Indlela entsha yokuxilonga umhlaza: Yonke into malunga ne-liquid biopsy!

Ngaba wakha weva ngegama elithi " i-biopsy yolwelo"? Mhlawumbi ugqirha wakho ukuxelele ngalo, okanye ukhe wafunda ngalo ndaweni ithile. Le yindlela entsha nebaluleke kakhulu yokuvavanya umhlaza. Ngoko ke, masithethe ngalo ngokulula nangokucacileyo namhlanje. Akukho nto yokoyika, kufana nomhlobo wakho ekuchazela into ethile.

Yintoni le biopsy yolwelo? Kulula kakhulu!

Ngamafutshane, i-liquid biopsy luvavanyo oluthatha igazi elincinci . Oku kunokufumanisa ukuba kukho na iithumba ezinomhlaza. Khawuthelekelele ukuba njengoko ithumba elinomhlaza likhula, iziqwenga zalo ezincinci zinokuqhekeka zingene egazini lakho. Ezo ziqwenga zifunyanwa yile liquid biopsy.

Olu vavanyo lujonga izinto ezimbini eziphambili:

• Iiseli zeTumor ezijikelezayo (ii-CTC): Ezi ziiseli zomhlaza eziphuma kwithumba zize zihambe egazini lakho, njengeempimpi ezincinci.
• I-DNA ye-tumor ejikelezayo (ctDNA): Ezi ziingceba ze-DNA eziphuma kwiiseli zomhlaza zingene egazini. Njengoko usazi, i-DNA ifana nencwadi equlethe ikhowudi yemfuza elawula indlela eziziphatha ngayo iiseli zethu. Ngoko ke, ezi zingceba ze-ctDNA zinokusixelela okuninzi ngomhlaza.

Ukubakho kwezi `(CTCs)` okanye `(ctDNA)` egazini lakho bubungqina bokuba kukho ithumba elinomhlaza ndaweni ithile emzimbeni wakho. Kwakhona, ekubeni ezi ziqwenga zikwabonelela `(ulwazi lwemfuza )` lomhlaza, kuya kuba luncedo olukhulu kugqirha wakho ekugqibeni ukuba loluphi unyango olufanelekileyo kuwe.

Uvavanyo lwe-Liquid biopsy luvavanyo olutsha. Lunokwenza umahluko omkhulu kwicandelo lokunyanga umhlaza. Sele kukho iindlela ezahlukeneyo ezivunyiweyo yi-US Food and Drug Administration (FDA). Uphando malunga noku lusaqhubeka.

Yintoni umahluko phakathi kwe-liquid biopsy kunye ne-biopsy eqhelekileyo esiyaziyo?

Mhlawumbi ukhe weva nge-biopsy eqhelekileyo. Kuyo, ugqirha uthatha iqhekeza elincinci lesicubu ngqo kwithumba elinomhlaza aze alivavanye kwilebhu ukuze abone ukuba linazo na iiseli zomhlaza.

Nangona kunjalo, kwi-biopsy yolwelo, isiqwenga sethumba asithathwa ngqo . Endaweni yoko, sisetyenziselwa ukukhangela ubungqina bomhlaza, obuziiseli zomhlaza ``CTCs`` okanye i-``ctDNA`` yomhlaza esithethe ngayo ngaphambili, egazini.

Uvavanyo lwe-biopsy oluqhelekileyo okwangoku luthathwa njengeyona ndlela ilungileyo yokufumanisa ukuba umhlaza ukhona na. Ikwabizwa ngokuba "ngumgangatho wegolide."

Kwi-biopsy yolwelo, nokuba unomhlaza, akukho siqinisekiso se-100% sokuba uya kukwazi ukubona iimpawu zawo kwisampulu enye yegazi . Nangona kunjalo, ukuba umhlaza ufunyenwe kwi-biopsy yolwelo, ulwazi olulunikayo malunga neeseli zomhlaza luxabiseke kakhulu, kwaye lunokuba luncedo kakhulu koogqirha ekucwangciseni unyango.

Kweziphi iimeko apho kwenziwa khona i-liquid biopsy?

Ugqirha wakho unokucebisa ukuba kwenziwe i-biopsy yolwelo kwezi meko zilandelayo:

• Ukuba unomhlaza osasazeka kwamanye amalungu omzimba wakho kwaye unyango lwakho lwangoku alusebenzi njengoko bekulindelekile . Umhlaza osasazekayo luhlobo lomhlaza olunobundlongondlongo olusasazeka emzimbeni wakho wonke. Xa usasazeka ngolu hlobo, kunokwenzeka ukuba iziqwenga zomhlaza ziqhekeke zingene egazini lakho.

Ugqirha angayalela i-liquid biopsy ukuze afumanise izinto ezifana nezi:

• Misela i-prognosis: Iibhayopsies zolwelo zinokubona iiseli ze-tumor ezijikelezayo (ii-CTC) kwiintlobo ezininzi zomhlaza . Inani eliphantsi leeseli zomhlaza egazini libonisa i-prognosis engcono. Inani eliphezulu leeseli zomhlaza libonisa i-prognosis embi. Ngoko ke, ugqirha wakho unokwenza olu vavanyo rhoqo ukuze ajonge imeko yakho aze alungise unyango lwakho ukuba kuyimfuneko.
• Yenza izigqibo zonyango: Kukho unyango olujolise kwiiseli ezithile zomhlaza kuphela (unyango olujoliswe kulo). Oku kuthetha ukuba ukuba iseli yomhlaza inempazamo ethile (uguquko) kwi-DNA yayo, inokunikwa iyeza elithile elenzelwe ukuhlasela loo mpazamo. I-biopsy yolwelo inokufumana ezi mpazamo. Ugqirha wakho unokukunika unyango olujolise kuloo mpazamo.

Kwakhona, ungenza i-liquid biopsy nokuba i-biopsy eqhelekileyo ayinakwenzeka ukuze kufunyanwe umhlaza. Oku kungenxa yokuba i-biopsy eqhelekileyo yinkqubo ehlaselayo ngakumbi kune-liquid biopsy. Usenokungabi sempilweni ngokwaneleyo ukuba wenze i-biopsy. Okanye, kuxhomekeke kwindawo ekuyo i-tumor, kunokuba nzima ukususa iqhekeza layo ngaphandle kokonakalisa amalungu abalulekileyo akufutshane.

Zeziphi iimvavanyo ze-biopsy yolwelo ezivunyiweyo yi-FDA?

Uvavanyo oluvunyiweyo yi-U.S. Food and Drug Administration (FDA) lolo luphandwe ngokucokisekileyo kwaye lungqinwe lukhuselekile kwaye luchanekile. Uvavanyo oluninzi lwe-biopsy yolwelo lusekwinqanaba lophando. Kukho uvavanyo oluphambili olune oluvunyiweyo yi-FDA okwangoku:

1. Uvavanyo lweCell Search® Circulating Tumor Cell (CTC): Olu vavanyo lweCTC. Ibele, iprostateOku kusetyenziswa ukufumana umbono wemeko yexesha elizayo yabantu abanomhlaza oye wasasazeka waya kumathumbu amakhulu okanye kwi-rectum. Ukuba kukho ii-CTC ezimbalwa egazini, olo luphawu oluhle. Ukuba kukho ii-CTC ezininzi, oko akulunganga kangako.

2. Uvavanyo lwe-cobas® EGFR Mutation Test v2: Olu vavanyo luvavanya i-ctDNA. Lubona utshintsho kwi-gene ebizwa ngokuba yi-EGFR, oluqheleke kakhulu kumhlaza wamaphaphu ongengoweeseli ezincinci (i-NSCLC). Olu lwazi lunokunceda ugqirha wakho ukuba agqibe ukuba loluphi unyango olulungele ukujolisa olo tshintsho.

3. I-Guardant360® CDx: Oku kukwakhangela i-ctDNA. Isetyenziselwa ukubona iziphene zemfuza ezixhaphakileyo kwiiseli zomhlaza. Oku kunceda ugqirha ukuba akhethe unyango olusebenzayo.

4. I-FoundationOne® Liquid CDx: Oku kukwakhangela i-ctDNA. Oku kunceda ekufumaneni iziphene zemfuza (iinguqu) kwiintlobo ezahlukeneyo zomhlaza. Oku kunceda ugqirha ukuba agqibe ukuba loluphi unyango olufanelekileyo.

Yenziwa njani i-liquid biopsy? Ingaba ibuhlungu?

I-biopsy yolwelo luvavanyo lwegazi olulula kakhulu . Njengokuba ubuya kunika isampuli yegazi ukuze ihlolwe igazi rhoqo. Ugqirha okanye umongikazi uza kuthatha isampuli yegazi engalweni yakho aze alithumele kwilebhu ukuze livavanywe.

Kwilebhu, umatshini wahlula igazi lakho libe ziindawo zeseli (inxalenye eqinileyo) kunye neplasma (inxalenye engamanzi). Emva koko, ingcali yezifo, ingcali eqeqeshwe ukuhlalutya iisampulu zolwelo kunye nezicubu, ikhangela iimpawu zesifo kwinxalenye yeplasma, ebizwa ngokuba yi-CTCs okanye i-ctDNA.

Ingaba oku kuyabuhlungu? Hayi, i-biopsy yolwelo ifana nokunikela ngegazi. Xa inaliti ifakwa engalweni yakho, ungaziva urhawuzelelwa kancinci, njengokulunywa imbovane. Kodwa loo ntlungu iphela ngokukhawuleza.

Enye inzuzo ye-liquid biopsy kukuba ayingeni kakhulu kwaye ayibuhlungu kakhulu kune-biopsy eqhelekileyo.

Zithini iziphumo zolu vavanyo?

Iziphumo zovavanyo zikuxelela ukuba ingaba isampuli yegazi lakho linayo na `(CTCs)` okanye `(ctDNA)` (`positive`) okanye hayi (`negative`) .

• Ukuba iziphumo zithi ``positive`` , oko kuthetha ukuba izinto ezikhankanyiweyo zikhona egazini. Emva koko, ezi mvavanyo zinokukunceda ufumanise ukuba loluphi uhlobo lomhlaza onalo. Ngokukodwa, iimvavanyo ezikhangela ``(ctDNA)`` zinokuchonga neziphene eziqhelekileyo zemfuza ezinxulumene neentlobo ezithile zomhlaza.

Kuthatha ixesha elingakanani ukufumana iziphumo? Ichaneke kangakanani i-liquid biopsy?

Iziphumo zovavanyo zihlala zifumaneka kwiiveki ezimbini ukuya kwezintathu .

Ngoku makhe sijonge ukuchaneka koku. Uvavanyo lwe-biopsy oluyilwelo oluvunyiweyo yi-FDA, lwenzelwe ntoni, kwaye lwenza kanye loo msebenzi.

• Ugqirha unokufumana umbono wemeko yesifo sakho kwixesha elizayo aze ajonge imeko yesifo sakho ngokusebenzisa iimvavanyo ze-`(CTC)`.
• Ngenxa yokuba uvavanyo lwe-``(ctDNA)`` lunokufumanisa iziphene zemfuza kwi-DNA yeeseli zomhlaza, lunceda ekwenzeni izigqibo zonyango.

Nangona kunjalo, i-biopsy engamanzi ayinakusoloko ithembeka kuyo ukuze ifumanise umhlaza ngokuqiniseka okupheleleyo . I-biopsy eqhelekileyo iyafuneka ukuqinisekisa ukuba kukho umhlaza.

Uvavanyo lwe-biopsy yolwelo okwangoku luyindawo yophando olusebenzayo nophuhliso. Ukukwazi ukufumanisa nokujonga umhlaza ngovavanyo lwegazi olulula yinto enkulu. Uphando luyaqhubeka ukuphuhlisa uvavanyo lwe-biopsy yolwelo olunokufumanisa umhlaza ngaphambi kokuba ukhule. Nangona kunjalo, kufuneka uphando oluthe kratya ukuqonda amandla apheleleyo e-biopsy yolwelo. Sele zinceda ekuxilongeni ezinye iintlobo zomhlaza kwaye zenze izigqibo zonyango kwiimeko ezithile. Kwixesha elizayo, zinokuba neenzuzo ezinkulu nangakumbi.

Okokugqibela, izinto ekufuneka sizikhumbule

Kulungile, ngoko ke sithethe kakhulu nge-liquid biopsy. Nazi izinto ezimbalwa ekufuneka uzikhumbule:

• I-Liquid biopsy luvavanyo olutsha olukhangela iimpawu zomhlaza egazini .
• Oku kungafumanisa `(CTCs)` (iiseli zomhlaza) kunye `(ctDNA)` (iDNA yomhlaza).
• Akukho ntlungu okanye intlungu enkulu efana nokuhlolwa rhoqo kwezicubu zomzimba.
• Oku kunceda ekufumaneni umbono ngemeko yomhlaza kwixesha elizayo kunye nokwenza isigqibo malunga nonyango .
• Ezinye iimvavanyo ezivunyiweyo yi-FDA sele zikhona.
• Nangona kunjalo, ukuze kuqinisekiswe ngokuqinisekileyo ukuba umhlaza ukhona, i-biopsy eqhelekileyo inokufuneka .
• Le yiteknoloji esaphuhliswayo kwaye inokuba luncedo kakhulu kwixesha elizayo.

Eyona nto ibalulekileyo kukuba, ukuba unemibuzo okanye iinkxalabo malunga noku, ngokuqinisekileyo thetha nogqirha wakho. Angachaza yonke into kuwe ngendlela efanelekileyo kuwe.

Ndiyathemba ukuba olu lwazi luluncedo kuwe! Hlala usempilweni!

I- Liquid Biopsy, Umhlaza, Ukufunyanwa koMhlaza, i-ctDNA, ii-CTC, Uvavanyo lweGazi, Unyango loMhlaza