Pane dambudziko here neokisijeni muropa? Ngatidzidzei nezve methemoglobinemia!

Wakamboona ganda remumwe munhu nemiromo yake zvichichinja ruvara rwebhuruu here? Kana kuti wakambonzwa here kuti vamwe vana vanozvarwa vaine ruvara rwebhuruu? Chimwe chikonzero cheizvi chingave chirwere cheropa chisingawanzoitiki, asi chinogona kunge chakakomba. Nhasi tichataura nezvechimwe chirwere chakadai , methemoglobinemia . Vamwe vanhu vanochidanawo kuti "blue baby syndrome."

Chii chinonzi methemoglobinemia chaizvo?

Zvichitaurwa zviri nyore, methemoglobinemia chirwere chekuti masero matsvuku eropa ari muropa redu haakwanise kutakura okisijeni kuenda kune mamwe masero nematishu mumuviri. Funga nezvazvo, masero matsvuku eropa ndiwo anobatsira kutakura okisijeni mumiviri yedu, handiti? Aya masero matsvuku eropa ane puroteni yakakosha inonzi hemoglobin . Zvakafanana nebhazi, uye hemoglobin iyi inotakura okisijeni mumuviri wese.

Zvisinei, muchirwere ichi chinonzi ``Methemoglobinemia``, chinoitika ndechekuti ``Hemoglobin`` yedu inotakura okisijeni inoshanduka yova chinhu chakasiyana chinonzi ``Methemoglobin``. Dambudziko nderekuti, ``Methemoglobin`` iyi haigone kutakura okisijeni. Zvakafanana nebhazi rinotakura okisijeni rinoparara uye harigone kutakura vafambi.

Dambudziko iri rinogona kugarwa nhaka (nemajini) kune vamwe vanhu. Asi kazhinji rinokonzerwa nemimwe mishonga yatinoshandisa, mishonga yekuzvivaraidza, kana kusangana nemamwe makemikari . Dzimwe nguva rinogona kuisa hupenyu panjodzi, kunyanya muvana vanoberekwa vane chirwere ichi chakakomba uye muvanhu vanoshandisa zvinodhaka. Zvisinei, kazhinji, vanachiremba vanogona kunyora mishonga yekudzikisa huwandu hwe "Methemoglobin" uye kubvisa zviratidzo.

Izvi zvinokanganisa sei muviri wangu?

Vanhu vazhinji vane methemoglobinemia vanowana chirwere chinonzi cyanosis . Cyanosis inoitika kana nzara dzako, rurimi, miromo, neganda zvikaita ruvara rwebhuruu kana pepuru. Izvi zvinoitika kana ropa rako risina okisijeni yakakwana. Sezvandambotaura, masero matsvuku eropa ndiwo anowanzo takura okisijeni mumuviri wese. Puroteni inonzi hemoglobin inobatsira pane izvi.

Mu methemoglobinemia, ``Methemoglobinemia`` inoitika kana ``Hemoglobin`` yava ``Methemoglobin``, kungave nekuda kwekuchinja kwemajini kana chimwe chikonzero chekunze. Sezvo ``Methemoglobin`` isingakwanise kutakura okisijeni, huwandu hweokisijeni muropa hunoderera uye unotanga ``Cyanosis```.

Ndezvipi zviratidzo zveMethemoglobinemia?

Zviratidzo zvinogona kusiyana kubva pamunhu kuenda kune mumwe, uye zvinoenderanawo nerudzi rwechirwere chaunacho. Ngationei kuti zviratidzo izvi zvinowanzoonekwa sei.

Zviratidzo zveAcquired Methemoglobinemia

Vanhu vazhinji vanowana chirwere ichi mushure mekutora mimwe mishonga inonyaradza marwadzo, mishonga, kana kusangana nezvinhu zvine chepfu . Izvi zvinonzi acquired methemoglobinemia. Zviratidzo zvinogona kuitika zvinosanganisira:

• Ganda rakachenuruka (rakachenuruka)
• Kunzwa kuneta zvakanyanya (kuneta)
• Kushaya simba
• Musoro

Dzimwe nguva, vanhu vane acquired methemoglobinemia vanogona kuva nezviratidzo zvakakomba zvinoda kurapwa nekukurumidza . Izvi zvinosanganisira:

• Kusvotwa nekurutsa.
• Kurara zvakanyanya, kutaura zvisina kujeka, uye kunonoka kupindura: Izvi zvinogona kuva zviratidzo zvekuora mwoyo kwetsinga dzeropa .
• Kurasikirwa nepfungwa kana kufamba-famba kwemuviri kusingadzoreki (sekunge kubatwa nepfari): Izvi zviratidzo zvepfari ine pfari .
• Kufema nekukurumidza, kurova kwemoyo kwakanyanya, uye kuvhiringidzika: Izvi zviratidzo zvechirwere chinonzi metabolic acidosis .

Zvakakosha: Kana mumwe munhu wauinaye akaratidza zviratidzo zvepfari, `(Metabolic Acidosis)` kana `(Central Nervous System Depression)`, unofanira kufonera 1990 nekukasika wofonera amburenzi .

Zviratidzo zveCongenital Methemoglobinemia

Methemoglobinemia yekuzvarwa nayo chirwere chisingawanzoitiki. Pane nyaya shoma dzakataurwa pasi rose. Zvichibva paruzivo irworwo, vanachiremba vakaipatsanura kuita mhando nhatu huru: Type 1, Type 2, uye Hemoglobin M disease (HbM) .

• Vanhu vane chirwere che hemoglobin M (HbM) vanowanzova ne cyanosis (ganda rebhuruu), asi kazhinji vanenge vaine hutano hwakanaka.
• Kunyangwe vanhu vane Type 1 methemoglobinemia (Type 1 MetHb) vane cyanosis, mamwe matambudziko makuru ehutano haawanzoitiki.
• Zvisinei, vacheche vanozvarwa vane Type 2 methemoglobinemia (Type 2 MetHb) vanogona kuva nematambudziko makuru etsinga pavanosvika mwedzi mipfumbamwe. Zvinosuwisa kuti vacheche ava havararame kwenguva refu.

Sei methemoglobinemia ichiitika?

Dambudziko iri rinogona kugarwa nhaka, kana, sezvandambotaura, rinogonawo kukonzerwa gare gare nemamwe mishonga, mishonga, kana makemikari ane chepfu.

Zvikonzero zveAcquired Methemoglobinemia

• Mishonga inouraya marwadzo yakaita se benzocaine ne lidocaine (kunyanya iyo inowanikwa mumagels emudumbu uye maspray) uye mushonga unorwisa mabhakitiriya we dapsone zvinogona kukonzera izvi.
• Nitrates dzinoshandiswa mune mimwe mishonga, MaNitrite, anogona kuwanikwa muzvichengetedzo zvekudya uye mumvura yemutsime, uye kusangana nemimwe mishonga yekuuraya sora inoshandiswa mukurima ndizvo zvimwe zvinokonzerawo.
• Vanhu vanoshandisa zvinodhaka zvekuzvivaraidza zvakaita seamyl nitrite (inozivikanwawo sepoppers), nitrous oxide (gasi rinoseka), uye mimwe mishonga inonyaradza marwadzo yakasanganiswa nemishonga yakaita secocaine vari panjodzi huru yezvirwere zvinogona kutyisidzira hupenyu nekuda kwehuwandu hwakawanda hwemethemoglobin.

Zvinokonzera Congenital Methemoglobinemia

Congenital methemoglobinemia (Congenital MetHb) inokonzerwa nekuchinja kwemajini maviri akasiyana.

• Mumhando 1 ne2 , kuchinja kwejini reCYB5R kunokanganisa kuenzana kuripo pakati pehemoglobin nemethemoglobin mumasero matsvuku eropa.
• Chirwere cheHemoglobin M (HbM) chinokonzerwa nekuchinja kwemajini akawanda eHemoglobin M.

Congenital methemoglobinemia chirwere chinokonzerwa ne autosomal recessive disorder . Zvichitaurwa zviri nyore, kuti mwana awane chirwere ichi, vabereki vese vanofanira kunge vari ivo vanotakura gene mutation uye mwana anofanira kugara nhaka yemutation kubva kwavari vese.

Chirwere cheHemoglobin M (HbM) chirwere chinotonga muviri . Izvi zvinoreva kuti mwana anogona kuva nechirwere ichi kunyangwe akagara nhaka yekuchinja kwemajini kubva kumubereki mumwe chete.

Vanachiremba vanoongorora sei izvi?

Vanachiremba vanoongorora chirwere ichi nekutora nhoroondo yako yese yezvekurapa uye kuita ongororo yemuviri . Kana mumwe munhu aine zviratidzo zve acquired methemoglobinemia, vanogona kubvunza nezvemishonga yaanoshandisa kana makemikari ane chepfu angave akasangana nawo.

Ndedzipi bvunzo dzinoitwa kuti dzionekwe sedziri kuitika?

Miedzo iyi inowanzoitwa:

• Kuongororwa Kweropa: Ropa rinotorwa kubva mutsinga dzeropa dzevanhu vane chirwere ichi rinowanzova neruvara rwebrown. Ruvara urwu rwebrown rwunoreva kuti tsinga hadzina kutakura okisijeni zvakanaka muropa.
• Kuongororwa kweMethemoglobin (MetHb): Izvi zvinoyera kuti methemoglobin yakawanda sei muropa rako.
• Kushanda kweenzyme yeCYB5R: Kana kushanda kweenzyme iyi kwakaderera pane zvakajairwa, chiratidzo che methemoglobinemia yekuzvarwa nayo.
• Kuongororwa kweGenotyping: Kana uchifungidzira kuti une methemoglobinemia yekuzvarwa nayo, DNA yako ichaongororwa kuti ionekwe kuti yachinja sei majini kuti isimbise chirwere chacho. Izvi zvinogonawo kubatsira kuziva rudzi rwechirwere.
• Kushandiswa kweHemoglobin Electrophoresis:Iyi inzira yekuedza ``Hemoglobin`` mumasero matsvuku eropa. Iyi bvunzo inogona kushandiswa kuongorora chirwere chehemoglobin M``(HbM).``

Izvi zvinorapwa sei?

Nzira dzekurapa dzinosiyana zvichienderana nerudzi rwemethemoglobinemia yaunayo. Semuenzaniso, kurapwa kwemwana achangoberekwa ane chirwere cherudzi rwechipiri kwakasiyana zvikuru nekurapa kwemunhu akawana chirwere ichi kuburikidza nekushandisa kemikari ine chepfu kana mishonga.

• Vanhu vane chirwere cheType 1 Methemoglobinemia kana chirwere cheHemoglobin M vangasada kurapwa. Kana zvichidikanwa, vanachiremba vanogona kushandisa mishonga iyi kuderedza huwandu hweMethemoglobin:
• Methylene Bhuruu: Uyu ndiwo mushonga mukuru we methemoglobinemia.
• Vhitamini C nevhitamini B2.

Kurapa kweAcquired Methemoglobinemia

Zvichienderana nemamiriro ezvinhu, acquired methemoglobinemia inogona kunge iri dambudziko rehutano. Muzviitiko zvakadaro, hydration yemutsinga uye okisijeni zvinogona kudiwa . Kazhinji, vanhu vane acquired methemoglobinemia vanopihwa methylene blue .

Ndezvipi zvinetso zvinokonzereswa nekurapwa?

Kana munhu ane G6PD Deficiency (zvakare chirwere chemajini) akapihwa methylene blue nguva dzose, chirwere chinonzi hemolysis chinogona kuitika. Hemolysis ikuparara kwemasero matsvuku eropa nguva isati yakwana kana kuti zvisina kufanira.

Ndingaderedza here njodzi yangu yekubatwa nemethemoglobinemia?

• Vanhu vanogara nhaka rudzi rwechirwere ichi vanofanira kudzivisa makemikari ane chepfu (semuenzaniso mishonga yezvipembenene), mimwe mishonga, uye mishonga yakawanda inonyaradza marwadzo inogona kuwedzera huwandu hwemethemoglobin. Kana uine chirwere ichi, bvunza chiremba wako nezvezvinhu zvingangove zvichikukonzera allergy.
• Vanhu vanoshandisa zvinodhaka zvakaita seamyl nitrite kana cocaine vanozvipinza panjodzi huru yekubatwa nemethemoglobinemia. Kana muchishandisa mishonga iyi uye muchida rubatsiro rwekurega, taurai nachiremba nezvemishonga iripo.

Chii chinoitika kana ndikava nechirwere ichi?

Kazhinji, kurapwa kunogona kuderedza zviratidzo. Vanhu vazhinji vane Type 1 Congenital Methemoglobinemia, kana kuti Hemoglobin M disease, vane zviratidzo zvishoma. Vanowanzo rarama kwenguva yakareba seyemunhu asina chirwere ichi.

Ndinozvitarisira sei?

• Kazhinji, vanhu vanozvarwa vaine chirwere ichi vanofanira kungwarira mishonga nemakemikari zvinogona kuwedzera chirwere ichi. Sezvo mamiriro ezvinhu evanhu akasiyana zvishoma, zvakanaka kubvunza chiremba wako.
• Vanhu vane acquired methemoglobinemia (Acquired MetHb) vanofanira kudzivisa zvachose zvinhu zvakakonzera izvi - zvakaita semishonga, mishonga inonyaradza marwadzo, kana makemikari ane chepfu.

Ndinofanira kuona chiremba rini?

• Kana uine rudzi rwemethemoglobinemia rwaunowana kubva kuvabereki vako, enda kuna chiremba kana ukaona shanduko mumuviri wako, dzakadai sekuneta kana kuneta. Izvi zvinogona kunge zviri zviratidzo zvekuti masero matsvuku eropa haachakwanisi kutakura okisijeni mumuviri wako wese.
• Kana uine zviratidzo zvakakomba zvakaita se cyanosis (ganda rebhuruu) pamwe chete nepfari kana hope dzakanyanya, fonera 911 nekukasika kana kuenda kuchipatara chiri pedyo newe.

Mibvunzo ipi yandinofanira kubvunza chiremba?

Methemoglobinemia chirwere cheropa chisingawanzoitiki. Vamwe vanhu vane chirwere ichi chakagarwa nhaka (Congenital MetHb), asi vanhu vazhinji vanochiwana gare gare (Acquired MetHb). Zvichienderana nemamiriro ako ezvinhu, ungangoda kubvunza chiremba wako mibvunzo yakaita seyi:

Nezve Acquired Methemoglobinemia (Acquired MetHb):

• Sei izvi zvakaitika kwandiri?
• Kurapwa uku kuchapedza zviratidzo zvangu here?
• Zviratidzo zvangu zvingadzoka here?
• Ndingaitei kuti ndidzivise chimwe chinhu chakadai kuti chisaitike zvakare?

Nezve Type 1 Congenital MetHb:

• Ko cyanosis (ganda rebhuruu) idambudziko guru rehutano here?
• Ndichagara ndichitora mushonga wemethemoglobinemia (MetHb) here?
• Ndingave nezvimwe zviratidzo here?
• Vana vangu vanogona kugara nhaka chirwere ichi here?

Type 2 Congenital MetHb (kana iri mumwana):

• Dambudziko iri richakanganisa sei mwana wangu?
• Pane mishonga yekuderedza zviratidzo zvemwana wangu here?
• Ndingaitei kuti ndibatsire mwana wangu?
• Kana ndikava nevana vakawanda, izvi zvichaitikawo kwavari here?

Muchidimbu (Mharidzo Yekuenda Kumba)

Methemoglobinemia chirwere cheropa chisingawanzoitiki chinokanganisa kugona kwemasero edu matsvuku kutakura okisijeni mumuviri wese. Kune vamwe, inogarwa nhaka, asi kune vazhinji inokonzerwa nemishonga yakati, kusangana nemakemikari ane chepfu, kana kushandisa zvinodhaka zvekuzvivaraidza. Congenital methemoglobinemia (kunyanya rudzi rwechipiri) dzimwe nguva inogona kukonzera matambudziko makuru etsinga, asi kazhinji haikonzeri matambudziko makuru ehutano. Zvisinei, acquired methemoglobinemia (acquired methemoglobinemia) dzimwe nguva inogona kuisa hupenyu panjodzi.

Chinhu chinonyanya kukosha ndechekuti kana uchifunga kuti uri panjodzi yekubatwa nechirwere ichi, usatya kutaura nachiremba nezvazvo. Iye achafara kukubatsira.

` Methemoglobinemia, Methemoglobinemia, Blue baby syndrome, Cyanosis, Kushaikwa kweokisijeni muropa, Hemoglobin, Zvirwere zveropa, Zvirwere zvemajini