Unoziva here nezveMedullary Thyroid Cancer (MTC), rudzi rwekenza yethyroid?

Pamwe wakambonzwa nezve thyroid gland yakaita seshavishavi iri pamberi pemutsipa wako. Dzimwe nguva unogona kunzwa bundu diki mu gland iri. Kana kuti chiremba anogona kuriona paunenge uchikuongorora. Kunyange zvazvo bundu iri risingawanzo kuva nengozi, rinogona, muzviitiko zvisingawanzoitiki, kuva chiratidzo chekenza. Nhasi, tichataura nezverudzi rwekenza rwakakosha, asi rusingawanzoitiki, runoitika mu thyroid gland.

Chii chinonzi medullary thyroid cancer (MTC)?

Zvichitaurwa zviri nyore, Medullary Thyroid Cancer (MTC) igomarara rinokura mukati megland rako re thyroid. Chikamu chemukati chegland iri chinonzi 'medulla' . Kune rudzi rwakakosha rwesero mumedulla iyi, runonzi 'parafollicular C cells' . MaC cell aya anogadzira hormone inonzi 'calcitonin' . Saka, kana maC cell aya atanga kukura zvisingadzoreki, MTC inoitika. Funga nezvazvo sezvirimwa zvisingadiwe mubindu zvinopararira kwese kwese pasina kudzora.

Zvakajairika kuva nemibvunzo yakawanda uye kutya paunonzwa nezvegomarara, kunyanya kana riri rudzi rusingawanzoitiki. Asi yeuka, timu yako yezvekurapa inewe parwendo urwu. Kune nzira dzakawanda dzakasiyana dzekurapa MTC.

Kenza yemedullary thyroid cancer (MTC) yakajairika zvakadii?

Zvino ungave uchifunga kuti, "Oh, chirwere ichi chinowanikwa nemunhu wese here?" Usazvidya moyo. Kenza yethyroid yakajairika. Zvisinei, rudzi rwatiri kutaura nezvarwo , medullary thyroid cancer (MTC) , haruwanzoitiki . Kunyangwe munyika yakaita seUnited States, 4% kusvika 10% chete yekenza yethyroid inoshumwa inoonekwa seMTC. Izvi zvinoreva kuti vanhu vanosvika chiuru chete ndivo vanoonekwa vaine MTC ikoko gore rega rega. Saka, muSri Lanka, nhamba iyi inogona kunge yakaderera.

Ndezvipi zviratidzo zvekenza yemedullary thyroid (MTC)?

Saka zviratidzo zveMTC ndezvipi? Havasi vese vanowana zviratidzo zvakafanana. Zvisinei, kune zvimwe zvakafanana:

• Bundu (nodule) riri pamusoro pegland rako re thyroid rinonzwika. Ichi ndicho chiratidzo chikuru chinowanikwa muvanhu 75% kusvika 95% pavanoonekwa kuti vane chirwere ichi. Chinogona kunzwika sebundu diki, uye dzimwe nguva chinogona kuonekwa kana ukatarisa kumberi kwemutsipa wako.
• Malymph nodes akazvimba mumutsipa . Izvi zvinoonekwawo muvanhu vanosvika 70% pavanoonekwa kuti vane chirwere ichi. Izvi zvinogona kunzwikwa semapundu madiki kumativi ese emutsipa.

Zvisinei, kashoma, kana thyroid nodule ikava hombe, zviratidzo zvinotevera zvinogona kuitika:

• Kuchinja kwenzwi, kurira kwezwi.
• Kuomerwa nekumedza chikafu.
• Kutadza kufema zvakanaka.

Chinhu chakakosha ndechekuti vamwe vanhu vanogona kunge vaine MTC asi vasingaratidzi zviratidzo kwenguva yakareba. Izvi zvinokonzerwa nekuti bundu iri rine kenza.Kadiki zvikuru. Saka, kana ukaona chimwe chinhu chisina kujairika pamutsipa wako, zvakakosha kuti unyatsochiteerera.

Sei kenza yemedullary thyroid (MTC) ichikura?

Zvino ngationei kuti sei MTC iyi ichiitika. Pane zvikonzero zvakati wandei zveizvi. Zvikuru, kune nzira mbiri dzinoitika nadzo MTC.

MTC isingawanzoitiki

Vanenge 75% (vanenge vatatu pavana) vevarwere vane MTC vanokura chirwere ichi nguva nenguva . Izvi zvinoreva kuti hapana munhu mumhuri yavo akambova neMTC. Izvi zvinoitika pasina nhoroondo yemhuri. Masayendisiti haasati awana chikonzero chaicho cheMTC iyi isingawanzoitiki. Zvisinei, pakati pe40% ne50% yevanhu vanokura MTC nenzira iyi vane shanduko mujini rinonzi ``(RET)`` . Ichi hachisi chinhu chavanozvarwa nacho, asi kusarongeka kwemajini kunoitika gare gare muhupenyu.

MTC kubva kuchizvarwa kuenda kuchizvarwa

Kune rumwe rutivi, vanenge 25% yevarwere veMTC (anenge mumwe chete pavana) vanogona kunge vaine chirwere chekuzvarwa nacho chinonzi 'Multiple Endocrine Neoplasia type 2' (MEN2) . Kune mhando dzakasiyana dze'MEN2':

• `(MEN2A)`: Vanhu vane chirwere ichi vane njodzi huru yekubatwa neMTC (inenge 90%) .
• `(MEN2B)`: Dzimwe nyaya dze `(MEN2B)` dzinogara nhaka. Zvisinei, kazhinji izvi hazvisizvo. Vanhu vane `(MEN2B)` vane mukana we100% wekuwana MTC vachiri vadiki kwazvo .

Kune rumwe rudzi rwechirwere ichi chinonzi `(MEN2B)`, chinonzi `Familial Medullary Thyroid Cancer (FMTC) . Vanhu vane `(FMTC)` vane `(RET)` gene mutation, asi vanongokura MTC (kwete mamwe marudzi ekenza).

Fungidzira, kana mumwe munhu mumhuri yako akawanikwa aine ``(RET)`` gene mutation iyi, unogona kudzivirira njodzi huru nekubviswa kwegland re thyroid kuburikidza nekuvhiyiwa kwekudzivirira kenza isati yatanga.

Kenza yeMedullary Thyroid Cancer (MTC) inoonekwa sei?

MTC inowanzoonekwa sebundu mugland re thyroid. Unogona kurinzwa iwe pachako, kana kuti chiremba wako anogona kuriwana paunonzwa mutsipa wako panguva yekuongororwa nguva dzose. Dzimwe nguva, bundu rinowanikwa netsaona panguva yekuongororwa kwemifananidzo kunoitwa nechimwe chikonzero.

Kana chiremba wako achifungidzira kuti une MTC, vangangoda bvunzo idzi:

• Kuongororwa kwemifananidzo: Izvi zvinogona kubatsira kuona zvakajeka thyroid nodule. Semuenzaniso , thyroid ultrasound , CT scan , uye/kana MRI.Unogona kuita bvunzo dzakadai. Kufanana nekutora mufananidzo nekamera, michina iyi inogona kuona zviri mukati memuviri.
• Kusveta tsono netsono zvishoma (biopsy yetsono): Chiremba wako angangokurudzira kutora sampuli diki yenyama (biopsy) kubva mugono re thyroid rako. Izvi zvinosanganisira kushandisa tsono diki kwazvo. Inonzwa kunge yakabayiwa netsono diki. Sampuro iyi yenyama inozoongororwa nemaikorosikopu kuti ione kana paine masero ekenza.
• Kuongororwa kweropa: Izvi zvinogona kusanganisira kuongororwa kunoyera huwandu hwezvinhu zviri muropa rako zvinonzi calcitonin uye carcinoembryonic antigen (CEA) . Mazinga aya anowanzo wedzera kune vanhu vane MTC.

Chiremba wako anogonawo kukurudzira kuongororwa kwemajini kuti vaone kana uine chirwere chemajini chinonzi ``MEN2''. Kana zvakadaro, vanogona kukurudzira kuongororwa kwemajini kune dzimwe hama dzeropa, sezvo izvi zvichigona kubatsira kuona kana vari panjodzi.

Ndeipi mishonga yekurapa cancer ye medullary thyroid (MTC)?

Zvakanaka, ngationei kuti ndeapi marapirwo aripo eMTC.

Kurapa kukuru kweMTC kuvhiyiwa kubvisa gland rese re thyroid (kuvhiyiwa kwe thyroid rese) . Kunyangwe izvi zvingaita sekunge kuvhiyiwa kukuru, ndiyo nzira yakanakisisa yekurapa gomarara iri.

• Kubviswa kwemasero emudumbu: Kana kenza yemudumbu yakapararira (yakapararira) kusvika kumamasero emudumbu ari mumutsipa wako, chiremba wezvekuvhiya angangobvisawo.
• Kurapa neMahormone: Mushure mekuvhiyiwa, uchafanirwa kutora mishonga yekutsiva mahormone ethyroid hupenyu hwako hwese. Nekuti mahormone anogadzirwa nethyroid gland akakosha mumuviri, anofanira kupihwa kunze kwemuviri semapiritsi.

Kuwedzera pakuvhiyiwa, chiremba wako anogona kukurudzira mamwe marapirwo, anosanganisira:

• Kurapa nemwaranzi: Nzira yekuparadza masero ekenza uchishandisa mwaranzi ine simba rakawanda.
• Kurapa nemakemikari: Nzira yekushandisa mishonga kuuraya masero ekenza.
• Mishonga yakanangana: Mune dzimwe nguva MTC, mishonga chaiyo inongonangana nekuchinja kweDNA chete ndiyo inoshandiswa. Mienzaniso inosanganisira vandetanib na cabozantinib .

Mushure mekurapwa kweMTC, chiremba wenyu anogara achiongorora mazinga eCEA neCalcitonin yenyu kuburikidza nekuongororwa ropa. Izvi zvichavabatsira kuziva kuti kurapa kwacho kunoshanda sei uye kana kenza yadzoka.

MTC igomarara rinogona kuva nehasha kupfuura mamwe marudzi egomarara rethyroid akajairika. Zvisinei, kana rikawanikwa risati rapararira kumalymph nodes mumutsipa kana kune dzimwe nhengo dzemuviri, zviri nyore kurapa, kurapa, uye kudzora.

Chii chingave chiri fungidziro yemunhu ane kenza yemedullary thyroid (MTC)?

Kufanotaura, kana kuti maonero, kune munhu ane MTC zvinoenderana nezvinhu zvakati wandei.

• Danho rekenza (ndiko kuti, kuti kenza yapararira kusvika papi).
• Kana kenza yapararira (yakapararira) kune dzimwe nhengo dzemuviri.
• Kubviswa kwebundu rekenza rakawanda sei panguva yekuvhiyiwa.
• Zera rako nehutano hwako hwese.

Kufanotaura kweMTC kazhinji hakuna kunaka sekenza yepapillary thyroid uye kenza yefollicular thyroid . Zvisinei, kana iwe nachiremba wako mukawana MTC nekukurumidza, inogona kuporeswa zvachose nekuvhiyiwa . Kunyangwe kana kuongororwa kwacho kunonoka, MTC inowanzopararira (inotowedzera kuipa) zvishoma nezvishoma .

Mikana yekupora inogona kunge yakaderera zvishoma kune vanhu vakaita seava:

• Vanhu vane makore anopfuura makumi matanhatu nemashanu ekuberekwa.
• Vanhu vari padanho repamusoro regomarara.
• Avo vane kenza isina kubviswa zvachose panguva yekuvhiyiwa.

Ndeipi nguva yekurarama nekenza yemedullary thyroid (MTC)?

Kana zvasvika pahuwandu hwevanhu vane MTC vanorarama, tsvakiridzo yazvino inoratidza kuti huwandu hwevanhu vanorarama kwemakore mashanu padanho rekutanga, rechipiri, nerechitatu reMTC hunosvika 93%. Zvisinei, padanho rechina, huwandu uhwu hunoderera kusvika 28%.

Zvisinei, chinhu chakakosha apa ndechekuti nekuda kwekuti vanhu vashoma vanobatwa neMTC vanoshumwa gore rega rega, mwero wekurarama kwavo ungasave wakarurama. Chikwata chenyu chekurapa chichakupai pfungwa iri nani yezvamunotarisira.

Ndeupi musiyano uripo pakati pekenza ye papillary ne medullary thyroid cancer?

Zvino pamwe uri kuzvibvunza kuti, 'Musiyano uripo pakati peMTC iyi nedzimwe mhando dzegomarara rethyroid ndeupi?'

Kenza yethyroid yepapillary ndiyo inonyanya kuwanikwa mukenza yethyroid . Ndiyo inoumba 80% yezvirwere zvegomarara rethyroid. Zvisinei, gomarara rethyroid remedullary (MTC) hariwanzoitiki .

Musiyano mukuru uri mumasero anotangira mhando mbiri idzi dzekenza.

• Kenza yethyroid yePapillary inotanga mumasero e follicular ari mu thyroid gland yako anogadzira thyroglobulin, protein.
• MTC inokura kubva kumasero eC ari mugland re thyroid anogadzira calcitonin . Calcitonin ihormone.

Chimwe chinhu ndechekuti kenza yethyroid yepapillary inowanzobatanidzwa nekuratidzwa kwemwaranzi, asi hapana hukama hwakajeka neMTC.

Pakupedzisira, yeuka izvi.

Kunzwa kuti une kenza, zvisinei nerudzi rwechirwere, chinhu chinotyisa zvikuru. Tese tinozviziva izvozvo. Asi kana zvasvika kune kenza yemedullary thyroid (MTC) , yeuka kuti inopindura zvakanaka kana ikaonekwa nekukurumidza .

Kunyangwe chikonzero chaicho chezviitiko zvakawanda zveMTC chisingazivikanwe, pane hukama hwakasimba nezvirwere zvenhaka. Saka, kana iwe kana nhengo yemhuri yepedyo (hama yepedyo - vabereki, vanun'una, vana) vakaonekwa vaine MTC, zvakakosha kuti muedze majini. Izvi zvinogona kubatsira zvikuru iwe nemhuri yako.

Kana muine mibvunzo nezvenjodzi yenyu yekubatwa neMTC, musatya kutaura nachiremba wenyu. Vanogara varipo kuti vakubatsirei uye vapindure mibvunzo yenyu. Chinhu chinonyanya kukosha ndechekugara muchiziva, kugara muchiziva, uye kutora matanho anodiwa.

` Kenza yegomarara remudumbu, MTC, gomarara regomarara, zviratidzo zvegomarara, kuyedzwa kwemajini, MEN2, kuvhiyiwa kwegomarara