Zvakaoma kutaura kutya nekuzvidya mwoyo kunonzwa munhu kana aonekwa kuti ane kenza. Asi nekufambira mberi kwesainzi yezvekurapa, nhasi uno kune nzira dzepamusoro-soro uye dzinobudirira dzekurapa kenza. Kusiyana nekare, ikozvino kune nzira dzakatarwa dzinongonanga nekurwisa masero ekenza chete. Nhasi, tiri kutaura nezvenzira yakakosha yekurapa inoshandiswa pakurapa kenza yemudumbu. Ndiyo Monoclonal Antibody Therapy.
Ndezvipi izvi zvinonzi Monoclonal Antibodies?
Tisati tanzwisisa izvi, ngatitarisei nezvekudzivirira kwemuviri wedu. Kana chinhu chinopinda kunze, senge utachiona kana hutachiona, chikapinda mumuviri wedu, masoja edu ekudzivirira muviri anogadzira mapuroteni akakosha ekuwana nekuaparadza. Tinodaidza kuti ma antibodies aya. Zvakafanana neuto riri kuchengetedza nyika.
Fungidzira kuti uto iri rine "chikwata chemauto akakosha" chakadzidziswa zvakanyanya uye chinoziva kurwisa chinangwa chimwe chete. MaMonoclonal Antibodies akafanana neaya. Aya ma antibodies chaiwo akagadzirwa murabhoritari. Akagadzirwa kuti awane chinangwa chimwe chete, ochibatanidza nacho, uye ochiparadza. Muchiitiko ichi, chinangwa ichocho iseli rekenza.
Chinhu chikuru chekurapa uku ndechekuti kwakanyatsojeka . Mishonga yechinyakare inouraya masero ekenza, inogonawo kukuvadza masero ane hutano mumuviri wedu. Ndosaka mishonga yekenza ichikonzera migumisiro yakadai sekurasikirwa nebvudzi uye kuneta. Asi kurapwa kweMonoclonal Antibody kwakaita se "guided rocket." Inoenda zvakananga kumasero ekenza. Saka, unogona kutarisira migumisiro mishoma.
Mishonga inomisa "nzira yehupenyu" yekenza
Kenza haisi masero akawanda chete. Yakafanana nefekitori diki. Inoda chikafu kuti ikure, ikure. Kuti iwane chikafu ichi, masero ekenza anozvigadzirira mitsipa mitsva yeropa. Mukurapa, tinoidaidza kuti maitiro aya angiogenesis . Kuburikidza nemitsipa iyi yeropa, kenza inowana chikafu chainoda kuti irarame.
Saka, zvinoitwa nemamwe ma antibodies e monoclonal kumisa kuumbwa kwetsinga dzeropa idzodzo. Zvakafanana nekudzima "kugovera" kwemafuta kugomarara. Mushonga mukuru mukirasi iyi ndiBevacizumab (Avastin) .
Avastin inoshanda sei?
Masero egomarara anoburitsa chiratidzo chakakosha chinonzi Vascular Endothelial Growth Factor (VEGF) . Kana chiratidzo ichi chagamuchirwa, muviri unotanga kugadzira mitsipa mitsva yeropa. Mushonga weAvastin unoshanda nekuvharira chiratidzo ichocho cheVEGF. Izvi zvinodzivirira kenza kuti isagadzire mitsipa mitsva yeropa. Zvadaro, pasina kudya, kukura kwegomarara kunodzikira kana kumira.
Avastin mushonga unotenderwa wegomarara remuura wakapararira (wakapararira) kune dzimwe nhengo dzemuviri. Kunyangwe usingarape gomarara zvachose, zvidzidzo zvakaratidza kuti Avastin, kana ikashandiswa chemotherapy, yakawedzera nguva yekurarama kwevarwere nemwedzi inosvika mishanu.
Mimwe yemishonga mitsva iri mukirasi iyi inosanganisira `Fruquintinib (Fruzaqla), `ramucirumab (Cyramza)` uye `ziv-aflibercept (Zaltrap).` Iyi inoshandawo nekukanganisa sisitimu yekutumira masaini yeVEGF.
Mapirwo eAvastin uye migumisiro yayo
Avastin mushonga unopihwa netsinga kana kuti neIV. Unowanzopihwa mavhiki maviri kusvika matatu ega ega pamwe chete nechemotherapy. Chinhu chakakosha kurangarira ndechekuti mushonga uyu unowedzera mhedzisiro yechemotherapy, asi hauna kuratidzwa kuti unoshanda zvakanaka kana uchipihwa wega kune varwere vane kenza yemuura.
Zvakakosha kutaura pachena nachiremba wako nezve chero kusagadzikana kwaungasangana nako usati watanga kurapwa uku uye panguva yacho.
| Migumisiro inogona kuitika yeBevacizumab (Avastin) | |
|---|---|
| Migumisiro inowanzoonekwa | |
| Kunzwa kuneta uye kusaziva hupenyu | Musoro |
| Kukwira kweropa | Kuda kudya |
| Manyoka (kurwadziwa kwemudumbu) | |
| Migumisiro yakakomba inofanira kuziviswa kuna chiremba nekukasika | |
| Kuboorwa kweura (kungada kuvhiyiwa) | Kukuvara kweitsvo uye kuwedzera kweprotein muweti |
| Kurwadziwa kwemoyo kana kurwadziwa kwechipfuva | Kupora kwemaronda kushoma (saka hazvifanirwe kushandiswa pakarepo mushure mekuvhiyiwa) |
| Matambudziko ekubuda ropa zvakanyanya kana kugwinha kweropa | |
Mishonga inodzima "kukura kwemasero" ekenza
Ngatitaurei nezverumwe rudzi rwe monoclonal antibody. Izvi hazvishande sezvatakambotaura. Mishonga iyi inotarisa zvakananga puroteni chaiyo pamusoro pemasero ekenza. Inonzi Epidermal Growth Factor Receptor (EGFR) .
Zvichitaurwa zviri nyore, EGFR iyi yakafanana ne "switch" inoudza sero rekenza kuti "rikure, rikure." Inenge 75% yekenza yemuura ine puroteni iyi yeEGFR.
Mishonga inonzi cetuximab (Erbitux) nepanitumumab (Vectibix) inoshanda nekubatanidza pa "switch" iyoyo inonzi EGFR uye kuidzima. Izvi zvinodzivirira chiratidzo chechisikigo chinoudza masero kuti akure kuti asabatane neswitch. Nekuda kweizvozvo, masero ekenza anomira kukura.
Erbitux neVectibix zvinoshandiswa naani?
Mishonga iyi yese inotenderwa kenza yemuura yakapararira (yakapararira) kune dzimwe nhengo dzemuviri. Asi pane chinhu chimwe chakakosha . Usati watanga kurapwa uku, unofanirwa kuongororwa majini (`genetic mutation test`) emasero ako ekenza. Kuongororwa ikoko ndiko kunosarudza kana mishonga iyi ichizoshanda pakenza yako kana kwete. Izvi hazvina kukodzera munhu wese.
Erbitux inopihwa nemutsinga kamwe chete pasvondo. Inopihwa yoga kana nemushonga wechemotherapy irinotecan (Camptosar). Vectibix inopihwa mavhiki maviri ega ega, kazhinji pamwe chete nemimwe mishonga yechemotherapy yakati wandei.
| Migumisiro inogona kuitika yeErbitux neVectibix | |
|---|---|
| Matambudziko eganda: maronda akaita semapundu, mapundu eganda, ganda rakaoma. (Yeuka, dzimwe nguva maitiro aya eganda anogona kuva chiratidzo chekuti mushonga uri kushanda kurwisa kenza!) | Kupindwa nechando |
| Kunzwa kuneta uye kusaziva hupenyu | Kuzvimba |
| Kurwadziwa kwedumbu | Kurwara nepfungwa dzakadai sekuoma kufema uye kuderera kweropa |
| Maitiro anoitika kana mushonga wacho wapihwa mumuviri | |
Kurapa kwose uku kwakanyatsojeka. Chiremba wako chete ndiye anogona kusarudza kurapwa kwakanakira iwe zvichienderana nerudzi rwegomarara uye hutano hwako. Usaite sarudzo zvichibva pane zvawaverenga pa internet kana zvakataurwa nemumwe munhu.
Mharidzo Yekuenda Nayo Kumba
- Monoclonal Antibody mushonga wakagadzirwa murabhoritari unongorwisa masero ekenza chete.
- Kune nzira dzakasiyana dzinoshanda nadzo. Mimwe mishonga inovhara ropa rinoenda kugomarara, nepo mimwe inomisa zviratidzo zvinoburitswa nemasero egomarara kuti akure.
- Mishonga iyi haifanani kune wese munhu. Mimwe mishonga isati yapihwa, ungangoda kuita bvunzo dzemajini kuti uone kana mushonga wacho uchizoshanda pagomarara rako.
- Kufanana nemishonga yese, iyi ine migumisiro yakaipa. Usaitye, asi taura nachiremba wako nezvazvo zvakajeka usati watanga kurapwa.
- Chiremba wako anokurapa chete ndiye anogona kukupa mazano akanakisisa uye gwara maererano nekurapwa kwako kenza, saka zvakakosha kuti utevedzere mirairo yavo.
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