Ngaba wakha wazibuza ukuba ingqondo yethu ixakeke kangakanani? Kufana neColombo Town, apho amawaka ezinto ezenzeka ngaxeshanye. Imiyalezo iyahamba isiya phambili, izigqibo zenziwa, iimvakalelo ziyalawulwa... konke oku kwenzeka ngenethiwekhi yezithunywa ezincinci zeekhemikhali. Ngoko ke, kwenzeka ntoni xa yonke into ihamba ngendlela exakeke kangaka? Yonke into iba yingxubakaxaka, akunjalo? Kukho umntu engqondweni yethu omisa loo ngxubakaxaka, athomalalise yonke into, aze ayilawule. Namhlanje siza kuthetha ngaloo mthunywa ubalulekileyo, oko kukuthi, 'ibhuleki' yendalo engqondweni yethu. Yiyo leyo iGABA.
Yintoni kanye kanye iGABA?
Ngamafutshane, iGABA , eyisishunqulelo se -gamma-aminobutyric acid, sisithunywa sekhemikhali engqondweni yethu. Kwizonyango, sizibiza ezi neurotransmitters. Njengabathunywa beposi, bathwala imiyalezo esuka kwiseli yemithambo-luvo ethile ebuchotsheni ukuya kwenye.
Kodwa umyalezo ophethwe yiGABA ukhethekile kancinci. Asingomyalezo othi "Khawuleza, baleka." Ngumyalezo othi "Kulungile, kulungile, kwanele ngoku. Yehlisa isantya kancinci, zola." Oko kukuthi, iGABA ilawula kancinci umsebenzi wenkqubo yethu yemithambo-luvo - oko kukuthi, ingqondo kunye nomqolo. Iyayithintela iiseli zemithambo-luvo ukuba zingavuselelwa ngokungeyomfuneko.
Yingakho sikholelwa ukuba iGABA idlala indima ebalulekileyo ekuzoliseni iingqondo zethu nasekulawuleni izinto ezinje ngoxinzelelo, uloyiko, kunye nexhala. Ifana nesithomalalisi sendalo sengqondo yethu.
Makhe sijonge ngokusondeleyo indlela esebenza ngayo iGABA.
Ukuze uqonde oku, khawucinge ukuba iiseli zemithambo-luvo ezikwingqondo yakho ziyathetha zodwa. Kodwa azidibananga. Kukho umsantsa omncinci phakathi kweseli enye nenye. Siwubiza ngokuba yi-synapse. Xa umyalezo kufuneka uthunyelwe, i-neurotransmitter ikhutshwa kwiseli enye, idada idlule kuloo msantsa, ize ibophelele kwi-receptor ekhethekileyo kwiseli elandelayo.
Kufana nesitshixo kunye nesitshixo. Asizizo zonke izitshixo ezinokuvula zonke izitshixo. Kwakhona, asizizo zonke 'iNeurotransmitter' ezinokuqhagamshela kwi-'Receptor' nganye. Isitshixo esibizwa ngokuba yiGABA sinokuvula kuphela 'iizitshixo' ezibizwa ngokuba ziiGABA receptors.
Xa iGABA isiya ize ibophelele kwi-'receptor' yayo, umyalezo ofunyanwa yiseli yemithambo-luvo elandelayo kukuba "unciphise umsebenzi wakho." Oko kukuthi, amandla aloo seli okufumana imiyalezo evela kwezinye iiseli, ukwenza imiyalezo emitsha, okanye ukuthumela imiyalezo kwezinye iiseli ayancipha. Ngale ndlela, umsebenzi wobuchopho uphela uyathomalaliswa. Njengaxa isibane sendlela siba bomvu kwindlela exakekileyo, iimoto ziyama kwaye ithrafikhi ilawulwa kancinci.
IGABA kunye neGlutamate - iinguqu ezimbini ze-'On' kunye ne-'Off' engqondweni
Ukuze ingqondo yethu isebenze kakuhle, ukulinganisela kubaluleke kakhulu. Xa sithetha ngeGABA, kufuneka sithethe nangayiphi na indlela echasene nayo, eyiGlutamate .
I-GABA kunye ne-glutamate zisebenza njengeendlela ezimbini zokutshintsha i-'On' kunye ne-'Off'.
- I-GABA yeyona nto iphambili engqondweni ethintela ukungasebenzi . Oko kukuthi, i-neurotransmitter ephambili eyeka ukusebenza kwaye ikuthomalalise.
- I-Glutamate yeyona nto iphambili engqondweni ethi 'On' switch . Oko kukuthi, 'yi-neurotransmitter' evuselela iiseli zemithambo-luvo kwaye yonyusa umsebenzi wazo.
Cinga ngayo njenge-accelerator kunye ne-brake emotweni. Ukuba ufuna ukuqhuba imoto ngokufanelekileyo, kufuneka uzisebenzise zombini ngokufanelekileyo nangexesha elifanelekileyo. Ukuba nenye kuphela akuyi kufaneleka. Ukuba une-accelerator kuphela, uya kuphahlazeka kuyo yonke indawo. Ukuba une-brake kuphela, awukwazi ukuya phambili. Ngokufanayo, ukuze ingqondo yethu isebenze kakuhle kwaye ngokufanelekileyo, kufuneka kubekho ulungelelwano oluncinci phakathi kweziphumo zokuzola ze-GABA kunye neziphumo ezivuselelayo ze-glutamate.
Okumangalisayo kukuba, le nto yokuthomalalisa ebizwa ngokuba yiGABA iveliswa sisivuseleli esifanayo, iglutamate. I-Glutamate iguqulwa ibe yiGABA ngesenzo se-enzyme ekhethekileyo.
Kuthekani ukuba amanqanaba eGABA akalingani?
Ukuba ibhalansi esithethe ngayo ilahlekile, ingakumbi ukuba umsebenzi we-GABA uyancipha, 'iibhuleki' zengqondo aziyi kusebenza kakuhle. Emva koko umsebenzi wobuchopho uya kwanda ngokungeyomfuneko, kwaye kunokuvela ingxaki emva kwenye. Makhe sijonge ezinye zeemeko zempilo ezicingelwa ukuba zinxulumene nokuncipha komsebenzi we-GABA ngezantsi.
| Imeko yezonyango | Ingcaciso elula |
|---|---|
| Ixhala kunye neengxaki zeMood | Xa i-GABA inganele ukuzolisa ingqondo, uloyiko olungeyomfuneko, iingcinga eziphazamisayo, kunye nemo yokungaphumli zinokwenzeka. |
| I-Schizophrenia | Isifo sengqondo esintsonkothileyo esichaphazela iingcinga, iimvakalelo kunye nokuziphatha. Kukho ubungqina bokuba ukungalingani kwe-GABA kunokubangela oku. |
| Ingxaki ye-Autism Spectrum | Imeko yophuhliso echaphazela ubudlelwane boluntu kunye nonxibelelwano. Inokubonwa kutshintsho kwinkqubo yeGABA. |
| Uxinzelelo | Usizi olude kunye nokuphelelwa ngumdla kwizinto. Oku kusenokunxulunyaniswa namanqanaba aphantsi e-GABA. |
| Ukuxhuzula/Ukuxhuzula | Ukwanda ngequbuliso, okungalawulekiyo komsebenzi wombane engqondweni. Isizathu esiphambili soku kubuthathaka kwenkqubo 'yokuqhobosha' yeGABA. |
| Isifo sikaHuntington | Isifo esizuzwa njengelifa esitshabalalisa iiseli zobuchopho kancinci kancinci. |
| I-Hypersomnia | Ukulala kakhulu emini okanye ukulala ixesha elide kunokubangelwa kukusebenza kakhulu kwenkqubo yeGABA. |
Ngaba kukho amayeza ajoliswe kwi-GABA?
Ewe. Ngenxa yokuba iGABA idlala indima ebaluleke kangaka engqondweni yethu, abavelisi bamayeza baye baphuhlisa amayeza amaninzi ajolise kwinkqubo yeGABA. La mayeza asebenza ngokuphucula imiphumo yendalo yokuzola yeGABA okanye ngokwenza njengeGABA.
Kubalulekile: La mayeza alandelayo yimizekelo kuphela. Musa ukuwasebenzisa okanye uyeke ukuwasebenzisa nangasiphi na isizathu ngaphandle kwengcebiso kunye nengcebiso kagqirha. Amanye ala mayeza anokuba ngumlutha kwaye anokubangela iziphumo ebezingalindelekanga.
| Udidi lweziyobisi / igama | Isetyenziselwa ntoni? (Umzekelo) |
|---|---|
| IiBenzodiazepines - umz. iDiazepam (Valium®), iAlprazolam (Xanax®) | Ukunciphisa ixhala, ukulawula ukuxhuzula, ukulawula iimpawu zokuyeka utywala, kunye nokuthomalalisa izihlunu. |
| IiBarbiturates | Ezi zikwaluhlobo lweyeza lokuthomalalisa. Zisetyenziselwa ukuxhuzula kunye ne-anesthesia. |
| I-Valproic Acid | Inikwa ukulawula ukuxhuzula kunye nokulawula imeko yengqondo. |
| I-Zolpidem (i-Zolpidem - i-Ambien®) | Ipilisi yokulala esetyenziselwa ukunyanga ukungalali. |
| I-Propofol | Iyeza elinamandla elisetyenziselwa i-anesthesia jikelele ngexesha lotyando. |
| IBaclofen | Iyeza elinikwa ukunciphisa ukuqina kwemisipha okungafunekiyo (ukuxinana). |
Inyaniso okanye ubuxoki malunga nezongezo zeGABA kunye nokutya
Mhlawumbi ukhe wazibona "iiGABA Supplements" zithengiswa kwiikhemesti okanye kwi-intanethi. Zithi ziyakunceda uphumle, ulale, kwaye unciphise uxinzelelo. Kodwa kukho ingxaki.
Ingqondo yethu yindawo ekhuselekileyo kakhulu. Ayivumeli nantoni na ingene. Kukho inkqubo yokhuseleko ekhethekileyo ejikeleze ingqondo ebizwa ngokuba yiBlood-Brain Barrier . Ifana nomsele ojikeleze inqaba. Zizinto ezibalulekileyo engqondweni kuphela ezivunyelweyo ukuba zidlule kule nkqubo yokhuseleko.
Abaphandi abaninzi bakholelwa ukuba amandla ezongezo zeGABA esizithathayo ngaphandle ukuze siwele umqobo wegazi-ubuchopho aphantsi kakhulu. Ngoko ke, indlela ezichaphazela ngayo ingqondo ayikacaci. Abanye abantu bathi baziva bezolile xa bethatha ezi zongezo. Akukabikho sivumelwano sesayensi malunga nokuba oku yiGABA efikelela engqondweni, okanye ingaba yimpembelelo ye-placebo.
Ngoko ke, qiniseka ukuba uthetha nogqirha wakho ngaphambi kokuba uthathe isongezelelo seGABA. Nguye umntu ofanelekileyo wokugqiba ukuba ingaba siyafaneleka na okanye asifanelekanga kwimeko yakho.
Ngaba kukho iGABA ekutyeni?
Ewe, iGABA ikhona ngokwemvelo kwezinye ukutya, ingakumbi ukutya okuvundisiweyo.
- UKimchi
- UMiso
- ITempeh
Ukongeza, iti eziluhlaza, ezimnyama, kunye ne-oolong nazo ziqulathe i-GABA. Kwakhona, kukho inkolelo yokuba ukutya okufana nerayisi emdaka, i-soy, i-broccoli, ispinatshi, iitumato kunye ne-cauliflower kunceda ekwandiseni imveliso ye-GABA emizimbeni yethu.
Kodwa njengakwizongezo, akukho bungqina bucacileyo obaneleyo bokubonisa ukuba iGABA evela kwezi zinto zokutya ifikelela kangakanani engqondweni. Kodwa ukutya ukutya okunesondlo nokunempilo kulungile emzimbeni ngazo zonke iindlela.
Umyalezo Wokuya Ekhaya
- I-GABA yeyona nto iphambili ethumela iikhemikhali 'ezizolisayo' engqondweni yethu. Isebenza 'njengebhuleki' engqondweni yethu.
- Ukulinganisela phakathi kwe-glutamate, eyonyusa umsebenzi wobuchopho, kunye ne-GABA, enciphisa umsebenzi, kubalulekile kwingqondo ephilileyo.
- Amanqanaba aphantsi e-GABA anokunxulunyaniswa neemeko ezininzi zonyango, ezinje ngokuxhalaba, ukudakumba, kunye nesifo sokuwa.
- Amayeza amaninzi abalulekileyo asetyenziswa kunyango ajolise kwinkqubo yeGABA. La mayeza kufuneka asetyenziswe kuphela phantsi kweliso likagqirha.
- Akukho bungqina besayensi obaneleyo malunga nokusebenza kakuhle kwezongezo zeGABA kwimarike, kwaye kuyathandabuzeka ukuba ziyangena na engqondweni.
- Ukuba unengxaki yokuxhalaba, uxinzelelo, okanye ukungakwazi ukulala, kubaluleke kakhulu ukubonana nogqirha ofanelekileyo kwaye ucele ingcebiso , kunokuthembela kuphela kwizongezo zokutya okanye ukutya.
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