Wakamboona here kuti muromo wako unogara wakaoma, maziso ako haana kujeka, kana kuti dumbu rako rinogara rakaoma nekuda kwemishonga yaunotora? Ungafunga kuti ichi chimwe chinhu chinokonzerwa nekurwara kwako. Zvisinei, chikonzero cheizvi chingave chekuti uri kutora mushonga usingazive une anticholinergic properties. Usazvidya moyo, izvi zvinowanzoitika. Nhasi, tichataura nezvazvo nenzira iri nyore yaunogona kunzwisisa.
Chii chaizvo chiri mishonga iyi yekurwisa cholinergic?
Zita iri ringanzwika serakaoma zvishoma. Asi nyaya yacho iri nyore kwazvo. Sisitimu yetsinga yemuviri wedu ine network inoshamisa kwazvo. Izvi ndizvo zvinodzora zvese kubva pakufunga kwedu, mafambiro, kufema, uye kurova kwemoyo. Kune "nhume" musisitimu iyi yetsinga dzinotakura mameseji. Kungofanana nevanhu vanotumira tsamba mupositi. Tinodana ava nhume kuti `(Neurotransmitters)`.
Imwe yenhume dzakakosha zvakadaro iacetylcholine .
Iye zvino ngationei kuti basa guru re'Acetylcholine' iyi chii. Kune zvikamu zviviri zvikuru zvehurongwa hwedu hwetsinga hwe autonomic.
1. Sisitimu yetsitsi: Iyi ndiyo sisitimu yedu ye "kurwa kana kutiza". Zvichitaurwa zviri nyore, sisitimu iyi inotigadzirira kutarisana nenjodzi, kutya, kana kutyisidzirwa. Zvakafanana neakisitorendi iri mumotokari. Kana yashanda, mwoyo yedu inorova nekukurumidza, maziso edu anovhurika, uye tinodikitira.
2. Parasympathetic system: Iyi ndiyo system yedu ye "kuzorora nekugaya". Izvi zvinoreva kuti system iyi inobatsira muviri kudzikama, kugaya chikafu, uye kuzorora. Yakafanana nemabhureki emotokari. Nhume yedu inonzi `Acetylcholine` inoshanda zvakanyanya musystem iyi.
Zvakanaka, ikozvino wava kunzwisisa nhoroondo yacho, handiti? Mishonga yeAnticholinergic inoshanda nekukanganisa basa remutumwa iyeye anonzi `Acetylcholine`. Izvi zvinoreva kuti kana mutumwa iyeye akaenda kunzvimbo yaanoda kuendesa shoko rake, nzvimbo iyoyo (receptor) inovharika. Zvadaro basa re "kudzikamisa" system iyoyo (Parasympathetic) rinodzikira zvishoma.
Zvichitaurwa zviri nyore, mishonga yekudzivirira cholinergic inovhara kwenguva pfupi mashandiro emutumwa anodzora zororo uye kudzikamisa muviri wedu.
Mushonga uyu unoshandiswa kuzvirwere zverudzii?
Kune mishonga inodarika mazana matanhatu ine simba rekurwisa cholinergic. Mimwe mishonga yakagadzirirwa kushandisa simba iri rekurwisa cholinergic kurapa zvirwere. Mimwe mishonga ine simba iri semhedzisiro.
Mutafura iri pazasi, ngatitarisei mhando dzakasiyana dzemishonga dzinonyanya kushandisa simba iri rekurwisa cholinergic kurapa zvirwere.
| Zita remushonga (muenzaniso) | Mashandisirwo enyaya uye tsananguro iri nyore |
|---|---|
| Atropine | Uyu mushonga unowanzo shandiswa muEmergency Department (ETU). Unoshandiswa kurapa bradycardia kana kurova kwemoyo kuchinonoka, uye semushonga wekurapa chepfu inobva kune mimwe mishonga inouraya zvipembenene. Kana paine chepfu, chiremba wako achabata National Poisons Information Center paNational Hospital kuti awane mamwe mazano. |
| Ipratropium / Tiotropium | Izvi zvinowanikwa mumishonga inofema inopiwa vanhu vane zvirwere zvekufema zvakaita seasthma neCOPD. Mishonga iyi inobatsira kuwedzera nzira dzekufema uye kuita kuti kufema kuve nyore. |
| Oxybutynin / Solifenacin | Iyi mishonga inopihwa kurapa kusagadzikana kwekuzvidzora, chirwere chekuti unofanira kuita weti nguva nenguva uye unonetseka kudzora kuyerera kweweti yako. Mishonga iyi inoshanda nekuderedza kusimba kwetsandanyama dziri mudundira. |
| Scopolamine | Izvi zvinoshandiswa kurapa kurutsa uye kuda kurutsa kunokonzerwa nekufamba mumabhazi nengarava (kufamba netsoka). Dzimwe nguva zvinouya zvakaita sechigamba. |
| Benztropine / Trihexyphenidyl | Mushonga uyu unobatsira kudzora zviratidzo zvakaita sekubvunda kunokonzerwa nechirwere cheParkinson. |
| Diphenhydramine | Mishonga yakawanda inoshandiswa pakurapa allergies (semuenzaniso, piritan) ine izvi. Izvi zvinoderedza hope uye zvinoita kuti unzwe hope uye muromo wako uome kana uchinwa izvi. |
Mishonga ine hunhu uhwu semhedzisiro
Kune mimwe mishonga iyo, kunyange hazvo basa rayo guru riri chimwe chinhu chakasiyana, ine mhedzisiro yekuderedza cholinergic.
- Mimwe mishonga yekare yaishandiswa kurapa zvirwere zvakaita sekuora mwoyo (Tricyclic antidepressants). Mimwe mishonga ('Mishonga yeAntipsychotic') inopihwa kune zvirwere zvepfungwa zvakakomba zvakaita seschizophrenia .
- Mishonga yakawanda yekurapa allergies ('Antihistamines').
Ndeipi migumisiro yemishonga yekuderedza cholinergic?
Iye zvino pamwe wava kunzwisisa kuti sei mishonga iyi ichikonzera kuoma kwemuromo uye kusaona zvakanaka. Patinoderedza mashandiro e "system" iyoyo, zvinhu zvakawanda zvinodzorwa nesystem iyoyo zvinokanganiswa.
Pane chirevo cheChirungu chinoshandiswa navanachiremba kurangarira migumisiro iyi. "Kupisa setsuro, bofu sechiremwaremwa, kuoma sepfupa, kutsvuka sechiremwaremwa, kupenga sechiremwaremwa". Izvi zvinoreva kuti "Kupisa setsuro, bofu sechiremwaremwa, kuoma sepfupa, kutsvuka sechiremwaremwa, kupenga sechiremwaremwa". Izvi zvinoita kuti zvive nyore kurangarira migumisiro mikuru.
Ngatitarisei zviri nyore migumisiro iyi nezvikonzero zvayo mutafura iri pazasi.
| Mhedzisiro Yepadivi | Zvichitaurwa zviri nyore, chii chinoitika? |
|---|---|
| Muromo wakaoma nemaziso | Sisitimu "yakadzikama" inokurudzira kugadzirwa kwemate nemisodzi. Kana isingashande zvakanyanya, mate nemisodzi hazvibudiswiwo zvakanyanya. |
| Kuona kusina kujeka | Tsandanyama dzinochinja saizi yemwana wechikoro dzinokanganiswa, zvichiita kuti zviome kuona zvinhu zviri pedyo. Vana vechikoro vanokura (vana vechikoro vakakura). |
| Kuoma kwekuita weti (Kuramba urini) | Tsandanyama dzedundira padzinenge dzisingachanyanyi kuchinjika, zvinova zvakaoma kubvisa tsvina yese mudundira. |
| Kuzvimba | Kufamba kwemukati kwakabatana nekugaya chikafu kunononoka. |
| Kurova kwemoyo nekukurumidza (Tachycardia) | Kurova kwemoyo kunowedzera kupfuura mwero wenguva dzose nekuti "bhureki" rinodzora kurova kwemoyo rinodzikira. |
| Kuvhiringidzika / Kuchinja kwemamiriro epfungwa | Acetylcholine inokoshawo pakurangarira nekufunga muuropi. Kana ikakanganiswa, kunyanya kuvanhu vakuru, inogona kukonzera kuvhiringidzika. |
| Ganda rakanyorova uye rakanyorova | Kudikitira inzira yemuviri yekudzora tembiricha. Mishonga iyi inogona kuderedza kudikitira, izvo zvinogona kuwedzera tembiricha yemuviri. |
Inguvai yaunofanira kuona chiremba?
Kana wakanyorerwa mushonga wekudzivirira chirwere checholinergic, mabhenefiti ekuutora anopfuura zvakanyanya migumisiro yacho. Zvisinei, kana ukasangana nechimwe chezvinotevera, iva nechokwadi chekutaura nachiremba wako.
- Kana chirwere chako chisiri nani kana ukashandisa mishonga.
- Kana zvichikuomera kutora mushonga sezvawakarairwa nachiremba (semuenzaniso kana uri kunetseka nekuda kwemigumisiro yakaipa).
- Kana migumisiro yemushonga wacho yakanyanya kukwana kukanganisa mabasa ako ezuva nezuva (kuenda kubasa, kutyaira, kudzidza).
Fungidzira, une asthma, uye mushonga wekufemesa waunopiwa unoita kuti zvive nyore kufema, asi muromo wako wakaoma zvikuru. Kana kuti unonetseka kudzora weti yako uye mushonga waunopiwa unoita kuti maziso ako asaone zvakanaka. Muchiitiko chakadaro, paunotaura nachiremba wako, anogona kuchinja mushonga kana kunyora mumwe mushonga unopa mhedzisiro yakafanana.
Chinonyanya kukosha ndechekuti, kana uine dambudziko, usarega kutora mushonga wako kana kuchinja mwero wemushonga wega. Gara uchitaura nachiremba wako uye tevera mazano avo.
Mharidzo Yekuenda Nayo Kumba
- Mishonga yeAnticholinergic inoshanda nekudzivirira kushanda kwemutumwa wemakemikari (Acetylcholine) anoshanda mu "kudzikamisa" muviri wedu.
- Mushonga uyu unoshandiswa kurapa zvirwere zvakasiyana-siyana, zvakaita seasthma, chirwere cheParkinson, uye kusagona kudzora weti.
- Mimwe mishonga yekurapa allergies uye kuora mwoyo inewo hunhu uhwu hwekurwisa cholinergic semhedzisiro.
- Migumisiro inowanzo sanganisira muromo wakaoma, kuona zvisizvo, dumbu rakasuruvara, kurova kwemoyo nekukurumidza, uye kuvhiringidzika.
- Kana uchinetseka nezvemigumisiro yemushonga wauri kutora, usatya kutaura nezvazvo kana kuita sarudzo wega, asi taura nachiremba wako.
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