Mudiwa wako, pamwe amai vako, baba, ambuya kana sekuru, vane chirwere cheAlzheimer here? Tose tinoziva kusuruvara nekushaya simba kunouya nekurasikirwa nendangariro zvishoma nezvishoma uye kukanganwa zviso zvaunoziva. Chirwere cheAlzheimer chirwere chinogona kukonzera kurasikirwa nendangariro, kukuvara kwepfungwa uye kunyange kufa. Kunyangwe pasina mushonga wechirwere ichi, kune mishonga inogona kuchideredza uye kupa zororo kumurwere. Nhasi tichataura nezveimwe mhando yemishonga yakadaro. Ndiyo NMDA Receptor Antagonists . Kunyangwe zita racho rakaoma zvishoma, ngatirinzwisise zviri nyore.
Nyaya diki yemakemikari inoitika muuropi
Uropi hwedu inzvimbo inoshamisa. Hune mabhiriyoni emasero etsinga, kana kuti 'ma neuron'. Masero aya anogadzira ruzivo, anoyeuka ruzivo, uye anoudza dzimwe nhengo dzemuviri zvekuita nekutumirana zviratidzo zvemagetsi nemakemikari.
Tinodaidza vatumwa vanotakura zviratidzo zvemakemikari izvi kuti 'neurotransmitters'. Mumwe wevatumwa ivavo ndi 'glutamate' .
Ingofunga nezve glutamate sechikepe chinotakura meseji kubva kune imwe tsinga kuenda kune imwe. Chikepe ichi chinoda doko rakakosha kuti chiende kune imwe sero nedoko. Dock iyoyo ndiyo yatinodaidza kuti NMDA receptor (`N-methyl-D-aspartate` receptor. Kana chikepe chinonzi glutamate chikabatana nechiteshi ichi cheNMDA, chinotumira chimwe chinhu chakakosha chinonzi `calcium` musero. Calcium iyi ndiyo inopedzisa meseji iyoyo uye inotibatsira kudzidza nekurangarira chimwe chinhu. Iyi inzira yakajairika muuropi hune hutano.
Saka chii chinoitika muchirwere cheAlzheimer?
Mumasero europi emunhu ane chirwere cheAlzheimer , glutamate yakawandisa inotanga kubudiswa . Chinoitika ndechekuti calcium yakawandisa inoyerera mumasero etsinga iwayo. Fungidzira kuti chii chinoitika kana ukazadza tangi remvura nemvura yakawandisa? Inozara. Saizvozvowo, kana calcium yakawandisa ikaungana mukati memasero, masero iwayo anotanga kukuvara. Kukuvadzwa uku ndiko kunowedzera zviratidzo zveAlzheimer's zvishoma nezvishoma.
Heino nzira iyo NMDA Receptor Antagonists inobatsira nayo
Kirasi yemishonga inonzi NMDA receptor antagonists inoshanda nekuderedza huwandu hwenzvimbo dzinogona kumisa ngarava idzodzo dzeglutamate paNMDA receptor. Kureva kuti, mushonga uyu unovhara mamwe emachiteshi. Asi chinonyanya kukosha ndechekuti mishonga iyi inobvumira mameseji akakosha kuyerera . Kureva kuti, inongodzora huwandu hwecalcium inoparadza pasina kukonzera kukanganisa kukuru pakushanda zvakanaka kweuropi. Izvi zvinoderedza kukuvara kwemasero etsinga uye zvinodzora kumhanya kwechirwere.
Mukurapa chirwere cheAlzheimer, vanachiremba vanowanzo shandisa mishonga inorwisa imwe neurotransmitter inonzi acetylcholine. Asi NMDA receptor antagonists imhando yakakosha yemishonga inoshanda nenzira yakasiyana.
Mushonga mukuru weNMDA receptor antagonist parizvino wabvumidzwa kurapa chirwere cheAlzheimer iMemantine (zita rekuti `Namenda XR`). Kazhinji inonyorerwa navanachiremba padanho riri pakati nepakati kusvika padanho rakasimba rechirwere. Dzimwe nguva, Memantine inopihwa pamwe chete ne `cholinesterase inhibitors` dzambotaurwa, izvo zvinowedzera mazinga eacetylcholine. Izvi zvinogona kutungamira kumhedzisiro iri nani kune vamwe varwere.
Asi yeuka, mishonga iyi haishande zvakafanana kune wese munhu.
Ngatiziveiwo nezvemigumisiro yacho.
Kufanana nemishonga yese, iyi inogona kuva nemigumisiro midiki.
- Dzungu ndicho chiratidzo chinowanzoonekwa.
- Pamusoro pezvo, zvinhu zvakaita semusoro uye kuzvimba zvinogonawo kuitika.
- Kashoma, pane mukana wekuvhiringidzika muuropi .
Kana iwe kana murwere wako mukasangana nechimwe cheizvi, munofanira kuzivisa chiremba wenyu nekukasika . Hazvina kunaka kurega kutora mishonga kana kuchinja mwero wemushonga wega.
Mimwe mishonga mumhuri iyi uye mashandisirwo ayo
Kune mimwe mishonga mumhuri iyi inonzi NMDA receptor antagonists. Mimwe yacho tinoiona muhupenyu hwezuva nezuva. Mimwe yacho ine njodzi zvishoma, uye inoshandiswa zvisina kunaka semishonga. Masayendisiti ari kutsvagisawo mabhenefiti emhando iyi yemishonga kune zvimwe zvirwere zvetsinga, zvakaita seParkinson's disease neALS (amyotrophic lateral sclerosis).
Ngatidzidzei zvakawanda nezvazvo kubva patafura iri pazasi.
| Zita reMushonga | Kushandiswa kukuru | Pfungwa dzakakosha nenjodzi |
|---|---|---|
| Dextromethorphan | Iri mumasipi ekukosora. | Kazhinji zvakachengeteka, asi zvinogona kuva nengozi kana zvikatorwa zvakanyanya. |
| Ketamine | Mushonga unonyaradza marwadzo (wevanhu nemhuka). | Inoshandiswa kuderedza marwadzo panguva yekuvhiyiwa. Asi inoshandiswa zvisina kunaka se "mushonga wekirabhu". Inogona kukonzera kuona zvinhu zvisipo uye kunzwa sekunge yabviswa mumuviri. Kutsvagurudza kuri kuitwa pakushandiswa kwayo pazvirwere zvakaita sekuora mwoyo. |
| Phencyclidine (PCP) | Kushandiswa zvisina kunaka semushonga. | Pakutanga yakagadzirwa semushonga unonyaradza marwadzo, yakabviswa pakushandiswa nekuda kwemigumisiro yakaipa (kufungidzira, kuvhiringidzika). Mushonga une njodzi unozivikanwa se "Angel Dust". Wakabatana nemaitiro echisimba. |
Mharidzo Yekuenda Nayo Kumba
- Kunyange hazvo chirwere cheAlzheimer chisingagoni kurapwa zvizere, mishonga inodzivirira masero eNMDA receptor yakadai sememantine inogona kubatsira kudzora matanho ari pakati nepakati kusvika akanyanya echirwere nekuderedza kukuvara kwemasero europi.
- Mishonga iyi inoshanda nekudzivirira masero etsinga kubva ku glutamate yakawandisa muuropi.
- Sezvinongoita chero mushonga, migumisiro yakadai sedzungu inogona kuitika. Gara uchikurukura izvi nachiremba wako. Usambofa wakachinja dosi kana kurega kutora mushonga wega.
- Rudzi urwu rwemishonga, senge Ketamine nePCP, inoshandiswa zvisina kunaka semishonga inodhaka uye ine njodzi huru. Pane musiyano mukuru pakati pemishonga iyi nemishonga inorayirwa chirwere cheAlzheimer.
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