Njodzi yekenza yemuura mukuru (HNPCC) - ngatitaurei nezvazvo

Wakambonzwa here kuti nhengo dzinoverengeka dzemhuri yako dzakabatwa nekenza yemudumbu, kunyanya vasati vasvitsa makore makumi mashanu? Kana kuti pane kuwanda kwekenza yemudumbu pakati pevakadzi mumhuri yako here? Zvakajairika kunzwa kutya uye kunetseka patinonzwa zvinhu zvakadai. Asi zvakakosha kupfuura kutya kuziva izvi. Nhasi tichataura nezvechirwere chegomarara chinogona kupfuudzwa kubva kuchizvarwa kuenda kune chimwe. Tinochidana kuti HNPCC.

Chii chaizvo chinonzi HNPCC?

Zvichitaurwa zviri nyore, HNPCC ipfupiso yeHereditary Nonpolyposis Colorectal Cancer . MuchiSinhala, zvinoreva chimwe chinhu chakaita sekuti "Hereditary Nonpolyposis Colorectal Cancer." Asi mazwi iwayo akaomarara, handiti? Saka ngatingoirangarira seHNPCC.

Iyi injodzi yegomarara inogona kugara nhaka kubva kuchizvarwa kuenda kune chimwe nekuda kwekuchinja kwakasiyana (kuchinja) mumajini edu. Izvi zvinonyanya kukanganisa ura hukuru, hunova chikamu chekupedzisira chegomarara rako. Asi zita rekuti "Nonpolyposis" rinoreva "non-polyposis". Chikonzero cheizvi ndechekuti, kazhinji, matumbu madiki anonzi "polyps" anoumbwa mugomarara remudumbu risati ratanga. Zvisinei, munhu ane HNPCC haakure nenhamba yakawanda yemapolyps akadaro, asi ane njodzi yakakura yegomarara.

Saka Lynch syndrome zvakare iHNPCC here?

Ehe, mazita maviri aya anowanzo shandiswa pachirwere chimwe chete. Asi pane musiyano mudiki wehunyanzvi. Lynch syndrome ndiyo mamiriro ejini anokonzera. Kureva kuti, kana munhu aine gene mutation ine chekuita neLynch syndrome, ane mukana wakakura wekuva nechirwere chegomarara chinonzi HNPCC.

Kazhinji, kana munhu ari pasi pemakore makumi mashanu akabatwa nekenza ine chekuita neLynch syndrome, yakadai sekenza yemuura, kenza ye endometrial, kenza yemuura mudiki, kana kenza yemuura, mhuri iyi inonzi ine chirwere chinonzi HNPCC. Magomarara aya anowanzo wanikwa kurudyi rwematumbu makuru.

Chirwere ichi chakajairika zvakadii? Zviratidzo zvacho ndezvipi?

HNPCC inoumba 2% kusvika 4% yegomarara remudumbu pasi rose. Izvi zvinoreva kuti gomarara remudumbu rinosvika 2 kusvika 4 pa100 rinokonzerwa nechirwere ichi. Kunyangwe ichigona kukanganisa chero munhu, chinowanzoonekwa muvanhu vari pasi pemakore makumi mashanu.

Pakutanga, HNPCC haiwanzo kukonzera zviratidzo. Ndiyo inonyanya kutyisa. Asi kenza painokura, unogona kutanga kuona zviratidzo zvakaita seizvi.

Sei HNPCC ichikura? Inotapukira here?

Chikonzero chikuru cheizvi majini edu. Fungidzira kuti muviri wedu wakaita sebhuku guru, uye majini ndiwo mirairo yakanyorwa mubhuku iroro. Sero rega rega mumuviri wedu rinoshanda zvichienderana nemirairo iyi. Dzimwe nguva, pane zvikanganiso zvemapereti (mutations) mumirairo iyi.

Miviri yedu inowanzova nemajini akakosha anogona kuona nekugadzirisa zvikanganiso izvi. Semunhu ari kuverenga bhuku. MuLynch syndrome, aya ndiwo MLH1, MSH2, MSH6, PMS2, uye EPCAM.Kana majini aya anonzi "ekugadzirisa" akanganisa, haakwanise kugadzirisa zvimwe zvikanganiso kana masero akapatsanuka. Nekufamba kwenguva, masero aya ane dambudziko anowanzo ungana ova masero ekenza.

Ichi hachisi chirwere chinotapuriranwa. Haugoni kuchibata nekudya chikafu kana kuva nemunhu ane HNPCC. Zvisinei, kushanduka kwemajini kunokonzera chirwere ichi kunogona kupfuudzwa kubva kuchizvarwa kuenda kune chimwe. Fungidzira kuti amai kana baba vane kushanduka kwemajini uku. Ipapo pane mukana we50% wekuti mumwe wevana vavo achagara nhaka jini iroro. Izvi zvinoreva kuti kana paine vana vaviri, mumwe wavo anogona kugara nhaka jini iri rine njodzi. Ndosaka vanhu vakati wandei mumhuri dzakadaro vachirwara negomarara.

Chiremba anoongorora sei HNPCC?

Kana ukaenda kunoona chiremba ane zviratidzo zvawataura pamusoro apa, chinhu chekutanga chaachaita kunyatsoteerera zviratidzo zvako uye kuongorora muviri. Zvadaro, vachakubvunza mibvunzo yakawanda nezvenhoroondo yehutano hwemhuri yako.

• "Amai vako, baba vako, vanun'una vako vakamborwara nekenza here?"
• "Kana zvakadaro, kenza yerudzii? Yakatanga pazera ripi?"
• "Vanhu vangani mumhuri yako vakamborwara nekenza?"

Mibvunzo iyi inokosha zvikuru nekuti kana nhengo dzemhuri dzakawanda dzakambova nekenza yemuura kana yechibereko, kunyanya pazera diki, chiremba anogona kufungira HNPCC.

Tevere, bvunzo huru yekusimbisa kana une kenza yemuura ndeye colonoscopy . Izvi zvinosanganisira kuongorora ura hwako hwese uchishandisa chubhu ine kamera diki yakabatanidzwa. Kana paine chinhu chinofungirwa, chidimbu chidiki chenyama chinotorwa choendeswa kurabhoritari kuti chiongororwe (biopsy).

Kuti usimbise mamiriro eHNPCC, bvunzo dzinoverengeka dzakakosha dzinodiwa:

1. Kuongororwa Kwemajini: Muenzaniso weropa rako unotorwa woongororwa kuti uone kana paine shanduko dzemajini dzakabatana neLynch syndrome.

2. Kuongororwa kwenyama yegomarara: Kana paine kenza, masero egomarara anoongororwa zviratidzo zvine chekuita neHNPCC.

3. Kubvisa zvimwe zvirwere: Kune imwezve chirwere chenhaka chinonzi Familyal Adenomatous Polyposis (FAP) . MuFAP, mazana kana zviuru zvemapolyps anokura muura. Izvi hazviitike muHNPCC. Saka, chiremba wako achatarisa kuti aone kuti ndechipi chezvirwere zviviri izvi chaunacho.

Ndeapi marapirwo eHNPCC?

Kana kenza yemuura ikabuda nekuda kweHNPCC, mushonga mukuru ndewokuvhiya kubvisa kenza nenyama dzakapoteredza. Kuvhiya uku kunonzi colectomy . Kunogona kuitwa nenzira dzakasiyana.

• Kubviswa kwechikamu chedumbu (Partial Colectomy): Chikamu chedumbu riri mudumbu ndicho chinobviswa chete.
• Kuvhiyiwa kweColon:Dumbu rese rinobviswa. Kuvhiyiwa uku kunowanzo kurudzirwa kune munhu ane HNPCC kuderedza njodzi yekuve nekenza mune ramangwana.
• Kubviswa kwechibereko: Dumbu rinobviswa pamwe chete neura hukuru.

Mamwe marapirwo

Kana kenza yapararira (yapararira) kune dzimwe nhengo dzemuviri, mamwe marapirwo angangodiwa kuwedzera pakuvhiyiwa.

• Kurapa nemakemikari: Kupa mishonga ine simba yekuparadza masero ekenza.
• Kurapa Nezvirwere Zvinodzivirira Muviri: Kukurudzira masoja emuviri wedu kurwisa masero egomarara. Kurapa uku kunowanzo budirira pagomarara rinokonzerwa neHNPCC.

Zvinhu zvinofanira kuzivikanwa nemunhu anogara neHNPCC

Kana ukaonekwa uine HNPCC, zvinoreva kuti uri panjodzi huru yekubatwa nekenza yemudumbu kwete chete, asiwo nedzimwe mhando dzakasiyana dzekenza kupfuura munhuwo zvake. Saka, kugara uchiongororwa nachiremba kunofanira kuva chikamu chehupenyu hwako.

Chiremba wako anogona kukukurudzira kuti ugare uchiongororwa magomarara aya:

• Chizvaro
• Ovarian
• Dumbu
• Itsvo uye weti system
• Uropi
• Ganda

Izvi zvinganzwika sekutyisa. Asi chinhu chakanakisa pano ndechekuonekwa nekukurumidza . Nekuongororwa nguva dzose, kunyangwe kenza ikatanga kukura, inogona kubatwa pachidanho chekutanga. Ipapo mikana yekurapwa nekupora zvachose yakakwira zvikuru.

Lynch syndrome haigone kurapwa, sezvo iri chinhu chiri mumajini edu. Zvisinei, kenza inokonzerwa neHNPCC inogona kurapwa. Kuvhiyiwa kwakadai sekuvhiyiwa kwecolectomy kunogonawo kudzivirira kenza yemuura.

Ndingagadzirisa sei njodzi yangu?

Kana uine nhoroondo yemhuri yeHNPCC kana Lynch syndrome, chinhu chekutanga chaunofanira kuita kutaura nachiremba wako nezvazvo. Iye ndiye achasarudza kana uchida kuongororwa majini.

Kana zvikaonekwa kuti une chirwere cheLynch syndrome gene mutation, chiremba wako angangokurayira kuti utange kuongororwa kenza yemuura, yakadai secolonoscopy, mumakore ako ekuma20.

Pamusoro pezvo, unogona kuderedza njodzi yako yekubatwa negomarara nekugara uine mararamiro ane hutano:

• Dzivisa kusvuta zvachose.
• Idya chikafu chine hutano uye chakaringana (sanganisira miriwo yakawanda, michero, uye chikafu chine fiber yakawanda).
• Rovedza muviri nguva dzose.
• Deredza kunwa doro.
• Ramba uine huremu hwakanaka hwemuviri.
• Wana bvunzo dzese dzakakurudzirwa nachiremba nenguva.