Pamwe chiremba akataura nenhengo yemhuri kana shamwari nezve 'kuisirwa stem cell'. Kana kuti pamwe wakakurudzirwa kurapwa uku kwechirwere chakadai seleukemia. Zvakajairika kunzwa kutya uye kutya kana ukanzwa zita iri. Asi uku kurapa kwakakosha kunogona kuponesa hupenyu hwakawanda. Saka nhasi, ngatitaurei zviri nyore uye zvakajeka nezve 'Allogeneic Stem Cell Transplant' iyi, kuti inoitwa sei, uye njodzi dzayo ndedzipi.
Zvichitaurwa zviri nyore, chii chinonzi allogeneic stem cell transplant?
Izvi zviri nyore kunzwisisa. Kuisirwa kwemasero eropa anokonzerwa ne allogeneic kunoitika kana masero ako eropa ane chirwere abviswa otsiviwa nemasero eropa kubva kune mumwe munhu ane hutano uye anoenderana neako. Mamasero aya imhando yemasero anowanikwa mumongo wedu wemapfupa anogona kukura kuita chero rudzi rwemasero eropa (masero matsvuku eropa, masero machena eropa, maplatelet).
Kana masero aya ane hutano apinda mumuviri wako, anoenda kumongo wako wemapfupa otanga kugadzira masero matsva eropa ane hutano. Uku kurapa kwakasimba kunogona kutorapa zvirwere zvakakomba. Vanachiremba vanowanzo tora mushonga uyu kana mamwe marapirwo akundikana kana chirwere chacho chadzoka.
Kurapa uku kunoshandiswa pamamiriro ezvinhu api?
Kuisa masero emuviri anoshandiswa ne allogeneic stem cell kunonyanya kushandiswa pazvirwere zvine chekuita neropa nemasoja emuviri.
| Matambudziko makuru anorapwa |
|---|
| Acute Lymphoblastic Leukemia (YOSE) |
| Chirwere cheAcute Myeloid Leukemia (AML) |
| Aplastic Anemia - Kukundikana kwemubofu |
| Lymphoma - kenza yema lymph nodes |
| Chirwere cheMyelodysplastic |
| Mapundu eMyeloproliferative (MPN) |
| Chirwere cheSickle Cell |
Unogadzirira sei usati warapwa?
Sezvo iri kurapa kukuru, vanachiremba vachakuitira bvunzo dzakawanda kuti vaone kuti muviri wako wakasimba here usati watanga kurapwa kuti vave nechokwadi chekuti unokwanisa kutsungirira migumisiro yekurapwa.
Miedzo mikuru yakaitwa
Chikwata chenyu chekurapa chichaita bvunzo dzakati wandei, dzakadai se:
- Kuverengwa Kweropa Kwakakwana (CBC): Kunoongorora huwandu hwemasero matsvuku eropa, masero machena eropa, uye maplatelet.
- Echocardiogram: Ona kuti mwoyo uri kushanda zvakanaka sei.
- Electrocardiogram (EKG): Inotarisa kuti mwoyo uri kushanda sei.
- Kuongororwa kwebasa rechiropa neitsvo.
- Kuongororwa kweBone Marrow Biopsy: Kana uine kenza, sampuli diki yebone marrow yako inotorwa yoongororwa. Izvi zvinobatsira kuongorora shanduko muchirwere uye njodzi yekuti chirwere chidzoke mushure mekurapwa.
Kugadzirisa Kudyara Mwana Asati Aiswa Mumuviri
Mushure mekuongororwa uku, muchapinda muchipatara mopiwa mushonga unonzi 'conditioning'. Izvi zvinosanganisira kushandisa chemotherapy yakasimba uye/kana kurapwa nemwaranzi yemuviri wese . Izvi zvine zvinangwa zvitatu:
1. Kuparadza masero egomarara asara mumuviri wako.
2. Kugadzira nzvimbo mumongo wemapfupa ako kuti masero matsva emuviri akure.
3. Kuderedza simba remuviri wako rekudzivirira chirwere. Izvi zvinoderedza kugona kwemuviri wako kurwisa (kuramba) masero matsva.
Maitiro aya ekugadzirisa muviri anowanzo tora vhiki imwe kana maviri.
Chii chinoitika panguva yekuisirwa stem cell?
Izvi hazvinyanyi kurwadza. Chikwata chenyu chekurapa chichaisa chubhu diki inonzi central venous catheter (CVC) mutsinga huru iri pamusoro pechipfuva chenyu. Masero matsva emuviri achapihwa mumuviri wenyu kuburikidza nechubhu iyi.
Inzira iri nyore, sekunge kupa ropa. Masero emuviri ane hutano ari mubhegi remunyu anoiswa muropa rako kuburikidza nechubhu yeCVC. Kubva ipapo, anofamba achienda kumongo wako wemapfupa.
Maitiro aya anotora maminetsi angangoita makumi matatu kusvika makumi matanhatu. Munguva iyi, timu yezvekurapa ichagara padivi pako ichitarisa zviratidzo zvako zvehupenyu. Vachanyatso tarisa chero migumisiro. Migumisiro yacho haiwanzoitiki uye kazhinji idiki. Semuenzaniso, unogona kunzwa kudedera zvishoma, kunetseka kufema, kana fivha.
Chii chinonyanya kukonzera dambudziko iri?
Dambudziko guru uye rakakomba rekuisirwa allogeneic chirwere chegraft-versus-host (GVHD) .
Zvichitaurwa zviri nyore, apa ndipo apo masero matsva ekudzivirira muviri ane hutano anobva kumupi (chibage) anotanga kurwisa masero ane hutano nenyama mumuviri wako (mupi). Zvakafanana neuto idzva rinorwisa vanhu vari munyika yako. Dambudziko iri rinogona kukanganisa ganda, chiropa, uye kugaya chikafu. Asi haufanirwe kunetseka, vanachiremba vanogona kukupa mishonga inodiwa yekudzora nekurapa chirwere ichi.
Chii chinoitika mushure mekurapwa? Zvinotora nguva yakareba sei kuti munhu apore?
Mushure mekuisirwa masero emuviri, uchafanira kugara muchipatara kwemavhiki mashoma. Munguva iyoyo, timu yezvekurapa ichakutarisira zvakanaka. Ucharamba uchiwana mishonga inodzvinyirira immune system kudzivirira muviri wako kuti usarambe masero matsva akaisirwa masero. Ungangodawo kuwedzerwa ropa kusvika masero matsva akwanisa kugadzira masero matsva eropa.
Maitiro anoitwa nemasero matsva kupinda mumongo wemapfupa otanga kugadzira masero matsva eropa anonzi 'engraftment' . Izvi zvinogona kutora mazuva angangoita gumi kusvika gumi nemana. Zvisinei, zvinogona kutora mwedzi yakati wandei kusvika pagore kana kupfuura kuti masoja emuviri wako apore zvizere. Munguva iyi, zvakakosha zvikuru kuzvidzivirira kubva kuzvirwere.
Zvinogona kutora makore maviri kana kupfuura kuti munhu apore zvizere, saka rwendo urwu runoda mwoyo murefu uye kutevedzera mirairo yachiremba wako.
Ndezvipi zviratidzo zvinoda kuti uone chiremba nekukasika?
Paunodzokera kumba mushure mekurapwa, unofanira kunyatsoteerera muviri wako. Kana ukaona chimwe chezviratidzo zvinotevera, fonera timu yako yezvekurapa nekukasika .
| Chikamu chezviratidzo | Zvinhu zvekutarisa |
|---|---|
| Zvinogona kuva zviratidzo zvechirwere che graft-versus-host (GVHD) | |
| Sisitimu yekugaya chikafu | Kurwadziwa kwemudumbu, manyoka, kuda kurutsa, uye kurutsa. |
| Ganda nemaziso | Kukwenya uye kukwenya ganda, kutsvuka kweganda uye/kana maziso (jaundice). |
| Zvingave zviratidzo zvehutachiona | |
| Hunhu hwakawanda | Fivha inosvika 38 Celsius (100.4 Fahrenheit) kana kupfuura, dzihwa, kukosora, kuhotsira, mhino inoyerera. |
| Zvimwe zvinhu | Dzungu , kunetseka kufema, kuita weti kakawanda, kana kupisa panguva yekuita weti. |
Ndeupi musiyano uripo pakati pekuisirwa allogeneic ne autologous?
Musiyano mukuru pakati pezviviri izvi ndiwo manyuko emasero emuviri.
Kuisirwa kweAllogeneic: Masero emuviri anowanikwa kubva kune mumwe munhu (anopa).
Kuisirwa kwemasero emuviri (Autologous transplant): Masero emuviri anotorwa kubva kwauri (masero ako anotorwa usati wapiwa chemotherapy yakasimba, wozodzorerwa mumuviri wako).
Kuisirwa allogeneic kunogona kurapa zvimwe zvirwere zvinouraya. Izvi zvinowanzo kwanisika nemutsa wevatorwa. Ava ndivo vanhu vanopa masero ekutanga emuviri. Dzimwe nguva vanopa masero acho inhengo dzemhuri. Pane njodzi dzinosanganisirwa mukugamuchira masero anopiwa. Tora nguva yekunzwisisa mabhenefiti nenjodzi dzemaitiro aya. Chiremba wako anogona kukubatsira kuyera njodzi nezvakanaka kuitira kuti uve nechivimbo musarudzo yako.
Mharidzo Yekuenda Nayo Kumba
- Kuisa masero emuviri anokonzera allogeneic inzira yekushandisa masero ane hutano kubva kune mumwe munhu kurapa zvirwere zvakakomba zveropa zvakaita seleukemia.
- Muviri usati warapwa, unogadzirwa nekurapwa kwakasimba kwakadai se chemotherapy.
- Pane njodzi yekuti masero emupi weropa arwise muviri wemurwere (chirwere chegraft-versus-host), asi vanachiremba vanongwarira zvikuru nezveizvi.
- Zvinotora nguva yakareba kuti munhu apore zvizere, uye kutevedzera mazano echiremba uye kuongororwa nguva nenguva kwakakosha panguva iyi.
- Taura pachena nachiremba wako nezvemibvunzo, kutya, kana zvinokunetsa. Ndiyo nzvimbo yakanakisisa yekuwana ruzivo rwakarurama uye zororo.
💬 Comments (0)
Hapana zvakataurwa parizvino. Isa mhinduro yako pano kekutanga.
Wedzera zvaunofunga