Wakamboomerwa here nekudzora cholesterol yako, kunyangwe wakamboedza mishonga yakasiyana-siyana, kudya, uye kurovedza muviri? Dzimwe nguva zvinoitika. Izvi zvinonyanya kuoma kana uine nhoroondo yemhuri ine cholesterol yakakwira. Nhasi, tiri kutaura nezvemhando itsva yemishonga inogona kubatsira. Idzi dzinonzi PCSK9 inhibitors.
Ndezvipi izvi zvinonzi PCSK9 Inhibitors?
Zvichitaurwa zviri nyore, iyi mishonga ine simba inoderedza cholesterol inopiwa sejekiseni. Inonyanya kunanga cholesterol yeLDL (Low-Density Lipoprotein Cholesterol) , iyo "cholesterol yakaipa" yatinoziva tese seyakaipa kumiviri yedu. Vanachiremba vanowanzo nyora mishonga iyi kuvanhu vasina kuwana mhedzisiro yaidiwa kubva kune mimwe mishonga yecholesterol, senge statins, kana kune vanhu vane nhoroondo yemhuri yecholesterol yakakwira.
Mushonga uyu unoshanda sei mumuviri?
Kuti tinzwisise izvi, ngatitorei muenzaniso mudiki. Fungidzira kuti cholesterol yakaipa (LDL) iri muropa rako rudzi rwemarara. Kuti tibvise marara aya uye tichenese ropa, chiropa chedu chine "gaba remarara" rakakosha pamusoro paro. Izvi ndizvo zvatinodaidza kuti ma LDL receptors . Zvinoitwa nema receptors aya kubata cholesterol yeLDL muropa uye kuiisa muchiropa kuti iparadzwe.
Zvino heino imwezve. Iyoyo ipuroteni inonzi PCSK9 . Iyi inogadzirwawo nechiropa chedu. Asi basa repuroteni iyi yePCSK9 nderekuparadza ma LDL receptors (magaba edu emarara) anobvisa cholesterol. Kana huwandu hwePCSK9 hwawedzera mumuviri, ma LDL receptors akawanda anoparadzwa. Ipapo kubviswa kwecholesterol muropa kunoderera, uye huwandu hwecholesterol muropa hunowedzera.
Saka, zvinoitwa nejekiseni rePCSK9 inhibitor inhibitor kuvharira puroteni iyoyo inoparadza yePCSK9 uye kuimisa kushanda kwayo. Zvadaro ma LDL receptors edu haaparadzwe, uye anogona kushanda zvakasununguka. Mugumisiro wacho ndewokuti cholesterol yakawanda yeLDL inobviswa muropa, uye huwandu hwecholesterol hunodzikira zvakanyanya. Zviri nyore, handiti?
Mushonga uyu unokurudzirwa kushandisirwa ani?
Uyu hausi mushonga wemhando imwe chete. Chiremba wako ndiye achasarudza kana mushonga uyu wakakunakira zvichibva pane zvimwe zvinhu.
| Chinzvimbo | Tsananguro |
|---|---|
| Cholesterol yakakwira isingadzorwe nemimwe mishonga | Kana mazinga ako eLDL achiri akakwira pasinei nekutora statin yakawanda nemimwe mishonga yecholesterol. |
| Zvirwere zveropa zvine cholesterol yakakwira | Vanhu vane cholesterol yakakwira zvakanyanya kubvira paudiki nekuda kwezvirwere zvemajini zvakaita seFamilial Hypercholesterolemia. |
| Kune avo vari panjodzi huru yechirwere chemwoyo | Kana wakambova nechirwere chemwoyo kana sitiroko, uye njodzi yekuti chirwere chakadaro chiitike mune ramangwana yakanyanya. |
Ndingawana sei mushonga uyu?
Idzi dzinopihwa sejekiseni, kwete piritsi. Zvichienderana nekukurudzirwa nachiremba wako, unowanzo gamuchira jekiseni iri muchipatara kana kiriniki mavhiki mashoma kana mwedzi wega wega. Mhando mbiri huru dziri kushandiswa muSri Lanka parizvino ndiAlirocumab (Praluent®) neEvolocumab (Repatha®) .
Mushure mekutanga kurapwa uku, chiremba wako achaita bvunzo dzeropa nguva nenguva uye anotarisa huwandu hwecholesterol mumuviri wako kuti aone kuti inoshanda sei.
Ndezvipi zvakanakira uye migumisiro yazvo?
Chinhu chikuru chakanakira mushonga uyu ndechekuti unoshanda zvikuru mukuderedza huwandu hweLDL cholesterol. Sekureva kwezvimwe zvidzidzo, vanogona kuderedza huwandu hweLDL nepakati pe50% ne70% . Izvi zvinoderedza zvakanyanya njodzi yekurwara nemoyo, sitiroko, nezvimwe zvirwere zvemoyo.
Kunyange hazvo vanhu vazhinji vasingabatwe nemigumisiro yakaipa, vamwe vanogona kusangana nemimwe mishoma.
- Kuzvimba, kutsvuka, kana kurwadziwa panzvimbo yekubaiwa jekiseni
- Kunzwa kuneta (Kuneta)
- Kurwadziwa kwetsandanyama
- Zviratidzo zvakaita sechando
Kashoma, vamwe vanhu vanogona kusangana nematambudziko pakushanda kwechiropa kana itsvo dzavo. Ndosaka zvichikosha kuona chiremba wako nguva nenguva kuti aongororwe . Kana ukaona zviratidzo zvisingawanzoitiki, zivisa chiremba wako nekukasika.
Hazvina kukwana here kushandisa mushonga uyu chete?
Uyu mubvunzo unokosha zvikuru. Mhinduro ndeiyi, "Kwete, hazvina kukwana." Mishonga inodzivirira PCSK9 haisi mashiripiti. Inongova chikamu chimwe chete chechirongwa chekurapa.
Yeuka kuti kudzora cholesterol hakusi kungotora piritsi chete, asi kushandura mararamiro ako ese.
Paunenge uchitora mushonga uyu, unofanira kunyatsotevera zvinotevera:
- Kudya zvine hutano: Idya mafuta mashoma, shuga, nemunyu, uye idya michero nemiriwo yakawanda nezvikafu zvine fiber yakawanda.
- Kurovedza muviri nguva dzose: Ita maekisesaizi akadai sekufamba kana kumhanya kwemaminitsi makumi matatu pazuva, mazuva mashanu pasvondo.
- Kudzora kushushikana: Kuzorodza pfungwa kuburikidza nezvinhu zvakaita seyoga nekufungisisa.
- Kurara zvakakwana: Wana maawa manomwe kusvika masere ekurara zvakanaka zuva nezuva.
- Kurega kusvuta: Kurega zvachose kusvuta uye zvigadzirwa zvefodya.
Uchawana mhedzisiro yakanaka kubva kuPCSK9 inhibitor therapy kana ukasanganisa shanduko idzi dzemararamiro. Usamborega kutora mushonga kana kuchinja dose usina kurairwa nachiremba wako.
Mharidzo Yekuenda Nayo Kumba
- Mishonga inodzivirira PCSK9 imhando yejekiseni ine simba inoshandiswa kuderedza huwandu hweLDL cholesterol yakakwira iyo isingadzorwe nedzimwe nzira dzekurapa.
- Izvi zvinodzivirira ma LDL receptors echiropa uye zvinoita kuti nzira yekubvisa cholesterol muropa ishande zvakanaka.
- Uyu mushonga unongokurudzirwa nachiremba chete kune vanhu vakasiyana (semuenzaniso, cholesterol yakakwira kubva kuvabereki, njodzi yakakura yechirwere chemwoyo).
- Zvakakosha zvikuru kuchengetedza mararamiro ane hutano paunenge uchirapwa uku.
- Ramba uchirapwa nenzira iyi chete kana chiremba wako akurayira, uchiramba uchikurukura naye nguva dzose.
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