Chii chinonzi HNPCC (Hereditary Nonpolyposis Colorectal Cancer)? Pane nhoroondo yekenza mumhuri yako here?

Dzimwe nguva tinoona kuti nhengo dzinoverengeka dzemhuri dzinoita kenza yerudzi rumwe chete. Kana kuti zvinonzi nhengo dzemhuri imwe chete dzine mukana mukuru wekuwana chirwere ichi. Ndizvo zvatichataura nezvazvo nhasi. Kunyangwe iyi iri nyaya yakaoma, ngatiedzei kuinzwisisa zviri nyore.

Chii chinonzi HNPCC neLynch Syndrome?

Muchidimbu, HNPCC (Hereditary Nonpolyposis Colorectal Cancer) imhando yegomarara remudumbu rinokonzerwa nekuchinja kwemajini. Izvi zvinodaro nekuti mamwe majini atinogara nhaka kubva kuvabereki vedu anoita kuti tive negomarara remudumbu.

Ungave wakambonzwa nezveLynch syndrome, iyo inonziwo Lynch syndrome . HNPCC neLynch syndrome zvine hukama, asi hazvina kufanana. Isu tinonyanya kutaura nezveHNPCC sekenza ine chekuita neLynch syndrome inowanikwa isati yasvika makore makumi mashanu. Izvi zvinogona kusanganisira kwete kenza yemuura chete, asiwo kenza yemukati mechibereko (endometrium), ura hudiki, ureter, uye pelvis yetsvo. MuHNPCC, kenza inonyanya kuwanikwa kurudyi kweura.

HNPCC yakajairika zvakadii?

HNPCC inoumba pakati pe2% ne4% yekenza yemudumbu. Inogona kuitika chero pazera ripi zvaro, asi zviratidzo zvinowanzoonekwa uye chirwere ichi chinoonekwa vasati vasvitsa makore makumi mashanu.

Ndezvipi zviratidzo zveHNPCC?

Pakutanga, HNPCC inogona kusakonzera zviratidzo. Izvi zvinoreva kuti kenza inogona kukura mumuviri wako usinganzwe chero chinhu. Asi kenza painokura, unogona kuona zviratidzo zvakaita se:

• Kurwadziwa kwemudumbu kana kuzvimba.
• Chikafu hachina kunaka.
• Ropa riri mutsvina. (Ichi chiratidzo chakakosha, usachiregeredza!)
• Kunzwa kuneta nguva dzese (Kuneta).
• Kuderedza uremu pasina chikonzero chakajeka.

Ndezvipi zvikonzero zveHNPCC?

Sezvatakambotaura, HNPCC inokonzerwa nekuchinja kwemajini kunobva kuvabereki vedu. Kana zvikanganiso izvi zvemajini zvikapfuudzwa kubva kuchizvarwa kuenda kune chimwe, njodzi yekubatwa nekenza inowedzera mumhuri iyoyo. Tinoidaidza kuti 'chirwere chekenza yemhuri'.

Chirwere chikuru chegomarara remhuri chinokonzera HNPCC iLynch syndrome . Chinokonzerwa nekuchinja kwemajini MLH1, MSH2, MSH6, PMS2, uye EPCAM . Basa remajini aya nderekugadzirisa zvikanganiso zvinoitika panguva yekudzokororwa kweDNA apo masero edu anopatsanuka. Fungidzira, kana majini aya asiri kushanda nemazvo, zvikanganiso izvozvo hazvigadziriswe. Ipapo mikana yekuti masero akajairwa ave masero egomarara yakakwira zvikuru.

HNPCC inotapukira here?

Kwete, HNPCC haisi chirwere chinotapuriranwa. Izvi zvinoreva kuti hachitapurirwi kubva kumunhu mumwe kuenda kune mumwe nekubata kana kuhotsira. Zvisinei, kuchinja kwemajini kunokonzera HNPCC kunopfuudzwa kubva kuchizvarwa kuenda kune chimwe chizvarwa . Nokudaro, nhengo dzinoverengeka dzemhuri dzine kuchinja kwemajini uku dzinogona kuva nekenza yemuura kana mamwe magomarara ane chekuita neLynch syndrome.

Chinhu chakakosha ndechekuti majini aya asina kunaka uye njodzi yekubatwa neHNPCC zvinogona kugarwa nhaka kubva kuvabereki kuenda kuvana.

Vanachiremba vanoongorora sei kenza yemudumbu?

Vanachiremba vanowanzoita ongororo yemuviri kuti vaone kana kenza yemuura. Vanobva vakurudzira kuti upinze chubhu diki ine chiedza kuburikidza nepaburi remudumbu kuti uongorore mukati memuura.

Kana paine munhu mumhuri yako ane HNPCC, unofanira kuudza chiremba wako . Zvakakosha zvikuru.

Ndedzipi bvunzo dzinoitwa kusimbisa HNPCC?

Chiremba wako anogona kukurudzira kuongororwa kwemajini kuti uone kana uine gene mutation inobatanidzwa neLynch syndrome. Chiremba wako achakubvunzawo nezve:

• Pane mumwe munhu wemumhuri mako (amai, baba, vanun'una kana hanzvadzi) akamborwara nekenza yemuura here? Kunyanya kana yakamboonekwa isati yasvika makore makumi mashanu.
• Zvinoitawo kuti uve nechokwadi chekuti hauna imwe kenza yemudumbu inogarwa nhaka inonzi Familyal Adenomatous Polyposis (FAP) , iyo inokonzerwa nekuchinja kwemajini kwakasiyana neHNPCC.

Kuvhiyiwa kunodiwa here paHNPCC?

Ehe, HNPCC inowanzo shandiswa kuvhiya. Kuvhiya uku kunonzi colectomy . Kunosanganisira kubvisa chikamu cheura kana ura hwese. Kune mhando dzakasiyana dzekuvhiya:

• Kubviswa kwechikamu chedumbu kana kuvhiyiwa kwechikamu chedumbu: Mukuita izvi, chikamu chedumbu chine kenza chete ndicho chinobviswa.
• Kubviswa kweproctectomy: Izvi zvinosanganisira kubviswa kweura guru nerectum.
• Kubviswa kwemasero ese emudumbu: Mukuita izvi, ura hwese hunobviswa.

Ndedzipi dzimwe nzira dzekurapa dziripo dzeHNPCC?

Kana kenza yemuura yapararira (yakapararira) kune dzimwe nhengo dzemuviri, chiremba wako anogona kukurudzira kurapwa kwakadai se:

• Kurapa nemakemikari: Izvi zvinosanganisira kupa mishonga inoparadza masero ekenza.
• Kurapa nekudzivirira kenza: Izvi zvinosanganisira kukurudzira masoja emuviri wedu kuti arwise masero ekenza.

Vanachiremba vanowanzo farira kurapwa nemuviri nekuti kazhinji kunoshanda zvakanyanya uye hakuna migumisiro yakawanda.

HNPCC inogona kudzivirirwa here?

Matambudziko egomarara aya anokonzerwa nekuchinja kwemajini kwakagara nhaka. Saka, hapana nzira yekudzivirira kuchinja kwemajini uku kuti kusaitike . Zvisinei, kana mumwe munhu mumhuri yako aine chirwere cheLynch syndrome kana HNPCC, zvakakosha kutaura nachiremba wako nezvekuti unofanirawo kuongororwa majini here.

Kuongororwa nguva dzose uye, kana zvichidikanwa, kuvhiyiwa kwekudzivirira kunogona kuderedza njodzi yekufa kwevanhu vane HNPCC.

Ndingaziva sei kana ndiri panjodzi yekubatwa neHNPCC?

Kana kuongororwa kwemajini kukaratidza kuti une gene mutation inokonzerwa neLynch syndrome, chiremba wako anogona kukurudzira kuongororwa kenza yemudumbu kutanga mumakore ako ekuma20 . Kana kenza ikaonekwa nekukurumidza, mikana yekurapwa inobudirira yakanyanya.

Kana ndine HNPCC, chii chimwe chandinofanira kutarisira?

Kana uine HNPCC, unogona kunge uri panjodzi huru yekubatwa nedzimwe kenza dzine chekuita neHNPCC. Saka chiremba wako anogonawo kugara achikuongorora mhando idzi dzekenza:

• Kenza yehuropi
• Kenza yeitsvo
• Kenza yechiropa
• Kenza yemudumbu
• Kenza yemudumbu
• Kenza yeganda
• Kenza yechibereko/Endometrial

HNPCC inogona kurapwa here?

Lynch syndrome haigone kurapwa zvachose nekuti chirwere chinokonzerwa nemajini. Zvisinei, kuvhiyiwa kubvisa ura hwese (total colectomy) kunogona kurapa HNPCC uye kudzivirira kukura kwekenza yeura .

Chii chingave chiri fungidziro yevanhu vane HNPCC?

Vanhu vanosvika 60% vakaonekwa vaine HNPCC vachiri vapenyu mushure memakore mashanu . Izvi zvinoreva kuti varwere makumi matanhatu pa100 vachiri vapenyu mushure memakore mashanu mushure mekuonekwa kwavo neHNPCC. Huwandu hwevanhu vane Lynch syndrome hwekurarama kwemakore gumi huri pakati pe70% ne88%. Nhamba idzi dzingaita sedzinotyisa, asi yeuka kuti nekuonekwa nekukurumidza uye kurapwa kwakakodzera, chirwere ichi chinogona kudzorwa zvakanyanya .

Ndingazvitarisira sei kana ndine HNPCC?

Kana uine zviratidzo zvitsva zvegomarara remuura, udza chiremba wako nekukasika . Kuti ubatsire kudzivirira gomarara remuura, unogona kuita zvinhu zvinotevera:

• Dzivisa kusvuta.
• Idya chikafu chine hutano.
• Rovedza muviri nguva dzose.
• Wana kuongororwa kwegomarara kwese kwawakakurudzirwa nachiremba wako.
• Deredza kunwa doro.
• Ramba uine huremu hwakanaka.

Mwana wangu ari panjodzi yekubatwa nechirwere cheHNPCC here?

Kana uine chirwere cheLynch syndrome, mwana wako ane mukana we50% wekugara nhaka gene mutation inoikonzera. Izvi zvinoreva kuti kana uine vana vaviri, mumwe anogona kugara nhaka gene uye mumwe anogona kusagara nhaka. Kana gene mutation yakadaro ikagara nhaka, mwana iyeye ane mukana wakakura wekuva neHNPCC.

Ko kenza yeFAP neHNPCC muura yakafanana here?

HNPCC neFAP (Familial Adenomatous Polyposis) ese ari maviri magene colon cancer, asi anokonzerwa nekuchinja kwemajini akasiyana .

Vanhu vane FAP vanokura mapolyps akawanda muura hwavo. Dzimwe nguva kune zviuru zvezvipenyu zvidiki izvi zvinonzi mapolyps. Zvisinei, vanhu vane HNPCC havakure mapolyps akawanda, uye dzimwe nguva kenza inogona kukura isina mapolyps. Mapolyps anokura muHNPCC anowanzova akati sandara.

Mapolyps anokura mumamiriro ese aya anoonekwa seasina kenza , zvichireva kuti anogona kushanduka kuita kenza munguva pfupi.

Zvinhu zvinonyanya kukosha zvatinofanira kurangarira kubva munyaya iyi ndeizvi:

HNPCC (Hereditary Nonpolyposis Colorectal Cancer) imhando yegomarara remudumbu rinokonzerwa nekusakwana kwemajini kunopfuudzwa nezvizvarwa. Inobatanidzwawo neLynch syndrome.

• Kana paine nhoroondo yemhuri yekenza, zvakakosha zvikuru kutaura nachiremba wako nezvazvo.
• Kunyangwe usina zviratidzo, kana uri panjodzi , gara uchiongororwa nguva nenguva.
• Kana zvikaonekwa nekukurumidza, kurapwa kunobudirira.
• HNPCC haisi chirwere chinotapukira, asi chinogona kugarwa nhaka semajini.
• Zvakakosha zvikuru kurarama hupenyu hune hutano uye kutevedzera mazano echiremba.

Kana muine mimwe mibvunzo nezvenyaya iyi, musatya kubvunza chiremba wenyu. Vachakubatsirai.

HNPCC , chirwere cheLynch, kenza yemudumbu, kenza yemuura, kenza yemudumbu, kushanduka kwemajini, kenza yenhaka, kuongororwa kwekenza, colonoscopy, kuvhiyiwa, chemotherapy, immunotherapy