here? Ngatikurukurei nezveizvi (Adrenocortical Carcinoma)!

Uri kurwadziwa mudumbu here kana kuti kuwedzera uremu kamwe kamwe? Dzimwe nguva izvi zvinogona kukonzerwa nechirwere chatisingataure zvakawanda nezvacho, asi chakakosha kuziva nezvacho. Chirwere chinonzi Adrenocortical Carcinoma . Usazvidya moyo, zita racho ringanzwika serakaoma, asi ngatirambei takariverenga.

Chii chinonzi Adrenocortical Carcinoma?

Zvichitaurwa zviri nyore, adrenocortical carcinoma igomarara rinokura muchikamu chekunze cheadrenal glands yako, adrenal cortex . Funga nezvemaglands aya sengowani mbiri diki dziri pamusoro peitsvo dzako. Akakosha zvikuru nekuti anogadzira mahormone anodzora zvinhu zvakawanda mumuviri wedu, kusanganisira metabolism yedu, BP, uye maitiro atinoita kana tasangana nekushushikana.

Zvino, muchiitiko ichi che adrenocortical carcinoma, bundu rekenza rinokura muma adrenal glands aya. Dzimwe nguva bundu iri rinogona kugadzira huwandu husina kujairika hwemahormone. Ipapo mahormone mumuviri anowedzera zvakanyanya, izvo zvinogona kukanganisa mashandiro emuviri wedu. Mamwe bundu anogona kukura nekukurumidza uye anogonawo kumanikidza dzimwe nhengo dzakavapoteredza. Kunyangwe vanachiremba vachigona dzimwe nguva kurapa chirwere ichi, dzimwe nguva chirwere ichi chinogona kudzoka.

Kunyangwe chirwere ichi chichinyanya kuitika muvanhu vakuru, dzimwe nguva chinogona kuitika muvana vadiki. Zvisinei, munyaya ino, tichanyanya kutarisa nezvekenza ye adrenocortical, iyo inobata vanhu vakuru.

Kune mhando dzekenza ye adrenocortical here?

Ehe, kune mhando mbiri huru. Zviratidzo zvemhando mbiri idzi zvakasiyanawo.

1. Matumbu anoshanda: Iri ndiro rudzi rwakajairika. Matumbu aya anoburitsa mahormone akawanda akadai sealdosterone , cortisol , estrogen, uye testosterone kupfuura zvaanofanira kuita. Saka, zviratidzo zvinoenderana nerudzi rwemahormone ari kugadzirwa zvakanyanya.

2. Mabundu asingashande: Mabundu aya haakanganisi kugadzirwa kwemahormone. Zvisinei, anogona kukura uye kudzvanya nhengo nematishu akapoteredza, zvichikonzera kusagadzikana.

Dambudziko iri rakajairika zvakadii?

Kutaura zvazviri, iyi igomarara risingawanzoitiki . Kunyangwe iri iro gomarara rinowanzoonekwa muadrenal glands, hariwanzoitiki zvachose. Munhu mumwe chete pavanhu miriyoni ndiye anoonekwa aine chirwere ichi gore rega rega. Saka musavhunduke nezita racho.

Ndezvipi zviratidzo zve adrenocortical carcinoma?

Zvinoshamisa kuti vamwe vanhu vane kenza iyi asi vasina zviratidzo zvayo.Hazvibudi pachena. Ongororo dzakaratidza kuti pakati pe20% ne30% yevarwere ava vanoonekwa netsaona panguva yekuongororwa kwechimwe chirwere.

Zvisinei, kana zviratidzo zvikaonekwa, unogona kuona zvinhu zvakaita se:

• Kurwadziwa mudumbu kana kusagadzikana.
• Kukura kwebvudzi kusingajairika pachiso kana mumuviri wevakadzi (hirsutism). Zvinogona kunzwa sekunge ndebvu dzemurume dziri kukura.
• Mazamu akakura muvarume (Gynecomastia).
• Kukwira kweropa.
• Shuga yakawanda muropa.
• Kuwedzera huremu, kunyanya kumeso, mutsipa, uye chiuno. Zvinoita sekuti mumwe munhu akangoerekana akura.

Kanzera ye adrenocortical ine hukasha hwakadini?

Iyi igomarara rinotyisa zvikuru . Izvi zvinoreva kuti gomarara iri rinogona kukura nekukurumidza uye kupararira (metastasize) kunze kwegland readrenal kune dzimwe nhengo dzemuviri, dzakadai semapapu nemapfupa. Kana rikapararira, rinobva ranyanya kuoma kurapa.

Ndezvipi zvikonzero zve adrenocortical carcinoma?

Vaongorori havasati vawana chikonzero chaicho . Vamwe vanhu vanowana chirwere ichi nekuda kwemamwe majini anopfuudzwa kubva kuchizvarwa kuenda kune chimwe. Izvi zvinoreva kuti kana mumwe munhu mumhuri aine chirwere ichi, vamwe vari panjodzi huru yekuchiwanawo.

Mune zvimwe zviitiko, mamwe majini anochinja anoita seanowedzera njodzi. Semuenzaniso, tsvakurudzo yakawana kuti shanduko mumajini anodzvinyirira tumor (TP53) uye (IGF2) dzinogona kutungamira kugomarara iri. Zvichitaurwa zviri nyore, majini anodzvinyirira tumor majini anodzora kukura kwemasero edu. Kana paine shanduko mumajini aya, masero anogona kupatsanurana nekuwanda zvisingadzoreki uye kuita kenza.

Ndezvipi zvirwere zvenhaka zvinowedzera njodzi yangu?

Uri panjodzi huru yekubatwa ne adrenocortical carcinoma kana uine chimwe chezvirwere zvinotevera zvenhaka:

• chirwere cheBeckwith-Wiedemann
• Nzvimbo yeCarney
• Familyal adenomatous polyposis (FAP)
• Chirwere cheLi-Fraumeni
• Chirwere cheLynch
• Mhando dzakawanda dzezvirwere zve endocrine neoplasia rudzi 1 (MEN1)
• Neurofibromatosis Type 1 (NF1)
• Von Hippel-Lindau syndrome (VHL syndrome)

Kana paine munhu mumhuri yako ane zvirwere izvi, zvakanaka kutaura nachiremba wodzidza nezvekuongororwa kwemajini.

Ndezvipi zvinetso zvinogona kuitika zve adrenocortical carcinoma?

Kenza iyi inopararira (inokurumidza kupararira) nekukurumidza.Ehe. Zvinogona kuoma kurapa kana zvikapararira kunze kweadrenal gland. Zvakare, mamwe mabundu anogadzira mahormone anogona kukonzera zvirwere zvakaita se:

• Chirwere cheCushing: Izvi zvinokonzerwa nekuti ma adrenal glands anogadzira hormone inonzi cortisol yakawandisa. Zviratidzo zvinosanganisira kuzvimba kwechiso uye kuzvimba kwemuviri.
• Conn's syndrome: Dambudziko iri rinokonzerwa nekugadzirwa kwakanyanya kwehomoni inonzi aldosterone. Rinogona kukonzera zvinhu zvakaita seBP.

Kansa ye adrenocortical inoonekwa sei? (Kuongororwa)

Kana ukaonekwa uine bundu mu adrenal panguva yekuongororwa kwechimwe chirwere, kana kana uine zviratidzo zvataurwa pamusoro apa, chiremba wako achaita bvunzo dzakadai se:

• Kuongororwa kwemifananidzo: Kuongororwa kwakadai seMRI scan, CT scan, kana PET scan kuti vaone kana paine bundu.
• Kuongororwa kweropa uye kuongororwa kweweti: Tarisa huwandu hwemahormone ako.
• Kuongororwa kwemuviri: Kuongororwa uku kunoitwa kuti kuonekwe kana bundu iri riri rekenza kana kuti kwete uye kuti pave nesampuli dzenyama.

Ndezvipi zvikamu zve adrenocortical carcinoma?

Vanachiremba vanoshandisa nzira yekuongorora kenza kuronga kurapwa uye kuona kuti chii chingatarisirwa mushure mekurapwa (kufanotaura). Danho rekenza ye adrenocortical rinoenderana nehukuru hwebundu, nzvimbo yaro, uye kana rakapararira kune ma lymph nodes ari pedyo kana nhengo dziri kure.

Heano matanho makuru:

• Danho rekutanga: Bundu iri rine masentimita mashanu (anenge masendimita maviri) kana kuti diki. Harina kupararira kunze kweadrenal gland.
• Danho rechipiri: Bundu iri rakakura kupfuura masendimita mashanu, asi harina kupararira kupfuura adrenal gland.
• Danho rechitatu: Bundu racho rapararira kusvika kuma lymph nodes ari pedyo.
• Danho rechina: Bundu iri rapararira kusvika kuma lymph nodes ari pedyo, nhengo dziri pedyo, kana nhengo dziri kure.

Ruzivo nezvedanho regomarara dzimwe nguva rungaita serunovhiringidza. Saka usambozeza kubvunza chiremba wako kuti akutsanangurire. Uyewo, bvunza kuti izvi zvinokanganisa sei mamiriro ako ezvinhu.

Ndeipi mishonga yekurapa adrenocortical carcinoma?

Kurapa kunonyanya kushandiswa kuvhiyiwa kubvisa adrenal gland , uko kunosanganisira kubviswa kwe adrenal gland imwe chete kana ese ari maviri. Pamusoro pezvo, vanachiremba vanowanzo nyora mishonga yakaita se:

• Mitotane (Mitotane (Lysodren®)):Mushonga uyu unoshanda nekuderedza mashandiro eadrenal glands. Izvi zvinogona kuderedza njodzi yekudzoka kwegomarara. Mushonga uyu unoshandiswa mushure mekunge adrenal gland imwe yabviswa, kana kana kuvhiyiwa kusingagoneke. Nekuti mushonga uyu unomisa kugadzirwa kwemahormone, vanhu vanoutora vanofanirwawo kutora mapiritsi emahormone.
• Metyrapone (Metopirone®): Rudzi urwu rwemushonga runogona kunyorerwa kuderedza zviratidzo zvinokonzerwa nekuwanda kwemahormone anogadzirwa nemaovari.

Zvisinei, mune dzimwe nguva, bundu rinogona kunge rakakura zvekuti haribviswe zvakachengeteka kana chirwere chacho chaonekwa. Muzviitiko zvakadaro, vanachiremba vanogona kushandisa chemotherapy . Kunyange zvazvo kurapwa uku kusingakwanise kubvisa bundu rekenza zvachose, kunogona kuderedza zviratidzo uye kunonoka kukura kwebundu.

Ungangodawo kufunga nezvekuchengetedzwa kwevarwere sechikamu chekurapa kwako. Kutarisirwa kwevarwere kunobatsira kudzora zviratidzo nemigumisiro yekurapa. Nyanzvi dzekuchengetedzwa kwevarwere vanogonawo kukupa rutsigiro rwepfungwa nerwemanzwiro.

Ndezvipi zvinetso kana migumisiro yekurapwa?

Kuvhiyiwa nemishonga zvinogona kukonzera matambudziko akasiyana-siyana kana migumisiro yakaipa. Semuenzaniso, kuvhiyiwa kubvisa adrenal gland kunogona kukonzera zvinhu zvakaita se:

• Mhedzisiro pakugadzirwa kwemahormone: Kazhinji, adrenal gland yasara inotora basa regland yabviswa yoburitsa mahormone akakwana. Zvisinei, kana izvi zvikasaitika, ungangoda kunwa mamwe mapiritsi emahormone kusvika gland yasara yaburitsa mahormone nemazvo. Dambudziko iri rinonziwo adrenal insufficiency .
• Utachiona: Utachiona hunogona kuitika mudumbu kana panzvimbo yekuvhiyiwa.
• Kubuda ropa zvakanyanya: Izvi zvinogona kuitika panguva yekuvhiyiwa kana mushure mekuvhiyiwa.

Ndezvipi zvinetso kana migumisiro yemushonga?

Chiremba wako anogona kukukurudzira kuti utore mitotane kwemakore maviri kusvika mashanu mushure mekuvhiyiwa. Migumisiro yemitotane inogona kusanganisira:

• Kusvotwa nekurutsa
• Manyoka
• Mapundu paganda
• Kuvhiringidzika

Ndeipi mikana yekupona kwe adrenocortical carcinoma?

Kazhinji, 50% yevanhu vane adrenocortical carcinoma vanorarama makore mashanu mushure mekuonekwa kuti vane chirwere ichi. Zvisinei, mwero uyu wekurarama unoenderana nezvinhu zvakawanda. Semuenzaniso:

• Danho rekenza panguva yekuongororwa kwechirwere.
• Kungave bundu riri kushanda (rinoburitsa mahormone) kana kuti harishande.
• zera rako.
• Hutano hwako hwese.

Chiyero chekupona kwemakore mashanu nedanho chinotevera:

• Chikamu Chekutanga: 81%
• Chikamu chechipiri: 61%
• Chikamu Chechitatu: 50%
• Danho rechina: 13%

Nhamba idzi dzinogona kuita kuti unzwe kutya uye kunetseka. Izvozvo zvakajairika. Asi yeuka, nhamba idzi dzakavakirwa pane zvakaitika kare. Nyanzvi dzinoyera huwandu uhwu hwekupona makore mashanu ega ega. Zvakawanda zvinogona kuchinja mumakore mashanu, uye shanduko idzodzo dzinogona kukanganisa mhedzisiro. Zvakare, yeuka kuti huwandu uhwu hwekupona hausi fungidziro yekuti uchararama kwenguva yakareba sei.

Kana muine mibvunzo chaiyo nezvehuwandu hwevanhu vanorarama negomarara, taurai nachiremba wenyu. Iye ndiye anonyanya kukubatsirai, sezvo iye achinyatsoziva mamiriro enyu ezvinhu.

Ko adrenocortical carcinoma inogona kudzivirirwa here?

Kwete, hazvigone kudzivirirwa. Vaongorori vanoziva kuti hafu yekenza dzemudumbu dzinokonzereswa nekuchinja kwemajini mamwe kunoita kuti masero ekenza awedzere uye agadzire mapundu. Zvisinei, havasati vaziva kuti chii chinokonzera kuchinja uku. Saka, havakwanise kukurudzira nzira dzekudzivirira kuti zvisaitike.

Zvisinei, mamwe mamiriro ezvinhu anogarwa nhaka anowedzera njodzi yekubatwa nechirwere ichi. Kana uine nhoroondo yemhuri yezvirwere izvi, zvakanaka kutaura nachiremba wodzidza nezvekuongororwa kwemajini kunogona kuona shanduko dzemajini dzinokonzera matambudziko aya.

Ndinozvitarisira sei? (Ndingazvichengeta sei?)

Kansa yeAdrenocortical igomarara risingawanzoitiki, rinowanzo dzoka. Matambudziko maviri aya anogona kukuita kuti unzwe kutya, kusurukirwa, uye kunetseka. Nerombo rakanaka, kune mamwe matanho aunogona kutora kuti ubatsire:

• Tsvaga rutsigiro: Bvunza timu yako yezvekurapa nezvemapoka ekutsigira vanhu vane adrenocortical carcinoma. Kupedza nguva uye kutaura nevanhu vari kusangana nezvinhu zvakafanana nezvauri kusangana nazvo kunogona kubatsira.
• Funga nezvezvirongwa zvekuchengetedza kenza: Vanhu vazhinji vane adrenocortical carcinoma vanotya kuti kenza ichadzoka. Zvirongwa zvekuchengetedza kenza ndeimwe yenzira dzekubatsira kugadzirisa kuzvidya mwoyo ikoko.
• Ramba uchitarisirwa pakurapa kwekurwadziwa kwemusana: Kana ukapihwa chemotherapy mushure mekuvhiyiwa, ungangoda rubatsiro rwekutarisira migumisiro yekurapwa.

Ndinofanira kuona chiremba wangu rini?

Kansa yemudumbu inowanzo dzoka, kunyanya mukati memakore maviri ekutanga mushure mekuvhiyiwa. Chiremba wako acharonga nguva yekutevera kuti aongorore zviratidzo zvechirwere ichi. Semuenzaniso:

• Kuongororwa kwemifananidzo: Mwedzi mitatu yega yega kwemakore maviri, wozotevera mwedzi mitatu kusvika mitanhatu yega yega kwemakore matatu.
• Kuongororwa kweropa: Chiremba wako achaita bvunzo dzeropa nguva dzose kuti aone huwandu hwemahormone.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Kansa yemudumbu (adrenal cortical carcinoma) chirwere chisingawanzoitiki. Ungave nemibvunzo yakawanda pamusoro pezvaungatarisira. Heano mimwe mibvunzo yatinofunga kuti ingakubatsira:

• Zvinorevei kana bundu riri kushanda kana kuti risingashande?
• Bundu iri rapararira kunze kweadrenal gland yangu here? Kana zvakadaro, kusvika papi?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Ndezvipi migumisiro yekurapwa?
• Ndinofanira kuongororwa majini here kuti ndione kana paine shanduko dzemajini dzinokonzera kenza ye adrenocortical mumhuri yangu?
• Kana kurapwa kwacho kukabudirira, mikana yekuti bundu iri ridzoke ndeyei?

Kansa yeAdrenocortical igomarara risingawanzoitiki uye rinotyisa rinokanganisa adrenal gland yako. Ringasave nezviratidzo, uye vanhu vazhinji vanoonekwa panguva yekuongororwa kwechirwere chakasiyana zvachose. Ungave uchinetseka uye uchitya nezvekuonekwa kwako uye nhau yekuti kansa yako yeAdrenocortical inogona kudzoka mushure mekurapwa.

Kana uchinzwa kuremerwa nechirwere ichi, tora nguva yaunoda kuti unzwisise zviri kuitika. Usambozeza kubvunza mibvunzo nezvekurapa uye kuti kuchakukanganisa sei. Vanachiremba vako vachanzwisisa kuti sei uri kuita zvimwe zvinhu. Vachavepo kuti vapindure mibvunzo yako, kubva pakuongororwa, kuburikidza nekurapwa, uye makore ekutevera.

Mharidzo Yekuenda Nayo Kumba

Kunyange hazvo adrenocortical carcinoma iri chirwere chakakomba, zvakakosha kuziva nezvacho, kutsvaga mazano akakodzera ekurapa, uye kutsvaga rutsigiro.

• Iyi igomarara risingawanzoitiki: saka usaore mwoyo nezita racho.
• Ngwarira zviratidzo: Chenjerera zvinhu zvakaita sekushungurudzika mudumbu, kuwedzera huremu kusingawanzoitiki, uye kuchinja kwemahormone.
• Tsvaga rubatsiro rwechiremba nekukasika: Kana usina chokwadi, enda kuna chiremba wonoongororwa.
• Kune nzira dzekurapa: kuvhiyiwa, mishonga, chemotherapy, nezvimwewo. Chiremba wako ndiye achasarudza kuti ndeipi nzira yekurapa yakakunakira.
• Rutsigiro rwepfungwa rwakakosha: Hausi wega parwendo urwu. Taura nemhuri, shamwari, nemapoka ekutsigirana.

Yeuka, murwere wega wega akasiyana. Mamiriro ako ezvinhu, kurapwa kwako, uye rwendo rwako rwekupora zvakasiyana. Usambofa wakarasa tariro. Shanda pamwe chete nechikwata chako chekurapa uye tarisana nedambudziko iri nemaonero akanaka.

Kansa yeAdrenocortical , kenza yeadrenal, bundu readrenal gland, bundu rinogadzira mahormone, cortisol, aldosterone, kuvhiyiwa kweadrenal, mitotane