Ngatidzidzei nezvegomarara reDLBCL (Diffuse Large B-Cell Lymphoma) nenzira iri nyore.

Wakambonzwa nezvechirwere chinonzi `Diffuse Large B-Cell Lymphoma` kana kuti `DLBCL` here? Iyi imhando yegomarara rinopararira nekukurumidza. Asi usazvidya moyo, kana rikaonekwa nekukurumidza uye rikarapwa nemazvo , rinogona kurapwa . Nhasi, ngatitaurei nezve `DLBCL` iyi nemashoko akareruka.

Chii chinonzi DLBCL?

DLBCL igomarara reropa. Muchirwere ichi, rudzi rwemasero machena eropa anonzi B cells (anonziwo lymphocytes) mumuviri wedu anova gomarara. Iyi ndiyo mhando yelymphoma inonyanya kukura, inokura nekukurumidza, uye ine hukasha inonzi non-Hodgkin lymphoma. Sisitimu yedu yelymphatic inorwisa utachiona. Kana DLBCL ikakura, masero aya eB anova gomarara uye anokura nekukurumidza, achivhara masero ane hutano. Ipapo haakwanise kurwisa utachiona. Masero aya egomarara anogona kuumbwa chero kupi, kusanganisira lymph nodes, nzira yekugaya, uye uropi. Kunyangwe iri hombe, inogona kurapwa kana ikaonekwa nekukurumidza.

Ndeapi marudzi eDLBCL?

Sangano reWorld Health Organization (WHO) rakaona mhando dzakasiyana dzeDLBCL. Vanachiremba vanoshandisa mhando imwe neimwe kuona kuti kenza inofambira mberi sei uye kuti inopindura sei kana yarapwa. Kurongwa uku kunonyanya kukanganiswa ne:

• Kuchinja kwemajini mumasero.
• Nzvimbo mumuviri panotanga DLBCL (semuenzaniso, central nervous system - `CNS`).
• Kubatana nehutachiona (semuenzaniso Epstein-Barr virus - EBV).

Zvakakosha kubvunza chiremba wako nezverudzi rweDLBCL yaunayo.

Izvi zvakajairika zvakadii?

DLBCL ndiyo mhando inonyanya kuwanikwa ye lymphoma. Zvisinei, DLBCL haina kunyanya kuwanikwa pakati pemagomarara. Semuenzaniso, DLBCL inowanikwa muvanhu vanosvika 6 pavanhu 100,000. Izvi hazviwanzoitiki kana tichienzanisa nedzimwe kenza.

Ndezvipi zviratidzo zveDLBCL?

Chiratidzo chinowanzoonekwa cheDLBCL kuzvimba kwema lymph nodes mumutsipa, muhapwa, kana muzvidya . Izvi zvinogona kutanga sebundu, zvishoma nezvishoma zvichikura, uye zvingasarwadza.

Vamwe vanhu (anenge mumwe chete pavatatu) vanogonawo kusangana nezviratidzo zvakasiyana zvinonzi "zviratidzo zveB" :

• Fivha (inopfuura 39.5 Celsius) inogara kwemazuva anopfuura maviri kana kuti inouya yoenda.
• Kuderedza huremu hwemuviri hunopfuura 10% mumwedzi mitanhatu pasina chikonzero.
• Kudikitira zvakanyanya husiku, zvekuti machira emubhedha anonyorova.

Usatya kufunga kuti iDLBCL kunyangwe uine zviratidzo izvi. Zvisinei, kana zvikaramba zviripo kwemavhiki akati wandei, enda kuna chiremba.

Sei DLBCL ichikura? Ndezvipi zvinhu zvinokonzera njodzi?

DLBCL inokonzerwa nekuchinja kwemajini mumasero eB. Aya ndiwo magene anowanikwa muhupenyu hwese . Chikonzero chaicho hachizivikanwe, asi zvinhu zvinoverengeka zvakaonekwa zvinowedzera njodzi:

• Zera:Inonyanya kuwanikwa muvanhu vane makore ari pakati pe60 ne60. Avhareji yezera rekuongororwa chirwere ichi imakore angangoita makumi matanhatu nemana.
• Murume kana Mukadzi: Varume vanogona kukura nechirwere ichi zvishoma kupfuura vakadzi.
• Nhoroondo yemhuri: Kana hama yako yepakutanga (mubereki, mukoma kana munun'una, mwana) ine DLBCL, ungangove nenjodzi yakawedzera yekubatwa nayo (chikonzero hachisati chajeka).
• Utachiona: Mavhairasi akadai seEpstein-Barr virus (EBV), human immunodeficiency virus (HIV), uye hepatitis B naC.
• Kusasimba kwemuviri: Kuva ne "primary immunodeficiency" kana "autoimmune disorder", kana kutora "immunosuppressants" mushure mekuisirwa nhengo. Ichi chinhu chikuru chine njodzi.
• Higher body mass index (BMI) pazera diki uye kusangana nezvimwe zvinhu zvine chepfu zvinoshandiswa mukurima.

Kunyangwe zvinhu izvi zviripo, havasi vese vanozvigadzira, kana kuti vanogona kuzvigadzira. Asi zvakakosha kuziva izvi.

DLBCL inoonekwa sei? (Kuongororwa)

Vanachiremba vanosimbisa DLBCL kuburikidza ne lymph node biopsy (kutora chidimbu chidiki che lymph node yakazvimba kuti chiongororwe) uye kuongororwa kwemajini. Kana DLBCL ikasimbiswa, mimwe miedzo inoitirwa kuona kana kenza yapararira:

• Kuongororwa kweropa: Kuverengwa kweropa kwakazara (CBC), kuti utarise mavhairasi akadai seHIV, EBV, uye hepatitis.
• Kuongororwa kweLactate dehydrogenase (LDH): Iyi enzyme inowanikwa zvakanyanya muvarwere vazhinji veDLBCL.
• Miedzo yekufungidzira: CT scan, MRI scan, PET scan.
• `Kuongororwa kwemapfupa emubofu` .
• Kuboorwa kwemusana (kuongororwa kwemvura yemusana).

Vanachiremba vanoita sarudzo nezvechirwere chako uye vanoronga kurapwa zvichibva paruzivo rwakawanikwa kubva muongororo imwe neimwe iyi.

Matanho eDLBCL ndeapi?

Nzira dzekuongorora kenza dzinoshandiswa kuona kuti kenza yakura uye yapararira kusvika papi. Izvi zvinobatsira kuronga kurapwa uye kufanotaura mafambiro echirwere. Matanho eDLBCL ndeaya:

• Danho rekutanga: Gomarara iri muchikamu chimwe chete chelymph node, chikamu chimwe chete mu lymphatic system, kana chikamu chimwe chete chechikamu chimwe chete chiri kunze kwe lymphatic system.
• Danho rechipiri: Lymphoma inowanikwa mumapoka akasiyana-siyana ema lymph nodes ari kurutivi rumwe chete rwe diaphragm.
• Danho rechitatu: Gomarara rinowanikwa muma lymph nodes kumativi ese e diaphragm.
• Danho rechina:Kenza yeDLBCL yakapararira kunhengo dziri kunze kwe lymphatic system (semuenzaniso mumongo wemapfupa, chiropa, mapapu).

Vanachiremba vanoti matanho ekutanga neapashure pekutanga (I) uye matanho echitatu neapashure pechina (III) vanoti matanho epamusoro-soro (Advanced Stages).

Ndeapi marapirwo eDLBCL?

Mushonga unonyanya kushandiswa weDLBCL iR-CHOP . Izvi zvinosanganisira musanganiswa we monoclonal antibody inonzi rituximab, mhando dzakasiyana dze chemotherapy, uye corticosteroid. Kunyangwe kurapa uku kukabudirira, chirwere chinogona kudzoka (inenge 30%-40%). Kana izvi zvikaitika, chiremba wako anogona kukurudzira mamwe marapirwo:

• Kurapa kwechipiri uye `kuisirwa kwemasero emuviri anongoerekana afa`.
• `Kurapwa nemasero eCAR T`: Uku `kurapwa nemuviri`.
• `Kurapa kwakanangana`: Kurapa kunonangana nekuchinja kwemajini.

Yeuka kuti chiremba wako ndiye achasarudza mushonga wakanakira iwe zvichienderana nemamiriro ako chaiwo ehutano.

Kugadzirwa kweDLBCL kunogona kudzivirirwa here?

Hapana nzira yekudzivirira DLBCL zvachose. Pane zvinhu zvine njodzi zvatisingakwanise kudzora. Zvisinei, kune matanho atinogona kutora kuti tizvidzivirire kubva kuhutachiona hunogona kusanganiswa neDLBCL, senge hepatitis neHIV. Zvakanakawo kuedza kuchengetedza index yemuviri ine hutano (BMI). Izvi zvinogona kubatsira kuderedza njodzi yako kusvika pamwero wakati.

Chii chingatarisirwa nemunhu ane DLBCL?

Mamwe marudzi eDLBCL anogona kutyisidzira hupenyu uye kuoma kurapa. Zvisinei, vanachiremba vanowanzo rapa nekurapa chirwere ichi . Muzviitiko zvakawanda, kurapwa kwekutanga kunogona kuita kuti DLBCL iderere zvachose (mamiriro asina zviratidzo zvekenza). Vanhu vanosvika 60% vane DLBCL vanorapwa nekurapwa kwekutanga. Paavhareji, vanhu vasina kenza makore maviri mushure mekuonekwa vaine chirwere vanogona kutarisira kurarama hupenyu hwakajairika, hwakafanana nevamwe vanhu vezera ravo. Mwero wekurarama wakakwira zvakanyanya kana kenza ikaonekwa ichiri kutanga .

Zvisinei, ruzivo rwako ruchaenderana nezvinhu zvakawanda, kusanganisira rudzi rweDLBCL yaunayo, danho rekenza, uye hutano hwako hwese. Chiremba wako chete ndiye anogona kukupa ruzivo rwakanakisisa nezveizvi.

Ndinozvitarisira sei? (Kuzvitarisira)

Kurarama negomarara hakusi nyore, kunonetesa zvikuru. Zvakakosha kuzvitarisira paunenge uchirapwa `DLBCL`.

• Kudya Zvinovaka Muviri: Idya chikafu chakanaka uye chakaringana. Bvunza chiremba wako zvekudya uye zvekurega.
• Zororo:Kurapwa kunogona kukonzera kuneta. Zorora zvakakwana.
• Kurovedza muviri: Kurovedza muviri kushoma kunogona kuderedza kushushikana.
• Rutsigiro: Ichi chirwere chisingawanzoitiki, saka chinogona kunzwa kusurukirwa. Joyina mapoka ekutsigirana kune vanhu vakaita sewe. Taura nemhuri neshamwari.

Kuda kuona chiremba uye emergency

Uchaona chiremba wako nguva nenguva panguva yekurapwa. Kunyangwe kana kurapwa kwapera, uchafanirwa kumuona mwedzi mitatu kusvika mina yega yega kwemakore maviri ekutanga uye kashoma mumakore matatu anotevera. Izvi ndezvekutarisa kana chirwere chacho chadzoka zvakare. Kana uine zviratidzo zvekuti kenza yadzoka, taurira chiremba wako nekukasika.

Kurapa kwakadai se chemotherapy kunogona kuva nemigumisiro yakaipa. Kana zvinhu izvi zvikaitika , enda kuchipatara nekukurumidza :

• Migumisiro yakaipa kupfuura zvaitarisirwa.
• Fivha inodarika 38 Celsius (100.4 Fahrenheit).
• Kuzununguka kusingamisiki .
• Kurwadziwa kwakanyanya mudumbu kana manyoka asingaperi .

Mibvunzo yekubvunza chiremba wako nezveDLBCL

Zvakajairika kuva nemibvunzo yakawanda kana ukaona kuti une DLBCL. Zvakakosha kuti ubvunze chiremba wako mibvunzo yakaita seiyi:

• Rudzii rwe `Diffuse Large B-Cell Lymphoma` yandinarwo? Chii chinonzi `stage`?
• Ndeapi marudzi ekurapwa andinofanira kuwana? Ndezvipi zvimwe zvinokonzera?
• Mishonga iyi icharapa kenza zvachose here?
• Ndeapi marapirwo aripo kana kenza ikadzoka?
• Munganditumirewo kuboka rekutsigira vanhu vane kenza yerudzi urwu here?

Pamusoro pemibvunzo iyi, usatya kubvunza chiremba wako chero chauri kufunga nezvacho kana chero kusava nechokwadi kwaungave nako.

Pakupedzisira, yeuka (Mharidzo Yekuenda Kumba)

Vazhinji vedu patinonzwa izwi rekuti "hasha" patinenge tichitaura nezvegomarara, tinoriona sechirwere chisingarapiki uye chakaoma kurapa. Asi handizvo zvinoitika neDiffuse Large B-Cell Lymphoma (DLBCL). Kunyangwe DLBCL ichigona kupararira nekukurumidza, kurapwa kwegomarara kuripo pari zvino kunogona kuuraya masero aya egomarara. Vanachiremba vanotoshandisa mazwi akadai sekuti "kurapa" pavanenge vachitaura nezvezvirwere zvevamwe vanhu.

Chinhu chinonyanya kukosha kubvunza chiremba wako kuti kuongororwa kwako kuchakanganisa sei maonero ako ekurapwa. Saka, usatya, ziviswa, uye tevera zano rachiremba wako. Usakanganwa kuti DLBCL inogona kukundwa nekuonekwa nekukurumidza uye kurapwa kwakakodzera!

Kenza , lymphoma, B cells, lymph nodes, zviratidzo, kurapwa, DLBCL, chemotherapy, immunotherapy