Une gastrin yakawandisa mudumbu here? Ngatitaurei nezve (Hypergastrinemia)!

Unowanzo nzwa kusagadzikana mudumbu, kuguta, kana mamwe matambudziko ekugaya here? Dzimwe nguva chikonzero cheizvi chingave chekuti huwandu hwehormone inonzi `(Gastrin)` inogadzirwa mumuviri wako hwakakwira kupfuura zvakajairika. Nhasi, tichataura nezvechirwere ichi chinonzi `(Hypergastrinemia)` zvakadzama uye zviri nyore.

Chii chinonzi `(Hypergastrinemia)`? Ngatinzwisisei chaizvo!

Zvichitaurwa zviri nyore, `(Hypergastrinemia)` zvinoreva kuti huwandu hwe`(Gastrin)`, hormone inobatsira muviri wedu kugaya chikafu, hwakakwira kupfuura zvinodiwa. Iyi hormone `(Gastrin)` inogadzirwa nerudzi rwakakosha rwesero riri mudumbu riri muchikamu chezasi chedumbu redu, ndiko kuti, pedyo neura hudiki. Tinodaidza izvi kuti `(G cells)`.

Zvino tarisai, iyi hormone ye`(Gastrin)` ndiyo inoudza dumbu redu kuti, "Zvakanaka, zvino buritsa acid." Iyi acid yemudumbu, kureva `(gastric acid), inokosha zvikuru kwatiri. Nekuti, iyi acid yemudumbu inotibatsira kugaya chikafu chatinodya uye kupinza zvinovaka muviri zviri muchikafu ichocho, semuenzaniso `(amino acids)` nemapuroteni.

Zvisinei, zvinogona kuitika ne `(Hypergastrinemia)` zvakaoma zvishoma. Dzimwe nguva zvinogona kukonzera acid yakawanda mudumbu (`hyperchlorhydria`), uye dzimwe nguva zvinogona kukonzera acid shoma mudumbu (`hypochlorhydria`). Saka kuti `(Hypergastrinemia)` inokukanganisa sei zvinoenderana nezvimwe zvirwere zvawakaita, kuvhiyiwa kwawakaitwa, uye mishonga yauri kutora.

Ndiani ane mukana mukuru wekuwana chirwere ichi?

Kutaura zvazviri, chirwere ichi chinonzi "Hypergastrinemia" chinogona kuitika kune chero munhu, zvisinei nezera kana kuti murume kana mukadzi. Saka, zvakanaka kuti tose tizive izvi.

Ndezvipi zvinokonzera `(Hypergastrinemia)`?

Panogona kuva nezvikonzero zvakawanda zvechirwere ichi, zvinosanganisira "Hypergastrinemia." Zvimwe zvinokonzera kudzikira kwekugadzirwa kweasidhi mudumbu, nepo zvimwe zvichiwedzera kugadzirwa kweasidhi mudumbu. Ngatizvitarisei zvakasiyana.

Zvinokonzera kuderedzwa kweacid mudumbu

Kana "Hypergastrinemia" ikaitika, kugadzirwa kweasidhi mudumbu kunogona kudzikira nekuda kwezvikonzero zvinotevera:

• Mishonga inorwisa asidhi yekurwadziwa kwechirungurira kana chirwere cheGERD (Gastroesophageal Reflux Disease): Kana ukashandisa mishonga iyi nguva dzose , izvozvo zvinogonawo kuva chikonzero.
• Gastritis isingaperi: Apa ndipo apo madziro emudumbu anoderera zvishoma nezvishoma uye anozvimba nekufamba kwenguva.
• Kenza yemudumbu: Izvi zvinogonawo kukanganiswa.
• Utachiona hwe`(H. pylori)`: `(Helicobacter pylori)` ibhakitiriya inogona kugara mudumbu. Utachiona uhwu hunokonzerawo `(Hypergastrinemia).`
• Kutadza kushanda kweitsvo: Dambudziko iri rinogona kuitika kana itsvo dzisiri kushanda zvakanaka.
• Kushandisa Proton Pump Inhibitors (PPIs):Kushandisa kwenguva refu mishonga yePPI (yakadai seomeprazole) yekurapa gastritis, acid reflux, indigestion, kana chirwere chepeptic ulcer ndicho chimwe chezvikonzero zvikuru.
• Kubvisa nhengo dzemuviri: Izvi zvinosanganisira kubvisa chikamu chetsinga yemudumbu. Tsinga iyi inomhanya kubva muuropi ichienda mudumbu uye inotakura zviratidzo kumoyo nekugaya chikafu. Hypergastrinemia inogona kuitika mushure mekuvhiyiwa uku.

Zvikonzero zvekuwedzera kweacid mudumbu

Zvino ngatitarisei zvinokonzera kuwedzera kwe acid mudumbu (Hypergastrinemia):

• Antral G-cell hyperplasia (pseudo-Zollinger-Ellison syndrome / Ps-ZES): Ichi chirwere chisingawanzoitiki. Chakafanana neZollinger-Ellison syndrome, asi hapana bundu rinogadzira gastrin mupancreas kana chikamu chekutanga cheura diki (duodenum).
• Kuvharika kwenzira yekubudisa mvura mudumbu: Dambudziko iri rinogona kuitika kana nzira inoenda mudumbu ichipinda muura hudiki yavharika. Funga nezvazvo sepombi yemvura yakavharika.
• Multiple endocrine neoplasia type-1 (MEN-1): Chirwere ichi chinokonzera kuti bundu re neuroendocrine rikure muma adrenal glands, thyroid glands, kana parathyroid glands.
• Chirwere che "retained antrum syndrome": Chirwere ichi chinogona kuitika kana chikamu chidiki chepazasi pedumbu ( "antrum" " ...
• Zollinger-Ellison syndrome (ZES): Ichi chirwere apo bundu rinoita kuti gastrin iwedzere. Chirwere ichi (ZES) chinogona kukonzera maronda emudumbu.

Ndezvipi zviratidzo zvechirwere chinonzi `(Hypergastrinemia)`?

Kana uine `(Hypergastrinemia)`, unogona kuona zviratidzo zvakaita seizvi:

• Kurwadziwa mudumbu: Unogona kurwadziwa mudumbu kakawanda.
• Manyoka asingarapiki: Manyoka anogara kwemazuva akati wandei.
• Matumbu epancreatic: Aya anogona kunge ari matumbu ane kenza kana kuti asina njodzi.
• Maronda emudumbu: Maronda anoitika nekuzvimba kwemudumbu.
• Kuzvimba kwakanyanya uye kurwadziwa mugumbo.

Vanachiremba vanoongorora sei chirwere ichi?

Kuti vaongorore chirwere che hypergastrinemia nemazvo, vanachiremba vanofanira kuona kuti mudumbu mako mune acid yakawanda sei. Vanoyerawo huwandu hwe gastrin muropa rako.

• Chiremba wako achakuudza kuti utsanye (usadye) kwenguva yakati usati waongororwa.
• Zvakare, kana uri mushandisi we ``(PPI)``,Uchafanira kurega kutora mushonga iwoyo vhiki imwe chete usati waongororwa.
• Zvadaro, vanotora sampuro yeropa rako votarisa mazinga eGastrin yako. Dzimwe nguva, vanogona kutora sampuro idzi dzeropa kakawanda pazuva, kwemazuva akati wandei, kuti vaone kana mazinga eGastrin yako achichinja.

Kana chiremba wako achifungidzira kuti ane hypergastrinemia, anogona kuraira mimwe miedzo kuti aone kana paine zvimwe zvirwere, zvinosanganisira:

• Kuongororwa kweSecretin stimulation: Izvi zvinosanganisira kukupa hormone inonzi secretin, inogadzirwa nechikamu chekutanga cheura hwako hudiki (duodenum). Kana huwandu hwegastrin yako hukawedzera zvakanyanya, inogona kunge iri chiratidzo cheZollinger-Ellison syndrome.
• Kuongororwa kwepH yedumbu: Izvi zvinoongorora huwandu hweasidhi mudumbu mako. pH iri pasi pe2 chiratidzo chekuti ungangove uine Zollinger-Ellison syndrome.

Hypergastrinemia inorapwa sei?

Kurapa kwe hypergastrinemia kunoenderana nechikonzero chacho.

• Kenza yemudumbu, kuvharika kwegurokuro, chirwere cheitsvo, uye zvirwere zvakaita se `(MEN-1)` uye `(ZES)`: Kana zvirwere izvi zvikarapwa (kazhinji kuburikidza nekuvhiyiwa), zviratidzo zve `(Hypergastrinemia)` zvinoperawo.
• Atrophic gastritis (ACG) uye H. pylori infection: Matambudziko aya anogona kurapwa nemishonga inorwisa mabhakitiriya.
• Proton-pump inhibitors (PPIs): Kana uri kutora PPI, hypergastrinemia inowanzopera mukati memazuva mashanu kusvika manomwe mushure mekumira kushandisa mushonga.
• Retained antrum syndrome: Kubvisa nyama yemudumbu yasara iri pasi pedumbu kunogona kuderedza huwandu hweasidhi yemudumbu inogadzirwa.

Chinhu chinonyanya kukosha ndechekutaura nachiremba wako nezvekurapa kwakanakira chirwere chako.

Ndingaderedza here njodzi ye `(Hypergastrinemia)`?

Kana uri kushandisa mishonga inorwisa mabhakitiriya kana maPPI kwenguva yakareba, pane njodzi yekubatwa ne hypergastrinemia. Saka, zvakakosha kutaura nachiremba wako nezvekuti ungagadzirisa sei njodzi iyi.

Kana ndiine `(Hypergastrinemia)`, chii chandingatarisira? Chii chinoitika kana chikasarapwa?

Kana hypergastrinemia ikasarapwa nemazvo, huwandu hwemudumbu hunoramba hwakakwira. Vaongorori vanofungidzira kuti izvi zvinogona kukonzera kukura kwemasero ekenza. Semuenzaniso:

• Kenza dzeropa: dzakadai seleukemia, lymphoma, uye multiple myeloma.
• Kenza yemudumbu
• Kenza yepancreatic

Uyewo, `(Hypergastrinemia)` yenguva refu inogona kutungamira kumabundu emudumbu `(gastric carcinoids)` kana `gastric adenocarcinoma`. Kune mhando mbiri dze`(gastric carcinoids)`:

• Rudzi rwekutanga rwecarcinoids mudumbu: Izvi zvine chekuita nechirwere che chronic atrophic gastritis.
• Zvinowanzoitika kuvakadzi.
• Inogona kuonekwa munzvimbo dzakasiyana-siyana mudumbu.
• Mikana yekubatwa negomarara yakaderera.
• Rudzi rwechipiri rwecarcinoids yemudumbu: Izvi zvine chekuita nemamiriro ezvinhu eZES neMEN-1.
• Zvinogona kuitika kuvarume nevakadzi.
• Inogona kuonekwa munzvimbo dzakasiyana-siyana mudumbu.
• Dzimwe nguva zvinogona kuchinja kuita kenza (pakati pe7% ne12%).

Ndeipi tarisiro yemunhu ane `(Hypergastrinemia)`?

Hutano hwemunhu ane "Hypergastrinemia" hunoenderana nezvinhu zvakati wandei:

• Chikonzero chechirwere.
• Majini.
• Nhoroondo yehutano.
• Mararamiro.

Zvisinei, kana vakarapwa zvakanaka, vanhu vane "Hypergastrinemia" vanogona kurarama hupenyu hwemazuva ese.

Ndine `(Hypergastrinemia)`, ndingazvitarisira sei?

Kana uchitora mishonga inorwisa asidhi kana maPPI kwenguva yakareba, zvakakosha kuti ugare uchiongororwa nachiremba. Bvunza chiremba wako kuti akupe mazano.

Ndinofanira kuona chiremba rini?

Kana ukaona chimwe chezviratidzo zvitsva izvi, kana kuti uchinzwa kuti zviratidzo zvako zviri kuramba zvichiwedzera kuipa, iva nechokwadi chekuona chiremba woongororwa zvizere.

Zvinhu zvekurangarira muchidimbu

Zvakanaka saka, ngatirangarirei zvatakataura nezvazvo:

• Hypergastrinemia kuwedzera kwehomoni ye gastrin mumuviri.
• Homoni iyi (Gastrin) inokanganisa huwandu hweasidhi mudumbu (asidhi inogona kuwedzera kana kuderera).
• Panogona kuva nezvikonzero zvakawanda - zvinhu zvakaita se `(PPI)`/kushandisa mishonga inorwisa asidhi nguva dzose, `(H. pylori)` utachiona, gastritis, `(Zollinger-Ellison syndrome)`.
• Vanachiremba vanoongorora izvi nekuongorora huwandu hwe "Gastrin".
• Kurapa kunoenderana nechikonzero chaicho.
• Usaregeredza zviratidzo, nekuti zvinogona kukura kuita bundu negomarara kana zvikasarapwa! Tsvaga rubatsiro rwechiremba nekukasika.

Ndinovimba kuti ruzivo urwu runobatsira. Ramba uine hutano hwakanaka!

` Hypergastrinemia, Gastrin, Dumbu, Kugaya, Zollinger-Ellison syndrome, H. pylori, PPI, Gastritis, Kuzvimba kweDumbu