Ngatidzidzei nezveLynch Syndrome, iyo inowedzera njodzi yako yekubatwa nekenza.

Wakambonzwa here nezveshoko rekuti "Lynch Syndrome"? Iri ringave izwi idzva kwauri. Asi zvakakosha kuti isu tese tizive. Zvichitaurwa zviri nyore, Lynch Syndrome chirwere chinowedzera njodzi yekubatwa nekenza nekuda kwekuchinja kwemajini edu. Zvikuru sei, chinowedzera njodzi yekubatwa nekenza tisati tasvika makore makumi mashanu. Saka, ngatitaurei nezveizvi zvakadzama, handiti?

Chii chaizvo chinonzi Lynch Syndrome? Ndiani anoiwana?

Lynch syndrome chirwere chemajini chinogara nhaka . Kureva kuti, chinokonzerwa nekuchinja kwemajini mumajini atinotora nhaka kubva kuna amai kana baba vedu. Fungidzira kuti kana masero edu akapatsanuka, dzimwe nguva zvikanganiso zvidiki zvinogona kuitika. Miviri yedu ine majini akakosha anoona nekugadzirisa zvikanganiso izvi. Aya anonzi 'Mismatch Repair genes' (MMR genes). Munhu ane Lynch syndrome ane chikanganiso mune rimwe kana akawanda emajini aya e'MMR'. Zvadaro, zvimwe zvikanganiso hazvigone kugadziriswa kana masero iwayo akapatsanuka. Masero aya akakuvara anoungana ova kenza .

Izvi zvinogona kuitika kune chero ani zvake. Nekuti zvine chekuita nemajini. Dzimwe nguva, kunyangwe pasina munhu mumhuri akambova nechirwere ichi, munhu anogona kuchikonzera nekuda kwekuchinja kwemajini. Izvi zvinoreva kuti kungoti hapana nhoroondo yemhuri, hazvirevi kuti hazvizoitiki.

Zvichienderana nehuwandu hweUnited States, munhu mumwe chete pavanhu 279 anogona kunge aine chirwere cheLynch. Zvinonzi vanhu vanosvika 4,000 vane kenza yemudumbu uye vanosvika 1,800 vane kenza yemudumbu gore rega rega vanokonzerwa nechirwere cheLynch. Zvakakosha kuziva nezvechirwere ichi muSri Lanka zvakare.

Ndezvipi zviratidzo zveLynch syndrome?

Zviratidzo zvinogona kusiyana zvichienderana nekuoma kwechirwere uye rudzi rwekenza iri kukonzera. Zviratidzo zvinowanzoonekwa zvekenza yemudumbu zvinosanganisira:

• Ropa riri mutsvina yako.
• Kuzvimba kwemuviri .
• Kurwadziwa kwemudumbu kana kurwadziwa kwemudumbu.
• Manyoka kana tsvina diki pane zvakajairika.
• Kunzwa kuneta kwakanyanya nguva nenguva ('Kuneta').
• Kunzwa kuguta kana kuzvimba.
• Kusvotwa kana kurutsa.

Chinhu chakakosha ndechekuti vamwe vanhu vanogona kusaratidza zviratidzo kusvika kenza yakura zvakanyanya. Saka, kana uine chimwe chezviratidzo izvi, unofanira kuona chiremba nekukasika .

Ndeapi marudzi ekenza anogona kukonzerwa neLynch syndrome?

Izvi zvinogona kukanganisa nhengo dzakawanda dzemuviri. Heano mamwe marudzi egomarara anogona kukonzerwa neLynch syndrome:

• Kenza yehuropi
• Kenza yemudumbu nemudumbu - Iyi ndiyo hosha huru.
• Kenza yenyongo
• Kenza yechiropa
• Kenza yemudumbu
• Kenza yepancreatic
• Kenza yeprostate
• Kenza yeganda
• Kenza yemudumbu mudiki
• Kenza yemudumbu
• Kenza yemudumbu rekumusoro
• Kenza yechibereko (endometrial) - Imwe mhando yekenza inowanzobata vakadzi.

Kuchinja kuri kuita majini (`gene`) kunoratidza kuti ndeipi nhengo iri panjodzi huru yekubatwa nekenza. Kune majini mashanu makuru anobatanidzwa neLynch syndrome. Aya ndiwo: `MLH1`, `MSH2`, `MSH6`, `PMS2` uye `EPCAM`.

Kenza yemudumbu inokonzerwa neLynch syndrome inogona kukura nekukurumidza (mukati megore 1-2) kupfuura muvanhuwo zvavo. Kazhinji zvinotora makore angangoita gumi kuti kenza yemudumbu itange. Zvakare, munhu akambova nekenza yemudumbu ane mukana wakakura wekuwana kenza zvakare . Pane mukana we15% mukati memakore gumi ekuvhiyiwa kwekenza yekutanga, mukana we40% mukati memakore makumi maviri, uye mukana we60% mushure memakore makumi matatu.

Chii chinokonzera chirwere cheLynch?

Sezvambotaurwa, chikonzero chikuru cheizvi ikushanduka kwemajini mune rimwe kana kupfuura emajini mashanu anogadzirisa zvikanganiso muDNA yedu (jini re "mismatch repair" kana kuti "MMR gene"). Majini mashanu iwayo ndeaya:

• `MLH1`
• `MSH2`
• `MSH6`
• `PMS2`
• `EPCAM`

Kana uine chirwere cheLynch, majini ako e'MMR' haawani mirairo yaanoda kuti abvise masero akakuvara. Zvadaro masero iwayo akakuvara anoungana munyama uye anokonzera kenza.

Izvi zvinouya sei kubva kuchizvarwa kuenda kune chimwe chizvarwa?

Lynch syndrome chirwere chinonzi "autosomal dominant". Zvichitaurwa zviri nyore, kunyangwe kana mubereki mumwe chete ane jini rakachinja, mwana anogona kurigara nhaka . Izvi zvinoreva kuti pane mukana we50% wekuti mwana achavawo nechirwere ichi.

Kana wakamboonekwa uine chirwere cheLynch syndrome, zvakakosha kuzivisa nhengo dzemhuri yako uye kuvakurudzira kuti vatsvage mazano ezvemajini . Mazano ezvemajini anogona kukubatsira iwe nemhuri yako kunzwisisa chirwere chacho uye njodzi yekuti mwana wako agare nhaka. Kuongororwa kwemajini kunogonawo kuitwa kuti uone kana uine chirwere cheLynch syndrome gene mutation.

Chirwere cheLynch chinowanikwa sei?

Chiremba wako anogona kuongorora chirwere cheLynch kuburikidza nekuongororwa kwemwana asati aberekwa uye kuongororwa kwemajini. Kuongororwa kwemajini kunogona kuitwawo mushure mekunge mwana wako aberekwa.

Kuongororwa kwemajini kunosanganisira kutora ropa kana buccal swab kuti vaone kana paine shanduko mumajini ataurwa kare anonzi `MLH1`, `MSH2`, `MSH6`, `PMS2` kana `EPCAM`. Kana bvunzo yemajini ikaratidza kuvapo kwekushanduka kwakadaro, chiremba achaongorora chirwere cheLynch syndrome.

Ndezvipi zviedzo zvinoshandiswa kuona kenza ine chekuita neLynch syndrome?

Kana ukaonekwa uine chirwere cheLynch syndrome, chiremba wako anowanzo kurudzira bvunzo dzinoverengeka kuti aongorore kenza. Miedzo inowanzo onekwa ndeiyi:

• Colonoscopy: Izvi zvinosanganisira kuisa chubhu (scope) ine kamera yakasungirirwa kuburikidza nepaburi kuti iongorore mukati meura hukuru nerectum. Izvi zvinowanzoitwa kamwe chete pagore kana makore maviri ega ega.
• Ultrasound yeTransvaginal: Chinhu chidiki (probe) chinopinzwa nepanhengo yemukadzi kuti chiongorore mazamu nechibereko. Izvi zvinokurudzirwawo kamwe chete kana kaviri pagore.
• Kuongororwa kweweti: Muenzaniso weweti yako unotorwa kuti utarise zvinhu zvakaita semabundu eitsvo. Izvi zvinowanzoitwa kamwe chete pagore.
• Kuongororwa kwegomarara: Kana chiremba wako achifungidzira kuti une gomarara mumuviri wako, vanotora chidimbu chidiki charo vochiongorora murabhoritari kuti vaone kana riine masero egomarara.
• Kuongororwa kwepamusoro kwe endoscopy kana capsule endoscopy: Maitiro anoshandisa chubhu diki, rakatetepa (scope) kana kamera ine microscopic (chubhu diki, rakatetepa rinomedzwa sepiritsi) kutsvaga kenza mudumbu nemuura hudiki. Unogona kukumbirwa kuita izvi makore matatu kusvika mashanu ega ega.

Chirwere cheLynch chinorapwa sei?

Chinhu chikuru pakurapa chirwere cheLynch syndrome ndechekuona bundu nekukurumidza uye kubviswa kwaro nekuvhiyiwa . Izvi zvinoreva kuongororwa nguva nenguva uye kubata kenza nekukurumidza, kana iripo.

Ndiani anobata izvi?

Zvakanaka kutsvaga rubatsiro kubva kuchikwata chevanachiremba vane hunyanzvi panyaya yechirwere chakadai.Nekuti chirwere cheLynch chinogona kukanganisa nhengo dzakasiyana-siyana, timu yekurapa inogona kusanganisira nyanzvi dzakasiyana-siyana, kusanganisira vanachiremba vezvekudya, vanachiremba vekuvhiya, vanachiremba vezvirwere zvevakadzi, vanachiremba vezveuropathy, vanachiremba veganda, vanachiremba vezvirwere zvemajini, vanachiremba vezvirwere zvemajini, uye vanachiremba vezvirwere zvemajini.

Ko cancer ingadzoka here mushure mekurapwa?

Ehe, kunyangwe kenza ikabviswa nekuvhiyiwa, pane mukana wekuti kenza ichadzoka . Ndosaka zvichikosha kuti tirambe tichiongororwa.

Vamwe vanhu vane chirwere cheLynch syndrome, nekuti vari panjodzi huru yekubatwa nekenza, vanosarudza kuvhiyiwa kubvisa chibereko (hysterectomy), maovari (oophorectomy), kana chikamu cheura (colectomy kana kuvhiyiwa kwekubvisa ura) nekukurumidza. Ichi chisarudzo chikuru ndechemunhu, uye chinofanira kuitwa nekurairwa nachiremba.

Lynch syndrome inogona kudzivirirwa here?

Zvinosuwisa kuti chirwere cheLynch chirwere chinokonzerwa nemajini, saka hachigone kudzivirirwa zvachose . Zvisinei, vanhu vane chirwere cheLynch vanogona kuongororwa kenza muhupenyu hwavo hwese, kutanga pavanenge vakura, kuitira kuti kenza ikwanise kuonekwa nekukurumidza kana ikatanga .

Chii chinoitika kana uine chirwere cheLynch? Chii chaungatarisira?

Parizvino hapana mushonga weLynch syndrome. Zvisinei, mhedzisiro yakanaka inowanikwa kana kenza ikawanikwa yobviswa nekukurumidza, isati yapararira kune dzimwe nhengo dzemuviri . Saka, zvakakosha kuti vanhu vane Lynch syndrome vaongororwe gore rega rega, senge colonoscopy.

Ko chirwere cheLynch chichakonzera bundu muura hwangu here?

Vanhu vane chirwere cheLynch syndrome vanogona kuwana ma 'adenomas' akawanda, rudzi rwekukura kusiri kwekenza muura hwavo kana mudumbu. Kana ma 'polyps' aya akasaonekwa uye akabviswa, anogona kuva kenza. Ndosaka zvichikosha kuva necolonoscopy nguva dzose kuti utarise izvi uye uzvibvise kana zviripo.

Ndinofanira kuona chiremba rini?

Kana uine chirwere cheLynch, zvakakosha kuti ugare uchiongororwa gore rega rega uye uchiongororwa nguva nenguva .

Kana ukaona mapundu, mapundu matsva, kana shanduko yeganda chero kupi zvako mumuviri wako, enda kuna chiremba nekukasika , sezvo izvi zvinogona kuva zviratidzo zvegomarara.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

• Ndinofanira kuongororwa kenza kangani?
• Iri bundu riri pagomarara reganda rangu here?
• Chii chinonzi gene mutation chandinacho?
• Ndingaongororwa majini here ndisati ndaronga kubata pamuviri?

Lynch Syndrome neHNPCC zvakafanana here?

Lynch syndrome uye ``Heriditary Non-Polyposis Colorectal Cancer`` (``HNPCC``) dzimwe nguva zvinoshandiswa zvakafanana kureva mamiriro akafanana. Zvisinei, pane musiyano mudiki pakati pezviviri nenzira yazvinopfuudzwa nayo kuburikidza nezvizvarwa.

Chirwere cheLynch chinokonzerwa nekuchinja kwemajini e'MMR'. Kuchinja kwemajini kumwe chete uku kunokanganisawo vanhu vane 'HNPCC'. Zvisinei, zita rekuti 'HNPCC' rinopihwa kana chirwere ichi chikaitika nenhoroondo yemhuri . Izvi zvinoreva kuti 'HNPCC' inogara ichigara nhaka kubva kuchizvarwa kuenda kune chimwe. Chirwere cheLynch dzimwe nguva chinogona kuitika pasina mumwe munhu mumhuri ane chirwere ichi, uye chinogonawo kuitika nekuda kwekuchinja kwemajini. Ndosaka zita rekuti Lynch syndrome rave kushandiswa zvakanyanya.

Pakupedzisira, zvinhu zvekurangarira (Mharidzo Yekuenda Kumba)

Hapana anofarira kunzwa mashoko ekuti, "Une kenza." Paunoziva kuti une chirwere cheLynch, ungangofanira kunzwa mashoko iwayo kubva kuna chiremba wako. Asi hazvifanirwe kunge zvakaipa.

Kana wangoonekwa uine chirwere cheLynch syndrome, chiremba wako achashanda newe kuronga kuongororwa nguva nenguva kuti akubatsire kuona kenza nekukurumidza. Kuonekwa nekukurumidza uye kurapwa ndiyo nzira dzakanakisisa dzekuvandudza mikana yako yekupona . Ipapo unogona kurarama hupenyu hunofadza uye hune hutano.

Saka, pachinzvimbo chekutya ruzivo urwu, chenjera, tsvaga mazano echiremba kana zvichidikanwa, uye edza kurarama hupenyu hune hutano . Kana paine munhu mumhuri yako ane chirwere ichi, zvakakosha zvikuru kumuzivisa nezvazvo futi.

Lynch syndrome, HNPCC, kenza, majini akachinja, zvirwere zvenhaka, kenza yemuura, kenza yechibereko