Mapaipi emudumbu mako akakura here? Ngatikurukurei nezvechirwere cheCaroli!

Dzimwe nguva unonzwa sekuti muviri wako wava kuita yero here, kana kuti unonzwa sekuti uri kurwadziwa mudumbu rako rekurudyi? Vamwe vanhu vanogona kunzwa fivha uye kurutsa pamwe chete nezviratidzo izvi. Chimwe chikonzero chingave chiri shure kweizvi chirwere chatichataura nezvacho nhasi chinonzi 'chirwere chaCaroli.' Ngationei kuti chii, nei chichiitika, kuti chinoonekwa sei, uye kuti kurapwa kwacho ndekwei.

Zvichitaurwa zviri nyore, chii chinonzi Caroli Disease?

Fungidzira, mukati mechiropa chedu mune machubhu madiki anonzi bile ducts . Machubhu aya anotakura mvura yekugaya inonzi bile inogadzirwa muchiropa kuenda kuura hudiki. Zvino, chirwere ichi cheCaroli chirwere apo ducts dzebile dzinokura kupfuura zvakajairika, kureva kuti, dzinova dzakakura . Ichi chirwere chemajini , kureva kuti, chinokonzerwa nekuchinja kwemajini edu. Kana machubhu aya akura seizvi, bile inotanga kuungana panzvimbo pekuyerera zvakanaka. Kana izvi zvikaungana, matombo e bile ducts anogona kuumbwa, hutachiona hunogona kuitika, uye dzimwe nguva cysts dzinogona kutoumbwa.

Zvichitaurwa zviri nyore, nyongo inofanira kuyerera zviri nyore pasina kunamatira. Zvisinei, kana nyongo dzacho dzikakura zvakanyanya, nyongo inogona kuungana zviri nyore. Nekufamba kwenguva, nyongo iyi yakaungana inogona kuumba matombo madiki.

Kana uine chirwere cheCaroli, unogona kuona zviratidzo zvakawanda zvechirwere ichi muhupenyu hwako hwese. Zviratidzo zvinowanzotanga pazera remakore makumi matatu , asi zvinogona kuitika chero pazera ripi zvaro. Unogona kuona ganda rako nemachena emaziso ako zvichichinja kuita yero (tinoti jaundice ), uye unogona kutangawo kuwana zviratidzo zvakaita sedzihwa nefuruu kakawanda. Kunyangwe chirwere ichi chichigona kukanganisa hutano hwako uye hupenyu hwako, kune marapirwo anogona kubatsira kudzora zviratidzo zvako.

Pane mhando dzechirwere chaCaroli here?

Ehe, kune mhando mbiri huru dzeizvi:

• Chirwere cheCaroli: Rudzi urwu runongokanganisa ducts dze bile chete. Harukonzeri mamwe matambudziko nechiropa chako.
• Caroli syndrome: Iri ndiro rudzi rwakanyanya kuipa. Muizvi, chiropa chinova nemavanga, ayo atinodaidza kuti fibrosis .

Chirwere ichi chakajairika zvakadii?

Chirwere chaCaroli chirwere chisingawanzoitiki . Zvinofungidzirwa kuti munhu mumwe chete pavanhu miriyoni vanochiwana . Saka hachisi chirwere chinokanganisa vanhu vazhinji.

Saka, zviratidzo zvechirwere chaCaroli ndezvipi?

Kazhinji, matombo madiki anoumbwa mumaburi enyongo haakonzeri zviratidzo zvikuru. Zvisinei, kana dombo rikavhara dumbu renyongo, rinogona kuzvimba. Tinoridaidza kuti cholangitis . Apa ndipo panotanga kuoneka zviratidzo zvechirwere chaCaroli:

• Kurwadziwa kurudyi kwemuviri wako , kazhinji mudumbu repamusoro.
• Kurutsa .
• Fivha nechando .
• Kutsvuka kweganda uye machena emaziso (jaundice) .
• Kukwenya .

Kashoma, kuunganidzwa kwenyongori uku kunogona kukonzera kukura kwegomarara rekenza rinonzi cholangiocarcinoma mumigero yenyongori. Ndosaka zvichikosha kungwarira izvi.

Sei chirwere chaCaroli chichiitika? Ndezvipi zvinokonzera?

Chirwere cheCaroli chirwere chinokonzerwa nemajini . Izvi zvinoreva kuti chinokonzerwa nekuchinja kwemajini mumuviri wedu. Kazhinji, chinogona kuitika nguva nenguva, zvichireva kuti hachipfuurirwi kubva kuchizvarwa kuenda kune chimwe. Zvisinei, mune dzimwe mhuri, zvinonzi chirwere ichi chinotonga autosomal , zvichireva kuti kana mumwe mubereki aine chirwere ichi, vana vanogonawo kuchibata.

Caroli syndrome inokonzerwa nekuchinja kwemajini mujini rinonzi PKHD1 . Jini iri ndiro rinoita kuti pave neprotein inobatsira kuti ducts dze bile neitsvo zvikure panguva yekukura kwemwana ari mudumbu. Nekuti chirwere cheCaroli nechirwere cheCaroli zvakabatana, vaongorori vanotenda kuti jini rePKHD1 rinobatanidzwawo muchirwere cheCaroli. Zvisinei, kutsvagurudza kwakawanda kunodiwa kuti zvionekwe izvi.

Vanachiremba vanoongorora sei chirwere chaCaroli?

Kana ukaona chiremba, vanotanga vakuongororesa muviri wako vobvunza nezvezviratidzo zvako. Zvadaro, vanozoraira kuongororwa kweropa, senge Comprehensive Metabolic Panel (CMP), iyo inosanganisira ma enzymes echiropa . Kana paine patani yekukwirira muma enzymes aya, zvinogona kuratidza kuti duct ye bile yakavharwa.

Pamusoro pekuongororwa kweropa, chiremba wako angangoda bvunzo dzakawanda dzemifananidzo/radiology , idzo dziri bvunzo dzinotarisa mukati memuviri wako. Izvi zvinosanganisira:

• Ultrasound yemudumbu
• Kuongororwa kweCT (computer tomography scan)
• Kuongororwa kweMRI (magnetic resonance imaging scan)

Pamusoro pezvo, chiremba wako anogonawo kukukumbira kuti uedze ERCP (endoscopic retrograde cholangiopancreatography) . Izvi zvinosanganisira kuisa chubhu diki, inochinjika (inonzi endoscope ) nemuromo wako uye ichidzika mudumbu mako ichipinda mumigero ye bile. NeERCP iyi, chiremba wako anogona kutarisa migero ye bile nechiropa chako kuti aone kana paine bundu kana mavanga.

Chimwezve ndechekuti, chiremba wako anogonawo kukukumbira kuti uite rudzi rwakakosha rweMRI runonzi MRCP (magnetic resonance cholangiopancreatography) . Izvi zvinogona kuyera kuti ducts dze bile dzako dzakafara sei. Zvinogonawo kutarisa matombo emunduru.

Mishonga yeizvi ndeipi? Inogona kurapwa here?

Kutaura chokwadi, chirwere chaCaroliHapasati pave nemushonga. Zvisinei, kune mishonga inogona kubatsira kudzora zviratidzo uye kudzivirira matambudziko. Izvi zvinoda kuti ushande nechikwata chevanachiremba vane hunyanzvi muzvikamu zvakasiyana-siyana. Izvi zvinosanganisira:

• Nyanzvi yezvemajini
• Chiremba wezvematumbu
• Nyanzvi yechiropa/Hepatologist
• Chiremba wezvemudumbu ( sezvo itsvo dzichibatwawo)
• Chiremba ane ruzivo nezvezvirwere zveitsvo (Nephrologist)
• Radiologist ( yezvinhu zvakaita sekuskena)
• Chiremba wekuisa chimwe chibage (kana zvichidikanwa)

Kurapwa kwechirwere chaCaroli kunoenderana nekuti muchubhu wenyongo wakakura uri pachiropa.

• Dzimwe nguva kuvhiyiwa: Kana duct yenyongo yakakura iri kuruboshwe kana kurudyi kwechiropa chete, chiremba wako anogona kubvisa chikamu ichocho chechiropa nekuvhiyiwa. Izvi zvinonzi hemi-hepatectomy . Vanhu vanobviswa chikamu chechiropa nenzira iyi havawanzova nezviratidzo zvakare.
• Mishonga: Zvisinei, kana ducts dzenyongo dzakapararira muchiropa chose, chiremba wako anogona kukupa mishonga inorwisa mabhakitiriya kudzivirira hutachiona hunonzi cholangitis . Uyewo, mushonga unonzi ursodeoxycholic acid unogona kubatsira pamatambudziko anokonzerwa nechirwere cheCaroli.
• Mamwe maoparesheni: Dzimwe nguva, chiremba wako anogona kukurudzira kuti upinze nyongo mukati memudumbu kuti ubvise nyongo muchiropa.
• Kuisirwa chiropa: Muzviitiko zvakakomba, kuisirwa chiropa ndiyo nzira yakanakisisa yekurapa.

Unogona kurarama kwenguva yakareba sei nechirwere cheCaroli?

Chirwere cheCaroli hachitsananguri zvakananga kuti uchararama kwenguva yakareba sei. Nguva yaunotarisirwa kurarama inokanganiswa nematambudziko anokonzerwa nacho. Aya ndiwo:

• Cholangitis: Iyi acute cholangitis, iyo inogona kukonzerwa nematombo emunduru mumigero yenyongo, inoda kurapwa nekukurumidza uye inogona kuuraya mukati memaawa kana mazuva.
• Kenza yemudumbu wenyongo (cholangiocarcinoma): Kenza iyi inogona kukura nekuda kwekuzvimba kwenguva refu uye kuvharika kwemudumbu wenyongo. Kuonekwa nekukurumidza uye kurapwa kwakakosha kuti pave nemigumisiro yakanaka.
• Kukundikana kwechiropa:Kana kuzvimba kwemutsinga dzenyongo kukaramba kuripo, zvinogona kuzokonzera zvirwere zvakakomba zvakaita sekutadza kushanda kwechiropa.

Chinhu chinonyanya kukosha ndechekurapwa. Kana cholangitis ikarapwa nemazvo uye matambudziko akaongororwa nachiremba nguva nenguva, vanhu vane chirwere cheCaroli vanogona kurarama hupenyu hwakazara.

Pane nzira yekudzivirira chirwere ichi cheCaroli here?

Chirwere cheCaroli chirwere chinokonzerwa nemajini , saka hachigone kudzivirirwa nekuti chinhu chinouya nemajini edu.

Ndinofanira kuona chiremba rini?

Kana ukaona zviratidzo zvechirwere chaCaroli - zvakaita sekurwadziwa kurudyi kwedumbu, kurutsa, fivha, uye jaundice - unofanira kuona chiremba. Usanonoka.

Mibvunzo ipi yandinofanira kubvunza chiremba?

Zvakanaka kubvunza mibvunzo iyi kana waenda kuna chiremba:

• Ndine chirwere cheCaroli here kana kuti chirwere cheCaroli?
• Dambudziko rangu rakakomba zvakadii zvichibva pamigumisiro yekuongorora kwangu?
• Ndeipi nzira yakanakisisa yekurapa chirwere changu?
• Pane mishonga inogona kubatsira kudzora zviratidzo zvangu kana kudzivirira matambudziko here?
• Ndingavhiyiwa here? Kana zvakadaro, ndovhiyiwa rudzii?
• Ndezvipi njodzi uye mabhenefiti ekuvhiyiwa?
• Ndezvipi zviratidzo zvematambudziko andinofanira kuziva?

Chii chinosiyanisa chirwere chePolycystic Liver Disease (PCLD) nechirwere chaCaroli?

Chirwere chechiropa chinonzi Polycystic (PCLD) nechirwere cheCaroli zvese zvinokanganisa ducts dze bile muchiropa. Asi pane musiyano mukuru pakati pezviviri izvi. MuPCLD, ma cysts akawanda anoumbwa muchiropa chose. Aya akafanana nemasagi asina kujairika. Kunyangwe ma cysts achigonawo kuumbwa muchirwere cheCaroli, zvinonyanya kusanganisira kuwedzera kweducts dze bile mukati mechiropa.

Saka chii chiri hukama huripo pakati pechirwere chaCaroli ne choledochal cysts?

Chirwere cheCaroli chinokanganisa ducts dze bile dziri mukati mechiropa, idzo dziri ducts dze bile dziri mukati mechiropa . Ma cysts anoumbwa muducts dze bile dziri mukati mechiropa imhando ye choledochal cyst . Saka, kana uine akawanda ema cysts aya, anonzi chirwere cheCaroli. Zvichitaurwa zviri nyore, chirwere cheCaroli imhando ye choledochal cyst.

Chekupedzisira, zvinhu zvinonyanya kukosha zvaunofanira kurangarira

Chirwere cheCaroli chinogona kutyisa kunzwa nezvacho. Zvisinei, nekufambira mberi kwesainzi yezvekurapa, ikozvino kwava nenzira dzinoshanda dzekugadzirisa chirwere ichi. Nekuongororwa nguva dzose, iwe nachiremba wako munogona kutarisa mamiriro ako zvakanyanya. Vanhu vazhinji vane chirwere cheCaroli vanowana zororo kubva kuzviratidzo zvavo nemishonga , uyeZvishoma zvinokuvadza, zvichireva kuti hapana mavanga makuru, nzira dzekurapa dzinowanzo kuve sarudzo.

Yeuka, chinangwa pano ndechekukuchengetedza uine hutano uye uchishanda kwenguva yakareba sezvinobvira. Saka, usavhunduka, ingotevera mirairo yachiremba wako nokungwarira. Usatya kubvunza mibvunzo kana uine.

Chirwere cheCaroli , Chiropa, Dumbu reBile, Zvirwere zveMajini, Jaundice, Matombo eGallstone