Ngatidzidzei nezveHuman Growth Hormone (HGH) nenzira iri nyore.

Unonzwa sekuti mwana wako haasi kukura sezvaanofanira kuita here? Kana kuti unogara uchinzwa kuneta uye kuneta? Pamwe chikonzero cheizvi ikemikari diki inotumirwa mumuviri wako. Imwe hormone yakakosha pakukura kwemuviri wedu nezvimwe zvinhu zvakawanda inonzi human growth hormone . Tinoidaidza kuti HGH (Human Growth Hormone) muchidimbu. Vamwe vanoidaidzawo kuti somatotropin . Saka nhasi, ngatitaurei nezve iyi HGH zvakadzama, zviri nyore.

Chii chinonzi HGH? Inogadzirwa sei mumuviri wedu?

Zvichitaurwa zviri nyore, HGH ihormone yechisikigo inogadzirwa nemiviri yedu. Inogadzirwa negland diki riri pasi pehuropi hwedu, rakakura sebhonzo diki. Tinoridaidza kuti gland repituitary . Iyi HGH hormone inokanganisa nhengo dzakawanda dzemuviri wedu. Inonyanya kukosha pakukura kwevana . HGH inobatsira zvikuru muzvinhu zvakaita sekuita kuti mwana wako arebe uye kusimbisa mapfupa ake.

Zvisinei, kana takura, ndiko kuti, kana mapundu ekumera mumapfupa edu (epiphyses) avharika, HGH haichatiiti kuti tiwedzere kureba. Asi handizvo chete zvinoitwa neHGH. Kunyangwe takura, HGH inobatsira kuchengetedza chimiro chemuviri wedu uye kuchengetedza metabolism yedu ichishanda zvakanaka. Iyi metabolism ndiyo inoshandura chikafu chatinodya kuita simba. HGH inobatsirawo kuchengetedza huwandu hweshuga muropa (glucose) redu padanho rakati.

Mahormone makemikari ari mumiviri yedu. Anoshanda sevanhu vanotumwa. Anofamba neropa uye anoudza nhengo dzedu, tsandanyama, nedzimwe nyama zvekuita uye nguva yekuzviita. Kune anopfuura makumi mashanu emahormone aya mumiviri yedu!

Gland repituitary randambotaura riri pasi pehuropi, pasi pehypothalamus . Iyi hypothalamus inodzora zvinhu zvakawanda zvakaita sekumanikidzwa kweropa redu, kurova kwemoyo, tembiricha yemuviri, uye kugaya. Saka, iyi hypothalamus ndiyo inoudza gland repituitary kuti riburitse HGH. Homoni inobatsira neizvozvo inonzi GHRH (hormone yekukura-kuburitsa hormone) . Zvakare, rimwe hormone (somatostatin) rinobva kuhypothalamus kuti rimise kuburitswa kweHGH. Aya ndiwo madzorerwo anoitwa HGH.

Dzimwe nguva vanachiremba vanoshandisa HGH yekugadzira kurapa zvimwe zvirwere. Asi yeuka, usamboshandisa HGH yekugadzira isina kunyorerwa nachiremba.

Ndezvipi zvinhu zvinokanganisa kuburitswa kweHGH?

Gland redu repituitary rinowanzoburitsa HGH zvishoma mukati mezuva, zvinonzi pulses . Izvi zvinodzorwa zvakanyanya nemahormone maviri anobva kuhypothalamus anonzi GHRH uye somatostatin.

Kwete izvozvo chete, asi mamwe mahormone anobatanidzwa. Semuenzaniso,Insulin-like growth factor 1 (IGF-1) inoderedza kugadzirwa kweHGH, nepo mahormone akadai se thyroxine , glucocorticoids , uye ghrelin achiwedzera kuburitswa kweHGH.

IGF-1, iyo inoburitswa nechiropa chedu, ichibereko chikuru cheHGH. Iyi IGF-1 ndiyo inodzora kugadzirwa kwakawandisa kweHGH. Kureva kuti, HGH inokonzera kuti IGF-1 igadzirwe, uye IGF-1 inogadzirwa inoderedza kugadzirwa kweHGH zvakare. Zvakafanana nedenderedzwa.

Mumunhu ane hutano hwakanaka, kuburitswa kweHGH kunodziviswa nekuwedzera kweshuga muropa (hyperglycemia) . Pamusoro pezvo, kuburitswa kweHGH kunokurudzirwa nezvinhu zvakaita sekurara, kushushikana, kurovedza muviri, kuderera kweshuga muropa (hypoglycemia) , uye maamino acids .

Ndeapi mabasa makuru eHGH hormone?

HGH ine mabasa maviri makuru:

1. Kukurudzira kukura (kunyanya kuvana)

2. Kukanganisa mashandiro emuviri (nzira yatinoshandura chikafu chatinodya kuita simba)

HGH uye kukura

HGH inobatsira nhengo dzese dzemuviri wedu kukura. Asi inozivikanwa zvikuru nekubatsira mapfupa kukura kwegwara nemapfupa . Izvi zvinonyanya kukosha panguva yekuyaruka. Masero anonzi chondrocytes mugwara neosteoblasts mumapfupa anogamuchira zviratidzo kubva kuHGH kuti aparadzane uye akure.

Zvisinei, sezvandambotaura, HGH haiwedzere kureba mushure mekunge ma "growth plates" (epiphyses) mumapfupa emwana avharika. Pane kudaro, HGH inobatsira kuchengetedza chimiro chemuviri chakajairika muhupenyu hwese.

HGH uye metabolism

Metabolism inzira yemakemikari inoshandura chikafu chatinodya kuita simba. Sero rega rega mumuviri wedu rinoda simba kuti rishande zvakanaka.

HGH inokanganisa metabolism zvakanyanya nekuwedzera kugadzirwa kweIGF-1, iyo inoshandura maitiro ayo anokanganisa masero emuviri wedu. IGF-1 ihormone ine chimiro chakafanana neinsulin . Insulin ihormone inokosha inogadzirwa nepancreas yedu inoderedza huwandu hweshuga muropa (glucose) . IGF-1 inewo kugona kuderedza shuga muropa.

Kazhinji, miviri yedu inonyatso dzora huwandu hweshuga muropa redu. Shuga muropa, kana kuti shuga, ndiyo mhando huru yeshuga muropa redu. Tinoiwana kubva muzvikafu zvatinodya zvine makabhohaidhiretsi. Shuga iyi ndiyo inopa simba kunhengo dzedu, tsandanyama, uye tsinga.

Insulin ndiyo homoni huru inoderedza shuga muropa kana yakakwira. Uye homoni inonzi glucagon inowedzera shuga muropa kana yaderera. Zvisinei, HGH inowanzo wedzera shuga muropa kana yaderera. Zvisinei,Kana huwandu hweHGH mumuviri wako hukawedzera zvakanyanya, zvinogona kukanganisa mashandiro e insulin uye kukonzera kuti huwandu hweshuga muropa huwedzere.

HGH inokuita kuti urebe here?

Ehe, HGH inogona kuwedzera kureba kwevana. Asi izvi zvinongoitika chete ma growth plates ari mumapfupa avo asati abatana. HGH haigone kukuita kuti urebe mushure mekunge ma growth plates abatana. Pane kudaro, kana wasvika pahurefu hwako hwepamusoro, HGH inobatsira kuchengetedza chimiro chemuviri wako uye metabolism.

Ndeapi mazinga eHGH akajairika?

Sezvandambotaura, pituitary gland inoburitsa HGH muropa mukati mezuva. Mazinga aya anosiyana zvichienderana nenguva yezuva, zera, uye murume kana mukadzi. Saka, kuongororwa kweropa kamwe chete kuti uongorore HGH hakubatsiri zvakanyanya pakuongorora chirwere. Pane kudaro, vanachiremba vanoongorora mazinga eHGH kuburikidza nekuyedzwa kwakakosha (kuyedzwa kwekukurudzira kana kudzvinyirirwa).

Mazinga akajairika eHGH ndeaya anotevera:

• Varume vakuru: 0.4 kusvika 10 nanograms pa milliliter (ng/mL)
• Vakadzi vakuru: 1 kusvika 14 nanograms pa milliliter (ng/mL)
• Vana: 10 kusvika ku50 nanograms pa milliliter (ng/mL)

Asi yeuka, kukosha uku kunogona kusiyana zvishoma kubva murabhoritari kuenda kune imwe. Saka enzanisa nekwakajairika pamushumo wako werabhoritari. Kana uine chero zvinokunetsa, iva nechokwadi chekutaura nachiremba wako.

Chii chinoitika kana huwandu hweHGH hukadzikira? (Kushaikwa kweHormone Yekukura)

Kana huwandu hweHGH hwakaderera pane zvakajairwa, tinohudaidza kuti Growth Hormone Deficiency . Izvi zvinowanzo kukonzerwa nedambudziko kana kukuvara kwepituitary gland. Izvi zvinogona kutungamira kuchirwere chinonzi hypopituitarism . Izvi zvinoreva kuti rimwe kana akawanda mahormone anogadzirwa nepituitary gland anodzikira. HGH ihormone inogonawo kukanganiswa nenzira iyi.

Kushomeka kweHGH uku kunokanganisa vakuru nevana nenzira dzakasiyana.

Kana huwandu hweHGH hukadzikira muvanhu vakuru:

Kana huwandu hweHGH mumunhu mukuru hukadzikira, matambudziko anotevera anogona kuitika:

• Kudzikira kwemufaro nekugutsikana nehupenyu.
• Kuwedzera mafuta mumuviri.
• Kuwanda kwenjodzi yechirwere chemwoyo.
• Kushaya simba kwemoyo, tsandanyama nemapfupa.

Muvanhu vakuru, chirwere ichi chinogona kukonzerwa ne pituitary adenoma (iyi haisi kenza, asi bundu) kana kukuvara kwe pituitary gland/hypothalamus.

Kana vana vaine HGH shoma:

Kana huwandu hweHGH hwemwana hukadzikira, kukura kwake kunodzikira. Chiratidzo chikuru kuwedzera kwehurefu zvishoma nezvishoma mushure memakore matatu ekuberekwa kwemwana. Kureva kuti, pasi pe 1.4 inches pagore. Semuenzaniso, kana mwana wako achiratidzika kunge mupfupi kupfuura vamwe vana vari mukirasi, unofanira kunetseka.

Uyezve, mwana ane HGH kushomeka anogonawo kuva nezviratidzo zvakaita se:

• Chiso chinotaridzika sechiri chidiki kupfuura zera racho.
• Kukura kwebvudzi kusina kunaka.
• Kunonoka kuyaruka.

Vana vanogona kuzvarwa vaine chirwere ichi. Dzimwe nguva chikonzero hachizivikanwe (idiopathic), chinogona kunge chiri majini, kana kuti chinogona kukonzerwa nekukuvara kwegland repituitary panguva yekuzvitakura kana pakuzvarwa. Dzimwe nguva chinogonawo kukonzerwa nekukuvara kwegland repituitary kana hypothalamus pazera rekukura.

Chii chinoitika kana huwandu hweHGH hukawedzera?

Dambudziko guru rinokonzerwa nekuwedzera kweHGH kupfuura zvakajairika iacromegaly . Izvi zvinobatawo vakuru nevana zvakasiyana. Idambudziko risingawanzoitiki.

Acromegaly muvanhu vakuru

Vakuru vane acromegaly vanowanzo wedzera kana kuzvimba maoko netsoka uye kuchinja kwechiso .

Vanogonawo kuva nemapfupa akakora uye nhengo dzemukati dzakakura. Vane mukana mukuru wekuva nezvirwere zvakaita seBP , chirwere cheshuga cherudzi rwechipiri, uye chirwere chemwoyo. Zvinopfuura 99% zvezviitiko zveacromegaly zvinokonzerwa nemabundu asiri ekenza mugland repituitary rinonzi pituitary adenomas . Mabundu aya anogona kubereka HGH yakawandisa. Acromegaly inonyanya kuitika mushure mezera repakati, mushure mekunge kukura kwapera. Nokudaro, vakuru vane acromegaly havakure kureba. Pane kudaro, mapfupa avo anogona kukora.

Acromegaly (Gigantism) muvana

Kashoma, vana vanogona kuva nemazinga eHGH akakwira vasati vasvika pakureba kwavo kwakazara. Izvi zvinogona kukonzera kukura kwakanyanya kwemapfupa marefu, zvichikonzera vana varefu zvisina kujairika. Dambudziko iri rinonzi juvenile acromegaly . Dzimwe nguva rinonzi gigantism . Kana rikasarapwa, vana ava vanogona kukura kusvika pahurefu hwemamita maviri kana kupfuura. Vanogonawo kuona zviratidzo zvakaita sekuneta, kunonoka kuyaruka, uye musoro.

Izvi zvinowanzokonzerwawo ne pituitary adenoma.

Mazinga eHGH anoyerwa sei?

Kana iwe kana mwana wako muine zviratidzo zvinoratidza kuti ane matambudziko ane chekuita neHGH, chiremba wenyu anogona kuraira kuongororwa ropa kakawanda kuti aone huwandu hweHGH yenyu.

Sezvandambotaura, pituitary gland inoburitsa HGH muropa masikati ese uye nguva nenguva husiku. Saka, zvakaoma kunzwisisa mamiriro acho ezvinhu nemazvo nekutora ropa uye kuongorora HGH kamwe chete.

Saka, vanachiremba vanowanzo shandisa nzira dzinonzi kukura kwehomoni yekukurudzira uye bvunzo dzekudzvinyirira kuti vaone mamiriro ezvinhu anokonzerwa nekushaikwa kweHGH kana kuwanda kwayo.

Pamusoro pezvo, kuongororwa kweropa kunogona kuitwa kuti kutariswe mazinga eIGF-1 (insulin-like growth factor 1) .

HGH inoshandiswa sei semushonga?

Sangano reUnited States Food and Drug Administration (FDA) rakabvumidza mushonga weHGH wekugadzira kurapa mamwe mamiriro ezvinhu. HGH iyi yekugadzirwa inogona kuwanikwa chete netsamba yachiremba, uye inopihwa sejekiseni.

HGH inopihwa vana nekuda kwezvikonzero zvinotevera:

• Kushaikwa kwehomoni yekukura.
• Zvirwere zvinokonzera kupfupika kwehurefu, zvakaita sechirwere cheitsvo chisingaperi , Turner syndrome , uye Prader-Willi syndrome .

HGH inorayirwa vanhu vakuru nekuda kwezvirwere zvinotevera:

• Kushaikwa kwehomoni yekukura.
• Kurasikirwa nekukora kwetsandanyama nekuda kweHIV .
• Chirwere chemudumbu mupfupi .

Zvakakosha: Usamboshandisa HGH yakagadzirwa kunze kwekunge chiremba wako akakunyorera.

Ndezvipi migumisiro yeHGH yekugadzira?

Mimwe migumisiro inogona kuitika kana uchishandisa mushonga weHGH wekugadzira semushonga. Izvi ndeizvi:

• Carpal tunnel syndrome (tsinga yakamanikana muruoko).
• Kuwedzera kwekusakwanisa kwe insulin uye/kana chirwere cheshuga cherudzi rwechipiri.
• Kuzvimba kwemaoko netsoka (edema) .
• Kurwadziwa kwemajoini netsandanyama.
• Kukura kwenyama yemazamu muvarume (gynecomastia) .
• Kuwanda kwenjodzi yekubatwa negomarara.

Vaongorori vachiri vasina ruzivo rwakakwana nezvemhedzisiro yenguva refu yekurapa kweHGH yakagadzirwa.

Ndirini pandinofanira kuona chiremba nezvehuwandu hweHGH?

Kana iwe kana mwana wako muine zviratidzo zvine chekuita nekushomeka kweHGH kana kuwanda kwemasero (semuenzaniso, kukura zvishoma nezvishoma, makuriro emuviri akakura), iva nechokwadi chekuona chiremba wako.

Kana uri kutorapwa chirwere cheHGH, zvakakosha kuti ugare uchiona chiremba wako kuti uve nechokwadi chekuti kurapwa kwako kuri kushanda nemazvo.

HGH ihormone ine simba inokosha pamabasa akawanda akakosha mumuviri wedu. Dzimwe nguva pituitary gland yedu inogona kuigadzira zvakanyanya kana zvishoma. Kana iwe kana mwana wako muine chimwe chezviratidzo izvi, zvakanaka kutaura nachiremba. Varipo kuti vakubatsirei.

Mharidzo Yekupedzisira Yekuenda Kumba

Zvakanaka, saka tataura zvakawanda nezve HGH nhasi, handiti? Ngatipfupisei muchidimbu:

• HGH ihormone inokosha zvikuru pakukura kwedu, kunyanya panguva yehudiki, uye pakushanda kwemuviri wedu.
• Izvi zvinogadzirwa negland repituitary riri muuropi hwedu.
• Kana huwandu hweHGH hukadzikira, vana vanogona kunge vakanonoka kukura, uye vakuru vanogonawo kusangana nematambudziko akasiyana-siyana ehutano.
• Kana huwandu hweHGH hukawedzera, mamiriro akaita seacromegaly anogona kuitika.Muvana, izvi zvinogona kuoneka se gigantism, zvinoreva kukura kwenguva refu zvisingawanzoitiki.
• Kana muchifungidzira kuti imi kana mwana wenyu mungave nedambudziko neHGH, musazeza kutsvaga rubatsiro rwechiremba.
• Usamboshandisa HGH yekugadzira isina kunyorerwa nachiremba.

Yeuka kuti zvese izvi zvakagadzirirwa kukudzidzisa. Kana uine chero dambudziko rehutano, chiremba wako chete ndiye anogona kukupa mhinduro yakanakisisa. Ramba uine hutano hwakanaka!

` Mahormone Ekukura Kwemunhu, HGH, Gland rePituitary, Kukura Kwemwana, Kuwedzera Kureba, Metabolism, Kusawirirana Kwemahormone