Umlawuli oyimfihlo olawula uxinzelelo lwethu lwegazi: Konke malunga noRenin!

Ngaba wakha wazibuza ukuba zingaphi izinto ezimangalisayo ezenzekayo emizimbeni yethu? Ngamanye amaxesha, ngaphandle kokuba siqaphele, kukho iindlela ezininzi ezimangalisayo zokugcina imizimba yethu iphilile. Umzekelo, leyo inceda ekulawuleni uxinzelelo lwegazi ibizwa ngokuba yiRenin. Namhlanje, masithethe ngokuba yintoni iRenin, indlela esebenza ngayo, kunye nokuba ibaluleke kangakanani kwimpilo yethu.

Yintoni uRenin? Ngamafutshane...

Kulungile, ngoku masibone ukuba yintoni le renin. Ngamafutshane, i-renin yi -enzyme eyenziwe ziiseli ezikhethekileyo kwizintso zakho. Musa ukoyika i-enzyme, yiproteni enceda ukukhawulezisa iinkqubo ezahlukeneyo zeekhemikhali emizimbeni yethu.

Lo mfo ubizwa ngokuba yi-renin akasebenzi yedwa. Uyinxalenye yenkqubo enkulu ebizwa ngokuba yi-renin-angiotensin-aldosterone system (RAAS). Kufana nokusabela kwetyathanga. Injongo ephambili yale nkqubo yonke kukugcina uxinzelelo lwegazi lwakho luphantsi kolawulo. Ngokukodwa, i-renin ilawula ihomoni ebizwa ngokuba yi-aldosterone, eveliswa zii-adrenal glands zethu (ii-glands ezincinci ezikwiintso).

Ngoko ke, le Renin isebenza njani?

Nantsi ke inxalenye ebalulekileyo. Umsebenzi kaRenin ophambili kukulawula uxinzelelo lwegazi. Oku ukwenza kunye nezinye iihomoni ezimbini ezibalulekileyo ezibizwa ngokuba yi-angiotensin kunye ne-aldosterone. Xa zizonke, ezi zintathu zinceda ukugcina amanqanaba esodium (ityuwa) kunye ne-potassium emzimbeni wakho elawulwa.

Khawuthelekelele oku kusenzeka:

1. Okokuqala, i-renin iguqula i-angiotensinogen (eyandulela i-angiotensin) eyenziwa sisibindi sakho ibe yi-angiotensin I ( i-angiotensin, i-hormone enciphisa imithambo yegazi yakho).

2. Emva koko, le angiotensin I ijika ibe yi -angiotensin II .

3. Ngoku le angiotensin II yeyona isebenzayo. Inciphisa imithambo yegazi yakho kwaye ikwanceda ekukhupheni i-hormone aldosterone.

4. Okokugqibela, le aldosterone inceda izintso zakho ukuba zigcine amanzi kunye netyuwa (i-sodium) emzimbeni wakho. Oku kunyusa ubungakanani bolwelo emzimbeni wakho. Yiyo le nto inyusa uxinzelelo lwegazi lwakho.

Ngamafutshane, xa uxinzelelo lwegazi lusehla, kufika indoda ebizwa ngokuba yi-renin, iqokelela abanye abantu abambalwa, inciphise imithambo yegazi, igcine amanzi emzimbeni, ize ibuyisele uxinzelelo lwegazi esiqhelweni.

Ikhutshwa njani i-renin? Ngaliphi ixesha?

Kulungile, ngoku unombuzo: ingaba le renin yenziwa nje emzimbeni, okanye ikhutshwa ngamaxesha athile? I-Renin ikhutshwa egazini lakho xa uxinzelelo lwegazi lwakho luhla kakhulu, okanye xa ulahlekelwa yi-sodium (ityuwa) eyaneleyo emzimbeni wakho.

Ngokukodwa, ezi zinto zilandelayo zichaphazela ukukhutshwa kwe-renin:

• Ii-baroreceptors (ezi zii-receptors ezibuthathaka kuxinzelelo) kwimithambo yakho yegazi ziva uxinzelelo lwegazi oluphantsi.
• Ukuba izintso zakho zibona amanqanaba aphantsi etyuwa (i-sodium) emzimbeni wakho.
• Ii-receptor ze-adrenergic ze-Beta 1, ezilawula isantya sentliziyo yakho, umsebenzi weemvakalelo kwinkqubo yakho yemithambo-luvo enovelwano (oku kwenzeka xa sixhalabile okanye sisoyika).

Ngaba i-renin yodwa iyayonyusa uxinzelelo lwegazi?

Hayi, akunjalo. I-Renin yodwa ayichaphazeli uxinzelelo lwegazi lakho. Endaweni yoko, njengoko ebetshilo ngaphambili, isebenza kunye ne-angiotensin kunye ne-aldosterone. I-Angiotensin inciphisa imithambo yegazi yakho, kwaye i-aldosterone inceda izintso zakho zigcine amanzi kunye netyuwa. Yiyo le nto ibangela ukuba umzimba wakho ugcine ulwelo oluninzi kwaye unyuse uxinzelelo lwegazi lakho.

Iveliswa phi i-renin?

Mhlawumbi sele ukwazi oku ngoku. I-Renin iveliswa kwizintso zakho. Xa uxinzelelo lwakho lwegazi lwe-systolic (inani eliphezulu xa ulinganisa uxinzelelo lwegazi) lehla, okanye xa izintso zakho zibona ukuba umzimba wakho umanzi kancinci, zikhupha i-renin egazini lakho.

Yenziwe ngantoni i-renin? (Oku kungokwesayensi kancinci, kodwa kufanelekile ukukwazi.)

Le yingxaki enzulu kancinci, kodwa ukuyibeka ngokulula, i-renin inee-amino acid residues ezingama-340. Ii-amino acids zifana neebhloko ezincinci zokwakha iiproteni. Ezi ziyadibana ukuze zenze i-enzyme i-renin. Kufana nezitena ezininzi ezidibana ukuze zenze udonga.

Ziziphi iimeko zonyango ezinokunxulunyaniswa nokuveliswa kwe-renin?

Ngamanye amaxesha amanqanaba e-renin anokunyuka emzimbeni. Izinto ezinje ngezi zinokubangela oku:

• Uxinzelelo lwegazi oluphantsi (Hypotension) .
• Ukuba ulahlekelwe ligazi elininzi (umz. ngenxa yengozi).
• Ukuba izintso zakho zinciphise ukuhamba kwegazi .
• Ukuncipha komthamo (umz., ukuphelelwa ngamanzi emzimbeni ngenxa yokuhlanza okanye ukuphazamiseka kwesisu).
• Ukwanda komsebenzi wenkqubo yemithambo-luvo esebenzisana neemvakalelo (i-Sympathetic nerve activation) (kule meko, isantya sentliziyo, isantya sokuphefumla, uxinzelelo lwegazi luyanda, kwaye izangqa ezimnyama emehlweni ziya zikhula).

Ngaba kukho iimvavanyo zokujonga amanqanaba e-renin?

Ewe, ngokuqinisekileyo. Ugqirha wakho angenza uvavanyo lomsebenzi we-renin kunye novavanyo lwenqanaba le-aldosterone. Oku kuya kumxelela ukuba ingakanani i-aldosterone eveliswa zi-adrenal glands zakho.

Ukuba une-high blood pressure, ingakumbi ukuba ayilawulwa ngamayeza akho aqhelekileyo, ugqirha wakho unokuyalela olu vavanyo.Usenokuba nesifo esibizwa ngokuba yi -primary aldosteronism (PA) (ekwabizwa ngokuba yiConn's syndrome) . Kule meko, kuveliswa i-aldosterone eninzi kakhulu, nto leyo ebangela uxinzelelo lwegazi oluphezulu. Uvavanyo lwe-renin lunokunceda ekuqinisekiseni ukuba i-PA yimbangela yoxinzelelo lwakho lwegazi oluphezulu.

Ilinganiswa njani i-renin?

I-Renin idla ngokulinganiswa yinto ebizwa ngokuba ngumsebenzi we-plasma renin (PRA) . Oku kulinganisa indlela i-renin eyenza kakuhle ngayo i-angiotensin I (eyandulela i-angiotensin II). Ingalinganiswa njenge -renin ethe ngqo .

Kuthetha ukuthini ukuba inqanaba lakho le-renin liphezulu?

Ukuba inqanaba lakho le-renin liphezulu, kusenokuba ngenxa yezi zinto zilandelayo:

• Isifo sika-Addison (apho amadlala akho e-adrenal engavelisi iihomoni ezaneleyo) - ingakumbi xa ulwelo lomzimba lunciphile.
• Ukuphelelwa ngamanzi emzimbeni (ukungabikho kwamanzi emzimbeni).
• Amanqanaba aphantsi e-potassium egazini (i-hypokalemia) .
• Ukopha kwegazi (igazi elininzi eliphuma ngaphakathi okanye ngaphandle kwesitho somzimba).
• Iithumba zezintso ezivelisa i-renin .
• Uxinzelelo lwegazi oluphezulu lwezintso (uxinzelelo lwegazi oluphezulu olubangelwa kukucutheka kwemithambo yegazi ekhokelela kwizintso).
• Uxinzelelo lwegazi olubi (olu luxinzelelo lwegazi oluphezulu oluvela ngequbuliso, ngaphandle kwesilumkiso ).
• Uxinzelelo lwegazi oluphambili (olu luxinzelelo lwegazi oluphezulu olungengomphumo wesinye isifo).
• Ukusilela kwentliziyo okanye isifo sesibindi (xa umthamo wegazi osebenzayo emzimbeni wehla ngenxa yezi meko).

Kuthekani ukuba inqanaba le-renin liphantsi?

Kukwakho nezizathu zokuba amanqanaba e-renin anokuba phantsi. Umzekelo:

• I-aldosteronism eyintloko (PA)
• Ukuba usebenzisa amayeza e-steroid abangela ukugcinwa kwetyuwa emzimbeni.
• Uxinzelelo lwegazi olubangelwa yityuwa (abanye abantu banoxinzelelo lwegazi oluphezulu nokuba batya ityuwa eninzi, yimeko leyo).

Ndingawagcina njani amanqanaba am e-renin esempilweni?

Ukuba inqanaba lakho le-renin liphezulu okanye liphantsi ngendlela engaqhelekanga, ugqirha wakho uya kufumanisa unobangela oyintloko aze enze isicwangciso sonyango. Abayi kukunika amayeza okunciphisa okanye okunyusa i-renin yakho.

Umzekelo, ukuba unezinga eliphezulu le-renin kunye noxinzelelo lwegazi oluphezulu, ugqirha wakho unokukunika amayeza okunciphisa uxinzelelo lwegazi afana ne -beta-blockers kunye ne-clonidine .

Okokugqibela, yintoni ekufuneka uyikhumbule (Umyalezo Wokuya Ekhaya)

Ngoko ke, i-renin ayisiyo-enzyme nje kuphela. Yinxalenye ebaluleke kakhulu yenkqubo ye-renin-angiotensin-aldosterone (RAAS). Idlala indima enkulu ekugcineni uxinzelelo lwegazi lwakho luphantsi kolawulo.

Kunokubakho izizathu ezahlukeneyo zokuba amanqanaba akho e-renin angaqhelekanga. Ngoko ke ukuba unamathandabuzo, eyona nto ilungileyo onokuyenza kukubona ugqirha, ufumane unobangela ochanekileyo, kwaye ufumane unyango olufunekayo. Musa nje ukuhambisana nokuziva kwakho, kuba ezi zinto ziyinkimbinkimbi kancinci.

Ugqirha wakho angakunceda ngqo. Hlala usempilweni!

` I-Renin, Uxinzelelo lwegazi, Izintso, i-Aldosterone, i-Angiotensin, Uxinzelelo lwegazi oluphezulu, Uxinzelelo lwegazi oluphantsi, i-Renin, Uxinzelelo lwegazi, Izintso, i-Aldosterone, i-Angiotensin, i-RAAS