Dzimwe nguva unombozvibvunza here kuti sei ndaneta kudaro? Kana kuti pane mumwe munhu mumhuri mako ane matambudziko ehutano anopfuura rimwe chete, uye zvakaoma kuwana chikonzero chakajeka cheizvi? Dzimwe nguva chikonzero cheizvi chinogona kunge chiri kuchinja kwechimwe chezvinhu zvidiki zviri mumiviri yedu. Nhasi tichataura nezvechimwe chinhu chakaoma zvishoma, asi chakakosha kuziva. Izvozvo ndizvo zvirwere zveMitochondrial.
Chii chinonzi mitochondria? "Simba guru" remuviri?
Zvichitaurwa zviri nyore, mitochondria ndiwo magwenya madiki ari mukati mesero rega rega mumuviri wedu. Akafanana nechiteshi chemagetsi chinogadzira magetsi ekupa simba mudzimba dzedu. Tichishandisa chikafu chatinodya uye mweya watinofema, mitochondria idzi dzinoburitsa 90% yesimba rinodiwa nemiviri yedu kuti ishande. Ingofungai, pfungwa dzedu dzinoda simba kuti dzishande, moyo yedu inoda simba kuti irove, tsandanyama dzedu dzinoda simba kuti dzishande. Mitochondria ndiyo sosi huru yesimba iroro. Ndosaka dzichinzi "simba resero."
Saka chii chinonzi zvirwere zvemitochondrial?
Iye zvino wava kunzwisisa kukosha kwe mitochondria. Saka, kana magwenya aya anonzi mitochondria asingashande nemazvo, kana kuti asingakwanise kugadzira simba sezvaanoda, zvirwere zvinoitika zvinonzi mitochondria diseases. Kungofanana nekunge gwenya remagetsi richiparara uye basa redu rese richimira pasina mwenje, kana mitochondria ikasagadzira simba nemazvo, nhengo dzemuviri wedu hadzigone kuita mabasa adzo.
Zvirwere izvi zvinogona kukanganisa chero nhengo yemuviri. Semuenzaniso:
- Muuropi
- Sisitimu yetsinga
- Tsandanyama
- Itsvo
- Mwoyo
- Chiropa
- Maziso
- Nzeve
- Pancreas
Masero anogona kukanganiswa chero kupi zvako seizvi.
Kune marudzi ezvirwere zvemitochondrial here?
Ehe, chirwere chemitochondrial hachisi chirwere chimwe chete, kune mhando dzakawanda. Idzi dzakaoma zvishoma, uye vanachiremba ndivo vanodziongorora chaizvo. Asi kuti uzive zvakawanda, heano mamwe emhando dzakajairika:
- Mitochondrial encephalopathy, lactic acidosis, uye zviratidzo zvakafanana nestroke (MELAS syndrome)
- Leber nhaka yemaziso neuropathy (LHON)
- Leigh syndrome
- Kearns-Sayre syndrome (KSS)
- Chirwere cheMyoclonic epilepsy uye chirwere cheragged-red fiber (MERRF)
Mazita aya anganzwika seasinganzwisisike, asi aya ndiwo mazita anozivikanwa nezvirwere izvi mune zvesainzi yekurapa.
Zvirwere izvi zvakajairika zvakadii?
Zvinofungidzirwa kuti munhu mumwe chete pavanhu zviuru zvishanu anogona kunge aine chirwere chemitochondrial chinoberekwa nemajini.Asi izvi zvakaoma zvishoma. Nekuti zviratidzo zvezvirwere izvi zvakasiyana-siyana uye zvinokanganisa nhengo dzakasiyana dzemuviri, dzimwe nguva chirwere ichi chinogona kuonekwa pave paya, kana kuti chinogona kufungidzirwa kuti ndechimwe chirwere. Nokudaro, huwandu chaihwo hwevanhu vane chirwere ichi hunogona kunge hwakakwira zvakanyanya.
Ndezvipi zviratidzo zvezvirwere zvemitochondrial?
Izvi zvakakosha zvikuru. Zviratidzo zvezvirwere zvemitochondrial zvinogona kusiyana zvikuru kubva kumunhu kusvika kumunhu. Zvakare, zviratidzo zvinosiyana zvichienderana nerudzi uye nzvimbo yemasero akabatwa nechirwere. Kune vamwe vanhu, zviratidzo zvinogona kunge zvisinganzwisisike , nepo kune vamwe, zvinogona kunge zvakanyanya.
Zvimwe zvezviratidzo zvinowanzoonekwa ndeizvi:
- Kunonoka kukura (kunyanya kuvana vadiki)
- Kushaya simba kwetsandanyama, kurwadziwa kwetsandanyama, kana kudzikira kwetsinga
- Kutadza kuona kana kunzwa zvakanaka
- Kunonoka kukura kana matambudziko ekukura kwepfungwa (semuenzaniso, matambudziko ekudzidza)
- Matambudziko emudumbu akadai semanyoka kana kuvimbiwa
- Kurutsa pasina chikonzero
- Kusagadzikana kweacid uye/kana kuoma kumedza
- Kuva nepfungwa dzakapfava (pfari)
- Migraine
- Kuoma kufema
- Kufenda
Zviratidzo izvi zvinogona kutanga pakuzvarwa, kana kuti zvinogona kuonekwa pazera ripi zvaro muhupenyu. Chiremba anowanzo fungidzira rudzi urwu rwechirwere kana zviratidzo zvikaonekwa munhengo dzinopfuura imwe chete panguva imwe chete. Chinoshamisa ndechekuti kunyange vanhu vari mumhuri imwe chete vane chirwere chemitochondrial chinogona kuva nezviratidzo zvakasiyana.
Sei zvirwere izvi zvemitochondrial zvichiitika?
Zvichitaurwa zviri nyore, chikonzero chikuru chezvirwere zvemitochondrial kusakwanisa kwemitochondria mumasero edu kugadzira simba rakakwana. Kuti mitochondria igadzire simba, inofanirwa kugamuchira mirairo chaiyo kubva ku'DNA' yemuviri wedu (majini). Kana paine shanduko mu'DNA' iyi (vanachiremba vanodana izvi kuti 'mutation'), mitochondria haigamuchire mirairo iyoyo nemazvo. Zvadaro kugadzirwa kwesimba kunokanganiswa. Izvi zvinogona kukuvadza masero, kana kuti masero anogona kufa nekukurumidza. Izvi ndizvo zvinokanganisa mashandiro enhengo dzedu uye zvinokonzera zviratidzo.
Munhu anowana sei chirwere chemitochondrial?
Zvirwere zveMitochondria iboka rezvirwere zvemajini. Izvi zvinoreva kuti tinogona kuzvitora kubva kuvabereki vedu. Nhaka iyi inogona kuitika nenzira mbiri huru:
1. Autosomal dominant: Izvi zvinoreva kuti chirwere ichi chinogona kuitika kunyangwe jini rakachinjwa rinokonzera chirwere ichi rakatorwa kubva kumubereki mumwe chete.
2. Autosomal recessive: Muchiitiko ichi, jini rakakanganiswa rinofanira kugara nhaka kubva kuvabereki vese kuti chirwere chiitike.
Dzimwe nguva, kunyangwe pasina munhu mumhuri akamborwara nechirwere ichi, mumwe munhu anogona kurwara netsaona nekuda kwekuchinja kwemajini (izvi zvinonzi `de novo mutation`).
Chimwe chinhu chakakosha ndechekuti,Zvimwe zvirwere zvemitochondrial zvinogara nhaka kuburikidza ne'DNA' chaiyo kune mitochondria. Ehe, wazvinzwa izvozvo zvakanaka. Kuwedzera kune 'DNA' iri munucleus yemasero edu, mitochondria inewo 'DNA' yayo. Zvirwere zvemitochondrial zvinokonzerwa nekuchinja kwe'mitochondrial DNA' iyi zvinogara nhaka kubva kuna amai kuenda kuvana vavo chete.
Zvimwe zvirwere zvinogona kukonzera matambudziko emumitochondrial here?
Ehe, zvinonzi kusashanda zvakanaka kwemitochondrial secondary . Apa ndipo apo mitochondria isingashande zvakanaka nekuda kwechimwe chirwere kana mamiriro ezvinhu. Zvimwe zvezvirwere zvinogona kukonzera izvi ndeizvi:
- Chirwere cheAlzheimer
- Kusashanda kwetsandanyama
- Chirwere cheshuga cherudzi rwekutanga
- Multiple sclerosis (MS)
- Kenza
Kana uine chirwere chemitochondrial chisina kumira zvakanaka, hachisi chirwere chemitochondrial chinoberekwa nemajini.
Ndezvipi zvinhu zvinokonzera njodzi yekurwara nezvirwere zvemitochondrial?
Kana mumwe munhu mumhuri yako aine chirwere ichi, kana kuti uine chimwe chirwere chinokonzera kusashanda zvakanaka kwemuviri, uri panjodzi huru yekubatwa nechirwere chemitochondrial. Zvirwere izvi zvinogona kukanganisa vakuru nevana vadiki.
Ndezvipi zvinetso zvinogona kuitika nekuda kwezvirwere izvi?
Zvirwere zveMitochondria zvinogona kukanganisa mashandiro enhengo dzedu, zvichikonzera matambudziko akasiyana-siyana. Semuenzaniso:
- Njodzi yakakura yekutapukirwa
- Kurohwa
- Kukundikana kwepancreatic
- Kukundikana kweparathyroid
- Chirwere cheshuga
- Kukundikana kwechiropa
- Cardiomyopathy
- Chirwere cheitsvo
- Dementia (kukanganisika kwendangariro nepfungwa)
- Matambudziko emudumbu
- Maziso akarembera (Ptosis)
Mamwe ematambudziko aya anogona kutoisa hupenyu panjodzi, saka zvakakosha kuziva izvi.
Chirwere chemitochondrial chinoonekwa sei?
Iyi inzira yakaoma zvishoma. Chiremba anoongorora chirwere chemitochondrial mushure mekuongororwa kwakawanda. Izvi zvinogona kusanganisira:
- Ongororo yakakwana yenhoroondo yako yezvekurapa uye nhoroondo yezvekurapa yemhuri.
- Kuongororwa kwemuviri kwakakwana.
- Kuongororwa kwetsinga.
- Kuongororwa kwemuviri, kunosanganisira kuongororwa kweropa neweti. Kana zvichidikanwa, bvunzo ye cerebrospinal fluid (inozivikanwawo se spinal tap) inogonawo kuitwa.
- Kuongororwa kweDNA.
Zvichienderana nezviratidzo zvako uye nhengo dzemuviri wako dzakabatwa, bvunzo dzakanyatsojeka dzinogona kuitwa. Semuenzaniso:
- Kana paine zviratidzo zvematambudziko etsinga, bvunzo dzeMRI (Magnetic Resonance Imaging) kana MRS (Spectroscopy) dzinogona kuitwa.
- Kuongororwa kwe retina kana bvunzo yeERG (Electroretinogram) kunoitwa kuti kuonekwe matambudziko ekuona.
- Kuongororwa kweEKG (Electrocardiogram) kana Echocardiogram kunoratidza zviratidzo zvine chekuita nemoyo.
- Kuongororwa kwe'Audiogram' kwezvinetso zvekunzwa.
- Bvunzo ye `EEG (Electroencephalogram)` inoitwa kuti ione kana paine matambudziko ane chekuita neuropi sezvo fitness yasvika.
Miedzo yepamusoro-soro inogona kusanganisira kuyedzwa kwemakemikari emuviri, uko kunotsvaga shanduko mumakemikari emuviri anobatanidzwa mukugadzirwa kwesimba. Dzimwe nguva, chiremba anogona kutora sampuli diki yeganda rako kana tsandanyama (biopsy) oiongorora pasi pemaikorosikopu.
Zvakaoma here kuongorora zvirwere zvemitochondrial?
Ehe, kuongorora zvirwere zvemitochondrial dzimwe nguva kunogona kuoma. Izvi zvinodaro nekuti zvirwere izvi zvinokanganisa nhengo dzakasiyana-siyana dzemuviri, uye zviratidzo zvakasiyana-siyana. Hapana imwe bvunzo yemurabhoritari inogona kukuudza zvechokwadi kana uine chirwere ichi. Ndosaka zvichikosha kutsvaga kuongororwa nachiremba ane hunyanzvi muzvirwere izvi.
Zvirwere zvemitochondrial zvinorapwa sei?
Kurapwa kwechirwere chemitochondrial kunosiyana zvichienderana nerudzi rwechirwere uye zviratidzo zvako. Kurapwa kunogona kusanganisira:
- Kushandisa mishonga yekuderedza zviratidzo. Semuenzaniso, mishonga yekudzivirira chirwere chepfungwa kuti chisauye.
- Kutora mavhitamini kana zvekudya zvinovaka muviri. Semuenzaniso: Riboflavin, Coenzyme Q10, Carnitine.
- Kuchinja kwekudya (kudya kunovaka muviri) uye kurovedza muviri.
- Kurapa nemuviri, kurapwa nebasa, kana kurapwa nekutaura.
- Kupfeka zvinhu zvinobatsira munzeve zvakaita sezvinobatsira kunzwa.
Zvinosuwisa kuti pari zvino hapana mushonga wechirwere chemitochondrial. Kurapa kwacho kwakanangana nekudzivirira matambudziko anotyisidzira hupenyu uye kuvandudza hupenyu nekudzora zviratidzo. Zvinoshanda kune mumwe munhu zvinogona kusashanda kune mumwe, kunyangwe nechirwere chimwe chete.
Pane migumisiro yakaipa here yekurapwa kwacho?
Ehe, sekurapa kupi zvako, kune zvimwe zvinogona kukonzera migumisiro yakaipa. Zvakakosha kukurukura izvi nachiremba wako usati watanga kurapwa. Izvi zvichakubatsira kunzwisisa migumisiro chaiyo yekurapwa kwauri kugamuchira uye zvaunotarisira.
Zvirwere zvemitochondrial zvinogona kudzivirirwa here?
Parizvino hapana nzira inozivikanwa yekudzivirira chirwere chemitochondrial chinonzi genetic. Zvisinei, kana uine chirwere ichi, unogona kudzivirira zvimwe zvezvinhu zvinogona kuwedzera zviratidzo zvako. Semuenzaniso:
- Kusangana nechando chakanyanya uye/kana kupisa.
- Kusadya chikafu.
- Kusawana hope dzakakwana.
- Kushushikana.
Dzimwe nguva chiremba anogona kukukurudzira kuchengetedza simba rako. Izvi zvinoreva kuti usashandise simba rako rese munguva pfupi.
Unogona kurarama kwenguva yakareba sei uine chirwere chemitochondrial?
Chiremba wako anogona kupindura mubvunzo uyu zviri nani. Izvi zvinoenderana nezviratidzo zvako, nhengo dzakakanganiswa, uye hutano hwako hwese. Vamwe vana nevakuru vanorarama hupenyu hwakajairwa, kungofanana nemunhu asina chirwere. Kune vamwe, hutano hwavo hunogona kuchinja zvakanyanya munguva pfupi. Kune vamwe, zviratidzo zvinogona kuitika nguva nenguva muhupenyu hwavo hwese. Kunyangwe pasina mushonga wezvirwere zvemitochondrial, tsvakiridzo iri kuenderera mberi kuti uwane rumwe ruzivo.
Ndinofanira kuona chiremba rini?
Kana zviratidzo zvechirwere chako chemitochondrial zviri kukanganisa mabasa ako ezuva nezuva kusvika pakutadza kushanda zvakanaka, iva nechokwadi chekuona chiremba. Kana ukaona zviratidzo zvakakomba, zvakaita sepfari kana kunetseka kufema, fonera 911 kana nhamba yako yekukurumidzira yemunharaunda nekukasika.
Mibvunzo ipi yandinofanira kubvunza chiremba wangu?
Unogona kubvunza chiremba wako mibvunzo yakaita seiyi:
- Ndechipi chirwere chemitochondrial chakakonzera zviratidzo zvangu?
- Munokurudzira rudzii rwekurapwa?
- Pane migumisiro yakaipa here yekurapwa kwacho?
- Ndinofanira kutora mavitamini kana ma supplements kangani?
- Unokurudzira kudya kwerudzii?
- Ndingachengetedza sei simba rangu?
- Kune mapoka ekutsigira vanhu vane zvirwere zvemitochondrial here?
Pakupedzisira, zvinhu zvekurangarira (Mharidzo Yekuenda Kumba)
Kuziva kuti iwe kana waunoda ane chirwere chemitochondrial kunogona kuva sarudzo yakaoma. Nekuti chirwere ichi chinogona kukanganisa masisitimu mazhinji mumuviri, ungangoda kuchinja mararamiro ako. Asi yeuka, hausi wega. Kuwedzera pakutsigirwa nemhuri yako neshamwari, timu yako yehutano inogonawo kukubatsira kufamba nenzira idzi dzekuongorora nekurapa.
Kunyange hazvo pasina mushonga wechirwere chemitochondrial, kurapwa kunogona kubatsira kuderedza zviratidzo uye kunonoka kufambira mberi kwechirwere. Chinhu chakakosha ndechekugara uine tariro, kutevedzera zano rachiremba wako, uye kurarama hupenyu hwako zvizere.
Tinovimba kuti ruzivo urwu rwabatsira. Tichaonanazve neruzivo rwakakosha rwehutano rwakadai!
Mitochondria , zvirwere zvemitochondrial, zvirwere zvemajini, simba remasero, kugadzirwa kwesimba, zviratidzo, kurapwa
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