Zvakaoma kutaura kusuruvara kwaunonzwa paunoona nhengo yemhuri kana shamwari yepedyo ichikanganwa zvese zvishoma nezvishoma uye yotadza kuita mabasa ezuva nezuva yega. Chirwere cheAlzheimer chirwere chinoshungurudza zvikuru. Kusvika pari zvino, kwave kuine mishonga inodzora zviratidzo chete, asi ikozvino nyika iri kutaura nezvekurapa kutsva kunotarisa zvakananga chinokonzera chirwere ichi. Nhasi tiri kutaura nezvetariro itsva iyi, iyo inonzi Anti-Amyloid therapy.
Zvichitaurwa zviri nyore, chii chinonzi mushonga uyu weAnti-Amyloid?
Muuropi hwemunhu ane chirwere cheAlzheimer, rudzi rweprotein inonzi `beta-amyloid` runoungana zvisina kufanira. Funga nezvazvo semhepo inopfuura nepawaya yemagetsi, ndiyo nzira inofamba nayo ruzivo pakati pema neuron muuropi hwedu. Iyo protein ye`beta-amyloid` inoungana uye inoumba ma 'plaques' akaita sengura pakati pemasero aya etsinga. Izvi zvinobva zvakanganisa kufamba kwemashoko. Ichi ndicho chikonzero chikuru chekurasikirwa nendangariro uye kusakwanisa kufunga zvakajeka.
Rudzi rutsva rwemishonga iyi, inonzi anti-amyloid, inoshanda nekubvisa ma "beta-amyloid" akaunganidzwa muuropi. Izvi zvinoreva kuti inorwisa chikonzero chechirwere pane kungodzvinyirira zviratidzo. Tariro ndeyekuti nekubvisa ma "plaques" aya, masero europi achakwanisa kushanda zvakanaka kwenguva yakareba.
Izvi zviri muboka remishonga inonzi `immunotherapy`. Kutaura chokwadi, mishonga iyi inopiwa semhando yeantibody (monoclonal antibody) yakagadzirwa zvakanyanya murabhoritari. Kana ma antibodies aya apinda mumiviri yedu, anowana mapuroteni ane njodzi e`beta-amyloid`, onamatira paari, obva aaparadza.
Mishonga miviri mikuru yekurwisa amyloid yakatenderwa parizvino ndeiyi `donanemab (Kisunla)` uye `lecanemab-irmb (Leqembi)`. Kunewo mushonga unonzi `aducanumab (Aduhelm)` asi ikozvino wakabviswa pamusika nekambani yakaugadzira.
Ndingawana sei mushonga uyu? Pane mimwe migumisiro yakaipa here?
Mushonga uyu unopihwa kuburikidza nemushonga wesaline (IV infusion) mutsinga. Izvi zvinotora inenge awa imwe chete. `Leqembi` inowanzopihwa mavhiki maviri ega ega, uye `Kisunla` inowanzopihwa mavhiki mana ega ega. Unotanga nedosi diki wobva wawedzera zvishoma nezvishoma kusvika padosi rawakarairwa nachiremba wako.
Asi unofanira kuziva njodzi huru inouya nekurapwa uku. Inonzi `ARIA (Amyloid-Related Imaging Abnormalities)`.
Zvichitaurwa zviri nyore, izvi zvinogona kukonzera kuzvimba muuropi kana kuti kubuda ropa muuropi. Kunyangwe izvi zvichiwanzopera zvega, zvakakosha kuti urambe uchitarisa izvi. Ndosaka uchifanira kuongororwa uropi neMRI nguva dzose panguva yekurapwa uku.
| Rudzi rwemhedzisiro yakaipa | Tsananguro |
|---|---|
| Njodzi huru (ARIA) | Kuzvimba kana kubuda ropa kudiki muuropi. Izvi zvinogona kukonzera musoro, dzungu, kuda kurutsa, kuvhiringidzika, uye matambudziko ekuona. |
| Mimwe migumisiro yakaipa | - Kusawirirana kwemuviri - Mapopoma - Manyoka |
| Kutarisirwa kwakakosha | Masayendisiti anofungidzira kuti kurapwa uku kunogona kuwedzera njodzi yekubuda ropa muuropi kana kukapihwa kune mumwe munhu anotora mishonga yekuderedza ropa. Unofanira kutaura nachiremba wako nezvazvo. |
Mushonga uyu unoshanda zvakadini zvechokwadi?
Heino nyaya yakaoma. Ongororo dzakaratidza kuti mishonga iyi inogona kubvisa ma "beta-amyloid" plaques muuropi. Izvozvo zvakanaka.
Zvisinei, kuchine kusiyana kwemafungiro pamusoro pekuti ndangariro yemurwere uye kugona kwake kuita mabasa ezuva nezuva zvichavandudzika zvakadini mushure mekubvisa maplaque iwayo. Dzimwe ongororo dzakaratidza kuti izvi zvinogona kunonotsa zvishoma kufambira mberi kwechirwere. Izvi hazvirevi kuti chirwere chacho chapora zvachose, asi kuti zvinononotsa chirwere kubva pakuipa zvakanyanya.
Masayendisiti anotenda kuti mhedzisiro yakakura inogona kutarisirwa kana kurapwa uku kukatanga pakutanga kwechirwere , kusati kwanyanya kukuvara kuuropi.
Ndiani anogona kurapwa uku?
Iyi haisi mishonga inogona kupiwa kumurwere wese ane Alzheimer's. Parizvino, mishonga iyi inokurudzirwa chete kuvanhu vashoma kwazvo.
- Kune vanhu vari muchikamu chekutanga chechirwere: Kureva avo vane chirwere cheAlzheimer's chinotanga kare kana avo vane chirwere chinonzi 'mild cognitive impairment'. Hazvisati zvazivikanwa kana izvi zvichizobatsira vanhu vane chirwere chakanyanya kukura.
- Kune avo vakasimbiswa kuti vane amyloid plaques:Chiremba wako asati akupa mushonga uyu, anofanira kutanga aona kana ma plaque aya aripo muuropi hwako. Izvi zvinogona kusanganisira PET scan kana spinal tap.
Ndiani asingakwanise kurapwa uku?
Mushonga uyu hauna kudzidzwa mumiedzo yakawanda yekiriniki, saka zvingave nengozi kupa mushonga uyu kuvanhu vane matambudziko anotevera ehutano:
- Vanhu vari kutora mishonga inodzivirira kuumbwa kweropa (kunze kweaspirin).
- Avo vakambotambura nechirwere chemwoyo kana sitiroko.
- Vanhu vane matambudziko ekubuda ropa.
- Vanhu vane chirwere cheitsvo kana chiropa.
Chimwezve ndechekuti, kurapwa uku kunodhura zvikuru . Munyika yakaita seSri Lanka, zvinogona kuoma kuti vanhu vazhinji vawane kurapwa uku. Kurapa uku hakusati kwanyanya kuitika pari zvino.
Mharidzo Yekuenda Nayo Kumba
- Anti-amyloid imhando itsva yemushonga unobvisa ma "beta-amyloid" plaques anoungana muuropi uye anogona kukonzera chirwere cheAlzheimer.
- Izvi zvine chinangwa chekurapa chikonzero chikuru chechirwere kwete zviratidzo.
- Izvi zvinongopihwa chete kuvarwere vari muchikamu chekutanga chechirwere uye vakaonekwa kuti vane ma plaque muuropi.
- Nekuda kwengozi yekuzvimba kweuropi kana kubuda ropa kunonzi ARIA, kuongororwa nguva dzose neMRI scans kwakakosha panguva yekurapwa.
- Nzwisisa kuti kurapwa uku kuchiri muchikamu chekutsvagisa, kunodhura zvikuru, uye kunongowanikwa kuvanhu vashoma chete .
- Kana waunoda aine zviratidzo zveAlzheimer's, chinhu chakanakisa chekuita ndechekutaura nachiremba wako nezve rumwe ruzivo uye nzira dzekurapa dzakakunakira.
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