Zvaunofanira kuziva nezve Luminal B Breast Cancer!

Pamwe wakanzwa zvakawanda nezvegomarara remazamu. Asi waiziva here kuti kune mhando dzakasiyana dzegomarara remazamu? Nhasi tichataura nezvegomarara remazamu rinonzi Luminal B. Zita iri ringanzwika serakaoma, asi usazvidya moyo. Tichataura nezvaro nenzira iri nyore yaunogona kunzwisisa. Nekuti kuziva zvinhu zvakaita seizvi kunogona kukosha zvikuru kwauri nevadikanwi vako.

Chii chinonzi Luminal B? Ndezvipi zvinhu zvayo zvakakosha?

Zvichitaurwa zviri nyore, Luminal B imhando yekenza yemazamu ine hormone receptor-positive (HR+). Izvi zvinokonzerwa nekuti mamwe mapuroteni (receptors) ari mukati memasero ekenza anosunga kuhormone estrogen, zvichiita kuti kenza ikure. Izwi rekuti "luminal" rinoreva masero ari mukati memigero yemukaka muzamu rako. Funga nezvayo semukati mechubhu.

Iye zvino ngatitarisei zvimwe zvinhu zvakakosha zvemasero ekenza yeLuminal B. Izvi zvakafanana nekadhi rekuziva kenza iyi. Vanachiremba vachanyatsoongorora zvinhu izvi kuti vasarudze kuti ndeipi nzira yekurapa yakakunakira.

• Estrogen receptor positive (ER+): Ichi ndicho chinhu chinonyanya kukosha. Masero ekenza yeLuminal B ane mapuroteni anonzi Estrogen Receptors (ER) anogona kubatana nehomoni yeEstrogen. Estrogen ihomoni inogadzirwa mumuviri wechikadzi. Saka, kana homoni iyi yakabatana nemasero ekenza, kenza inowana simba rekukura. Zvakafanana nekudiridza nekupa chikafu chirimwa.
• Mapuroteni Akaderera Kana Asina Kunaka eProgesterone receptors (PR- kana PR yakaderera): Zvichienzaniswa neLuminal A type yekenza yemazamu, masero eLuminal B ane mapuroteni mashoma, kana kuti dzimwe nguva hapana, anobatana nemamwe mahormone makuru echikadzi, progesterone.
• Mamiriro eHER2 (HER2-positive (HER2+) kana HER2-negative (HER2-)): Ichi chinhu chakakoshawo. HER2 inomiririra puroteni inonzi 'Human Epidermal Growth Factor Receptor 2'. Ichi chinhu chinowanzo batsira masero kukura. Zvisinei, mamwe masero ekenza yemazamu anogadzira puroteni iyi yeHER2 yakawandisa, zvisingadzoreki. Mukenza yeLuminal B, puroteni iyi yeHER2 inogona kuvapo yakawandisa (HER2-positive / HER2+), kana kuti inogona kuvapo pamazinga akajairwa (HER2-negative / HER2-). Nzira dzekurapa dzinosiyana zvichienderana nemamiriro aya.
• Mapuroteni akawanda eKi-67 (Akawanda muKi-67):Ki-67 ipuroteni yakakosha inowanikwa chete mumasero anokamuka nekukurumidza. Kenza dzeLuminal B dzinowanzova nehuwandu hwakakwira hwepuroteni iyi. Izvi zvinobatsira vanachiremba kunzwisisa kuti masero ekenza ari kumuka nekukurumidza sei, zvinoreva kuti kenza iri kukura nekukurumidza sei. Ndosaka kenza dzeLuminal B dzichikura nekukurumidza kupfuura kenza dzeLuminal A.
• Giredhi repamusoro: Giredhi regomarara rinoratidza kufanana kana kusiyana kwakaita masero egomarara nemasero ane hutano kana akatariswa pasi pemaikorosikopu. Giredhi repamusoro rinoreva kuti masero egomarara akasiyana zvikuru nemasero ane hutano uye anogona kukura nekupararira nekukurumidza. Gomarara reLuminal B rinowanzova giredhi repamusoro pane reLuminal A. Izvi zvinoreva kuti rine hukasha, rinogona kukura, uye rinogona kudzoka mushure mekurapwa.

Unogona kuona, mabhii ese aya, nhamba, uye mapfupiso (akaita seER, PR, HER2, Ki-67) anowedzera ruzivo rwakawanda nezvemasero ekenza ari muzamhu rako. Nekuongorora ruzivo urwu, vanachiremba vanogona kuronga kurapwa kwakagadzirirwa iwe uye kufanotaura mhando yemhedzisiro yaungatarisira kubva mukurapwa.

Kenza yemazamu yeLuminal B yakajairika zvakadii?

Zvino ungave uchishamisika kuti, 'Vanhu vangani vane chirwere ichi?' Kutaura zvazviri, pakati pe15% ne20% yevanhu vane kenza yemazamu pasi rose vane rudzi urwu rwekenza. Iyi idiki zvishoma pane rudzi rwakajairika runonzi Luminal A. Asi, chikamu ichi hachisi chidiki, handiti? Ndosaka zvichikosha kuziva izvi.

Ndezvipi zviratidzo zvekenza yemazamu yeLuminal B?

Kazhinji, vanachiremba vanogona kuzviona usati wava nezviratidzo, kuburikidza nekuongororwa kwemazamu nguva dzose , senge mammogram. Ndosaka zvichikosha kuti uedze bvunzo idzi pazera rako. Asi dzimwe nguva unogona kusangana nechimwe chezviratidzo izvi:

• Bundu riri muzamu: Iri rinowanzova bundu rakaomarara, rakaita serabha risingafambi nyore nyore.
• Kurwadziwa kwezamu: Unganzwa kurwadziwa mune rimwe kana mazamu ese ari maviri.
• Kubuda kwemuzamu: Unofanira kunetseka kana uine kubuda kwemuzamu, kunyanya kana kwakasanganiswa neropa .
• Kuchinja kweganda: Unogona kuona ganda richidzikira, richikora, kana kuti richichinja ruvara rweganda rezamu.
• Kuzvimba pasi pehapwa: Ma lymph nodes ari muhapwa anogona kuzvimba.

Kana ukaona chiratidzo chakadai,Usavhunduke wobva waona chiremba nekukasika. Haasi bundu rese rine kenza, asi kuchenjera kuti riongororwe.

Chii chinokonzera kenza yemazamu yeLuminal B?

Kutaura zvazviri, kenza yemazamu yeLuminal B inotanga apo masero emazamu ane hutano anongoerekana achinja-chinja otanga kukura zvisingadzoreki. Asi nyanzvi hadzisati dzaziva kuti nei izvi zvichiitika. Zvinogona kukonzerwa nezvinhu zvakasiyana-siyana.

Sezvatakambokurukura, masero eLuminal B ane mapuroteni anokurudzira kukura kwegomarara kana akasungana nehormone yeestrogen. Saka, kana mazinga eestrogen yako akakwira kwenguva yakareba, zvinogona kuwedzera njodzi yako yekubatwa negomarara iri. Semuenzaniso:

• Kana nguva yako yekuenda kumwedzi yakatanga kare kupfuura yakajairika, kureva kuti, usati wasvika makore gumi nemaviri.
• Kana kuti kana kuenda kumwedzi, zvinoreva kuti kuenda kumwedzi zvachose, kuchiitika mushure memakore makumi mashanu nemashanu.
• Kana kuti wave uchitora mushonga wekutsiva mahormone (HRT) kwenguva yakareba kuti udzore zviratidzo zvine chekuita nemenopause.

Kuwedzera kune izvi, kune zvimwe zvinhu zvakawanda zvinogona kuwedzera njodzi yekenza yemazamu yeLuminal B:

• Nhoroondo yemhuri: Kana amai vako, hanzvadzi yako, mwanasikana wako, kana hama yako yepedyo yakambova nekenza yemazamu kana kenza yemazai, uri panjodzi yakakura zvishoma.
• Zera: Njodzi yekubatwa nekenza yemazamu inowedzera mushure memakore makumi mashanu.
• Nyama yezamu yakakora: Kana nyama yezamu ikaita seyakakora pakuongorora mammogram, izvozvo zvinogonawo kukonzera njodzi.
• Kusiyana kwemajini: Kuchinja kwemajini kwakagara nhaka mune mamwe majini, akadai seBRCA1 neBRCA2, kunogona kuwedzera zvakanyanya njodzi yekubatwa nekenza yemazamu.
• Kurapwa nemwaranzi kare: Kana wakamborapwa nemwaranzi pachipfuva kana pazamu nekuda kwechimwe chikonzero.

Kuva nezvinhu izvi zvine njodzi hazvirevi kuti uchazobatwa nekenza zvechokwadi. Zvisinei, zvakakosha kuti uzvizive.

Ko chirwere chekenza yemazamu cheLuminal B chinoonekwa sei?

Fungidzira uine zviratidzo zvegomarara remazamu, kana kuti mammogram inoratidza chimwe chinhu chinofungira. Chinhu chekutanga chinoitwa nachiremba ndechekuongorora muviri. Izvi zvinoreva kuti vachaongorora mazamu ako kuti vaone kana paine mapundu kana zvimwe zvinhu zvakachinja.

Zvadaro, kuti vawane rumwe ruzivo, vanowanzo raira mimwe miedzo yemifananidzo yakaita seiyi:

• Kuongorora mammogram: Izvi zvine ruzivo rwakadzama kupfuura mammogram yenguva dzose.
• Kuongororwa kweUltrasound: Izvi zvinogona kubatsira kuona kana bundu rakasimba kana kuti cyst yakazara nemvura.
• Kuongororwa kweMRI (Magnetic Resonance Imaging): Izvi zvinogonawo kudiwa mune dzimwe nguva.

Mushure mekuongororwa uku, chiremba achatora sampuro yenyama yezamu (breast biopsy) oitumira kuti iongororwe. Iyi ndiyo nzira chete yekuziva kana kenza iripo here kana kuti kwete, uye kana iripo, rudzii rwayo. Kuongororwa kunosanganisira kutora chidimbu chidiki chenyama kubva panzvimbo inofungidzirwa wochitumira kurabhoritari kuti chiongororwe pasi pemaikorosikopu.

Nyanzvi yezvirwere, chiremba ane hunyanzvi mukuongorora nyama, achaongorora sampuro yenyama yako kuti aone kana paine masero ekenza. Kana masero ekenza akawanikwa, achaita bvunzo dzemahormone receptor (dzeER, PR) uye bvunzo dzeHER2 kuti aone rudzi rwekenza. Pabvunzo idzi, inonyanya kushandiswa bvunzo inonzi immunohistochemistry (IHC) . Iyi inoshandisa dyes dze fluorescent nema enzymes kuratidza mamorekuru chaiwo pamasero ekenza. Dzimwe nguva, mazinga eKi-67 anoongororwawo nenzira iyi.

Kuongororwa uku kwenyama yako kunogona kubatsira timu yako yezvekurapa kuziva kuti ndeapi marapirwo achakubatsira zvakanyanya, pamwe nekukupa pfungwa yekuti kenza inogona kudzoka sei mushure mekurapwa.

Luminal B inoshandiswa sei kurapa kenza yemazamu?

Kurapwa kwekenza yemazamu yeLuminal B kunogona kusiyana kubva pamunhu kusvika pamunhu. Zvinoenderana nezvinhu zvakawanda, kusanganisira mamiriro ako ega, danho rekenza, mamiriro ako eHER2 (HER2+ kana HER2-), huwandu hwako hweKi-67, uye hutano hwako hwese. Chikwata chako chekurapa chichafunga nezvezvinhu izvi zvese kuti chigadzire hurongwa hwakanakisa hwekurapa kwako.

Nzira huru dzekurapa dzinoshandiswa ndeidzi:

• Kurapa nehomoni: Sezvo Luminal B iri kenza inokonzerwa nemahomoni (HR+), iyi ndiyo nzira inonyanya kushandiswa pakurapa. Izvi zvinoshanda nekudzivirira hormone estrogen kusvika kumasero ekenza, kana nekuderedza huwandu hweestrogen mumuviri. Mishonga yakaita seTamoxifen neAromatase Inhibitors inoshandiswa pakuita izvi.
• Kuvhiyiwa: Izvi zvinosanganisira kubvisa masero ekenza kubva pazamu.
• Kubviswa kweLumpectomy: Izvi zvinosanganisira kubvisa bundu rekenza chete pamwe chete nenyama shoma dzakaripoteredza, zvichiita kuti zamu rose rirambe rakasimba.
• Kubviswa kwezamu: Izvi zvinosanganisira kubviswa zamu rose.

Panguva yekuvhiyiwa, ma lymph nodes ari muhapwa anogona kubviswa kuti zvionekwe kana kenza yapararira.

• Kurapa nemwaranzi:Mushure mekuvhiyiwa, kurapwa nemwaranzi kunopihwa kuuraya chero masero ekenza asara munzvimbo iyi. Izvi zvinowanzoitwa, kunyanya kana bundu rakabviswa.
• Kurapa kwakanangana: Rudzi urwu rwekurapa runotarisa mamorekuru chaiwo anobatsira masero ekenza kukura. Semuenzaniso, kana kenza yeLuminal B iri HER2-positive (HER2+), mishonga inotarisa puroteni yeHER2 (semuenzaniso Trastuzumab) inogona kupihwa. Izvi zvinotsanangurwa nedanho rekenza uye mamwe ma receptor profiles.
• Kurapa nemakemikari: Mishonga yekurapa inogona kupihwa kuuraya masero ekenza asina kuparadzwa nedzimwe nzira dzekurapa, kana kudzivirira kenza kuti isapararire kune dzimwe nhengo dzemuviri. Kenza dzeLuminal B dzinokura nekukurumidza kupfuura Luminal A uye dzine mazinga eKi-67 akakwira, saka izvi zvinokurudzirwa kune vamwe varwere vane njodzi huru. Chiremba wako achakuudza kana iyi iri sarudzo yakanaka kwauri.

Yeuka, kurapwa kwemunhu ane kenza yeHer2-positive (HER2+) Luminal B kunogona kusiyana nekurapa kwemunhu ane kenza yeHer2-negative (HER2-). Ndosaka zvichikosha kuziva zvese izvi zvine chekuita nekenza yako.

Ndeipi fungidziro yevanhu vane kenza yemazamu yeLuminal B?

Kufanotaura kana kuti tariro yekupona uye kuporeswa kwemunhu ane kenza yemazamu yeLuminal B kunoenderana nekuti bundu racho rakura sei kana raonekwa (danho rekenza). Sezvakaita chero kenza, paunotanga kurapwa nekukurumidza, mikana yako yekupona inowedzera.

Zvichienderana nedanho rekuonekwa kwechirwere ichi, kenza yemazamu yeLuminal B inorapika , zvichireva kuti chirwere ichi chinogona kupera kana munhu achirapwa. Zvisinei, chinogona kudzoka zvakare. Kenza yeLuminal B ine mukana wekudzoka zvishoma pane Luminal A.

Njodzi yekudzoka kwegomarara inoenderana nezvinhu zvakati wandei, zvinosanganisira danho rechirwere, kukura kwaro, mazinga eKi-67, mamiriro eHER2, uye maitiro ako ekurapwa. Saka, kunyangwe uri mudambudziko, chiremba wako acharamba achitarisa hutano hwako. Zvakakosha kugara uchiongororwa. Vanogonawo kukurudzira mamwe marapirwo (akadai sekurapa nemahormone) mushure mekuvhiyiwa uye kurapwa nemwaranzi kuderedza njodzi yekudzoka kwegomarara.

Mwero weKupona kweKenza yeMazamu yeLuminal B

Ngatitaurei zvishoma nezve nhamba idzi. Asi idzi ingori avhareji yemitengo.Unofanira kuyeuka kuti idzi hadzisi fungidziro dzakarurama dzekuti uchararama kwenguva yakareba sei kana kuti uchaita sei kana warapwa. Dzakavakirwa padata kubva kuboka guru revarwere.

• Huwandu hwevanhu vane kenza yemazamu yeHR+/HER2+ (hormone receptor positive/human epidermal growth factor receptor 2 positive) hunosvika 91.5% . Izvi zvinoreva kuti pavanhu zana vane kenza yerudzi urwu, vanenge 91 vachararama makore mashanu mushure mekuonekwa vaine chirwere ichi.
• Chikamu ichi chevanhu vane kenza yemazamu yeHR+/HER2- (hormone receptor positive/human epidermal growth factor receptor 2 negative) chinosvika 95.1% .

Chinhu chinonyanya kukosha ndechekutaura pachena nachiremba wako kuti unzwisise kuti nhamba idzi dzinokubatsira sei. Iye anogona kukutsanangurira nenzira yakakodzera mamiriro ako ega.

Luminal B inoderedza sei njodzi yekenza yemazamu?

Hatigone kuchinja zvimwe zvinhu zvine njodzi, zvakaita senhoroondo yemhuri yechirwere ichi. Zvisinei, kuchinja mararamiro kunogona kubatsira kuderedza njodzi yekubatwa nekenza yemazamu, kusanganisira luminal B:

• Dzivisa kusvuta: Kusvuta chinhu chinokonzera kenza dzakawanda.
• Wedzera kurovedza muviri: Zvakanaka kwazvo kurovedza muviri kwemaminitsi makumi matatu mazuva akati wandei pasvondo.
• Deredza kunwa doro: Zvakakosha kuderedza kunwa doro.
• Ramba uine huremu hwakanaka: Kuchengetedza huremu hwakanaka zvichienderana nehurefu hwako kwakakosha zvikuru, kunyanya mushure mekuguma kuenda kumwedzi.
• Kudya kwakaringana: Idya chikafu chine michero yakawanda, miriwo, uye zviyo zvakakwana.

Ndinozvitarisira sei? Ndinofanira kuitei kana ndichirarama negomarara?

Luminal B Kurarama negomarara rezamu kunogona kuva kwakaoma zvikuru, mumuviri nemupfungwa. Mamwe mazuva unganzwa zvakanaka, uye mamwe mazuva unganzwa wakaremerwa, wakashushikana, wakasuruvara, uye uchitya. Izvozvo zvakajairika. Saka, zvakakosha kuti uzvitarisire zvakanaka panguva yese yekuongororwa kwako nekurapwa.

Heano zvimwe zvinhu zvinogona kukubatsira:

• Idya zvakanaka: Idya chikafu chinovaka muviri. Isa michero, miriwo, mapuroteni asina mafuta akawanda, uye zviyo zvakakwana mukudya kwako. Kana uchinzwa kurasikirwa nechido panguva yekurapwa, bvunza chiremba wako kana nyanzvi yezvekudya.
• Tsvaga nzira dzekugadzirisa kushushikana:Unogona kuzorodza pfungwa dzako nekuita zvinhu zvakaita sekufungisisa, yoga, maekisesaizi ekufema, uye kuita chimwe chinhu chinokufadza.
• Zorora zvakakwana: Kurara zvakakwana kwakakosha zvikuru. Usashande zuva rese, tora nguva yekuzorora pakati.
• Joyina nharaunda inotsigira: Bvunza chiremba wako nezvezvirongwa zvekuponesa kenza kana mapoka ekutsigira. Mapoka aya anogona kukubatsira kusangana nevanhu vari kusangana nezvinhu zvakafanana newe, kugovana mazano, uye kuderedza kunzwa kwekusurukirwa. Mhuri yako neshamwari vanogonawo kuva sosi huru yerutsigiro.

Ndinofanira kuona chiremba rini?

Panguva yekurapwa uye mushure mekurapwa, kana ukaona zviratidzo zvitsva kana kuti zviratidzo zvako zvikawedzera, taurira chiremba wako nekukasika. Zvakare, taurira chiremba wako kana uchinzwa kurwadziwa kana kushaya simba mune chero chikamu chemuviri wako. Usapotsa nguva yako yekutevera.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Kana ukaona kuti une kenza yemazamu yeLuminal B, zvakajairika kuva nemibvunzo yakawanda mupfungwa dzako. Usatya kubvunza chiremba wako chero mibvunzo yaunayo. Heano mimwe mibvunzo yaunogona kubvunza:

• Ko kenza yangu ine HER2-positive here kana kuti HER2-negative?
• Ko kenza yangu iri papi uye idanho ripi?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Kurapa uku kunoshanda sei?
• Ndinofanira kuona chiremba kangani mushure mekurapwa (kutevera)?
• Ndezvipi migumisiro yekurapwa? Ndinofanira kugadzirisa sei?
• Chii chinonzi Ki-67 percentage yangu? Zvinorevei?
• Chii chaungandiudza nezve fungidziro yangu yechirwere ichi?

Kunzwa mashoko ekuti "une kenza" kunogona kuva chinhu chinotyisa kupfuura zvese chauchazombonzwa. Zvakajairika kuva nemibvunzo yakawanda ichimhanya mupfungwa dzako sezvaunogadzirisa mamiriro ezvinhu matsva aya uye kusava nechokwadi. Chikwata chako chekurapa chiripo kuti chikubatsire. Vimba navo. Nekenza yemazamu yeLuminal B, vanogona kugadzirisa hurongwa hwako hwekurapa zvichibva paruzivo rwuri padanho remamorekuru emasero ako. Taura nachiremba wako kuti udzidze zvakawanda nezvekuti mhedzisiro yako yerabhoritari ichakanganisa sei hurongwa hwako hwekurapa. Yeuka, hausi wega.

Pakupedzisira, zvinhu zvekurangarira (Mharidzo Yekuenda Kumba)

Kenza yemazamu yeLuminal B imhando yekenza yemazamu inonzwa mahormone uye inowanzokura nekukurumidza. Inonzi estrogen receptor (ER) positive (+), HER2 status inogona kuva yakanaka (+) kana kuti yakaipa (-), uye Ki-67 levels inowanzova yakakwira.

• Chenjerera zviratidzo:Kana ukaona bundu riri pazamu rako, kurwadziwa, kubuda kwemvura kubva muzamu rako, kana shanduko dzeganda, tsvaga rubatsiro rwechiremba nekukasika.
• Kuongororwa kwechirwere nemazvo kwakakosha: Kuongororwa kweropa (biopsy) nedzimwe nzira dzakafanana ndiyo chete nzira yekuziva rudzi chairwo rwegomarara.
• Kune nzira dzekurapa: kurapwa nemahormone, kuvhiyiwa, kurapwa nemwaranzi, kurapwa kwakanangana, uye chemotherapy. Chiremba wako ndiye achasarudza zvakakunakira.
• Kurapwa nekukurumidza kunoita kuti pave nemigumisiro iri nani: Kuongororwa nekukurumidza uye kurapwa kunowedzera mikana yekupora.
• Hausi wega: Kune vanachiremba, vanamukoti, mhuri, shamwari, uye boka rekutsigirana kuti vakubatsire parwendo urwu.

Tinovimba kuti ruzivo urwu rwakubatsira kunzwisisa chirwere ichi. Ramba uine hutano hwakanaka!

` Kenza yemazamu yeLuminal B, kenza yemazamu, mahormone receptors, estrogen, HER2, hunhu hwekenza, kurapwa kwekenza, hutano hwevakadzi