Unodawo kuziva nezvePelger-Huet Anomaly here? Ngatikurukurei nezvazvo!

Wakamboudzwa here nachiremba nezvekuchinja kudiki mumasero machena eropa rako pawakaongororwa ropa? Zvingave zviri Pelger-Huet Anomaly. Zita racho ringanzwika sedambudziko guru, asi usazvidya moyo , kazhinji harisi dambudziko guru. Ngatitaurei nezvazvo zvakadzama, nenzira iri nyore.

Chii chinonzi Pelger-Huet Anomaly?

Zvichitaurwa zviri nyore, Pelger-Huet Anomaly (PHA) chirwere chemajini chinokanganisa ma neutrophils, rudzi rwemasero machena eropa mumuviri wedu. Ma neutrophils akafanana nemasoja madiki mumuviri wedu anobatsira muviri wedu kurwisa utachiona.

Dambudziko iri rinokonzerwa nekusiyana kuri muDNA yedu, kunyanya mujini rinonzi Lamin B Receptor (LBR gene). Iri jini reLBR ndiro rinobatsira masero e-neutrophil kukura nekukura zvakanaka.

Zvino tarisai, sero rega rega rema neutrophil rine nzvimbo yekudzora, yatinodaidza kuti nucleus . Iyi nucleus ine ruzivo rwese rweDNA runodiwa nesero kuti rishande uye rikure. Kazhinji, nucleus ye neutrophil ine hutano inokamurwa kuita zvikamu zvitatu kana kupfuura. Zvisinei, nucleus ye neutrophil mumunhu ane Pelger-Huette ine zvikamu zviviri. Yakaita se dumbbell, ine mafuta kumativi ese uye pakati payo pakatetepa. Kashoma, mune vamwe vanhu, iyi nucleus ye neutrophil inogona kunge yakaita sedenderedzwa, kureva kuti, yakaumbwa sezai.

Asi chinhu chakakosha pano ndechekuti kunyangwe kana wakazvarwa uine Pelger-Huette anomaly, kazhinji masero ako e-neutrophil anoshanda zvakanaka. Izvi zvinoreva kuti haana kukanganiswa zvakanyanya mukudzivirira kubva kuzvirwere. Saka, kazhinji haakonzeri matambudziko makuru ehutano.

Kune rimwe dambudziko rinonzi Pseudo Pelger-Huet Anomaly (PPHA) . Izvi zvinogona kuitika kune vamwe vanhu pave paya muhupenyu hwavo. PPHA inogona kuitika semhedzisiro yemishonga kana sechiratidzo cheimwe chirwere, senge hutachiona.

Ndezvipi zviratidzo zvePelger-Huette anomaly?

Pano tinofanira kutarisa pamhando mbiri dzatakambotaura nezvadzo.

Hereditary Pelger-Huet Anomaly (HPA)

Kana uine Pelger-Huette anomaly (HPA), iyo inogarwa nhaka, kazhinji hauna zviratidzo. Ungasatomboziva kuti une chirwere ichi. Chinowanzoonekwa netsaona kana ropa rako rikaongororwa nechimwe chikonzero.

Pseudo Pelger-Huet Anomaly (PPHA)

Zvisinei, kana uine pseudo-Pelger-Huette anomaly (PPHA), zvinoreva kuti yakazobuda gare gare, unogona kuona zviratidzo zvine chekuita nechirwere chakakonzera.Semuenzaniso, kana PPHA ikakonzerwa nehutachiona, panogona kunge paine zviratidzo zvakaita sefivha uye kurwadziwa kwemuviri zvine chekuita nehutachiona ihwohwo.

Chii chinokonzera Pelger-Huette anomaly?

Chikonzero cheizvi chinosiyanawo zvichienderana nemhando mbiri dzatakambokurukura.

Kusarongeka kweHereditary Pelger-Huette (HPA)

Izvi zvinokonzerwa nekuchinja kwejini reLamin B Receptor (LBR), sezvatakambotaura. Iri jini reLBR rinorayira muviri wedu kugadzira mapuroteni anodiwa kuchengetedza masero e-neutrophil uye kuapa chimiro chakakodzera. MuPelger-Huytt anomaly, kuchinja kwemajini uku kunokanganisa maitiro iwayo, zvichiita kuti nuclei dzema-neutrophil dzitore chimiro ichocho chedumbbell. Ichi chirwere chinogona kugarwa nhaka kubva kuvabereki kuenda kuvana.

Pseudo Pelger-Huette anomaly (PPHA)

Ichi hachisi chirwere chemajini. Pane zvinhu zvakawanda zvinogona kukonzera chirwere ichi:

• Zvirwere zvemubofu: Mienzaniso inosanganisira zvirwere zveleukemia zvakaita semyelodysplastic syndrome uye acute myeloid leukemia (AML).
• Zvimwe zvirwere: kunyanya zvirwere zvinotapukirwa nezvikwekwe.
• Mishonga inodzvinyirira muviri: Mishonga iyi, inopihwa kune zvimwe zvirwere, inogonawo kuva chikonzero.
• Kusangana nemwaranzi: Semuenzaniso, panguva yekurapwa kenza.

Kana chiremba akakuudza kuti une `PHA` kana `PPHA`, zvakakosha kuzivisa chiremba nezvemishonga yese yauri kutora, kunyangwe mavhitamini.

Ndezvipi zvinhu zvinokonzera njodzi yechirwere ichi?

Chinhu chikuru chinokonzera Pelger-Huette anomaly (PHA) kuva nemubereki wekubereka ane chirwere ichi. Izvi zvinoreva kuti kana amai vako kana baba vako vaine PHA, une mukana we50% wekuitora nhaka. Zvakafanana nekukanda mari, haugone kutaura chokwadi, asi zvinogona kuitika.

Panyaya ye `PPHA`, kusangana nematambudziko ehutano ataurwa kare kana kurapwa zvinhu zvine njodzi.

Pane matambudziko here nechirwere ichi?

Kazhinji, nhaka yePelger-Huette anomaly (PHA) haikonzeri matambudziko makuru. Nekuti, kunyangwe ichichinja chitarisiko chemasero ako e-neutrophil, haichinje zvakanyanya mashandiro awo. Inoramba ichirwisa utachiona.

Zvisinei, kana uine pseudopelgar-huwat anomalous (PPHA), chirwere chakakonzera chirwere ichi (chakadai seleukemia) chinogona kukonzera matambudziko. Saka, zvakakosha kutaura nachiremba wako nezveizvi uye kuziva zvekutarisira.

Vanachiremba vanoongorora sei Pelger-Huette anomaly?

Vanachiremba vanoshandisa bvunzo dzeropa zvakanyanya kuti vaone chirwere ichi.Kuongororwa kunonzi peripheral blood smear kunoitwa. Kuongororwa uku kunosanganisira kutora donhwe reropa rako, kuriparadzira zvishoma pagirazi, woritarisa pasi pemaikorosikopu.

Izvi zvinoongororwa nenyanzvi yezvirwere kana nyanzvi yeropa.

Kana uine Pelger-Huette anomaly, bvunzo iyi icharatidza zvakajeka chimiro chisina kujairika che nuclei dzemasero ako e neutrophil (senge dumbbell).

Pane mushonga wePelger-Huette anomaly here?

Heino mashoko akanaka! Hereditary Pelger-Huette anomaly (PHA) inowanzo ratidza zviratidzo, saka haidi kurapwa kwakakosha. Kunyangwe uine chirwere ichi, unogona kurarama hupenyu hwakajairika.

Zvisinei, kana paine `PPHA`, zvakakosha kurapa chirwere chakakonzera chirwere chacho. Kana chirwere ichocho chapera, chirwere che`PPHA` chinogonawo kupera.

Ndinofanira kuona chiremba rini?

Kana ukaona kuti une Pelger-Huette anomaly, iva nechokwadi chekuudza chiremba wako kana paine zviratidzo zvitsva (zvakadai sefivha, kuneta kwakanyanya, hutachiona hunowanzoitika). Chiremba wako anogona kuona kana zviratidzo zvine chekuita ne `PHA`, `PPHA`, kana chimwe chinhu.

Paunoenda kunoona chiremba, zvakanakawo kubvunza mibvunzo iyi:

• Ndine chirwere chePelger-Huette chisingawanzoitiki here kana kuti chenhando (HPA)`?
• Zvinokwanisika here kuti vana vangu vagare nhaka chirwere ichi? (Kana HPA)
• Ndinofanira kuona chiremba kangani?
• Ndezvipi zviratidzo zvandinofanira kunyanya kuziva?

Chii chandinofanira kutarisira nemamiriro ezvinhu aya?

Pelger-Huette anomaly (PHA) pachayo haikonzeri kurwadziwa kana kuita mutsauko mukuru muhupenyu hwako. Kazhinji haikanganisi mabasa ako ezuva nezuva.

Zvisinei, kana uine chirwere ichi (kunyanya rudzi rwe `PPHA`), chinogona kuva chiratidzo cheimwe chirwere chiripo. Ndosaka vanachiremba vachinetseka nacho. Kana chiremba wako achifungidzira kuti une `PHA` kana `PPHA`, achaita bvunzo dzinodiwa kuti asimbise, uye zvakare kutora matanho ekubvisa mamwe matambudziko ehutano.

Ungave uine Pelger-Huette anomaly (PHA) asi usingazvizive nekuti hauna zviratidzo. Ungafunga kuti, "Kana zvisingandinetse, sei ndiri kutofunga nezvazvo?" Ichokwadi kuti ungasanzwa kurwara nekuda kwekuchinja kwemasero uku. Asi zvakakosha kuzivisa chiremba wako nezvazvo. Chiremba wako aripo kuti akubatsire kuramba uine hutano. Uye zvinobatsira kuziva nezvezvinhu zvidiki izvi mumuviri wako. Kungoti une Pelger-Huette anomaly chimwe chinhu chinokuita "iwe." Hazvina basa kunetseka nazvo.

Pfupiso (Mharidzo Yekuenda Nayo Kumba)

Zvakanaka, ngatitaurei zvimwe zvezvinhu zvatakataura nezvazvo:

• Pelger-Huet Anomaly (PHA) chirwere chemajini chinokonzera chimiro chisina kujairika chenucleus yema neutrophils, rudzi rwemasero machena eropa.
• Izvi hazviwanzo kuva nengozi uye hazvikonzeri zviratidzo. Masero eNeutrophil anoshanda zvakanaka.
• Kune mhando mbiri dzeizvi: `HPA`, inova nhaka, uye `PPHA`, iyo inokonzerwa gare gare nezvimwe zvirwere kana mishonga.
• HPA kazhinji haidi kurapwa. Kana paine PPHA, chikonzero chacho chinorapwa.
• Chirwere ichi chinoonekwa kuburikidza nekuongororwa kweropa (peripheral blood smear).
• Kana ukaona kuti une chirwere ichi, usazvidya moyo. Zvisinei, taura nachiremba wako nezvazvo uye uwane mazano anodiwa. Zivisa chiremba wako kana zviratidzo zvitsva zvikaonekwa.

Ndinovimba kuti chinyorwa chino chapindura mibvunzo yako yakawanda nezvePelger-Huette anomaly. Yeuka, kana paine chero dambudziko rehutano, zvakanaka kutaura nachiremba wako pachena.

Pelger -Huet Anomaly, Neutrophils, Masero Machena Eropa, Zvirwere zveMajini, Kuedzwa kweRopa, PPHA, HPA