Une simbi yakawanda mumuviri wako here, asi hausi kunzwa zvakanaka? Ingava sideroblastic anemia here?

Unowanzo nzwa kuneta uye kushaya mweya wekufema here? Dzimwe nguva unonzwa sekunge une BP yakaderera here? Izvi zvinogona kuva zviratidzo zveanemia yakajairika. Zvisinei, dzimwe nguva panogona kunge paine chikonzero chakaoma kunzwisisa chiri shure kweizvi. Nhasi tichataura nezvechirwere cheropa chisingawanzoitiki, asi chakakosha kuziva nezvacho. Icho chirwere che sideroblastic anemia, kana sekudanwa kwazvinoitwa navanachiremba `(Sideroblastic Anemia - SA)`.

Saka chii chinonzi Sideroblastic Anemia?

Zvichitaurwa zviri nyore, ichi chirwere chisingawanzoitiki chinokanganisa mashandiro anoita miviri yedu masero matsvuku eropa, masero matsvuku muropa redu. Kana uine chirwere ichi, une nhamba shoma yemasero matsvuku eropa, zvinoreva kuti une anemia. Asi panguva imwe chete, zvinoshamisa kuti unewo huwandu hwakawanda hwesimbi. Sei izvi zvichiitika? Nekuti muviri wako hausi kushandisa simbi, unoda kugadzira masero matsvuku eropa nemazvo.

Ndiani anonyanya kukanganiswa nemamiriro ezvinhu aya?

Dambudziko iri rinonzi `(Sideroblastic Anemia)` rinogona kuitika nenzira mbiri. Imwe i congenital sideroblastic anemia kana kuti CSA . Kureva kuti, vamwe vacheche vanozvarwa vaine chirwere ichi. Imwe i acquired sideroblastic anemia . Iri ndiro rudzi rwakajairika. Rinogona kukonzerwa nezvimwe zvirwere zvine chekuita neropa, kushandiswa kwemishonga, kana kunwa zvakanyanya mamwe mamineral.

Chimbofungai, vacheche nevana vadiki vanozvarwa vaine chirwere ichi dzimwe nguva vanogona kuva nematambudziko ehutano anotyisidzira hupenyu nekuda kwesimbi yakawandisa mumiviri yavo, inozivikanwa se "iron overload." Kana vanhu vakuru vakabatwa nechirwere ichi, vanogona kuva nematambudziko akadai sechirwere chemwoyo uye cirrhosis yechiropa.

Pane mashoko akanaka! Kunyange hazvo vanachiremba vasingakwanise kurapa zvachose chirwere chekuzvarwa nacho (Sideroblastic Anemia), kune mishonga inogona kudzora zviratidzo uye kudzivirira matambudziko akakomba. Zvisinei, mamwe marudzi e `(Sideroblastic Anemia)` anokura gare gare muhupenyu anogona kurapwa.

Chirwere ichi, chinova rudzi rwechirwere chinoonekwa pakuzvarwa, chinogona kubata vacheche, vana vadiki, uye kunyange vakuru vechidiki. Dzimwe nguva zviratidzo zveCSA hazvina kunyanya kuipa. Saka kunyangwe kana wakazvarwa nacho, vamwe vanhu vanogona kusave nematambudziko makuru ehutano kusvika vakura.

Rudzi rwekupedzisira, runonzi ``Acquired CSA,'' runowanzoonekwa muvanhu vane chirwere cheropa chinonzi ``myelodysplastic syndrome.'' Runogonawo kukonzerwa nekusangana nezvicherwa zvakaita se lead ne zinc, kushandiswa kwemishonga yakati, kana chero chinhu chinokanganisa kugona kwemuviri kushandisa mhangura.

Dambudziko iri rinokanganisa sei muviri wangu?

Vanhu vane sideroblastic anemia vanowanzoratidza zviratidzo zveanemia. Kureva kuti, vanonzwa kuneta zvakanyanya pasina chikonzero.Kunzwa kuneta, kunetseka kufema, nezvimwewo. Kwete izvozvo chete, vanogona kunge vaine "macrocytic anemia" (masero matsvuku eropa akakura kupfuura akajairwa) uye "microcytic anemia" (masero matsvuku eropa madiki pane akajairwa). Mhando dzese dzeanemia dzinogonawo kuva zviratidzo zvemamwe marudzi eanemia.

Ndezvipi zvikonzero zve sideroblastic anemia?

Sezvatakambokurukura, izvi zvinogona kuvapo pakuzvarwa, kana kuti zvinogona kuitika gare gare nekuda kwechimwe chirwere, kusangana nezvimwe simbi, zvicherwa, kana mishonga.

Kuti tinzwisise zvinokonzera chirwere che congenital sideroblastic anemia (congenital SA), zvinobatsira kuziva zvishoma nezve mashandiro anoita masero edu matsvuku eropa.

Nhanganyaya pfupi yemasero matsvuku eropa

Masero matsvuku eropa ndiwo anonyanya kuwanikwa muropa redu. Masero matsvuku ane hutano uye akura akakosha pakutakura okisijeni kuenda kunhengo dzemuviri wedu. Masero matsvuku eropa anoita izvi nerubatsiro rwepuroteni inonzi hemoglobin. Hemoglobin ndiyo inopa masero matsvuku eropa ruvara rwawo rutsvuku.

Masero matsvuku eropa anoda iron kuti agadzire hemoglobin. Kazhinji, muroro wedu wemapfupa unogadzira masero ekutanga. Masero aya anozokura kuita masero matsvuku eropa asina kukura anonzi erythrocytes. Masero aya asina kukura ane huwandu hwakakwana hwe hemoglobin ne iron inodiwa kuti pave nemasero matsvuku ane hutano uye akura.

Asi, kana uine sideroblastic anemia, muviri wako haugone kushandisa iyi iron. Izvi zvinokonzera matambudziko maviri. Pasina iron, masero matsvuku eropa rako haagadzire hemoglobin yakakwana yekutakura okisijeni mumuviri wako wese. Kune rumwe rutivi, iron isingashandiswe inoungana mumapfupa ako. Izvi zvinokonzera rudzi rusina kujairika rwesero runonzi ringed sideroblast . Sideroblast iseli dzvuku reropa risati rakura rine ring yesimbi yakakomberedza nucleus yaro. Vanachiremba vanogona kuona idzi rings pavanotarisa masero estem mubone marrow vachishandisa maikorosikopu. Sideroblastic anemia inowana zita rayo kubva kuaya masimbi rings. Aya masimbi rings anoratidza kuti masero ari kuchengeta iron pachinzvimbo chekuishandisa. Kuunganidzwa uku kweiron kunonzi iron overload . Uku overload kweiron ndiko kunokonzera matambudziko mazhinji ehutano anogona kuitika nekuda kwe sideroblastic anemia.

Ndeapi marudzi eCongenital Sideroblastic Anemia (CSA)?

Kune mhando nhatu dzeSA dzekuzvarwa nadzo. Idzi dzinokonzerwa nekuchinja kwemajini mune mamwe majini kunokanganisa mashandiro emasero matsvuku eropa. Ngatitarisei kuti ndeapi:

• Kupererwa kweropa kweropa kwakabatana neX:Iyi ndiyo mhando yeanemia inowanikwa zvakanyanya mukuzvarwa nayo. Inokonzerwa nekuchinja kwemajini kunogadzira enzyme inonzi ``ALAS2``, zvichikonzera kushomeka kwehemoglobin. Vanhu vane chirwere ichi vane masero matsvuku eropa madiki, madiki pane akajairwa (microcytic). Vanewo iron yakawandisa mumiviri yavo.
• Autosomal recessive sideroblastic anemia (ARCSA): Iyi ndiyo mhando yechipiri inonyanya kuwanikwa. ARCSA inobata vacheche nevana vadiki kwazvo. Idambudziko rakakomba iro dzimwe nguva rinogona kuisa hupenyu panjodzi. Rinoitika kana huwandu hwesimbi muropa hwanyanya.
• Amai: Vanenge 20% yevarwere vese veCSA vanowira muchikamu ichi. Izvi zvinodaro nekuti jini reMT-ATP6 rinochinja-chinja, zvichikanganisa mashandiro e mitochondria yako. (Mitochondria ndiwo ma organelles ari mukati memasero edu. Ndiwo anokonzera simba guru remasero. Mitochondria inoshandura simba kubva muchikafu kuita fomu rinogona kushandiswa nemasero.)

Ndedzipi mhando dzeanemia inowanikwa kubva ku sideroblastic dzinoitika gare gare muhupenyu?

Kune mhando mbiri dze sideroblastic anemia dzinokura pazera rehupenyu - primary ne secondary. Primary SA zvinoreva SA ine chekuita nechirwere chinonzi myelodysplastic syndrome. Secondary SA zvinoreva SA inogona kukura mushure mekusangana zvakanyanya nesimbi, makemikari, nemishonga. Zvinhu zvinogona kukonzera secondary sideroblastic anemia zvinosanganisira:

• Doro: Kusashanda zvakanaka kwedoro ndicho chikonzero chikuru chekuva neanemia ye sideroblastic anemia gare gare.
• Chepfu ine simbi yakawanda: Izvi zvinosanganisira chepfu ine mutobvu uye chepfu yearsenic.
• Kushaikwa kweVitamin B: Vitamin B inobatsira kugadzira chinhu chinonzi heme, icho chinoshandurwa kuita hemoglobin. Heme ndiyo inobatsira kutakura okisijeni.
• Kushaikwa kwemhangura: Mhangura inobatsira kugadzira enzyme inodzivirira kubva kusimbi yakawandisa.
• Kunwa zinc yakawandisa: Kunwa zinc yakawandisa kunogona kukanganisa mashandisiro anoita muviri iron uye kunwisa mhangura. Vamwe vanhu vanotora mishonga yekuwedzera zinc uye izvi zvinogona kuitika.
• Mishonga: Mimwe mishonga inorwisa mabhakitiriya, chemotherapy, mahormone, uye mishonga inopedza mhangura inogona kukonzera anemia ye sideroblastic secondary. Vanachiremba vanorapa rudzi urwu rweSA nekuyedza mishonga yauri kutora uye kubvisa mishonga inofungidzirwa kuti ndiyo inokonzera SA.

Ndezvipi zviratidzo zve sideroblastic anemia?

Kufanana nemhando dzakawanda dzeanemia, zviratidzo zve sideroblastic anemia zvinosanganisira:

• Kuneta kwakanyanya:Izvi zvinoreva kunzwa kuneta zvekuti haugone kuita mabasa ezuva nezuva.
• Kushaya simba: Uku kunzwa kwekushaya mweya kana kufema zvakaoma.
• Kurova kwemoyo: Uku kunzwa kwekuti moyo uri kurova nekukurumidza zvakanyanya, kana nenzira isina kujairika.
• Musoro.

Vanhu vane X-linked sideroblastic anemia vanogona kuwana zvimwe zviratidzo nekuda kwekushaya hemoglobin yakakwana uye kuwedzera kwesimbi mumuviri. Zviratidzo izvi zvinosanganisira:

• Chiropa chakakura: Chiropa chako chinoita mabasa akawanda akakosha mumuviri.
• Chirwairira chakakura: Chirwairira chako inhengo yakakura sechibhakera chakabatiswa chiri mudumbu repamusoro. Ungasaona kuti chirwairira chako chakakura kupfuura zvakajairika, kana kuti unganzwa kurwadziwa kusingafadzi mudumbu rako repamusoro.
• Ganda rine ruvara rwebhuronzi: Kana muviri wako ukachengeta iron yakawandisa, ganda rako rinogona kuva neruvara rwebhuronzi-brown.
• Chirwere cheshuga chisingadzoreki.

Vanachiremba vanoongorora sei sideroblastic anemia?

Nekuti sideroblastic anemia inogona kuvapo pakuzvarwa kana kukura gare gare, chiremba wako anotanga akuyedza kuti asimbise kana kubvisa acquired sideroblastic anemia. Kana vakasarudza kuti haisi acquired sideroblastic anemia, vachaita mimwe miedzo kuti vaone kuti rudzii rwe congenital sideroblastic anemia yaunayo. Heano mimwe yemiedzo yavangaita:

• Kuverengwa kweropa kwakazara (CBC): Mhedzisiro ye `(CBC)` inoratidza saizi uye chimiro chemasero ari muropa rako, kuti muviri wako uri kugadzira masero matsva mangani, uye, muchiitiko che `(SA)`, kuti une masero matsvuku mangani akura uye asina kukura.
• Kuongororwa kweropa: Iyi inzira inoshandiswa navanachiremba kuongorora masero eropa. Kunyange zvazvo kumwe kuongororwa kweropa kuchishandisa muchina kuaongorora, muchiitiko ichi, vanachiremba vanoongorora masero eropa vachishandisa maikorosikopu.
• Zvidzidzo zvesimbi: Bvunzo iyi inoratidza huwandu hwesimbi yako.
• Kusveta mapfupa emubofu: Iyi inzira yekutora sampuli yechikamu chemvura chemapfupa ako emubofu.
• Kuongororwa kwemapfupa emubofu: Muongororo iyi, vanachiremba vanotora sampuli diki yemapfupa ako emubofu voongorora masero emapfupa emubofu.
• Kuongororwa kwemajini:Kuongororwa kwemajini kunogona kubatsira kusimbisa kana kubvisa mamiriro chaiwo emajini. Kunogonawo kukubatsira kunzwisisa mukana wekupa chirwere ichi kuvana vako.

Vanachiremba vanorapa sei sideroblastic anemia?

Vanachiremba vanoshandisa nzira dzakasiyana dzekurapa chirwere chekuzvarwa nacho nechirwere che sideroblastic anemia. Nzira idzi dzinosiyana zvichienderana nemamiriro ako ezvinhu, saka chiremba wako achakurukura nzira yakanakira iwe. Semuenzaniso, mumwe munhu ane X-linked SA (CSA) anogona kupihwa vhitamini B6 nemishonga inoderedza iron. Kana SA ichikonzerwa nehuturu hwe lead, chiremba wako acharapa huturu hwe lead. Zvakanaka kutaura nachiremba wako nezveizvi.

Ndingadzivirira sei izvi?

Sideroblastic anemia inowanzo kukonzerwa nekuchinja kwemajini. Kunyangwe rudzi urwu rwe congenital sideroblastic anemia rusingadzivirirwi, runogona kurapwa. Kana uine X-linked `(CSA)` uye zviratidzo zvako zviri zvishoma, kana kana mumwe munhu mumhuri yako (vabereki, vanun'una, kana vana) aine `(CSA)`, zvakanaka kubvunza chiremba wako nezvekuongororwa kwemajini.

Zvisinei, pane zvinhu zvaunogona kuita kudzivirira mamwe marudzi eCSA akawanikwa kuti asazotanga kukura gare gare. Matanho aya anosanganisira:

• Kudzivirira kubatwa netsaona nemutobvu kana chepfu yearsenic.
• Kana uri kutora mishonga yekuwedzera zinc yekurapa dzihwa, bvunza chiremba wako nezvemupimo wakakodzera.
• Deredza kunwa kwako doro. Kunwa doro kunogona kukonzera sideroblastic anemia. Edza kuderedza huwandu hwedoro raunonwa zuva rega rega. Kana uchida rubatsiro, kumbira chiremba wako kuti akurudzire mapurogiramu akakodzera.

Chii chandingatarisira nemamiriro ezvinhu aya?

Kufanotaura kwako kunoenderana nerudzi rwe sideroblastic anemia yaunayo. Semuenzaniso, kana uine X-linked congenital sideroblastic anemia, chiremba wako anogona kurapa chirwere chako nevhitamini B6 nemishonga inoderedza iron. Kana wakambowana sideroblastic anemia, iyo inokonzerwa nehupfu hwe lead, chiremba wako anogona kurapa hupfu hwe lead.

Ndinozvitarisira sei?

Vanhu vazhinji vane sideroblastic anemia vanofanira kugara vachiongororwa huwandu hwesimbi yavo kuti vasanyanya kuwanda kwesimbi. Kana wakambova ne sideroblastic anemia kare, bvunza chiremba wako zvaunogona kuita kudzivirira SA itsva.

Sideroblastic anemia chirwere cheropa chisingawanzoitiki. Vamwe vanhu vanoziva kuti nei vaine sideroblastic anemia, asi vamwe vangasaziva. Kana uine sideroblastic anemia, ungada kubvunza chiremba wako mibvunzo iyi:

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* Rudzii rwe `(SA)` rwandinarwo?

* Sei ndakawana `(SA)`?

* Ndedzipi nzira dzekurapa dzandingasarudza?

* Ndezvipi migumisiro yekurapwa?

* Chii chandingatarisira mushure mekurapwa?

* Ndingapa vana vangu `(SA)` here?

Saka, ndezvipi zvinhu zvakakosha zvatinofanira kurangarira kubva munyaya iyi?

Sideroblastic anemia chirwere cheropa chisingawanzoitiki asi chinogona kunge chakakomba. SA inokonzerwa nechimwe chinhu chinokanganisa kugona kwemuviri kugadzira masero matsvuku eropa ane hutano. Vanhu vane SA vanowanzova nesimbi yakawandisa muropa ravo. Kazhinji, iyi iron yakawandisa inorapwa zviri nyore. Zvisinei, muvacheche nevana vadiki vanoberekwa neSA, iron yakawandisa inogona kukonzera matambudziko ehutano anotyisidzira hupenyu.

Fungidzira, kana mwana wako akazvarwa aine sideroblastic anemia, vanachiremba vavo vaizotanga kurapa chirwere ichi nekukasika. Kuva nemwana kana mwana mudiki anorwara zvakanyanya kunogona kutyisa uye kunetesa. Vanachiremba vako vanonzwisisa izvi uye vachaita zvese zvavanogona kuti vakubatsire iwe nemwana wako panguva yekurapwa uye mushure mekurapwa. Saka, kana iwe kana mumwe munhu mumhuri yako aine zviratidzo izvi, zvakakosha kuona chiremba nekukasika kuti akupe mazano.

Iron , anemia, sideroblasts, bone morrow, hemoglobin, majini, zvirwere zveropa