Uri kunetseka here nekukura kwemwana wako? Izvi zvinogona kunge zviri Growth Hormone Deficiency (GHD) here?

Mwana wako ari kukura zvishoma pane vamwe vana vezera rake here? Kana kuti unofunga kuti anotaridzika mupfupi pane zera rake here? Zvakajairika kuti vabereki vazvidye mwoyo nezvezvinhu zvakaita seizvi dzimwe nguva. Zvisinei, zvingasava nyaya iri nyore nguva dzose. Nhasi tichataura nezvechirwere chinogona kuuya mupfungwa panguva dzakadaro, asi chisingawanzoitiki. Izvozvo zvinoreva 'Growth Hormone Deficiency', inonziwo 'GHD' muchidimbu.

Chii chinonzi `Growth Hormone Deficiency (GHD)`? Ngatizvinzwisise zviri nyore!

Zvichitaurwa zviri nyore, GHD chirwere apo gland diki riri muuropi hwedu, pituitary gland, harigadzi huwandu hunodiwa hwehormone yekukura (GH), iyo inokosha pakukura kwemuviri. Vamwe vanhu vanodanawo izvi kuti "pituitary dwarfism." Chirwere ichi chinogona kukanganisa vacheche, vana, nevakuru. Vana vane GHD vanowanzova vapfupi pane zera ravo, asi mimwe miviri yavo inogona kunge yakajairika.

Unoziva, mahormone akafanana nemakemikari ari mumiviri yedu. Anofamba neropa oudza nhengo dzedu, tsandanyama, nedzimwe nyama zvekuita uye nguva yekuzviita.

Gland redu re'Pituitary' i'Endocrine Gland' diki, asi rinokosha zvikuru. Riri pasi pehuropi hwedu, pasi pe'Hypothalamus'. Rine zvikamu zviviri zvikuru: 'Anterior Lobe' ne'Posterior Lobe'. Ndiro 'Anterior Lobe' rinoburitsa 'Growth Hormone (GH)' nemamwe mahormone angangoita masere.

Dzimwe nguva vanhu vane GHD vanogonawo kuva nechirwere chinonzi hypopituitarism, chinova kushomeka kwemamwe mahormone anogadzirwa nepituitary gland. Mahormone aya anosanganisira:

• `Antidiuretic Hormone (ADH kana Vasopressin)`
• `Hormone inokurudzira follicle`
• `Luteinizing Hormone`
• Homoni inokurudzira thyroid (TSH)
• `Adrenocorticotrophic Hormone (ACTH)`

Saka iyi 'Growth Hormone' inoita sei?

Homoni yekukura (GH) inokosha zvikuru pakukura kwevana. Inokanganisa nhengo dzakawanda dzemuviri. Inokosha pakukura kwakajairika, simba remhasuru nemapfupa, uye kupararira kwemafuta mumuviri .

Kana mapundu ekukurira (epiphyses) ari mumapfupa edu avharika, zvichireva kuti hatichakure, GH haichatibatsiri kukura. Zvisinei, miviri yedu ichiri kuda GH. Sezvatinokura, GH inobatsira kuchengetedza chimiro chemuviri chakajairika, inoita kuti metabolism ishande zvakanaka, uye inobatsira kuchengetedza huwandu hweshuga muropa .

Saka, unogona kuona kuti kungave uri mwana, wechidiki, kana mukuru, kana usina hormone yekukura yakakwana mumuviri wako, inogona kukukanganisa nenzira dzakasiyana zvichienderana nezera rako. Muvana nevechidiki, GHD inogona kukonzera kuti utadze kukura zvakanaka. Muvanhu vakuru, inogona kukonzera matambudziko akadai sekuwedzera kwemafuta mumuviri uye huwandu hweshuga muropa.

Kune mhando dzakasiyana dze `Growth Hormone Deficiency (GHD)` here?

Ehe, kune mhando nhatu huru dze `GHD`:

• Congenital GHD: Ichi chirwere chinowanikwa pakuzvarwa. Chinogona kukonzerwa nekuchinja kwemajini kana dambudziko nechimiro chehuropi hwemwana.
• Kuwana GHD: Izvi zvinokonzerwa nekukuvara kwegland repituitary mukukura. Vana nevakuru vanogona kuwana GHD nenzira iyi.
• Idiopathic GHD: Mukurapa, "idiopathic" zvinoreva kuti chikonzero hachizivikanwe . Mune dzimwe nguva GHD, hapana chikonzero chaicho chinogona kuwanikwa.

GHD inorongwawo zvichienderana nezera rekutanga kwayo, sezvo zviratidzo nenzira dzekuongorora dzichisiyana zvichienderana nekuti inotanga pamwana here kana kuti pamunhu mukuru.

Chirwere ichi chinonzi `GHD` chakajairika zvakadii?

Kushomeka kwehomoni yekukura (GHD) chirwere chisingawanzoitiki . Zvichitaurwa zviri pachena, GHD inobata munhu mumwe chete pavana 4,000 kusvika mumwe chete pavana 10,000. GHD inotanga kukura idambudziko risingawanzoitiki, rinobata munhu mumwe chete pavanhu 10,000.

Ndezvipi zviratidzo zve `Growth Hormone Deficiency (GHD)`?

Zviratidzo zveGHD zvinosiyana zvichienderana nezera rawakatanga chirwere ichi.

Zviratidzo zveGHD muvana vacheche nevana

Kana vacheche nevana vaine GHD, kukura kwavo kunononoka. Chiratidzo chikuru kuwedzera kwehurefu kunononoka gore rega rega mushure memakore matatu ekuberekwa kwemwana . Izvi zvinoreva kuti vanowanzo kuwedzera pasi pe 1.4 inches pagore.

Zvimwe zvinhu ndeizvi:

• Chiso chinotaridzika sechidiki kupfuura zera racho.
• Bvudzi risina simba uye kukura kwenzara.
• Kunonoka kubuda kwemeno.
• Kunonoka kuyaruka .
• Kuderera kweshuga muropa (`Hypoglycemia`) muvacheche nevana vadiki.
• Nhengo yemurume yevana vacheche idiki zvikuru (`Micropenis`).

Zviratidzo zveGHD zvinotanga munhu mukuru

Zviratidzo zveGHD zvinotanga munhu mukuru zvinogona kuoma kuona. Zviratidzo izvi zvinosanganisira:

• Kunzwa kushaya mufaro nekugara zvakanaka.
• Kunetseka uye/kana kuora mwoyo.
• Kuderera kwesimba remuviri.
• Kuwedzera kwemafuta, kunyanya kutenderedza dumbu .
• Kuderera kwetsinga.
• Kudzikira kwehuwandu hwemapfupa kunogona kukonzera zvirwere zvakaita se osteoporosis.
• Kusakwanisa insulin mumuviri kunogona kukonzera chirwere cheshuga cherudzi rwechipiri.
• Kuwedzera kweLDL-cholesterol netriglycerides kunowedzera njodzi yezvirwere zvemwoyo.

Ndezvipi zvikonzero zvechirwere ichi chinonzi `GHD`?

Zvikonzero zveGHD zvinogona kusiyana zvichienderana nezera rinotanga chirwere ichi. Dzimwe nguva, pane dzimwe nguva apo hapana chikonzero chingawanikwe (idiopathic).

Zvinokonzera Congenital GHD

Congenital GHD inokonzerwa nekuchinja kwemajini . Dzimwe nguva izvi zvinogona kusanganiswa nematambudziko muchimiro cheuropi kana kusarongeka pakati pechiso (semuenzaniso, cleft palate, single central incisor).

Masayendisiti akaona shanduko dzakasiyana-siyana dzemajini dzinokonzera GHD. Dzimwe dzacho ndedzinotevera:

• Kushaikwa kwehomoni yekukura iri yoga rudzi rweIA: Kuchinja kwemajini uku kunoita kuti kukura kunonoke muchikamu chemwana ari mudumbu, uye mwana mudiki zvikuru pane zvaitarisirwa pakuzvarwa. Vanhu ava vanotanga kupindura zvakanaka kurapwa nehomoni yekukura yakagadzirwa (GH), asi gare gare vanogadzira masoja ekudzivirira chirwere anorwisa homoni iyi. Izvi zvinoguma nekusakura zvakanaka uye kureba kwenguva pfupi kwemunhu mukuru.
• Kushaya homoni yekukura iri yoga rudzi rweIB: Izvi zvakafanana nerudzi rweIA, asi vana ava vane GH yechisikigo mumiviri yavo pakuzvarwa. Vanogamuchirawo kurapwa kweGH kwekugadzira muhupenyu hwavo hwese.
• Kushaya homoni yekukura iri yoga rudzi rwechipiri: Vanhu ava vane huwandu hwakaderera hweGH, uye panogona kuva nekuderera kwakasiyana-siyana kwehurefu. Kukundikana kukura kunowanzoonekwa muhudiki hwepakutanga kana hwepakati. Inenge hafu yevanhu ava vane pituitary gland isina kukura zvakanaka (Pituitary Hypoplasia).
• Kushaya homoni yekukura iri yoga rudzi rwechitatu: Kufanana nerudzi rwechipiri, vanhu ava vane huwandu hwakaderera hweGH uye vanogona kusangana nematanho akasiyana-siyana ekumira. Kukundikana kukura kunowanzoonekwa muhudiki hwepakutanga kana hwepakati. Vanogonawo kunge vaine dziviriro yemuviri isina simba uye hutachiona hunowanzoitika.

Maitiro ekugara nhaka erudzi urwu rwekushaikwa kwehomoni yekukura anogona kusiyana kubva kuchizvarwa kuenda kuchizvarwa.

Zvikonzero zveKuwana GHD

GHD, iyo inoitika pazera rekukura, inokonzerwa nekukuvara kwegland repituitary. Kukuvadzwa uku kunoita kuti gland rirasikirwe nekugona kwayo kugadzira nekubudisa mahormone ekukura. Vana nevakuru vanogona kukura GHD nenzira iyi.

Gland repituitary rinogona kukuvara nekuda kwemamiriro ezvinhu kana zviitiko zvakaita se:

• Pituitary adenoma (bundu risiri rekenza).
• Kurapa nemwaranzi kune pituitary gland kana nzvimbo yakapoteredza.
• Kukuvara kwakanyanya kwemusoro kana `Kukuvara Kwepfungwa Dzakakuvara (TBI)`.
• Kusafamba zvakanaka kweropa kuenda kunhengo yepituitary gland.
• Kukuvara netsaona kana kusingadzivisiki panguva yekuvhiyiwa kweuropi kana kuvhiyiwa kubvisa pituitary adenoma.
• `Kutapukirwa neSistimu Yetsinga Yepakati`.
• Zvirwere zvinopararira mumuviri, zvakaita seLangerhans cell histiocytosis, sarcoidosis, uye TB.
• Mamota ari mu hypothalamus anogona kukonzera kumanikidzwa kwepituitary gland.

Vanachiremba vedu vanoongorora sei chirwere ichi che 'GHD'?

Chirwere cheGHD chinowanzoonekwa muvana vane makore maviri. Chekutanga chinowanikwa pazera remakore mashanu, apo vana vanotanga chikoro . Izvi zvinodaro nekuti vabereki vanogona kuenzanisa kureba kwemwana wavo nekwevamwe vana vari mukirasi yavo. Zera rechipiri riri pakati pemakore gumi kusvika gumi nematatu kuvasikana uye 12 kusvika gumi nematanhatu kuvakomana . Aya ndiwo makore anowanzotanga kuyaruka. Kunonoka kuyaruka kunogona kukonzera kufungira nezveGHD.

Chinhu chinonyanya kukosha pakuongorora GHD muvana kukura kuri kuwedzera . Uku ndiko kukura kwemwana. Kukura kunowanzo tevera maitiro akasiyana. Kana kukura kwacho kukatariswa kwemwedzi mitanhatu kusvika gumi nemiviri uye kuri mukati menguva yakatarwa munguva iyoyo, hapana mukana wekuti pave nedambudziko rekukura.

GHD, iyo inotanga munhu mukuru, inogona kuoma kuiongorora nekuti zviratidzo zvayo hazvina kujeka uye zvinoita sezvinhu zvakajairika. Izvi zvinogona kuita kuti kuongororwa kwechirwere kuve kwakaoma.

Ndedzipi bvunzo dzinoitwa pavana kuti vaone `GHD'?

Chiremba wemwana wenyu achanyatsoongorora nhoroondo yake yezvekurapa uye machati ekukura kuti aone zviratidzo zvekukundikana kukura, zvinhu zvinokonzera njodzi yeGHD, nezvimwe zvirwere zvinogona kukanganisa kukura.

Mamwe matambudziko ehutano anogona kukanganisa kukura ndeaya:

• Hypothyroidism (thyroid gland isingashande zvakanaka).
• Kunonoka kuyaruka.
• Chirwere cheCeliac.
• Kushaya chikafu chakakwana.

Nekuti huwandu hwehormone yekukura muropa redu hunochinja-chinja zvakanyanya mukati mezuva, kuongororwa kweropa chete hakugone kuona kushomeka kweGH. Saka, chiremba wemwana wako anogona kuraira bvunzo dzakadai sedzino kusimbisa GHD uye/kana kubvisa zvimwe zvirwere zvinogona kukanganisa kukura:

• X-ray: X-ray yeruoko inogona kuitwa kuti iongorore kukura kwemapfupa (zera remapfupa) uye mukana wekukura kwawo.
• Kuongororwa kweropa nedzimwe bvunzo dzemurabhoritari:Kumwe kuongororwa kweropa kunogona kubatsira kubvisa zvimwe zvirwere zvinokanganisa kukura kana kubatsira kuona GHD. Kuongororwa kweropa kwakanangana ne insulin-like growth factor-1 (IGF-1) uye insulin-like growth factor binding protein-3 (IGFBP-3).
• Kuongororwa kweKukurudzira Kukura kweHormone: Iyi ndiyo bvunzo huru inoshandiswa navanachiremba kuongorora GHD. Muongororo iyi, mwana wenyu anopiwa mushonga unokurudzira pituitary gland kuti ibudise GH. Chiremba anobva atora ropa oyera huwandu hweGH. Kana zvabuda muongororo yeropa zvisingaratidze kuti huwandu hweGH hwakwira kusvika padanho rinotarisirwa, zvinoreva kuti pituitary gland haisi kugadzira GH yakakwana.
• Mufananidzo weMagineti weResonance (MRI): Chiremba wemwana wako anogona kurayira kuti apihwe MRI yemusoro. Izvi zvinogona kubatsira kuona chikonzero cheGHD nekutsvaga matambudziko mugland repituitary kana uropi.

Ndedzipi bvunzo dzinoitwa pavanhu vakuru kuti vaone `GHD`?

Bvunzo inonyanya kushandiswa kuongorora GHD muvanhu vakuru ndeye Insulin Tolerance Test . Insulin ihormone inogadzirwa nepancreas yedu.

Mubvunzo uyu, chiremba achakupa jekiseni re insulin yekugadzira kuti aderedze huwandu hweshuga muropa rako. Zvadaro, vachatora sampuli yeropa voyera huwandu hwehormone yekukura muropa rako.

Kana huwandu hweshuga muropa redu hwaderera (hypoglycemia), hormone yekukura inowanzo buritswa. Kana bvunzo dzeropa rako dzikaratidza kuti huwandu hwehormone yekukura kwako hwakaderera pane zvaitarisirwa muongororo yekushivirira insulin, izvi zvinosimbisa chirwere cheGHD.

Panogona kunge paine mimwe miedzo:

• `Kuyedzwa kwekukurudzira Glucagon`
• `Kuyedzwa kwekukurudzira kweMacimorelin`
• `Kuyedzwa kwekukurudzira arginine`
• `Kuyedzwa kwekukurudzira clonidine`

`Kushomeka kweHormone Yekukura (GHD)` kunorapwa sei?

Kurapa kweGHD kuvana nevakuru kubaiwa jekiseni re synthetic growth hormone (Recombinant Human Growth Hormone) . Izvi zvinogona kupihwa kumba. Vanhu vane GHD vanowanzo fanirwa kubaiwa jekiseni zuva nezuva .

Kurapa kwemakemikari ekukura kunotora nguva refu , dzimwe nguva kwemakore akati wandei. Zvakakosha kuona chiremba wako nguva nenguva kuti uone kana kurapwa kuri kushanda nemazvo uye kana muyero wacho uchida kugadziriswa.

Kana iwe kana mwana wako muine kusakwana mune mamwe mahormone epituitary, muchadawo kurapwa kuti mugadzirise kusakwana ikoko.

Migumisiro yekurapwa kwe 'GHD'

Matambudziko mashoma kana ari pakati nepakati anobva mujekiseni remahormone ekukura pakurapwa kweGHD haawanzoitiki. Zvisinei, anogona kusanganisira:

• Musoro.
• Kurwadziwa kwetsandanyama kana majoini.
• Hypothyroidism iri nyore.
• Kuzvimba kwemaoko netsoka.
• Kuwedzera kwekukombama kwemusana kune vanhu vane scoliosis.

Migumisiro isingawanzoitiki, asi yakakomba inogonawo kuitika:

• Musoro wakakomba unoperekedzwa nematambudziko ekuona.
• Kusabatana zvakanaka kwepfupa rehudyu (kusanamira zvakanaka kwepfupa rehudyu).
• Pancreatitis (kuzvimba kwepancreas).

Kana uine chimwe chezviratidzo izvi, zvakakosha kutaura nachiremba wako nekukasika . Muyero wemushonga wako ungangoda kugadziriswa.

Ndezvipi zvinhu zvinokonzera njodzi yekuva ne `GHD`?

Zvinosuwisa kuti nyaya zhinji dzeGHD hadzigone kudzivirirwa. Zvisinei, zvimwe zvinhu zvinogona kuwedzera mukana wekuti iwe kana mwana wako muwane GHD. Izvi zvinosanganisira:

• Kurapwa kenza usati wasvika pakureba.
• Kurapwa nemwaranzi mumusoro kana muuropi.
• Kuvhenekerwa Kwemuviri Wose.
• Kuvhiyiwa kweuropi, kunyanya chikamu chepakati cheuropi pane pituitary gland.

Kana chimwe chezvinhu izvi zvine njodzi chikaitika kwauri kana kumwana wako, zvakakosha kuti uzive zviratidzo zveGHD uye utaure nachiremba wako nezvazvo.

Chii chinonzi fungidziro yeGHD?

Kune vana vane GHD, chirwere ichi chikakurumidza kurapwa, mukana wekuti mwana akure kusvika pahurefu hwemunhu mukuru wakajairika ndewekuti akure . Vana vazhinji vanokura masendimita mana kana kupfuura mugore rekutanga rekurapwa. Vanokura masendimita matatu kana kupfuura mumakore maviri anotevera. Mushure meizvozvo, kukura kwemwana kunoderera.

Vanhu vane chirwere cheGHD chinowanikwa muvanhu vakuru, kana vakarapwa zvakanaka, vanowanzova netariro yakanaka uye vanogona kurarama hupenyu hwakanaka.

Ndezvipi zvinetso zvinogona kuitika nekuda kweGHD?

Kana chirwere cheGHD muvana chikasarapwa, chinogona kukonzera kukura kwenguva pfupi uye kunonoka kuyaruka .

Kunyangwe kana vakarapwa zvakanaka, vanhu vane chirwere chemwoyo chinotanga kukura vane njodzi yakakura yezvirwere zvemwoyo nestroke . Njodzi iyi inogona kuderedzwa netsika dzakanaka dzakadai sekudya chikafu chakakwana uye kurovedza muviri nguva dzose.

Vanhu vane GHD vanotanga vakura vanewo mukana wakawedzerwa wekuwana osteoporosis. Izvi zvinoreva kuti vane mukana wakakura wekutyoka mapfupa nekuda kwekukuvara kudiki kana kuwa. Kuti uderedze njodzi idzi, zvakakosha kudya chikafu chine calcium yakawanda uye kutora mavhitamini D sezvakakurudzirwa nachiremba wako.

Ndirini pandinofanira kuona chiremba nezve GHD?

Pane zvikonzero zvakawanda zvinoita kuti vana vakure zvishoma nezvishoma uye vapfupi pane zvakajairwa. Dzimwe nguva, kukura kunonoka kunogona kuva kwakajairika uye kwenguva pfupi. Semuenzaniso, kana kuyaruka kwava kusvika. Kana uchinetseka nezvekukura kwemwana wako, ona chiremba wevana kana mumwe chiremba . Vanogona kukubatsira kuona kana kukura kwemwana wako kuri chinhu chekunetseka nacho.

Kana uri munhu mukuru uye uine zviratidzo zveGHD, taura nachiremba wako.

Kana iwe kana mwana wako mukaonekwa kuti mune chirwere cheGHD, munofanira kuona chiremba wenyu nguva nenguva kuti muve nechokwadi chekuti kurapwa kuri kushanda nemazvo .

Kana mukaona mwana wenyu achinonoka kukura, zvakakosha kutaura nachiremba wenyu nekukurumidza. Kunyangwe zvisingaite kuti GHD ndiyo inokonzera, zvakakosha kutarisa chero shanduko dzinonetsa. Kana vanhu vane GHD vakaonekwa nekukurumidza, vane tarisiro iri nani uye vanowanzo rarama hupenyu hwakanaka. Kana muine mibvunzo nezvekukura kwemwana wenyu, musatya kubvunza chiremba wenyu. Varipo kuti vakubatsirei.

Mharidzo Yekupedzisira Yekuenda Kumba

Saka, pamwe unonzwisisa kuti `Growth Hormone Deficiency (GHD)` chii uye kuti inogona kukanganisa sei vana nevakuru zvakafanana. Chinhu chakakosha kusatya nezvazvo, uye kuona chiremba nekukurumidza kana uine chero chinokunetsa . Nekuongororwa nekukurumidza uye kurapwa kwakakodzera, vanhu vazhinji vane `GHD` vanogona kurarama hupenyu hunobudirira uye hune hutano. Kana uine chero chinokunetsa nezvekukura kwemwana wako kana hutano hwako, hazvisati zvanyanya kunonoka kutaura nachiremba nezvazvo.

Kushaikwa kweHormone Yekukura, GHD, Kushaikwa kweHormone Yekukura, Gland yePituitary, Kukura Kwemwana, Kupfupika, Matambudziko eHormone, GH