Uri kurwadziwa zvakanyanya zvekuti haugone kufungidzira here? Pamwe kurwadziwa kwemusana, kenza, kana kurwadziwa kwetsinga. Kazhinji, zvinonetsa kudzora kurwadziwa kwakanyanya kudaro nemishonga inoderedza marwadzo yakaita sePanadol neibuprofen. Dzimwe nguva, kunyangwe kana mishonga ine marwadzo akasimba ikapihwa, vamwe vanhu vane mimwe migumisiro yakaipa. Saka, nhasi tichataura nezvemushonga unoshandiswa navanachiremba kana mimwe mishonga yese ikatadza kushanda. Ndiwo mushonga weZiconotide.
Zvichitaurwa zviri nyore, chii chinonzi Ziconotide?
Ziconotide mushonga unoshandiswa kurapa marwadzo akasimba uye asingaperi . Hauna kufanana nemushonga wekurwadziwa wenguva dzose. Kazhinji, piritsi ratinonwa kana tichirwadziwa rinoshanda nekuenda kunzvimbo ine marwadzo mumuviri. Asi Ziconotide inoshanda neimwe nzira.
Zvichitaurwa zviri nyore, patinonzwa kurwadziwa mumuviri wedu, ndipo patinonzwa chiratidzo chichibva panzvimbo yekurwadziwa chichienda kuuropi kuburikidza netsinga. Chinoitwa neZiconotide ndechekuvhara zviratidzo izvi zvekurwadziwa zvinofamba nemusana zvichienda kuuropi . Zvinoita sekunge shoko rekurwadziwa rinomira pakati penguva risati rasvika kuuropi. Ndokusaka richigona kudzora kunyange kurwadziwa kwakanyanya uko mimwe mishonga isingakwanise kudzora.
Chinonyanya kukosha ndechekuti, izvi zvinongoitwa chete kana mimwe mishonga yese inoderedza marwadzo yakundikana kana kuti migumisiro yayo isingatsungiririki, uye pasi pekutarisirwa kwakasimba kwenyanzvi.
Mushonga uyu unopihwa sei? Jekiseni iri rinoitwa nguva dzose here?
Kwete. Iyi haisi nzira yekubaya nayo pfudzi kana matako. Izvi zvinopihwa nenzira yakasarudzika.
Mushonga uyu unopinzwa zvakananga mumvura yakatenderedza musana wako (cerebrospinal fluid) . Izvi zvinonzi jekiseni remukati memusana. Nekuti zvakaoma kupa jekiseni iri zuva nezuva, vanachiremba vanoisa pombi yakakosha (implantable pump) pasi peganda rako, kazhinji mudumbu mako.
Pombi iyi yakaita sekombuta diki. Inogona kuburitsa mushonga panguva yakatarwa, pachiyero chakatarwa. Chiremba anoronga pombi iyi uye anoizadzazve panguva dzakatarwa. Chikwata chekurapa chichakudzidzisawo mashandisirwo epombi iyi.
Sei hurongwa hwakaoma kudaro?
Nzira iyi inoshandiswa nekuti mushonga uyu unofanirwa kuenda zvakananga kutsinga dzemuviri. Zvikasadaro, kana ukapihwa muropa semazuva ese, hauzoshande zvakanaka uye une mimwe migumisiro yakaipa.
Zvinhu zvaunofanira kuudza chiremba wako usati watanga kurapwa
Nekuti uyu mushonga une simba guru, zvakakosha kuudza chiremba wako nezvenhoroondo yako yese yehutano usati watanga kurapwa. Iva nechokwadi chekuvaudza kana uine chimwe chezvirwere zvinotevera:
- Matambudziko ehutano hwepfungwa: Wakambosangana nedambudziko rakadai sekuora mwoyo, kuzvidya mwoyo, psychosis , kana kuti iwe kana mumwe munhu mumhuri mako akamboedza kuzviuraya here?
- Matambudziko ekubuda ropa: Une dambudziko here neropa rako risingagwambi nyore nyore?
- Utachiona: Tiudzei nezvehutachiona huripo mumuviri wenyu, kunyanya hutachiona hwemusana.
- Kuvharika kwemusana wemusana: Chiremba akambokuudza here nezvekuvharika kwemusana wemusana?
- Kurwara: Kana uine allergy yemushonga uyu weziconotide kana chero mumwe mushonga, chikafu, kana dhayi.
- Kubata pamuviri: Kana uri nepamuviri, uchiedza kubata pamuviri, kana kuyamwisa, iva nechokwadi chekuzivisa chiremba wako.
Ndezvipi zvingakonzera migumisiro yekutora mushonga uyu?
Kufanana nemushonga upi zvawo, ziconotide inogona kukonzera migumisiro yakaipa. Mimwe yakaipa, asi mimwe inowanzoonekwa. Zvakakosha kuziva izvi.
| Migumisiro uye zvekuita | |
|---|---|
| Migumisiro yakakomba inofanira kuziviswa kuchikwata chenyu chekurapa nekukasika | |
| Kusawirirana neAllergy | Mapundu paganda, kuvaviwa, kuzvimba kwechiso, miromo, rurimi kana pahuro. |
| Kuchinja kwepfungwa nemaitiro | Kusagadzikana kwakanyanya, kusagadzikana, kuvhiringidzika, kuona kana kunzwa zvinhu zvisiri zvechokwadi (kufungidzira zvinhu zvisipo), kufunga nezvekuzviuraya, kuwedzera kuora mwoyo. |
| Zviratidzo zveMeningitis | Fivha, kuoma kwemutsipa, kuoma kutarisa chiedza, musoro wakakomba, kuda kurutsa, uye kurutsa. (Izvi zvinogona kuva zviratidzo zvehutachiona muuropi kana musana). |
| Kukuvara kwetsandanyama (Rhabdomyolysis) | Kushaya simba kusingawanzoitiki, kurwadziwa kwetsandanyama, weti yero yakasviba kana yebrown, kudzikira kwehuwandu hweweti. |
| Kuomerwa nekufunga nekuyeuka | Kuomerwa nekuisa pfungwa pachinhu chimwe chete, kurasikirwa nendangariro, kuoma kutaura. |
| Migumisiro isingawanzova yakakomba, asi inofanira kutaurwa kuna chiremba kana ikaramba iripo | |
| Kuvhiringidzika | Kuvhiringidzika kudiki. |
| Dzungu | Dzungu, kurasikirwa nepfungwa dzakanaka. |
| Kusvotwa | Kuuya kuzorutsa. |
| Kusakwanisa kudzora maziso | Kufamba-famba kwemaziso kusingadzoreki. |
Zvinhu zvakakosha zvekungwarira
Doro nezvimwe zvinodhaka
Usanwe doro paunenge uchitora mushonga uyu chero chikonzero chipi zvacho . Ziconotide inogona kukanganisa kungwarira kwako, kuenzana, uye nguva yekuita chimwe chinhu. Kunwa doro kunogona kuita kuti chirwere ichi chiwedzere kuipa.
Uyewo, unofanira kungwarira zvikuru paunenge uchitora mimwe mishonga inokonzera hope (semuenzaniso, mishonga yekukosora, mishonga yekurwara nepfungwa, mapiritsi ekurara). Udza chiremba wako nezvemishonga yese yaunotora, kunyangwe mavhitamini nemishonga yemishonga.
Kutyaira nekushandisa michina
Dzivisa kutyaira kana kushandisa michina ine njodzi kusvika waziva kuti mushonga uyu unokubatsira sei. Uyewo, kuti usanzwa dzungu kana kupera simba, usamuka kamwe kamwe kubva panzvimbo yawakagara kana kuti wakarara. Simuka zvishoma nezvishoma.
Ko kana dose ikawedzera?
Sezvo izvi zvichipiwa kuburikidza nepombi, dose yacho haiwanzowedzerwa. Zvisinei, kana uchifungidzira kuti watora mushonga wakawandisa nekuda kwekusashanda zvakanaka kwepombi kana chimwe chikonzero, kurumidza kubata National Poisons Information Centre paColombo National Hospital, kana kuenda kuEmergency Treatment Unit (ETU) yechipatara chiri pedyo.
Zadzazve Nguva Dzekugadzwa
Chiremba wako achakupa zuva rekuzadza pombi yako nemishonga. Usadarike mazuva aya. Kana nekuda kwechimwe chikonzero usingakwanise kusvika, fonera timu yako yezvekurapa nekukasika worongazve nguva.
Mharidzo Yekuenda Nayo Kumba
- Ziconotide mushonga une simba unoshandiswa chete pakurwadziwa kwakanyanya, kusingaperi uko kusina kupindura kune mamwe marapirwo.
- Izvi zvinoendeswa kumvura yakakomberedza musana kuburikidza nepombi yakakosha inoiswa pasi peganda.
- Unofanira kuudza chiremba wako nezvezvirwere zvako zvese, kunyanya matambudziko epfungwa uye allergies, usati watanga kurapwa.
- Tsvaga rubatsiro rwechiremba nekukasika kana ukasangana nematambudziko akakomba akadai sekuvhiringidzika, kuchinja maitiro, fivha, uye kuomarara kwemutsipa.
- Usanwe doro zvachose paunenge uchitora mushonga uyu. Chenjerera zvikuru paunenge uchityaira uye uchishandisa michina.
- Kana paine shanduko, kuwedzera, kana kurwadziwa kutsva mukurwadziwa kwako, udza chiremba wako.
👩🏽⚕️ Mibvunzo yekuwedzera (Mibvunzo Inowanzo bvunzwa)
💬 Mushonga weZiconotide / Prialt unoshandiswa pakuita chii?
Uyu hausi mushonga wekurwadziwa kwemoyo wakajairika! Uyu mushonga une simba guru (usiri weopioid) unopihwa muchipatara kuburikidza ne'Intrathecal pomp' yakaiswa nachiremba mukati memusana/musana wemurwere kuti abvise 100% ye'Severe Chronic Pain' isingatsungiririki isingarapike kunyangwe nemushonga wakasimba (Morphine) wevarwere vegomarara neavo vane matambudziko makuru etsinga!
💬 Mushonga uyu (Ziconotide) unogadzirwa nei, une simba kupfuura morphine?
Nyaya inoshamisa! Mushonga uyu wakawanikwa uye wakagadzirwa nehupfu hunouraya (Conotoxin) hunogadzirwa nehozhwa ine njodzi huru/ine chepfu (Conus magus / Cone hozhwa)! Kana chepfu iyi yasvika kumusana, inovhara/kuvhara 100% yemagedhi ecalcium (N-type calcium channels) mutsinga dzinotakura marwadzo kuenda kuuropi. Izvi zvinobvisa zvachose meseji yekurwadziwa inoenda kuuropi.
💬 Ndezvipi migumisiro ine njodzi zvikuru yekupa mushonga uyu kumusana (Intrathecal)?
Migumisiro yeizvi yakanyanya kuipa! (Nyevero yeBlack Box). Nekuti mushonga uyu unoenda zvakananga kuuropi/musana, vamwe varwere vanotanga schizophrenia/kupenga kusingatsungiririki (Hallucinations). Uyewo, kuzvidya mwoyo kwakanyanya, paranoia, uye 'pfungwa dzekuzviuraya' zvinoparadza zvinoitika pakarepo! Chimwe chinonetsa zvikuru ndechekuti murwere ane mukana mukuru wekusayeuka chero chinhu (Cognitive impairment).
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