Ngaba uzive ubuthathaka? Ngaba amalungu akho omzimba ayaqaqamba? Masifunde nge-CIDP (Chronic Inflammatory Demyelinating Polyneuropathy)!

Ngaba ngamanye amaxesha uziva udiniwe kakhulu, iingalo nemilenze yakho zibuthathaka, okanye uziva urhawuzelelwa? Ngamanye amaxesha usenokungazinaki kangako ezi zinto. Nangona kunjalo, kwiimeko ezingaqhelekanga, ezi mpawu zinokuba luphawu lwento enzulu ngakumbi. Enye imeko engaqhelekanga kodwa ebalulekileyo ekufuneka uyiqaphele ibizwa ngokuba yi -CIDP (Chronic Inflammatory Demyelinating Polyneuropathy) . Nangona igama lisenokubonakala lide kancinci, masiligcine lilula.

Yintoni i-CIDP (Chronic Inflammatory Demyelinating Polyneuropathy)?

Nangona eli gama lisenokubonakala liyinkimbinkimbi kancinci, ukuba singalichaza kakuhle intsingiselo yalo, sinokufumana umbono ongcono ngesi sifo.

• Isifo Esingapheliyo: Oku kuthetha "ixesha elide." Oku kuthetha ukuba i-CIDP ayiveli ngequbuliso kwaye iphucuke ngokukhawuleza. Ikhula kancinci, kangangeeveki ezisibhozo ubuncinane. Ngamanye amaxesha iimpawu ziyaphela zize ziphinde zivele emva kweenyanga okanye iminyaka. Kufana nengxaki ephindaphindayo.

• Ukudumba: Oku kuthetha "ukudumba" . Xa sifumana ukwenzakala kwindawo ethile emzimbeni wethu, kuyadumba kuze kube bomvu, akunjalo? Yiyo loo nto. Kodwa kwi-CIDP, oku kudumba kwenzeka ngenxa yengxaki ethile kwinkqubo yethu yokuzikhusela yomzimba. Ngamafutshane, amajoni afanele ukukhusela imizimba yethu aqala ukuhlasela imithambo-luvo yethu ngempazamo. Oku kubizwa ngokuba yi- "Autoimmune Attack" . Ukudumba okugqithisileyo okubangelwa koku konakalisa imithambo-luvo yethu. Le mithambo-luvo ye-peripheral yimithambo-luvo ephuma kwingqondo nakwi-spinal cord.

• Ukususa imyelin: Eli ligama elinzulu kancinci. Ii-neurons zethu zinesigqubuthelo esikhuselayo esizijikelezileyo. Sifana nesigqubuthelo seplastiki esijikeleze ucingo lombane. Esi sigqubuthelo sibizwa ngokuba yi -` (Myelin Sheath)` . Esi sigqubuthelo semyelin sivumela imiyalezo yemithambo-luvo ukuba ihambe ngokukhawuleza nangokuchanekileyo. `(Ukususa imyelin)` kuthetha ukuba isigqubuthelo semyelin siyatshatyalaliswa okanye sonakele. Emva koko, njengaxa iplastiki ekwicingo isusiwe, ukuvuza kwangoku, kunye nemiyalezo yemithambo-luvo azihambi kakuhle.

• I-Polyneuropathy: Igama elithi "Poly" lithetha "ezininzi." Igama elithi "Neuropathic" lithetha umonakalo kwimithambo-luvo. I-Polyneuropathy ithetha umonakalo kwimithambo-luvo emininzi emzimbeni ngaxeshanye. Oku kunokubangela iingxaki ezahlukeneyo ezifana nobuthathaka bemisipha, ukungaziva, kunye ne-paresthesia.

Ngoko ke, ngokufutshane nje, i-CIDP yimeko yexesha elide apho i-myelin sheath ejikeleze imithambo-luvo engaphandle yonakele ngenxa yokungasebenzi kakuhle kwenkqubo yethu yokuzikhusela, nto leyo ebangela ukungasebenzi kakuhle kwemithambo-luvo emininzi. Uyaqonda?

Yintoni umahluko phakathi kweGuillain-Barré Syndrome (GBS) kunye neCIDP?

MhlawumbiUsenokuba ukhe weva nge- ` (Guillain-Barré Syndrome)` okanye ` (GBS) .` Isifo i-CIDP sifana kakhulu ne-GBS. Oogqirha bacinga ukuba i-CIDP luhlobo lwe-GBS oluhlala ixesha elide. I-GBS ikwasisifo esingaqhelekanga apho amajoni ethu omzimba ahlasela khona imithambo-luvo engaphandle.

Kodwa umahluko ophambili lixesha. Eyona nto imbi kakhulu kwi-GBS idla ngokuza emva kweeveki ezimbini ukuya kwezintathu emva kokuba iimpawu ziqalile. Kodwa uninzi lwabantu luya luphucuka kancinci kancinci emva koko. Kodwa i-CIDP ihlala ixesha elide. Iimpawu ziya zisiba mandundu kancinci kancinci kwiiveki ezisibhozo ubuncinane .

Ixhaphake kangakanani i-CIDP?

I-CIDP yimeko engaqhelekanga kakhulu . Ngokutsho kwabaphandi, inani lamatyala amatsha e-CIDP eMelika liphakathi kwe-0.8 ne-8.9 kubantu abayi-100,000 ngonyaka. Olu luhlu lukhulu kancinci, kuba i-CIDP inokuchaphazela abantu abahlukeneyo ngeendlela ezahlukeneyo, kwaye kuba kunzima ukuyifumanisa le sifo.

I-CIDP inokukhula nokuba ingakanani na iminyaka.

Zithini iimpawu ze-CIDP?

Iimpawu ze-CIDP zinokwahluka ngokuxhomekeke kuhlobo lwazo. Nangona kunjalo, uphawu oluqhelekileyo kubuthathaka bemisipha obuqhubeka buhlala ubuncinane iiveki ezisibhozo. Oku kudla ngokuchaphazela amacala omabini omzimba ngokulinganayo. Ngokukodwa:

• Imisipha yendawo yesinqe nethanga
• Imisipha yegxalaba kunye nendawo engasentla yengalo
• Isandla neminwe
• Iinyawo neenzwane

Khawuthelekelele, ngequbuliso ufumana kunzima ukuphakama esitulweni, uzive ngathi awukwazi ukunyuka izinyuko, okanye ukufumana kunzima ukukama iinwele zakho okanye ukubamba ikomityi. Izinto ezinje zinokwenzeka.

Ezinye iimpawu ezinokubonwa ziquka:

• Ukuwohloka kwemisipha echaphazelekayo
• Ukuba ndindisholo, ukurhawuzelela, okanye ukulahlekelwa yimvakalelo kwiminwe nakwiinzwane (iParesthesia)
• Ubunzima bokugcina ulungelelwano lomzimba kunye nokungasebenzi kakuhle kolungelelwaniso (njengokukhubeka)
• Ubunzima bokuhamba okanye ukulahleka ngokupheleleyo kokuhamba
• Ukulahlekelwa okanye ubuthathaka be-deep tendon reflexes (oku kuya kuvavanywa ngugqirha ngokucinezela idolo ngesando esincinci)
• Intlungu ye-Neuropathic. Le yintlungu evakala ngathi kukutsha okanye ukuthuthumela ngombane.

Kunqabile kakhulu, unokubona neempawu ezifana nezi:

• Ubunzima bokuginya (i-Dysphagia) kunye nobuthathaka bentamo engentla
• Umbono ophindwe kabini

Ezi mpawu zinokutshintsha ngokuhamba kwexesha. Zisenokuqala kancinci, okanye ziqhubeke ngokukhawuleza. Ngamanye amaxesha zinokufika ziphele, ziphele emva kweentsuku ezimbalwa, zize zibuye. Ukuba unale mpawu, kubalulekile ukubona ugqirha ngokukhawuleza.Ukuxilongwa kwangoko kunye nonyango kunceda kakhulu ekubuyiseleni ubomi.

Ngaba kukho iintlobo ezahlukeneyo ze-CIDP?

Ewe, kukho iintlobo ezahlukeneyo ze-CIDP, kwaye iimpawu zazo zahlukile kancinci.

Uhlobo oluqhelekileyo yi-CIDP eqhelekileyo , ebangela ubuthathaka bemisipha kunye neempawu zokuva (ezifana nokungaziva) kumacala omabini omzimba.

Ezinye iinguqulelo ezingaqhelekanga zezi:

• ` (I-Multifocal Motor Neuropathy)`: Oku kubandakanya ubuthathaka bemisipha kuphela. Obu buthathaka abulingani, oko kuthetha ukuba bunokuchaphazela indawo enye kuphela kwicala elinye lomzimba, okanye iindawo ezininzi ngeendlela ezahlukeneyo.
• (Isifo sikaLewis-Sumner): Oku kubandakanya ubuthathaka bemisipha obungalinganiyo kunye neempawu zeemvakalelo.
• ` (I-Pure Sensory CIDP)`: Oku kunokubangela ukungaziva, iintlungu, iingxaki zokulinganisela, kunye nokuhamba okungaqhelekanga. Kodwa akukho buthathaka bemisipha.
• `(Pure Motor CIDP):`: Kule nto, ubuthathaka bemisipha kunye nokulahlekelwa ziimpendulo ezichaphazela amacala omabini omzimba kunokubonwa, kodwa akukho zimpawu zeemvakalelo.

Abaphandi basafunda ezinye iintlobo ze-CIDP.

Yintoni ebangela i-CIDP?

Njengoko besikhe sathetha ngaphambili, abaphandi bakholelwa ukuba i-CIDP ibangelwa kukungasebenzi kakuhle kwenkqubo yethu yokuzikhusela komzimba . Nangona unobangela ochanekileyo ungekaziwa okwangoku, inkqubo yethu yokuzikhusela komzimba ibona i-myelin sheath njengotshaba ize emva koko iqale ukuyihlasela (impendulo yokuzikhusela komzimba).

I-myelin sheath yilaphu elikhuselayo elijikeleze iiseli zethu zemithambo-luvo. Ijikeleza inxalenye ende ye-nerve fiber (axon). I-Myelin yiyo evumela ii-electrical impulses ukuba zihambe kakuhle kwi-nerve. Xa i-myelin yonakele, ezi -electrical impulses zihamba kancinci kakhulu, okanye zilahleka ngokupheleleyo. Emva koko "imiyalezo" ayifiki apho kufuneka iye khona. Yiyo loo nto ibangela iimpawu ze-CIDP.

Khawucinge ngentambo yombane egqunywe kakuhle. Iqhuba umsinga kakuhle. Kodwa kwenzeka ntoni ukuba ishelufu yeplastiki kuloo ntambo iphuma kwiindawo ezithile? Umsinga uyavuza, okanye awuhambi kakuhle, akunjalo? Yiloo nto eyenzekayo xa ishelufu ye-myelin yonakele.

Ifunyaniswa njani i-CIDP?

Ukuchonga i-CIDP kunokuba nzima kuba iintlobo ezahlukeneyo zineempawu ezahlukeneyo. Ukuze afumanise i-CIDP, ugqirha wakho uya:

• Baza kumamela ngenyameko iimpawu zakho baze bakubuze ngembali yakho yezonyango .
• Kuyenziwa uvavanyo lomzimba kunye novavanyo lwemithambo-luvo .
• Kunokufuneka uvavanyo olukhethekileyo oluninzi ukuqinisekisa ukuxilongwa okanye ukuthintela ezinye iimeko.

Zeziphi iimvavanyo ezisetyenziswayo ukuxilonga i-CIDP?

Ezi ziimvavanyo ezinokunceda ukuqinisekisa i-CIDP kunye nokuthintela ezinye izizathu:

• Uvavanyo lwe-Electromyography (EMG) kunye noVavanyo lokuHanjiswa kweNerve: Olu vavanyo lujonga impilo kunye nokusebenza kwezihlunu zakho kunye nemithambo-luvo ezilawulayo. Olu vavanyo luluncedo kakhulu ekujongeni utshintsho olususa imyelin (ukudluliselwa kancinci kwemiqondiso yemithambo-luvo, ukuvaleka, njl.njl.) njenge-CIDP. Oku kunokunceda ukwahlula i-CIDP kwezinye iintlobo eziqhelekileyo ze-polyneuropathies.

• Ukubethelwa koMgogodla/Ukubhaqwa kweLumbar: Kolu vavanyo, ugqirha ufaka inaliti encinci emqolo wakho ongezantsi aze athathe isampuli yolwelo lwakho lwe-cerebrospinal (CSF) . Le sampuli ithunyelwa kwilebhu ukuze ivavanywe. Kwi-85% ukuya kwi-90% yabantu abane-CIDP, inani leeseli ezimhlophe zegazi liqhelekile, kodwa inqanaba leproteni liphezulu. Ezinye iingxaki kwi-CSF zinokubonisa enye imeko.

• Iskeni yeMagnetic Resonance Imaging (MRI) yomqolo ongezantsi: Ukuba iingcambu zemithambo-luvo kumqolo wakho ongezantsi zifunxa idayi yomahluko ngexesha leskeni ye-MRI, inokunceda ekuxilongeni i-CIDP.

• Uvavanyo lweGazi: Ugqirha wakho unokuyalela uvavanyo lwegazi ukuze akhuphe ezinye iimeko ezinokubangela i-neuropathy, ezifana nesifo seswekile, ukungabikho kweevithamini, isifo se-thyroid, isifo seLyme, i-HIV/AIDS, kunye ne-lymphoma. Banokujonga nee -antibodies ezithile ezifunyenwe zidibene ne-CIDP.

• I-Neural Biopsy: Kunqabile kakhulu ukuba ugqirha acebise ukuba kwenziwe i-nerve biopsy, apho kususwa khona iqhekeza le-nerve lize lihlolwe ukuze kubonwe ukuba i-myelin sheath yonakele na.

Ziziphi iindlela zonyango ze-CIDP?

Kukho iindlela ezintathu eziphambili zonyango lwe-CIDP (lokuqala):

• Ii-Corticosteroids: Amayeza e-steroid, anjenge-prednisolone, anceda ekunciphiseni ukudumba. Kubantu abaninzi, ezi steroids zodwa zinokunceda ekunciphiseni iimpawu. Nangona kunjalo, ii-steroids zinokuba nemiphumo emibi kakhulu, ngoko ke ukusetyenziswa kwala mayeza ixesha elide kulinganiselwe. Ugqirha wakho unokukunika amanye amayeza (i-immunosuppressants) kunye nee-steroids.

• Ukutshintshwa kwePlasma / iPlasmapheresis: Kolu nyango, umatshini wahlula iplasma egazini lakho, uyinyange, uze uyibuyisele iplasma kunye negazi emzimbeni wakho. Ngamafutshane, ihluza ii-antibodies eziyingozi kwiplasma ezihlasela imithambo-luvo yakho. Ukutshintshwa kweplasma kudla ngokusebenza iiveki ezimbalwa kuphela. Kusenokufuneka ukuba olu nyango luvulwe luze lucinywe kangangeenyanga, okanye iminyaka.

• Unyango lwe-Immunoglobulin efakwa kwiMitha (IVIG): Kolu nyango, iiproteni ezibizwa ngokuba yi-immunoglobulin (iiproteni ezenziwa yinkqubo yethu yokuzikhusela ngokwemvelo ukuhlasela abahlaseli) zinikwa ngemithambo yegazi (IV). Le immunoglobulin ifunyanwa egazini lamawaka abantu abaphilileyo. I-IVIG inokunciphisa umonakalo owenziwa yinkqubo yakho yokuzikhusela kwimithambo-luvo. I-IVIG inokunikwa ngeedosi eziphezulu kakhulu ekuqaleni, kwaye unokufuna ukufumana olu nyango rhoqo kangangeenyanga, okanye iminyaka.

Abaphandi okwangoku bafunda ezinye iindlela zonyango ze-CIDP. Usenokufumana ithuba lokuthatha inxaxheba kuvavanyo lweklinikhi lwe-CIDP. Thetha nogqirha wakho ngale nto.

Bunjani ubomi nge-CIDP? (Ingxelo yokuxela kwangaphambili)

Imbonakalo yexesha elide yesi sifo ixhomekeke kwizinto ezininzi:

• Uneminyaka yakho xa i-CIDP yaqala.
• Indlela esikhula ngayo esi sifo kunye nohlobo lwesifo .
• Indlela esi sifo esafunyaniswa ngayo ngokukhawuleza kwaye unyango lwaqala ngayo .
• Indlela umzimba wakho osabela ngayo ekuqaleni kunyango.

Malunga nama-90% abantu abane-CIDP banokunyangwa ngonyango. Kodwa malunga nama-50% abantu baphinda babuyele kwisifo. Ngokubanzi, ukuqikelela ixesha elide kwabantu abafunyaniswe bene-CIDP besebancinci kulungile. Ukuba awufumani naluphi na unyango lwe-CIDP, umonakalo osisigxina wemithambo-luvo unokwenzeka, nto leyo enokubangela ukukhubazeka okuthile.

Ugqirha wakho uya kukwazi ukukunika umbono olungileyo wento omawuyilindele kwixesha elizayo ngokusekelwe kwimeko yakho ethile.

Ngaba i-CIDP iyabunciphisa ubomi obulindelekileyo?

I-CIDP ayisosifo esibulalayo. Abantu abanesi sifo badla ngokuba nobomi obufanayo nomntu ongenaso esi sifo. Ngoko ke akukho nto inokubangela ixhala.

Ngaba i-CIDP ingathintelwa?

Ngenxa yokuba abaphandi abakafumani sizathu sithile se-CIDP, okwangoku akukho ndlela eyaziwayo yokuthintela ukuba esi sifo singabikho.

Ndifanele ndimbone nini ugqirha? / Ndifanele ndiye nini kwigumbi likaxakeka?

Ukuba ufunyaniswe une-CIDP, kufuneka ubone ugqirha wakho rhoqo ukuze ajonge iimpawu zakho aze afumane unyango. Iimpawu ze-CIDP zinokufika ziphele kangangeenyanga okanye iminyaka, ngoko ke unyango oluqhubekayo lunokufuneka.

Amaxesha amaninzi, i-CIDP inokuchaphazela izihlunu ezifunekayo ukuze uphefumle . Ukuba unengxaki yokuphefumla , fowunela u-911 (okanye inombolo yakho yongxamiseko yasekuhlaleni) ngoko nangoko, okanye uye kwigumbi longxamiseko elikufutshane. Le yingxamiseko.

Okokugqibela, izinto ekufuneka uzikhumbule

Kunokuba yinto eyoyikisayo ukuziva ngathi awukwazi ukulawula umzimba wakho. Kodwa iindaba ezimnandi zezokuba iimpawu ze-CIDP (Chronic Inflammatory Demyelinating Polyneuropathy) zinokunyangwa, ingakumbi ukuba uqala unyango kwangethuba. Khumbula ukuba iqela lakho lezonyango likunye nawe kuyo yonke inyathelo lokujongana nale meko. Ngoko ke yiba nesibindi kwaye ulandele icebiso likagqirha wakho.

` I-CIDP, I-Neuropathy, Ubuthathaka Bemisipha, Ukungabi Nangqondo, Inkqubo Yokuzikhusela, I-Myelin, Inkqubo Yeemvakalelo, Unyango lwe-CIDP, I-Chronic Inflammatory Demyelinating Polyneuropathy