Usenokuba ukhe wabona umntu kusapho lwakho, isalamane okanye umhlobo efumana unyango lomhlaza. Umele ukuba uvile ngonyango olubizwa ngokuba yi "Chemotherapy" xa efumana unyango olunjalo. Mhlawumbi uyazi nokuba ngexesha lonyango lwe-chemo, inani leeseli ezimhlophe zegazi ezilwa nezifo emzimbeni liyancipha. Kwimeko enjalo, kweli nqaku, siza kuthetha ngamayeza akhethekileyo asetyenziswa ngoogqirha ukunceda inkqubo yokuzikhusela yomzimba wethu. Loo nto yi-G-CSF.
Yintoni kanye kanye i-G-CSF?
Ngamafutshane, i-G-CSF liyeza elinceda imizimba yethu ukuba yenze iiseli ezimhlophe zegazi ezingaphezulu, ingakumbi uhlobo olubizwa ngokuba yi- "neutrophils."
Khawuthelekelele ukuba imizimba yethu ifana nelizwe. Ezi neutrophils zifana namajoni akuloo lizwe. Ngala majoni abizwa ngokuba zii-neutrophils alwa neentsholongwane zangaphandle, oko kukuthi, iintshaba ezifana neebhaktheriya kunye neentsholongwane, kwaye asikhusele kwizifo kunye nosulelo. Ngoko ke kwenzeka ntoni ukuba la majoni ancipha? Ilizwe lethu, oko kukuthi, imizimba yethu, liba semngciphekweni wezifo lula.
Nangona igama elithi G-CSF lisenokubonakala liyinkimbinkimbi kancinci, ukuba singalichaza kakuhle intsingiselo yalo, lilula kakhulu.
- I-Granulocyte: Eli ligama elinikwa uhlobo lweseli emhlophe yegazi. Ii-neutrophils zikwaluhlobo lwe-granulocyte.
- I-Colony-Stimulating Factor: Le yinto "eyalela" okanye "evuselela" iiseli. Njengomphathi wefektri onika abasebenzi imisebenzi, le protein iya kumongo wethu wethambo ize ithi, "Kulungile, qala ukwenza ii-neutrophils ngoku."
Ngoko ke into eyenziwa leli yeza elibizwa ngokuba yi-G-CSF kukuba liya kumongo wethambo , oyinxalenye efana nesiponji emathanjeni ethu, kwaye lixelela iiseli ze-stem apho, "Nina bantu kufuneka nibe zii-neutrophils ngokukhawuleza, kwaye ii-neutrophils ezikhoyo mazihlukane kwaye zande." Emva koko la majoni amatsha e-neutrophil ajoyina igazi aze aqalise ukusebenza ukuze asikhusele.
Into ebalulekileyo kukuba, nangona i-G-CSF iyisiyobisi esenziwe ngokwenziwa, ifana nenkqubo yeproteni eveliswa ngokwendalo emzimbeni wethu.
Kuphantsi kweziphi iimeko apho i-G-CSF isetyenziswa khona?
I-G-CSF isetyenziswa kakhulu ukunyanga nokuthintela imeko ebizwa ngokuba yi- "neutropenia." I-Neutropenia linani eliphantsi kuneliqhelekileyo lee-neutrophils egazini.
Kunyango lomhlaza (iChemotherapy)
Amayeza e-chemotherapy asetyenziswa kunyango lomhlaza enzelwe ukubulala iiseli zomhlaza ezahlula ngokukhawuleza. Nangona kunjalo, la mayeza awakwazi ukubona iiseli zomhlaza kuphela, kodwa neeseli eziphilileyo ezahlula ngokukhawuleza emzimbeni wethu. Ngoko ke, ekubeni ii-neutrophils, eziveliswa kumongo wethambo, zikwaluhlobo lweeseli ezahlula ngokukhawuleza, zonakaliswa namayeza e-chemotherapy.
Oku kufana nokutshiza i-herbicide ukuze kususwe ukhula, kodwa konakalisa nezityalo ezilungileyo.
Yingakho i-neutropenia ixhaphake kakhulu emva kwe-chemotherapy. Ukuba le meko iba mandundu, nosulelo oluncinci lunokuba yingozi ebomini. Kwiimeko ezinjalo, oogqirha bacebisa i-G-CSF ukunciphisa umngcipheko wosulelo nokubuyisela ukhuselo lomzimba.
Xa kufakelwa i-stem cell
Kwezinye iintlobo zomhlaza kunye neengxaki zegazi, kufuneka utyando lwe-stem cell. I-G-CSF isetyenziswa ngaphambi nasemva kwale nkqubo.
- Ngaphambi kokufakelwa: Xa isigulana sinikwa i-G-CSF, umongo wethambo uvelisa inani elikhulu lee-stem cells kwaye uzikhuphele egazini. Emva koko oogqirha baqokelela ezo stem cells ziphilileyo egazini.
- Ngexesha lokufakelwa isibeleko: Okulandelayo, unyango oluphezulu lwe-chemotherapy okanye unyango lwe-radiation lutshabalalisa naziphi na iiseli ezingaqhelekanga eziseleyo emzimbeni.
- Emva kokufakelwa: Ekugqibeleni, iiseli zokuqala eziphilileyo ebeziqokelelwe ngaphambili zibuyiselwa emzimbeni. Ezi seli kamva ziya kuba ziiseli zegazi ezintsha neziphilileyo.
Ukuba ungumnikeli weeseli ze-stem, unokufuna ukufumana inaliti ye-G-CSF ngaphambi kokuba kwenziwe inkqubo.
Ezinye iimeko ezibangela i-neutrophils ephantsi
Amanqanaba e-neutrophil anokuba phantsi ngenxa yeemeko ezithile ezikhoyo ekuzalweni (i-neutropenia enzulu yokuzalwa) okanye kwiimeko apho imbangela ingaziwa (i-idiopathic neutropenia). Kwiimeko ezinjalo, i-G-CSF isetyenziselwa ukwandisa amanqanaba e-neutrophil.
Iintlobo ze-G-CSF kunye nendlela ezinikwa ngayo
I-G-CSF iyafumaneka kwimarike ngamagama ahlukeneyo. Iindidi ezimbini ezisetyenziswa kakhulu zezi:
1. I-Filgrastim: Olu luhlobo olusebenza ngokukhawuleza. Ludla ngokufuna ukujovwa yonke imihla.
2. I-Pegfilgrastim: Olu luhlobo lweyeza olusebenza ixesha elide, ngoko ke kudla ngokwanela ukufumana inaliti enye phakathi kweendlela ezimbini ze-chemotherapy.
La mayeza afumaneka phantsi kwamagama eempawu ezahlukeneyo kunye ne-biosimilar. Umzekelo, ugqirha wakho unokukwazi ukukuxelela ngamagama afana neNeupogen®, Neulasta®, Nivestym®, kunye neZarxio®.
| Uhlobo lwe-G-CSF | Inani lamaxesha anikiweyo (ngesiqhelo) |
|---|---|
| I-Filgrastim (yexesha elifutshane) | Imihla ngemihla (iintsuku okanye iiveki ezimbalwa) |
| I-Pegfilgrastim (ixesha elide) | Kanye nge-chemo cycle nganye |
Eli yeza linikwa njani emzimbeni?
I-G-CSF idla ngokunikwa njengenaliti engaphantsi kwesikhumba , kodwa kwezinye iimeko inokunikwa njenge-IV infusion .
- Kusenokufuneka uye ekliniki yonke imihla ukuze ugonywe.
- Okanye, umongikazi uza kukufundisa ngokucacileyo wena okanye ilungu losapho indlela yokufaka isitofu ekhaya. Akunzima kangako.
Ngaba wonke umntu uyayidinga i-G-CSF?
Hayi. I-G-CSF ayinikwa wonke umntu ofumana i-chemotherapy okanye one-neutrophils ephantsi. Njengalo naliphi na iyeza, i-G-CSF ineenzuzo kunye nemingcipheko yeziphumo ebezingalindelekanga. Ugqirha wakho uza kuqwalasela izinto ezininzi ngaphambi kokuba anike eli yeza.
- iminyaka yakho
- Imeko yakho yempilo iyonke
- Uhlobo lomhlaza onalo
- Uhlobo lwe-chemotherapy oyifumanayo
- Nokuba sele uneempawu ze-neutropenia (ezifana nomkhuhlane)
Ngoko ke, isigqibo sokuba i-G-CSF iyafuneka na okanye ayifuneki senziwa ngugqirha okunyangayo. Akufuneki ukhathazeke ngaso.
Iingenelo kunye nemiphumo emibi enokubakho ye-G-CSF
Ukuba kucetyiswa i-G-CSF, khumbula ukuba iingenelo zingaphezulu kakhulu kuneengozi.
Iingenelo eziphambili:
- Umngcipheko wosulelo olunzima nolunokubeka ubomi esichengeni uncitshiswa kakhulu.
- Amanqanaba aphantsi e-neutrophil anokuthintela ukuba i-chemotherapy ingalibaziseki okanye incitshiswe kwidosi , nto leyo evumela ukuba unyango lomhlaza luqhubeke njengoko bekucwangcisiwe.
Iziphumo ebezingalindelekanga ezinokubakho
Uninzi lweziphumo ebezingalindelekanga zezokwexeshana kwaye ziyaphela emva kokuba i-G-CSF iyekiwe.
| Imiphumela | Inkcazo kunye nolawulo |
|---|---|
| Iziphumo ebezingalindelekanga eziqhelekileyo | |
| Intlungu emathanjeni nakwimisipha | Esi sesona siphumo sixhaphakileyo. Kufana "neentlungu zokukhula" kuba umongo wethambo ngequbuliso wenza iiseli ezininzi kakhulu. Ungabuza ugqirha wakho malunga nokuthatha iyeza lokubulala iintlungu elifana neparacetamol. |
| Ukudinwa | Usenokuziva udiniwe kuba umzimba wakho usebenzisa amandla amaninzi ukuvelisa iiseli ezintsha. Phumla ngokwaneleyo. |
| Intloko ebuhlungu, isicaphucaphu, urhudo | Ezi zihlala zithambile. Ugqirha uya kunika amayeza afanelekileyo. |
| Ubomvu, ukurhawuzelela, okanye intlungu kwindawo yokujova | Oku kudla ngokuphela emva kosuku okanye ezimbini. |
| Iimpawu ezinzima (kodwa ezingaqhelekanga) ekufuneka zixelwe kugqirha ngoko nangoko | |
| Iimpawu zosulelo | Umkhuhlane, ukubanda, umphimbo obuhlungu, ukukhohlela. Ezi zisenokuba ziimpawu zosulelo. Xelela ugqirha wakho ngoko nangoko. |
| Iimpawu zempendulo ye-allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso okanye imilebe, ubunzima bokuphefumla. Le yingxamiseko. Yiya kwiSebe leNgxamiseko lesibhedlele (ETU) ngokukhawuleza. |
| Intlungu ebukhali kwinxalenye ephezulu yasekhohlo yesisu | Oku kungaba luphawu lwengxaki engaqhelekanga kakhulu kwi-spleen. |
| Ukudumba ngequbuliso kwamalungu omzimba, ubunzima bokuphefumla | Ezi zisenokuba ziimpawu zeemeko ezingaqhelekanga kodwa ezinzulu ezifana ne-capillary leak syndrome okanye i-ARDS. Funa uncedo lwezonyango ngokukhawuleza. |
Izinto ekufuneka uzikhumbule xa uthatha i-G-CSF
- Xelela ugqirha wakho imbali yakho epheleleyo yezonyango. Qiniseka ukuba umazisa ngazo naziphi na ezinye izifo onazo kunye nayo nayiphi na eminye imithi oyithathayo (kuquka neevithamini).
- Akukhuthazwa ukuthatha i-G-CSF ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa . Thetha nogqirha wakho ngale nto.
- Musa ukukhathazeka ngemiphumo emibi. Ukuba ufumana nayiphi na imiphumela emibi, xelela ugqirha wakho okanye umongikazi. Baza kukunceda ukuba uyilawule.
- Yenza uvavanyo lwegazi lakho ngexesha elifanelekileyo. Ugqirha wakho uza kujonga amanqanaba akho e-neutrophil aze agqibe ukuba unyango luza kuthatha ixesha elingakanani.
I-G-CSF sisixhobo esibaluleke kakhulu kwinkqubo yokunyanga umhlaza. Inika inkxaso enkulu ekwenzeni unyango lwe-chemotherapy lukhuseleke kwaye luphumelele ngakumbi. Ukuba unemibuzo engaphezulu malunga noku, nceda ungathandabuzi ukubuza ugqirha wakho onyangayo.
Umyalezo Wokuya Ekhaya
- I-G-CSF liyeza elonyusa ukuveliswa kohlobo lweseli emhlophe yegazi ebizwa ngokuba yi-neutrophils emzimbeni.
- Oku kunciphisa umngcipheko wosulelo olunzima olunokwenzeka ngexesha lonyango lwe-chemotherapy.
- Intlungu yamathambo nemisipha yeyona miphumo ixhaphakileyo kwaye idla ngokulawulwa.
- Ukuba uqalisa ukuba nomkhuhlane, ubunzima bokuphefumla, okanye iimpawu eziqatha zokunganyamezelani komzimba, yazisa ugqirha wakho ngoko nangoko okanye uye esibhedlele.
- Ukuba unenkxalabo malunga nale mithi, ungaze ungathandabuzi ukuyixoxa nogqirha wakho.
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