Mwana wako mudiki anorwara nguva dzese here? Kana chirwere chimwe chikava nani, chimwe chinouya. Dzimwe nguva anowana hutachiona hwakakomba muganda, mumapapu, kana kunyange mumuviri? Vabereki vazhinji vanonetseka nezvematambudziko akadaro. Nhasi tichataura nezvechirwere chisingawanzoitiki asi chakakosha chemajini chinogona kukonzera hutachiona hwakadaro. Tinodana chirwere ichi kuti Chronic Granulomatous Disease, kana kuti CGD muchidimbu pakati pevanachiremba.
Zvichitaurwa zviri nyore, chii chinonzi CGD?
Kuti tinzwisise izvi, ngatitangei tataura zvishoma nezvedziviriro yemuviri wedu. Fungidzira kuti muviri wedu wakaita senyika. Une uto rinokwanisa kuudzivirira kubva kuvavengi vekune dzimwe nyika (majemusi). Ndiwo uto redu rekudzivirira muviri . Chikamu chakakosha cheuto iri chinonzi masero machena eropa .
Zvino, hezvino zvinoitika kumunhu ane CGD. Kune boka rakakosha remasero machena eropa rinonzi masoja, semuenzaniso, `(neutrophils)`, `(monocytes)`, `(macrophages)` uye `(eosinophils)`. Basa guru remasero aya nderekutsvaga mamwe marudzi emabhakitiriya nefungus anopinda mumuviri, oabata, uye oaparadza.
Asi mumunhu ane CGD, masoja aya akakosha, kana masero machena eropa, haakwanise kushandisa zvombo zvavo nemazvo. Havakwanise kugadzira enzyme chaiyo yavanoda kuti vauraye utachiona ihwohwo. Zvakafanana nekuva nepfuti asi pasina mabara. Saka chii chinoitika? Masoja edu ekudzivirira muviri anokundwa, haakwanise kurwisa mamwe mabhakitiriya nefungus zvinopinda mumuviri.
Nekuda kwechikonzero ichi, vanhu vane CGD vanowanzo rwara nehutachiona hwemabhakitiriya nefungus, dzimwe nguva hwakakomba. Vanogonawo kukuvara kwenguva refu mumuviri.
Utachiona uhwu hunowanzo itika paganda, mumapapu, muma lymph nodes, nechiropa . Hunowanzo gadzira matumbu , ayo ari mapundu azere netumbu mukati menhengo dzemuviri.
Ichi chirwere hachiwanzoitika. Munhu mumwe chete pavanhu vaviri nehafu pasi rose anowana chirwere ichi. Zvakare, zvakaonekwa kuti vakomana ndivo vanowanzowana chirwere ichi .
Ndezvipi zviratidzo zvinoratidzwa nemunhu ane CGD?
Zviratidzo zveCGD zvinowanzotanga muhudiki. Zvisinei, dzimwe nguva zvinogona kuonekwa pazera ripi zvaro. Chiratidzo chikuru uye chinowanzoonekwa hutachiona hwakakomba hwemabhakitiriya nefungus hunodzokororwa.
Ngatitarisei zviratidzo izvi kuti tinzwisise zviri nyore kuti chii.
| Chiratidzo | Tsananguro iri nyore |
|---|---|
| Mapundu anowanzoitika nezvimwe zvirwere | Kurwara kunowanzoitika mumapapu, ganda, chiropa, mapfupa, kana ma lymph nodes. |
| Matumbu | Kuumbwa kwema cysts ane urwa munhengo dzakadai sechiropa, mapapu, chirebvu, kana ganda. |
| Manodhi elymph akazvimba | Kuzvimba kweganda munzvimbo dzakadai semutsipa, muhapwa, uye muzvidya. |
| Matambudziko eganda | Kugara uchivaviwa, kutsvuka, uye utachiona hweganda. |
| Granulomas | Mapundu madiki emasero ekudzivirira muviri anoumbwa panzvimbo dzine hutachiona kana kuzvimba anogonawo kukonzera matambudziko. |
| Matambudziko ekugaya chikafu | Kurwadziwa kwemudumbu kwenguva refu, manyoka, kuda kurutsa, uye kurutsa. |
| Zvimwe zvinhu | Mhuno inoyerera nguva dzose, kurwadziwa pachipfuva pakufema, uye bvunzo dzekushanda kwechiropa zvisina kunaka. |
Sei chirwere ichi cheCGD chichiitika? Chii chinokonzera?
Zvichitaurwa zviri nyore, CGD chirwere chinokonzerwa nemajini.Izvi zvinoreva kuti ichi chinhu chatinogara nhaka kubva kuvabereki vedu. Basa rega rega mumuviri wedu rinodzorwa nezvinhu zvinonzi majini. Masero machena eropa atakataura nezvawo kare ane 'mirairo' inogadzira ma enzyme anodiwa kuuraya utachiona.
MuCGD, pane shanduko mune rimwe remajini mashanu ane mirairo iyi. Nekuda kwekushanduka uku, masero machena eropa haagone kugadzira enzyme, kana kuti kana akaigadzira, haishande nemazvo. Mugumisiro wacho ndewekuti haakwanise kurwisa utachiona.
CGD yakakamurwa kuita mhando mbiri zvichienderana nekuti dambudziko iri remajini rinoitika sei.
- CGD ine X-linked: Iyi ndiyo mhando inonyanya kuwanikwa. Inokonzerwa nekuchinja kwemajini (gene re'CYBB`) pachromosome yeX. Varume vane chromosome imwe chete yeX, ukuwo vakadzi vane machromosome maviri eX. Ndokusaka chirwere ichi chichiwanzoitika muvakomana .
- Autosomal recessive CGD: Izvi zvinokonzerwa nekuchinja kwemajini mune mamwe majini (`CYBA`, `NCF1`, `NCF2`, `CYBC1` kana `NCF4`). Rudzi urwu runogona kukanganisa varume nevakadzi zvakaenzana.
Ndezvipi njodzi nematambudziko zvinogona kuitika nekuda kwechirwere ichi?
Munhu ane CGD ndiye ari panjodzi huru kana mumwe munhu mumhuri make aine chirwere ichi. Zvisinei, kashoma kuti pave nezviitiko zvechirwere ichi zvinongoerekana zvaitika, pasina nhoroondo yemhuri.
Kune matambudziko akawanda anogona kuitika nekuda kweCGD.
- Matambudziko ekugaya: Maronda nekuzvimba muura zvinogona kukanganisa kugaya chikafu.
- Zvirwere zvemudumbu: Semuenzaniso, kune njodzi yakakura yekubatwa nezvirwere zvakaita seInflammatory Bowel Disease (IBD), inova kuzvimba kwenguva refu kwemudumbu.
- Matambudziko ekukura: Kana vana vadiki nevacheche vaine chirwere ichi, kukura kwavo mumuviri kunogona kunonoka.
- Zvimwe zvirwere: Zvichienderana nerudzi rwechikanganiso chemajini chinokonzera CGD, vamwe vanhu vari panjodzi yekubatwa nechirwere chemwoyo, chirwere cheitsvo, chirwere cheshuga, kana zvimwe zvirwere zve autoimmune.
Unoziva sei kana uine CGD?
Chiremba wako achatanga abvunza iwe nemwana wako nezvezviratidzo zvenyu uye nhoroondo yezveutano hwemhuri yenyu. Zvadaro, vacharaira bvunzo dzinoverengeka kuti vasimbise chirwere chacho.
- Kuongororwa kwemuviri: Chiremba anoongorora muviri nokungwarira kuti aone kana paine kuzvimba, maronda, uye granulomas.
- Kuongororwa kweropa: Kune bvunzo yeropa yakakosha inogona kuona CGD nemazvo. Iyi inonzi bvunzo yeDHR (dihydrorhodamine test) . Iyi bvunzo inoyera kugona kwemasero machena eropa kuuraya utachiona.
- Kuongororwa kwemajini:Sample yeropa kana kuti tissue inotorwa kuti ione kana paine dambudziko remajini rinokonzera CGD. Izvi zvinogonawo kubatsira kuona rudzi chairwo rwechirwere.
Ndezvipi zvirongwa zvekurapa CGD?
Kunyange hazvo CGD isingarapike zvachose, pari zvino kune nzira dzakawanda dzakanaka dzekurapa dzinogona kubatsira kudzora zviratidzo, kudzivirira kubva kuzvirwere zvakakomba, uye kubatsira vanhu kurarama hupenyu hwakajairika.
Kurapa nemishonga
- Mishonga inorwisa mabhakitiriya: Varwere vazhinji vane CGD vachafanira kutora mishonga inorwisa mabhakitiriya kweupenyu hwavo hwese kudzivirira hutachiona hwemabhakitiriya uye kurapa hutachiona hunokura.
- Mishonga inorwisa fungus: Mishonga yakaita se `(itraconazole)` inoshandiswa kudzivirira nekurapa hutachiona hwefungus.
- Majekiseni eInterferon-gamma: Iyi ipuroteni yakagadzirwa nemasoja edu ekudzivirira chirwere. Jekiseni iri rinobatsira kuderedza kuwanda kwezvirwere.
Vamwe varwere, kunyanya avo vane zvirwere zvakakomba, vanogona kuisirwa stem cell . Izvi zvinosanganisira kubaya stem cells kubva kumunhu ane hutano mumuviri wemurwere, izvo zvinotsiva masero machena eropa asina kushanda zvakanaka nemasero ane hutano. Zvisinei, iyi ikurapa kwakaoma uye kune njodzi, saka vanachiremba vanokurudzira izvi zvichibva pazvinhu zvakawanda, zvakaita sezera remurwere nehutano hwake.
Chii chatinofanira kuita kuti tizvidzivirire kubva kuzvirwere?
Sekukosha kwakaita kurapa munhu ane CGD, kuzvidzivirira kubva kuzvirwere zvakanyanya sezvinobvira. Zvinhu zvidiki zvinogona kuita mutsauko mukuru.
- Chenjerera nemvura: Usashambire munzizi, mumakungwa, nemumadhamu zvachose. Izvi hazvina chlorine, saka utachiona hunokonzera utachiona hunogona kupinda mumuviri wako zviri nyore. Saka, kana ukashambira, shandisa dziva rine chlorine chete .
- Chengetedza bindu rako: Dzivisa kubata kana kutenderedza marara emubindu, mirwi yemanyowa, huswa, nemashizha akaoma. Humwe hwehuswa hunowanikwa mune izvi hunogona kukonzera pneumonia yakanyanya iyo inogona kuisa hupenyu panjodzi kana ikafemerwa nemurwere weCGD. Saka, unofanira kungwarira zvikuru nezveizvi.
Zvinhu zvekuziva nezvekurarama nechirwere ichi
Kunzwa nezvechirwere ichi kunogona kutyisa. Asi chokwadi ndechekuti, kana ukarapwa zvakanaka uye ukasangana nachiremba wako nguva dzose, vanhu vazhinji vane CGD vanogona kurarama hupenyu hwakajairika, hune simba, uye hunofadza. Chinhu chakakosha kuziva hutachiona uye kutanga kurapwa nekukurumidza, zvisati zvanyanya kuipa.
Kana iwe kana mwana wako muchirwara nezvirwere zvisingatsananguriki, kurumidza kuonana nachiremba wako motaura nezvazvo.
Kana mwana wako aine chirwere cheCGD, nzwisisa kuti haisi mhosva yako. Inyaya yemajini. Nekurapwa kwakakodzera, mwana wako ane mukana wekurarama hupenyu hurefu uye hunofadza. Chinhu chakakosha ndechekuziva nezvechirwere ichi uye kutevedzera mirairo yachiremba wako nokungwarira.
Mharidzo Yekuenda Nayo Kumba
- CGD chirwere chisingawanzoitiki chinokanganisa masoja emuviri, zvichideredza kugona kwawo kurwisa mamwe majekiseni.
- Chiratidzo chikuru chirwere chinodzokororwa chebhakitiriya nefungus.
- Chirwere ichi chinogona kuongororwa nemazvo kuburikidza nekuongororwa kweropa, kuongororwa kweDHR, uye kuongororwa kwemajini.
- Kurapwa kunoda mishonga yekudzivirira hutachiona yehupenyu hwese uye kurapwa nekukurumidza kwezvirwere zvinoitika.
- Kudzivirira matsime emvura asina chlorine uye marara emubindu kwakakosha zvikuru kudzivirira hutachiona.
- Kana varwere veCGD vakarapwa zvakanaka uye vakabatwa zvakanaka, vanogona kurarama hupenyu hurefu uye hune simba. Kana iwe kana mwana wako muchirwara nezvirwere kakawanda, ona chiremba wako nekukasika.
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