Chii chinonzi Kushaikwa kweG6PD? Ngatidzidzei tisingatyi!

Wakambonzwa nezvekushaya G6PD here? Pamwe zita racho risinganzwisisike. Asi chaizvoizvo chirwere chemajini chinokonzerwa nevanhu vazhinji pasi rose, asi kazhinji hachikonzeri matambudziko makuru. Saka, nhasi tichataura nezvekuti kushomeka kweG6PD uku chii, nei kuchiitika, uye zvatinofanira kuziva. Hapana chikonzero chekutya, ngatitsanangurei zvese zviri nyore.

Chii chaizvo chinonzi G6PD Deficiency?

Zvichitaurwa zviri nyore, kushomeka kweG6PD chirwere chemajini umo muviri wako une huwandu hwakaderera hweG6PD. Zvakanaka, ikozvino uri kubvunza kuti G6PD chii. G6PD (Glucose-6-Phosphate Dehydrogenase) ienzyme inokosha kwazvo mumuviri wedu. Basa guru reenzyme iyi nderekudzivirira masero edu matsvuku eropa kubva mukukuvadzwa kwakasiyana-siyana.

Kushaikwa uku kunoitika kana munhu akazvarwa aine shanduko, kana kuti mutation, mujini rinogadzira enzyme yeG6PD. Nekuda kweizvozvo, masero matsvuku eropa haagadzire enzyme yeG6PD yakakwana.

Asi hechino chinhu. Vanhu vazhinji vane kushomeka kweG6PD havana zviratidzo . Vanorarama hupenyu hwakajairika. Zvisinei, dzimwe nguva, matambudziko anogona kukonzerwa nezvinhu zvakaita semishonga, hutachiona, kana zvimwe zvekudya (tichataura nezvazvo gare gare). Muzviitiko zvakadaro, chirwere chinonzi hemolytic anemia chinogona kukura. Izvi zvinoreva kuti masero matsvuku eropa anoputsika nekukurumidza uye anoparadzwa. Dzimwe nguva, vacheche vachangoberekwa vanogona kuva nejaundice yakanyanya nekuda kwekushomeka kweG6PD.

Kushomeka kweG6PD chirwere chinowanzoitika kupfuura zvaungafunga. Zvinofungidzirwa kuti vanhu vari pakati pe400 ne500 miriyoni pasi rose vane chirwere ichi. Saka kana uine chirwere ichi, chiremba wako anogona kukubatsira kuchengetedza masero matsvuku eropa rako ari padanho rakachengeteka.

Ndezvipi zviratidzo zvekushomeka kweG6PD?

Sezvatakambotaura, vanhu vazhinji vane dambudziko reG6PD havawanzova nezviratidzo. Zvisinei, zviratidzo zvinongoonekwa chete kana chimwe chinhu chinokonzera masero matsvuku eropa chichikonzera kuti aputsike (hemolysis). Kana izvozvo zvikaitika, zvinhu zvakaita seizvi zvinogona kuitika:

• Kunzwa kuneta zvakanyanya
• Kurova kwemoyo nekukurumidza ( tachycardia )
• Kutadza kufema zvakanaka ( Dyspnea )
• Kutsvuka kweganda kana kuchena kwemaziso (izvi zviratidzo zvejaundice )
• Ganda rakachenuruka (miromo nerurimi zvinogona kutochenuruka)
• Weti yero yakasviba, yeorenji, kana kuti yakaita setii
• Chirwatata chakakura

Kana zviratidzo izvi zvikaitika kamwe kamwe uye zvakanyanya, zvinonzi dambudziko rehemolytic . Kana ukasangana neizvi , zvakakosha kutsvaga rubatsiro rwechiremba nekukasika.

Zviratidzo zvekushaya G6PD muvana vachangoberekwa

Vana vacheche havawanzo kuva nezviratidzo zvinooneka zvekushaikwa kweG6PD. Chiratidzo chinowanzoitika ijaundice . Izvi zvinowanzoonekwa mukati memazuva mashoma ekuzvarwa. Kana ikasarapwa zvakanaka, jaundice yakanyanya inogona kukonzera kukuvara kweuropi mumwana. Izvi zvinonzi kernicterus . Ndosaka vanachiremba vachiongorora vacheche vacheche kuti vaone kana vaine G6PD deficiency kana vachifungidzira kuti ndizvo.

Chii chinokonzera kushomeka kweG6PD?

Kushaikwa kweG6PD kunokonzerwa nekusiyana (variant) kwejini rako reG6PD. Kusiyana uku kunotadzisa muviri wako kugadzira enzyme yeG6PD nemazvo. Unogara nhaka iyi genetic variation kubva kuvabereki vako, kuburikidza neX chromosome .

Kuva nekuchinja kwemajini uku zvinoreva kuti masero matsvuku eropa rako ane huwandu hwakaderera hweG6PD. Iyo enzyme yeG6PD inokosha zvikuru nekuti inodzivirira masero matsvuku eropa kuti asaunganidze "free radicals " dzakawanda. Mafree radicals kazhinji zvinhu zvisina njodzi. Anowanikwa munharaunda, mune zvimwe zvekudya (semuenzaniso fava beans), uye mumishonga.

Zvisinei, kana usina G6PD yakakwana, zvimwe zvinokonzera (semuenzaniso kudya fava beans) zvinogona kukonzera kuti ma free radicals akawanda aungane mumasero ako. Izvi zvinokonzera chirwere chinonzi oxidative stress , chinoisa stress pamasero matsvuku eropa. Pakupedzisira, masero aya anoputsika uye anoparadzwa. Izvi zvinoderedza huwandu hwemasero matsvuku eropa, zvichikonzera hemolytic anemia .

Ndezvipi zvinokonzera anemia ye hemolysis inokonzerwa nechirwere ichi?

Sekureva kwevamwe vaongorori, kudya bhinzi dzefava ndicho chinhu chinonyanya kukonzera chirwere ichi . Kana munhu ane dambudziko rekushaya G6PD akaonekwa aine anemia mushure mekudya bhinzi dzefava, zvinonzi favism . Zvimwe zvinokonzera chirwere ichi ndeizvi:

• Utachiona: Utachiona hwakadai seHepatitis A neHepatitis B , Typhoid Fever , uye Pneumonia .
• Mimwe mishonga inoshandiswa pakurapa marariya: Semuenzaniso , Primaquine .
• Mimwe mishonga inorwisa mabhakitiriya : yakaita senitrofurantoin , dapsone, uye sulfa drugs .
• NSAIDs (mishonga inouraya marwadzo): Seaspirin neibuprofen .
• Kusvuta uye kunwa doro zvakanyanya.
• Kushushikana kwepfungwa kwakanyanya.
• Kurovedza muviri zvakanyanya.

Ndezvipi zvinhu zvinokonzera njodzi?

Kune zvinhu zvakawanda zvinowedzera njodzi yekuzvarwa nayo nekushaya G6PD:

• Murume kana Mukadzi:Varume vane mukana mukuru wekushaya G6PD. Izvi zvinodaro nekuti varume vane X chromosome imwe chete ine genetic mutation iyi. (Sezvo vakadzi vaine X chromosome mbiri, pane dzimwe nguva apo dambudziko nerimwe rinogona kugadziriswa nerimwe.)
• Nzvimbo: Dambudziko iri rinowanzoitika kuvanhu vanogara muAfrica iri pasi peSahara, dunhu reMediterranean, uye kuSoutheast Asia.
• Rudzi: Vaongorori vanofungidzira kuti varume vanopfuura 10% vanobva kuAfrica muUnited States vane dambudziko rekushaya G6PD.

Kushomeka kweG6PD kunoonekwa sei?

Vanachiremba vanowanzotanga nekubvunza nezvenhoroondo yako yese yehutano uye voita bvunzo yemuviri. Vanogonawo kubvunza kana wakachinja mishonga yako munguva pfupi yapfuura kana kuti wava nehutachiona. Vachatarisawo kana paine munhu mumhuri mako ane chirwere cheG6PD.

Miedzo yekuongorora kushomeka kweG6PD ndeiyi:

• Kuverengwa Kweropa Kwakakwana (CBC): Kunoongorora huwandu hwemasero matsvuku eropa rako.
• Kusveta ropa muropa: Kunoongorora zviratidzo zveanemia muropa, kureva kuti, masero matsvuku eropa asina chimiro chisina kujairika kana kuti saizi.
• Kuongororwa kweBilirubin: Tarisa huwandu hwebilirubin, tsvina inoumbwa nemasero matsvuku eropa akaputsika.
• Kuongororwa kweG6PD: Tarisa huwandu hweenzyme yako yeG6PD.

Kushomeka kweG6PD kunorapwa sei?

Vanachiremba vanorapa chirwere ichi zvichienderana nechirwere chacho. Semuenzaniso, kana uine jaundice isina kunyanya kuoma uye uchiziva kuti une G6PD deficiency, vanotanga varapa zviratidzo zvejaundice. Zvadaro, vanozokuudza zvinokonzera zvaunofanira kudzivirira.

Zvisinei, kana zviratidzo zvacho zvakanyanya, kurapwa kwacho kwakasiyana. Kana uine chirwere chehemolytic anemia chakanyanya, ungangoda kuwedzerwa ropa .

Kana mwana wako achangoberekwa aine jaundice, chiremba wako anogona kumurapa ne phototherapy (kurapa uchishandisa chiedza chechisikigo kana chekugadzira). Muzviitiko zvakakomba, mwana wako angangoda kuwedzerwa ropa remwana . Izvi zvinosanganisira kubvisa ropa risina kunaka remwana woritsiva neropa rine hutano, rakapihwa.

Kushomeka kweG6PD kunogona kudzivirirwa here?

Sezvo ichi chiri chirwere chemajini, hazvigoneke kudzivirira kuti chisaitike. Zvisinei, kune nzira dzekuchiziva chisati chakonzera matambudziko makuru ehutano. Izvi zvinosanganisira:

• Kuongororwa kwevana vachangoberekwa: Munyika dzakawanda umo chirwere ichi chakajairika, kune zvirongwa zvekuongorora kuti vaone kushomeka kweG6PD muvana vachangoberekwa.
• Kuongororwa kwemajini: Kana mumwe munhu mumhuri yako aine dambudziko reG6PD, ungangodawo kuongororwa kweDNA.Chiremba wako anogona kukukurudzira kuti uite izvozvo.

Chii chandingatarisira kana ndine chirwere ichi?

Hapana mushonga wekusingaperi wekushaya G6PD. Zvisinei, vanhu vazhinji vanogona kurarama vasina matambudziko kana vakadzivisa zvinovakonzera. Uye hazvikanganisi hupenyu hwavo.

Zvisinei, chirwere ichi hachibate munhu wese zvakafanana. Vanhu vazhinji vane G6PD deficiency vangasatomboziva kuti vanayo nekuti havana zviratidzo. Vanhu vazhinji vane zviratidzo zvacho havanyanyi kurwara. Zvisinei, kune vamwe, kana vakasangana nechinhu chinokonzera chirwere ichi, vanogona kuva nedambudziko rehemolytic, iro rinogona kuisa hupenyu hwavo panjodzi.

Chiremba wako anogona kutsanangura zvakanakisisa zvaunogona kutarisira zvichibva pane zvawakaona.

Ndingazvitarisira sei?

Bvunza chiremba wako kuti ndezvipi zvekudya nemishonga zvaunofanira kurega. Heano mamwe mazano:

• Deredza kunwa doro: Kunwa doro rakawandisa kunogona kukonzera kumanikidzwa kwemasero matsvuku eropa.
• Dzivisa kusvuta: Kusvuta kunogona kukonzera kuti mafree radicals aungane mumasero matsvuku eropa.
• Kurovedza muviri zvine mwero: Kurovedza muviri zvakanyanya kunogona kuwedzera kushushikana kwe oxidative.
• Edza kuzorora zvakakwana: Kurara kunosimbisa masoja emuviri wako, izvo zvinobatsira kurwisa hutachiona hunogona kukonzera anemia mukuwedzerwa ropa.
• Dzora kushushikana: Kana uri kunzwa kushushikana kwakanyanya, kumbira chiremba wako kuti akubatsire kudzora kushushikana kwako.

Zvakakosha: Kana mwana wako achangoberekwa aine dambudziko reG6PD, unofanira kudzivisa kudya fava beans paunenge uchiyamwisa . Mishonga inogona kukonzera anemia inokuvadza inogona kupfuudzwa kumwana kuburikidza nemukaka wemuzamu.

Ndinofanira kuona chiremba wangu rini?

Ona chiremba wako chero nguva kana ukaona zviratidzo zvekushaikwa kweG6PD. Kana zviratidzo zvacho zvakanyanya uye zvikakurumidza kukura (zviratidzo zvedambudziko rekubuda ropa), tsvaga rubatsiro rwechiremba nekukasika .

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Heano mimwe mibvunzo yekubvunza kana uine dambudziko reG6PD:

• Dambudziko rangu rakakomba zvakadii?
• Ndezvipi zvekudya nemishonga zvandinofanira kudzivisa?
• Pane zvinhu zvinokonzera zvakatipoteredza zvandinofanira kudzivisa here?
• Mikana ipi yekuti mwana wangu achagara nhaka yekushaya G6PD?

Pakupedzisira, zvekurangarira (Mharidzo Yekuenda Kumba)

Kuonekwa kwekushomeka kweG6PD kunogona kukanganisa munhu wese zvakasiyana. Kunyange hazvo kusingarapike, kazhinji chirwere chinorapika. Chinokosha ndechekuona nekudzivirira zvinhu zvinokonzera njodzi yekuve neanemia inouraya.Izvi zvingareva kudzivisa fava beans nezvimwe zvinokonzera chirwere ichi. Zvakakoshawo kuti uzviite tsika dzine hutano, dzakadai sekuzorora zvakakwana uye kusasvuta. Bvunza chiremba wako kuti akubatsire kugadzirisa kuti kushomeka kweG6PD kunokanganisa sei hupenyu hwako. Usavhunduke, kuziva ndiyo nzira yakanakisisa yekudzivirira!

Kushaikwa kweG6PD , kupererwa neropa, jaundice, zvirwere zvemajini, masero matsvuku eropa, fava beans, ma enzymes