Oligodendroglioma: Ngatidzidzei nezverudzi urwu rwegomarara remuuropi nemashoko ari nyore

Unowanzo rwara nemusoro pasina chikonzero here? Kana kuti wakamboerekana wabatwa nepfari kekutanga muhupenyu hwako here? Dzimwe nguva chikonzero chakakomba chezvinhu izvi ibundu remuuropi. Kunyangwe kunzwa mashoko aya kunotityisa zvikuru, handiti? Asi nhasi tichataura nezverudzi rwebundu remuuropi risingawanzoitiki, asi rinopindura zvakanaka pakurapwa. Ndiyo oligodendroglioma.

Zvichitaurwa zviri nyore, chii chinonzi oligodendroglioma?

Oligodendroglioma ibundu rinokura muuropi. Kashoma, rinogonawo kukura mumuzongoza. Mabundu aya anokura kubva mumhando yemasero chaiwo mutsinga dzedu dzinonzi glial cells. Kutaura chokwadi, kubva mumasero anonzi 'oligodendrocytes' pakati pemasero eglial.

Zvino ungave uchishamisika kuti aya masero eglial, maoligodendrocytes, chii. Fungidzira kuti sisitimu yedu yetsinga ikambani hombe. Basa guru mairi rinoitwa nevashandi vanonzi ma neuron. Ndivo vanotakura mashoko kubva kuuropi kuenda kumuviri uye kubva kumuviri kuenda kuuropi. Saka kune boka revabatsiri vanobatsira ma neuron aya, vanoadzivirira, uye vanoapa chikafu chavanoda. Aya ndiwo masero eglial .

Saka chii chinonzi oligodendrocytes idzi?

Zita iri rinonzwika serisinganzwisisike, handiti? Rakagadzirwa nemashoko akati wandei echiGiriki.

• Oligo (Oligo-): diki
• Dendro (-dendro-): semuti
• MaCytes (-cytes): masero

Zvichitaurwa zviri nyore, zvinoreva "masero madiki ane matavi akaita semuti." Basa remasero aya rakakosha zvikuru. Maneuron edu ane ruoko rurefu runonzi axon. Apa ndipo panofamba zviratidzo zvemagetsi. Sewaya yemagetsi . Saka pane sheath inodzivirira yakakomberedza axon iyi. Inonzi myelin sheath. Izvi zvinoita kuti zviratidzo zvifambe nekukurumidza uye pasina kubuda. Kuti myelin sheath inogadzirwa nemasero aya anonzi oligodendrocytes . Sero rimwe chete reoligodendrocyte rinogona kugadzira myelin sheath yakakomberedza axon ine maneuron angangoita 30-40 kumusoro nepasi. Ndosaka zvichinzi rine matavi akaita semuti.

Saka, oligodendroglioma bundu rinokura kubva mukupatsanurwa kusingadzoreki kwemasero e-oligodendrocyte, ayo anoita basa iroro rinokosha.

Kune mhando dzenzungu idzi here?

Ehe. Sangano reWorld Health Organization (WHO) rakapatsanura mabundu aya muzvikamu (magiredhi) zvichienderana nekuoma kwawo. Saka, kune mhando mbiri huru dzeoligodendroglioma. Ngatitarisei izvi nenzira iri nyore kuti tizvinzwisise.

Ndezvipi zviratidzo zve oligodendroglioma?

Kazhinji, zviratidzo zvemabundu emuuropi zvinoonekwa kana bundu racho rakakura zvakakwana kuti ritange kudzvanya tsinga dzeuropi dzakapoteredza. Zviratidzo zviviri zvinonyanya kuzivikanwa zve oligodendroglioma misoro nepfari . Kutaura zvazviri, vanhu vanosvika 80% vane chirwere ichi vanobatwa nepfari.

Izvi zvinodaro nekuti rudzi urwu rwebundu runowanzo buda muuropi hwedu, chikamu chekunze, chakakombama. Nzvimbo iyi ine nzvimbo dzinoita mabasa edu ezuva nezuva, akadai sekuona, kutaura, uye kudzora tsandanyama. Kana bundu rikawedzera nzvimbo idzi, pfari dzinogona kuitika.

Pamusoro pepfari, "zviratidzo zvefocal" zvinogonawo kuitika, zvichiratidza dambudziko munzvimbo chaiyo yeuropi. Izvi zvinosanganisira:

• Kushaya simba kwetsandanyama kana kuoma mitezo kune rumwe rutivi rwemuviri kana rumwe rutivi rwechiso .
• Kurasikirwa nekunzwa.
• Kuomerwa nekutaura kana kunzwisisa zvinotaurwa nevamwe (aphasia).
• Kuona kusina simba, kuona kaviri, kuona zvisipo.
• Matambudziko ekurangarira.
• Kuomerwa nekufunga uye kuisa pfungwa pachinhu chimwe chete.

Chii chiri kukonzera mamiriro ezvinhu aya?

Iyi inyaya inokosha zvikuru. Kuti munhu aonekwe aine oligodendroglioma, panofanira kunge paine shanduko mbiri dzemajini.

Fungidzira kuti kune bhuku guru remaresipi rinopa mirairo kumasero ari mumuviri wedu. Tinoridaidza kuti DNA. Zvinhu zvinosanganiswa neDNA iyi zvinonzi machromosome. Masero paanopatsanurana, bhuku iri remaresipi rinokopwa. Dzimwe nguva zvikanganiso zvinogona kuitika panguva yekukopa. Zvakanaka, zvikanganiso zviviri zvakadaro ndizvo zvinokonzera izvi.

1. 1p/19q co-deletion: Zvikamu zviviri zvidiki zvema chromosome edu nhamba 1 nenhamba 19 zvinobviswa. Ichi ndicho chiratidzo chikuru chemajini mumabundu aya.

2. Kuchinja kweIDH1 kana IDH2: Kuchinja kunoitika mujini rinogadzira enzyme inobatsira mukugadzirisa muviri mumuviri wedu.

Kusvika pari zvino, hapana zvimwe zvinhu zvakawanikwa zvinokonzera chirwere ichi.

Ndezvipi zvinetso zvinogona kukonzera izvi?

Matambudziko egomarara remuuropi anoenderana nenzvimbo yaro uye saizi yaro. Mamwe ematambudziko makuru ekutarisira ndeaya:

• Kuchinja kunokuvadza: Dzimwe nguva, bundu remhando yepasi (Giredhi 2) rinogona kuchinja nekufamba kwenguva rozova kenza yepamusoro (Giredhi 3).
• Zvirwere zvakafanana nestroke: Bundu richikura, kumanikidzwa mukati meuropi kunowedzera, zvichiita kuti tsinga dzeropa dzizvimbe, zvichikonzera zvirwere zvakafanana nestroke.
• Kuchinja kwemapfupa edehenya: Mabundu aya anogona kuoma nekuda kwecalcium deposits. Bundu rinokura zvishoma nezvishoma rinogonawo kukanganisa mapfupa edehenya.

Nzira yekuziva sei chirwere ichi?

Kana ukaenda kunoona chiremba wako kana uine zviratidzo, achatevera matanho mashoma.

1. Kuongororwa kwemuviri netsinga: Chiremba achaongorora kuenzana kwako, simba remhasuru, kuona kwako, uye simba remuviri wako.

2. Kuongororwa kwemifananidzo: Kuongororwa kunoitwa kuti vatarise mukati memusoro.

• CT scan (Computed Tomography): Izvi zvinowanzoitwa kekutanga kana paine chimwe chinhu chakaita sepfari. Mabundu aya anogona kuonekwa zvakanaka paCT scan nekuti ane calcium.
• Kuongororwa kweMRI (Magnetic Resonance Imaging): Izvi zvinogona kupa ruzivo rwakadzama pamusoro penyama yeuropi, saizi, uye nzvimbo yebundu.

3.Kuongororwa kweUropi: Iyi ndiyo bvunzo inosimbisa chirwere ichi 100% . Kuongororwa kwega hakugone kuratidza zvechokwadi kuti ioligodendroglioma. Mukuongorora, chiremba wepfungwa anovhiya kubvisa chidimbu chidiki chebundu racho ochitumira kurabhoritari. Ikoko, masero anotariswa nemaikorosikopu. Vanoongororawo kuvapo kweshanduko dzemajini dzatakambotaura nezvadzo, 1p/19q co-deletion uye IDH mutation . Kana zvese zviripo, ioligodendroglioma zvechokwadi.

Mishonga yacho ndeipi? Zvinokwanisika here kuirapa zvachose?

Mashoko akanaka ndeekuti, zvichienzaniswa nedzimwe mhando dzemabundu emuuropi, oligodendroglioma ndeimwe yemabundu anorapika uye anorapika zvakanyanya. Inowanzo rapwa nekurapwa kwakabatana.

Kuvhiya

Chinangwa chekutanga uye chinonyanya kukosha ndechekubvisa bundu rakawanda sezvinobvira kuburikidza nekuvhiyiwa. Dzimwe nguva bundu rinogona kubviswa zvachose. Izvi zvinoenderana nezvinhu zvakawanda, kusanganisira saizi yebundu, nzvimbo yaro, uye ruzivo rwachiremba wako.

Kurapwa nemakemikari

Mishonga yemakemikari inopiwa kuuraya chero masero angasara mushure mekuvhiyiwa. Kune mishonga yakawanda inoshanda ye oligodendroglioma.

• Nzira yekurapa nePCV: Uyu musanganiswa wemishonga mitatu: procarbazine, lomustine, uye vincristine.
• Temozolomide: Mushonga uyu dzimwe nguva unoshandiswa panzvimbo pePCV nekuti une migumisiro mishoma uye wakafanana zvikuru nePCV.

Kurapa Nemwaranzi

Izvi zvinosanganisira kunanga mwaranzi ine simba guru (yakafanana neX-rays) kunzvimbo ine bundu, kuparadza chero masero ekenza asara ukuwo zvichideredza kukuvara kwenyama yakakomberedza ine hutano.

Chiremba wako nechikwata chevanachiremba vachasarudza pamwe chete kuti ndeipi mishonga yakakunakira, kuti ichagara kwenguva yakareba sei, uye kana uchida kurapwa nechemotherapy kana nemwaranzi mushure mekuvhiyiwa.

Hupenyu huchava hwakaita sei nechirwere ichi? (Outlook)

Zvinonzwisisika kuti chero munhu atye uye avhunduke paanonzwa nezvegomarara remuuropi. Asi oligodendroglioma haisi chirwere chekurasa tariro machiri.

Huwandu hwevanhu vanorarama kwemakore mashanu - huwandu hwevanhu vanorarama makore mashanu mushure mekuonekwa kuti vane chirwere ichi - huri pakati pe69% ne90% yemamota asina kukura. Kunyangwe kumamota ane kukura, huri pakati pe45% ne76%. Aya manhamba chete, mamiriro ako ezvinhu anogona kunge ari nani zvikuru.

Uyewo, tsvakiridzo iri kuenderera mberi pamishonga mitsva inorwisa mabundu aya ane IDH mutation, saka tinogona kuva netariro yakanaka yeramangwana.

Zvinhu zvaunogona kuita uye mibvunzo yekubvunza chiremba wako

Kana uine chirwere ichi, zvakakosha kutevedzera mirairo yakapihwa nechikwata chako chekurapa. Zvakakosha kuenda kunorapwa nenguva uye kutora mishonga yako nemazvo. Kurapwa kunogona kuva nemigumisiro yakaipa. Usatya kutaura nachiremba wako nezvazvo uye kudzidza nezvezvingaitwa nezvazvo.

Usazeza kubvunza chiremba wako mibvunzo iyi:

• Bundu rangu riri padanho ripi (giredhi)?
• Izvi zviri kupi muuropi? Zvingakanganisa hunyanzvi hupi?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Bundu iri rinogona kubviswa zvachose nekuvhiyiwa here?
• Ndezvipi migumisiro kana matambudziko ekurapwa?
• Ndinoda chemotherapy, radiation therapy, kana zvese zviri zviviri here?
• Purogiramu yekurapwa yakaita sei?
• Ndezvipi zviratidzo zvandinofanira kutsvaga rubatsiro rwechiremba panguva yekurapwa kana mushure mekurapwa? (semuenzaniso, musoro wakanyanya, pfari dzinogara dzichiitika).