Zvaunofanira kuziva nezve mushonga wekudzivirira cholesterol (PCSK9 Inhibitors) wazvino uno.

Uri kunetsekawo necholesterol here? Pamwe uri kutora mushonga wawakanyorerwa nachiremba wako, kudzora kudya kwako , uye kurovedza muviri. Asi zvichiri kuoma kuderedza cholesterol yako, handiti? Dzimwe nguva, zvisinei nekuti unoedza sei, cholesterol yakaipa mumuviri wako inogona kuramba yakakwira. Muchinyorwa chino, tichataura nezvemhando itsva yemishonga inogona kubatsira vanhu vakadaro.

Zvichitaurwa zviri nyore, chii chinonzi PCSK9 Inhibitors idzi?

Izvi zvinganzwika sezita rakaoma kunzwisisa, asi zvinoshanda zviri nyore. Mishonga inodzivirira PCSK9 imhando yemishonga inoderedza cholesterol. Kunyanya, inonyanya kurwisa cholesterol yeLDL (Low-Density Lipoprotein) , inova "cholesterol yakaipa" inokuvadza miviri yedu. Vamwe vanhu vane cholesterol yakakwira muhupenyu hwavo hwese. Kune vanhu ivavo, rudzi urwu rwemushonga runogona kubatsira zvikuru.

Zvakanaka, ngationei zvinorehwa nezita rekuti `PCSK9`. `PCSK9` imhando yeprotein inogadzirwa nechiropa chedu. Zita reprotein iyi ndi` proprotein convertase subtilisin/kexin type 9`. Chainoita ndechekudzora zvinhu zvinonzi `LDL receptors` mumuviri wedu. Zvidzidzo zvekurapa zvakawana kuti kana muviri wemunhu uchigadzira mapuroteni akawanda e`PCSK9`, munhu iyeye ane mukana wekuva necholesterol yakakwira .

Ndiani anoda mushonga uyu?

Uyu mubvunzo unokosha zvikuru. Nekuti mushonga uyu haupiwi kune wese munhu ane cholesterol yakakwira. Kazhinji pane mamiriro maviri makuru apo chiremba wako anogona kukupa mushonga uyu we 'PCSK9 inhibitor':

1. Kana cholesterol isingadzorwi nemimwe mishonga: Kana uchitoshandisa mimwe mishonga inoderedza cholesterol, yakaita se `(statins)` asi huwandu hwecholesterol yako huchiri pamusoro, unogona kufunga nezvemushonga uyu sedanho rinotevera.

2. Mune mamwe mamiriro ezvinhu emumajini: Vamwe vanhu vane chirwere chekuzvarwa nacho checholesterol yakakwira. Izvi zvinonzi ``familial hypercholesterolemia`` mune zvesainzi yekurapa.Mushonga uyu unobatsirawo zvikuru kune vanhu vane chirwere ichi.

Mushonga uyu unoshanda sei mumuviri?

Kuti tinzwisise izvi, ngatitorei muenzaniso mudiki.

Fungidzira kuti muviri wako une "maoko anobata cholesterol." Tinoadaidza kuti "LDL receptors." "Mareceptor" aya anowanikwa zvakanyanya pamusoro pemasero edu echiropa. "Maoko" aya anobata cholesterol yakaipa iri kuyerera muropa (LDL cholesterol) oiisa muchiropa. Chiropa chinozopwanya cholesterol iyoyo yoibvisa mumuviri. Iyi inzira yakajairika.

Asi pane kamuipi pano. Ndiyo puroteni ye`(PCSK9)` yatakambotaura nezvayo. Iyi puroteni ye`PCSK9` inoshanda se`chigero`. Chainoita kuparadza maoko anobata cholesterol, kureva `LDL receptors`, uye kuderedza mashandiro awo. Kana puroteni ye`PCSK9` ikawedzera mumuviri, huwandu hwe`maoko` anobata cholesterol hunoderera. Ipapo cholesterol yakaipa muropa haigone kubviswa nechiropa uye inoungana muropa.

Iye zvino ungangove wava kunzwisisa zvinoitwa nemushonga we `PCSK9 inhibitor`. Kutaura chokwadi, mushonga uyu unodzivisa puroteni ye `PCSK9` inoshanda sechigero. Izvi zvinoreva kuti, kana mushonga uyu ukatorwa, puroteni ye `PCSK9` haigone kuparadza maoko iwayo anotora cholesterol (LDL receptors).

Chii chinoitika ipapo?

• Kune mareceptor eLDL anoshanda zvakanyanya.
• 'Maoko' aya anoshanda anobata cholesterol yakaipa yakawanda muropa oiendesa kuchiropa.
• Chiropa chinobvisa cholesterol iyoyo mumuviri.

Mugumisiro wacho kudzikira kukuru kwehuwandu hwecholesterol yakaipa muropa rako.

Mushonga uyu unoshanda zvakadii? Uye ndeapi marudzi acho?

Mishonga inodzivirira PCSK9 imhando yemishonga yakaratidzwa kuti inoshanda zvikuru kune vamwe vanhu. Dzimwe ongororo dzakawana kuti mishonga iyi inogona kuderedza huwandu hwecholesterol yakaipa (LDL cholesterol) kusvika ku70% uye inogonawo kuderedza njodzi yekurwara nemoyo neinenge chikamu chimwe muzvitatu.

Kune mhando mbiri dzemishonga inonzi `PCSK9 inhibitors` dziri kushandiswa zvakanyanya muSri Lanka nepasi rose:

• `Alirocumab` (zita rechiratidzo: Praluent®)
• `Evolocumab` (zita rechiratidzo: Repatha®)

Unotora mushonga uyu sei?

Iri harisi piritsi rekunwa zuva nezuva. `PCSK9 inhibitors` inopihwa sejekiseni.Kazhinji uchafanirwa kuwana mushonga uyu mavhiki mashoma ega ega kana mwedzi mishoma yega yega, sezvakatarwa nachiremba wako.

Paunenge uchitora mushonga uyu, chiremba wako achaita bvunzo dzeropa nguva nenguva kuti aone kuti mushonga wacho unoshanda sei. Dzimwe nguva mushonga uyu unogona kupihwa wega, uye dzimwe nguva unogona kupihwa pamwe chete nemushonga wauri kutotora, wakadai se statin.

Ndezvipi zvakanakira uye migumisiro inogona kuitika?

Kufanana nemushonga upi zvawo, mushonga uyu unogona kuva nezvakanaka uye zvikanganiso zvidiki. Zvisinei, vanhu vazhinji havasangani nematambudziko akakomba.

Mushonga chete ndiwo wakakwana here? Kwete, ichi chikamu chechirongwa chikuru.

Izvi zvakakosha zvikuru. Kunyangwe uchitora mushonga wePCSK9 inhibitor kana mumwe mushonga unoderedza cholesterol, chikamu chimwe chete chechirongwa chako chekurapa. Kune zvimwe zvinhu zvakawanda zvaunogona kuita kuchengetedza hutano hwemwoyo wako, usingangovimbi nemishonga chete.

• Kudya kwakanaka: Idya mafuta mashoma, shuga, nemunyu, uye idya miriwo yakawanda, michero, miriwo, nezvikafu zvine fiber yakawanda.
• Kurovedza muviri: Ita maekisesaizi ane hutano hwemoyo, akadai sekufamba nekukurumidza, kumhanya, kana kutasva bhasikoro, kwemazuva mashoma pasvondo.
• Kudzora kushushikana: Kuzorodza pfungwa dzako kuburikidza nezvinhu zvakaita sekufungisisa neyoga.
• Kurara zvakanaka: Rara kwemaawa manomwe kusvika masere husiku hwega hwega.
• Dzivisa kusvuta: Kana ukasvuta, rega zvachose.

Uchawana mhedzisiro yakanaka kana ukasanganisa shanduko idzi dzemararamiro nemishonga.

Mishonga inodzivirira PCSK9, cholesterol, cholesterol, LDL cholesterol, chirwere chemwoyo, sitiroko, hypercholesterolemia yemhuri, statin, Alirocumab, Evolocumab